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RISS 인기검색어
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- 저자 : Huimin Peng (검색결과 4 건)
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Nobiletin promotes adipogenesis in 3T3-L1 cells through the activation of Akt
Huimin Peng,Xiayu Tian,Lu Gan,Xiangliang Yang 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.1
The objective of the study was to investigate the effect of nobiletin on adipogenesis in 3T3-L1 cells. Here, we found that nobiletin could promote adipogenesis in 3T3-L1 cells in the absence of adipogenic inducers such as insulin, 3-Isobutyl-1-methylxanthine and dexamethasone. In addition, Real time quantitative PCR showed that the expression of adipogenic genes such as CCAAT/enhancer binding proteins, peroxisome proliferator-activated receptors-γ and fatty acid-binding protein aP2 were up-regulated in 3T3-L1 cells in the presence of nobiletin. Next, we investigated the role of Akt in the effect of nobiletin on the adipogenesis in 3T3-L1 cells by LY294002 blocking PI3K/Akt pathway. The experimental results showed that the promotive effect of nobiletin on adipogenesis was attenuated, accompanied by the down-regulation of adipogenic genes expression, after the activity of Akt was inhibited, suggesting that Akt plays an important role in the effect of nobiletin on promoting adipogenesis in 3T3-L1 cells. Still, the inhibition of Akt pathway by LY294002 was attenuated in the presence of nobiletin. These findings provide a possibility that nobiletin may be a potential candidate agent for stimulating Akt pathway in 3T3-L1 cells.
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Huimin Xu,Shujun Dai,Keying Zhang,Xuemei Ding,Shiping Bai,Jianping Wang,Huanwei Peng,Qiufeng Zeng 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.12
Objective: An experiment was conducted to investigate the effects of dietary non-phytate phosphorus (nPP) deficiency on intestinal pH value, digestive enzyme activity, morphology, nutrient utilization, and gene expression of NaPi-IIb in meat ducks from 1 to 21 d of age. Methods: A total of 525 one-d-old Cherry Valley ducklings were fed diets (with 7 pens of 15 ducklings, or 105 total ducklings, on each diet) with five levels of nPP (0.22%, 0.34%, 0.40%, 0.46%, or 0.58%) for 21 d in a completely randomized design. Five experimental diets contained a constant calcium (Ca) content of approximately 0.9%. Body weight (BW), body weight gain (BWG), feed intake (FI), and feed to gain ratio (F:G) were measured at 14 and 21 d of age. Ducks were sampled for duodenum and jejunum digestion and absorption function on 14 and 21 d. Nutrient utilization was assessed using 25- to 27-d-old ducks. Results: The results showed ducks fed 0.22% nPP had lower (p<0.05) growth performance and nutrient utilization and higher (p<0.05) serum Ca content and alkaline phosphatase (ALP) activity. When dietary nPP levels were increased, BW (d 14 and 21), BWG and FI (all intervals), and the serum phosphorus (P) content linearly and quadratically increased (p<0.05); and the jejunal pH value (d 14), duodenal muscle layer thickness (d 14), excreta dry matter, crude protein, energy, Ca and total P utilization linearly increased (p<0.05); however, the serum ALP activity, jejunal Na+-K+-ATPase activity, and duodenal NaPi-IIb mRNA level (d 21) linearly decreased (p<0.05). Conclusion: The results indicated that ducks aged from 1 to 21 d fed diets with 0.22% nPP had poor growth performance related to poor intestinal digestion and absorption ability; but when fed diets with 0.40%, 0.46%, and 0.58% nPP, ducks presented a better growth performance, intestinal digestion and absorption function.
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SOFTWARE PERFORMANCE TESTING BASED ON LINUX KERNEL
Yuan Yuan Li,Peng Xiao,Huimin Meng 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-
Linux has created a huge new playing field for enterprises, academia, and governments. But lack and instability of applications have stopped many users from strategic, wholesale migrations to Linux. With more and more applications running on Linux system, for example mozilla fire fox, openoffice, GCC, etc. the software performance testing is becoming important on Linux platform. The kernel of an operating system has a significant impact on the overall performance of a computer system [1]. To test a software performance based on system kernel can give us a unique insight into the software, provide us useful information in determining the bottlenecks and weaknesses of the software, and thus enable us to improve it. This paper discusses the methodologies of software performance testing based on Linux kernel, which include design workload, get system parameter, time measurement and CPU utilized. We have done experiments on a computer running Linux; experiment results show that the methodologies of software performance testing based on Linux kernel is completely realizable and efficacious. Even though this paper is not intended to provide a comprehensive software test suite, the methodologies presented here can be extended to build such programs.
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Study on the pore/scratch-strength response of ZrB2–SiC ceramic via laser processing
Wang Anzhe,Wang Shuai,Yin Huimin,Zhou Peng,Liu Dazhao 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.6
Defects, such as pores and scratches, are inevitably introduced during preparation and processing of ceramics. How they aff ect the mechanical properties of materials is worthy of attention. Here, artifi cial surface pores and notches introduced by femtosecond/nanosecond lasers are regarded as inherent pore- and scratch-like defects. Bending test results indicated that a small-sized fl aw with the length and depth of ~ 10 μm could lead to a strength reduction up to ~ 40% in sharp fl aw case, while only slight attenuation (< 10%) occurs in blunt fl aw case. Linear extrapolation result reveals that the maximum strength in notch cases, when the depth reaches the atomic scale, is ~ 34 GPa, which is in the range of the theoretical value of 24–48 GPa. Furthermore, the calculated critical fl aw size ( ac) may tend to be overestimated, given that the artifi cial defect, which is smaller than the ac value, also results in signifi cant strength decay. This study could provide guidance for strength evalu- ation and high-strength design of ceramics.
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