Yogurt Containing the Probacteria Lactobacillus acidophilus Combined with Natural Antioxidants Mitigates Doxorubicin-Induced Cardiomyopathy in Rats

Nashwa M. Abu-Elsaad,Ahmed G. Abd Elhameed,Amr El-Karef,Tarek M. Ibrahim 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.9

Probiotics and antioxidants have a definite improving effect in cardiovascular diseases. This study aims at mitigating doxorubicin toxicity on cardiac function through consuming a functional food. Five groups of adult male Sprague-Dawley rats were used along 22 weeks. Group I received 30 g/kg/day food enriched with yogurt, green tea extract, and carrots (80, 0.84, and 100 g/kg diet, respectively) from the first week, group II received carvedilol 30 mg/kg/day orally from week 17, group III received both carvedilol and tested food, and groups IV and V were + ve and –ve control groups, respectively. In week 17, cardiomyopathy was induced by i.p. injection of 2.5 mg/kg doxorubicin every 48 h for 2 weeks. Histopathological and electrophysiological examinations and biochemical analysis were done. Lipid peroxidation, antioxidant effect, heart failure compensatory mediators, and proinflammatory cytokines were assessed. Tested food normalized time between the start of Q wave and the end of T wave on electrocardiogram (QT interval) and heart rate compared to the doxorubicin group (P < .05). It also improved hypertrophy indicated by a significant (P < .05) decrease in heart/body weight ratio, angiotensin-II (Ang-II), and atrial natriuretic peptide (ANP) serum levels. Histopathological examination of cardiac sections from the tested food group revealed less marked vacuolization and low perivascular fibrosis percentage (0.7803 ± 0.04). A significant (P < .001) decrease in serum creatine kinase-membrane bound, lactate dehydrogenase, triglycerides, cholesterol, low-density lipoprotein cholesterol, and tissue malondialdehyde (MDA) levels was observed in addition to an increase in serum Na+/K+ ATP1A1 and cardiac reduced glutathione (GSH) levels. Tested food also lowered the inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) serum levels significantly (P < .01). Probiotic food containing Lactobacillus acidophilus, green tea, and carrots can improve membrane integrity and cardiac contractility in doxorubicin-induced cardiomyopathy by decreasing TNF-α, IL-6, MDA, increasing GSH, and modulatingcompensatory mediators such as Ang-II and ANP.

Design and Workspace Analysis of a New Endoscopic Parallel Manipulator

Khalil Ibrahim,Ahmed Ramadan,M. Fanni,Yo Kobayashi,A. A. Abo-Ismail,Masakatus G. Fujie 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10

This paper describes the development of a dexterous endoscopic parallel manipulator for laparoscopic surgery using rigid mechanism. Based on the concept of virtual chain and screw theory, previous endoscopic parallel manipulators are deeply investigated to put their synthesis in a systematic rigorous procedure that helps in proposing the new 4-DOF endoscopic parallel manipulator. The inverse and forward kinematics solutions are derived analytically and numerically respectively. The known problem of limited bending angles was solved in the proposed manipulator as it can reach ± 90o in any direction. The proposed manipulator consists of four legs; two legs are 2-PUU (each leg consists of one active prismatic joint and two passive hook joints); the other two legs are 2-PUS (each leg consists of one active prismatic join, one passive hook joint and one passive spherical joint). Four linear motors are used to drive the mechanism. The performance is investigated through simulation by ADAMS software. Dexterous workspace is obtained and this validates the advantageous bending capability of the new proposed manipulator compared to previous ones.

Syntheses of 3-Pyrimidyl- and 3-Pyranyl-5,6-benzocoumarin Derivatives

El-Deen, Ibrahim M.,Al-Wakeel, El-Sayed I.,El-Mawla, Ahmed G. Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.4

A competitive enzyme-linked immunosorbent assay (ELISA) was developed for the quantitative detection of organophosphorus insecticide cyanophos. An analogue (hapten) of cyanophos was synthesized and was coupled to BSA to produce polyclonal antibodi es from rabbits. The antisera were screened against another hapten coupled to ovalbumin (OVA). Using the sera of highest specificity, an antigen-coated ELISA was developed, which showed an I50 of 310 ng/mL with the detection limit of 20 ng/mL. The antibodies showed negligible cross-reactivities with other organophosphorus pesticides except for parathion-methyl, which makes the assay suitable for the selective detection of cyanophos.

