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Eom, Hyeon Soo,Lee, Eun Jee,Yoon, Byong Su,Yoo, Byung Sun Taylor Francis 2010 NATURAL PRODUCT RESEARCH Vol.24 No.4
<P> Propolis, a natural product derived from plant resins collected by honeybees, has been reported to exert a wide spectrum of biological functions. This research aimed at investigating the effect of propolis on the proliferation of human leukaemia HL-60 cells and whether propolis might induce apoptosis in HL-60 cells. The results showed dose- and time-dependent decreases in the proliferation of HL-60 cells treated with propolis (above 3 µg mL-1 of propolis). Further studies revealed that the anti-proliferative effects of propolis were caused by inducing apoptosis. Agarose electrophoresis of genomic DNA of HL-60 cells treated with propolis showed the ladder pattern typical for apoptotic cells. Propolis induced the activation of caspase-3 and cleavage of poly (ADP-ribose) polymerase in HL-60 cells. Propolis also induced the release of cytochrome c from mitochondria to cytosol. Taken together, these findings demonstrate that the inhibitory effect of propolis on HL-60 cell proliferation is caused by inducing apoptosis through the mitochondrial pathway.</P>
Eom, Hye Ri,Kim, Min Kyung,Kim, Moon Su,Kim, Gil-Pyo,Baeck, Sung-Hyeon American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.3
<P>In this work, rechargeable lithium-air battery using MnO2/MWNTs nanocomposites as a catalyst was studied. MnO2/MWNTs nanocomposites were synthesized by a hydrothermal method, and their physical and chemical properties were investigated. X-ray diffraction (XRD) was used to examine crystallinity and morphology was investigated by transmission electron microscopy (TEM). Charge-discharge behavior and cell impedance with electrolyte replacement were investigated, and charge-discharge capacity decreased with cycles mainly due to the decomposition of carbonate-based electrolyte.</P>
Plastic Hinge Relocation Methods for Emulative PC Beam-Column Connections
Eom, Tae-Sung,Park, Hong-Gun,Hwang, Hyeon-Jong,Kang, Su-Min American Society of Civil Engineers 2016 Journal of structural engineering Vol.142 No.2
<P>Various plastic hinge relocation methods were studied to improve the earthquake resistance of emulative precast concrete (PC) beam-column connections using PC U-shell beams. The present study used two strengthening methods (hooked bars and headed bars) and a weakening method (reduced beam bar section), to relocate the plastic hinge zone of beams away from the weak beam-column joint. Five full-scale test specimens including a conventional reinforced concrete (RC) specimen were tested to evaluate the earthquake resistance. The test results showed that the used relocation methods significantly decreased that bond-slip of beam flexural bars and joint shear cracking. As a result, the energy dissipation capacity significantly increased, compared to those of the conventional RC specimens and PC specimens without relocation methods. On the basis of the test results, design recommendations are suggested for plastic hinge relocation design of emulative PC beam-column connections. (C) 2015 American Society of Civil Engineers.</P>
( Cheol Su Kim ),( Ho Sup Lee ),( Chang Ki Min ),( Je Jung Lee ),( Ki Hyun Kim ),( Dok Hyun Yoon ),( Hyeon Seok Eom ),( Hyewon Lee ),( Won Sik Lee ),( Ho Jin Shin ),( Ji Hyun Lee ),( Young Park ),( Ja 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Many prognostic factors have been studied with development of treatment in MM. However, serologic infiammatory markers such as serum beta2-microglobulin (B2MG), albumin, absolute lymphocyte count(ALC), C-reactive protein (CRP), lactate dehydrogenase (LDH), serum ferritin level which were easily tested in patients to find disease status have been reported that these were correlated with prognosis in many studies, respectively. Therefore, the purpose of this study is to estimate correlation between frequency of combined infiammatory parameters such as ALC, LDH, B2MG, albumin, CRP, and ferritin and prognosis for survival in patients with MM treated with induction chemotherapy containing thalidomide underwent autologous stem cell transplantation (ASCT). Methods: Data from patients at thirteen university hospitals in South Korea between December 2005 and May 2013 were collected retrospectively. All included patients were treated with thalidomide containing chemotherapy and then underwent ASCT. The infiammatory score was defined that each infiammatory parameters including ALC level under 1000/μL, Serum B2MG level above 3.5 mg/L Serum albumin under 3.5 g/dL and LDH above 450 IU/L were scored 1 point and sum of those were used infiammatory scores such as 0 to 4 points. Results: In the multivariate analysis, Infiammatory score (<2) was only independent prognostic factor for superior PFS (RR;0.618, 95% C.I. 0.409-0.933, p=0.022) and platelet counts of more than 100×109/L, infiammatory score of less than 2 were independent prognostic factors for superior OS (RR 7.856, 95% C.I. 2.502-24.670, p<0.001 and RR 0.216, 95% C.I. 0.067-0.696, p=0.010, respectively). Conclusions: Patients combined many infiammatory factors who treated with thalidomide induction chemotherapy underwent ASCT were shown significant short survival and these results might be helped to predict prognosis.
Na Sun Hee,Eom Joong Sik,Seo Yu Bin,Park Sun Hee,Kim Young Keun,Song Wonkeun,Lee Eunjung,Kim Sung Ran,Yoo Hyeon Mi,Chun Heekyung,Shin Myoung Jin,Kim Su Hyun,Choi Ji Youn,Cho Nan hyoung,Kim Jin Hwa,Son 대한의학회 2024 Journal of Korean medical science Vol.39 No.18
Background: Catheter-associated urinary tract infections (CAUTIs) account for a large proportion of healthcare-associated infections and have a significant impact on morbidity, length of hospital stay, and mortality. Adherence to the recommended infection prevention practices can effectively reduce the incidence of CAUTIs. This study aimed to assess the characteristics of CAUTIs and the efficacy of prevention programs across hospitals of various sizes. Methods: Intervention programs, including training, surveillance, and monitoring, were implemented. Data on the microorganisms responsible for CAUTIs, urinary catheter utilization ratio, rate of CAUTIs per 1,000 device days, and factors associated with the use of indwelling catheters were collected from 2017 to 2019. The incidence of CAUTIs and associated data were compared between university hospitals and small- and medium-sized hospitals. Results: Thirty-two hospitals participated in the study, including 21 university hospitals and 11 small- and medium-sized hospitals. The microorganisms responsible for CAUTIs and their resistance rates did not differ between the two groups. In the first quarter of 2018, the incidence rate was 2.05 infections/1,000 device-days in university hospitals and 1.44 infections/1,000 device-days in small- and medium-sized hospitals. After implementing interventions, the rate gradually decreased in the first quarter of 2019, with 1.18 infections/1,000 device-days in university hospitals and 0.79 infections/1,000 device-days in small- and medium-sized hospitals. However, by the end of the study, the infection rate increased to 1.74 infections/1,000 device-days in university hospitals and 1.80 infections/1,000 device-days in small- and medium-sized hospitals. Conclusion: We implemented interventions to prevent CAUTIs and evaluated their outcomes. The incidence of these infections decreased in the initial phases of the intervention when adequate support and personnel were present. The rate of these infections may be reduced by implementing active interventions such as consistent monitoring and adherence to guidelines for preventing infections.