Switching to Aflibercept in Diabetic Macular Edema after Unsatisfactory Response to Other Anti-vascular Endothelial Growth Factor Drugs

Walid S,Ibrahim,Zeiad H,Eldaly,Mohamed G,Saleh,Mahmoud F,Rateb,Ahmed H,Aldoghaimy 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.2

Purpose: To evaluate the efficacy of switching to aflibercept in diabetic macular edema (DME) with suboptimal response to previous anti-vascular endothelial growth factor (anti-VEGF) injections. Methods: A prospective interventional case series study recruited patients from a single center diagnosed with DME with suboptimal response to anti-VEGF injections. Three consecutive monthly injections of aflibercept were performed. The primary outcome measure was mean change in visual acuity after switching to aflibercept. Results: Forty-two patients (42 eyes) were included. Baseline logarithm of the minimum angle of resolution(logMAR) visual acuity was 0.87 ± 0.23 and improved significantly to 0.62 ± 0.29, 0.56 ± 0.34, and 0.46 ± 0.35 at 1, 2, and 3 months, respectively, after the first injection. Mean baseline retinal thickness was 451.57± 107.09 μm and decreased significantly at 1, 2, and 3 months after switching to aflibercept (346.52 ± 79.03, 328.24 ± 81.98, and 313.71 ± 85.79 μm, respectively). Both visual improvement and mean change in retinal thickness were significant in patients with pre-aflibercept best-corrected visual acuity less than 1.0 logMAR but were not significant in patients with best-corrected visual acuity more than 1.0 logMAR. Conclusions: Switching to aflibercept in DME patients with an unsatisfactory response to previous anti-VEGF injections provided acceptable short-term visual and retinal architectural improvement.

Switching to Aflibercept in Diabetic Macular Edema after Unsatisfactory Response to Other Anti-vascular Endothelial Growth Factor Drugs

Walid S. Ibrahim,Zeiad H. Eldaly,Mahmoud F. Rateb,Ahmed H. Aldoghaimy,Mohamed G. Saleh 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.2

Purpose: To evaluate the efficacy of switching to aflibercept in diabetic macular edema (DME) with suboptimalresponse to previous anti-vascular endothelial growth factor (anti-VEGF) injections. Methods: A prospective interventional case series study recruited patients from a single center diagnosedwith DME with suboptimal response to anti-VEGF injections. Three consecutive monthly injections of afliberceptwere performed. The primary outcome measure was mean change in visual acuity after switching toaflibercept. Results: Forty-two patients (42 eyes) were included. Baseline logarithm of the minimum angle of resolution(logMAR) visual acuity was 0.87 ± 0.23 and improved significantly to 0.62 ± 0.29, 0.56 ± 0.34, and 0.46 ±0.35 at 1, 2, and 3 months, respectively, after the first injection. Mean baseline retinal thickness was 451.57± 107.09 μm and decreased significantly at 1, 2, and 3 months after switching to aflibercept (346.52 ± 79.03,328.24 ± 81.98, and 313.71 ± 85.79 μm, respectively). Both visual improvement and mean change in retinalthickness were significant in patients with pre-aflibercept best-corrected visual acuity less than 1.0 logMARbut were not significant in patients with best-corrected visual acuity more than 1.0 logMAR. Conclusions: Switching to aflibercept in DME patients with an unsatisfactory response to previous anti-VEGFinjections provided acceptable short-term visual and retinal architectural improvement.

Nonlinear implicit fractional differential equation involving -Caputo fractional derivative

MOHAMMED S. ABDO,AHMED G. IBRAHIM,SATISH K. PANCHAL 장전수학회 2019 Proceedings of the Jangjeon mathematical society Vol.22 No.3

In this paper, we consider a nonlinear implicit fractional dierential equation with nonlocal condition and involving the Caputo fractional derivative with respect to another function. We investigate the existence, uniqueness of solution on subinterval of the original interval. Hence we give an estimation for this solution. Further, we discuss the continuous dependence of solution involved in the problem. The results obtained by means of a variety of tools fractional calculus including Banach contraction mapping principle. Illustrative examples are also given.

Versatile Roles of Microbes and Small RNAs in Rice and Planthopper Interactions

Abdelaziz Mansour,Mannaa Mohamed Ibrahim Mohamed Ahmed,Omar Hewedy,Mostafa G. Ali,정혜정,서영수 한국식물병리학회 2022 Plant Pathology Journal Vol.38 No.5

Planthopper infestation in rice causes direct and indirect damage through feeding and viral transmission. Host microbes and small RNAs (sRNAs) play essential roles in regulating biological processes, such as metabolism, development, immunity, and stress responses in eukaryotic organisms, including plants and insects. Recently, advanced metagenomic approaches have facilitated investigations on microbial diversity and its function in insects and plants, highlighting the significance of microbiota in sustaining host life and regulating their interactions with the environment. Recent research has also suggested significant roles for sRNA-regulated genes during rice–planthopper interactions. The response and behavior of the rice plant to planthopper feeding are determined by changes in the host transcriptome, which might be regulated by sRNAs. In addition, the roles of microbial symbionts and sRNAs in the host response to viral infection are complex and involve defense-related changes in the host transcriptomic profile. This review reviews the structure and potential functions of microbes and sRNAs in rice and the associated planthopper species. In addition, the involvement of the microbiota and sRNAs in the rice–planthopper–virus interactions during planthopper infestation and viral infection are discussed.

Simulation of Tempcore Process for 500 MPa Steel Bars

Sally Hosny,Mohamed A.‑H. Gepreel,Mona G. Ibrahim,Ahmed R. Bassuony 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.9

Tempcore process is an environmental friendly, simple and energy efficient technology for producing high strength reinforcingsteel rebars without requiring costly alloying addition. The mechanical properties of Tempcore treated steel rebarhave been previously investigated using various models, although they are still restricted to specific steel compositions,bar sizes, and/or process parameters. In this study, a methodology is developed to predict the internal microstructure andoverall mechanical properties (i.e., hardness, ultimate tensile strength, and yield strength) of Tempcore treated bars for anysteel compositions, bar sizes, process parameters, and simulation assumptions. Three sequential models are proposed: (1)thermal model to predict thermal profiles of bars using computational fluid dynamics CFD simulation, (2) metallurgicalmodel to estimate the internal microstructure change across the bar section using both; the JMatPro® and a derived equationthat calculates the martensite volume fraction (Vm%) of a functionally graded steel bar, and (3) Regression models basedon the rule of mixture to predict mechanical properties. The validation results show a good agreement between calculatedand experimental results; the mean absolute percentage errors are 2.8% for hardness, 2.8% for ultimate stress and 3.8% foryield stress. Eventually, the proposed methodology presented a sustainable, easy, fast, and cost-efficient solution to attainthe required mechanical properties of a steel bar treated by Tempcore process.

A novel 1,3,4‑thiadiazole modified chitosan: synthesis, characterization, antimicrobial activity, and release study from film dressings

Mohamed Ahmad E.,Elgammal Walid E.,Dawaba Aya M.,Ibrahim Ahmed G.,Fouda Amr,Hassan Saber M. 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.4

Herein, two new polymers designated as Cs-EATT and Cs-BATT have been synthesized via linking the chitosan with the synthesized 1,3,4-thiadiazole compounds. They were characterized using 1 H, 13 C-NMR, FT-IR, TGA, Elemental analysis, Mass spectrum, and UV–vis spectrophotometer. The synthesized polymers exhibit high activity to control the growth of pathogenic bacteria ( S. aureus , B. subtilis , E. coli, and P. aeruginosa ), and unicellular fungi ( C. albicans ). The MIC values were in the range of 25–100 µg mL –1 for Cs-EATT and 25–200 µg mL –1 for Cs-BATT with varied clear zones. The new polymers were mixed with three film-forming agents: polyvinyl alcohol, hydroxyethyl cellulose, and carboxymethyl cellulose to form six film dressings designated as E1, E2, and E3 for Cs-EATT, and B1, B2, and B3 for Cs-BATT, respectively. The evaluation of film dressings showed that the formed films had transparency, uniformity, homogeneity, elasticity, and non-irritation pH values for skin within the normal range. The maximum percentages of Cs-E/B-ATT content were recorded for film dressings E2 and B2, with values of 92.5% and 94.9%, respectively. Also, the release percentages varied according to film dressing formulation, with values in the ranges of 83.88–93.2% for Cs-EATT and (87.7–97.35%) for Cs-EATT after 9 h.