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Jeffrey S. Chang,Yen-Feng Chiu,Jih-Chang Yu,Li-Tzong Chen,Hui-Ju Ch’ang 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2
Purpose The role of consolidation chemoradiation (CCRT) after systemic chemotherapy in locally advanced pancreatic cancer (LAPC) is still controversial. We aim to evaluate the effectiveness of CCRT in LAPC using systematic review and meta-analysis of prospective studies. Materials and Methods Prospective clinical trials of LAPC receiving chemotherapy with or without subsequent CCRT were included in the analysis. We systematically searched in PubMed, MEDLINE, Embase, and Web of Science. The primary outcome of interest was 1-year survival. Secondary endpoints were median overall survival, progression-free survival, toxicity, and resection rate. Results Forty-one studies with 49 study arms were included with a total of 1,018 patients receiving CCRT after induction chemotherapy (ICT) and 954 patients receiving chemotherapy alone. CCRT after ICT did not improve 1-year survival significantly in LAPC patients compared with chemotherapy alone (58% vs. 52%). ICT lasted for at least 3 months revealed significantly improved survival of additional CCRT to LAPC patients compared to chemotherapy alone (65% vs. 52%). A marginal survival benefit of consolidation CCRT was noted in studies using maintenance chemotherapy (59% vs. 52%), and fluorouracil-based CCRT (64% vs. 52%), as well as in studies conducted after the 2010 (64% vs. 55%). Conclusion The survival benefit of ICT+CCRT over chemotherapy alone in treating LAPC was noted when ICT lasted for at least 3 months. Fluorouracil-based CCRT, and maintenance chemotherapy were associated with improved clinical outcomes.
Hui-Youn Shin,K. H. Park,K. T. Lee,M. J. Cho,S. K. Kwon,Y. I. Chang 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.4
The growth characteristics of a GaN layer deposited on a cone-shaped patterned sapphire substrate (PSS) by using metalorganic chemical vapor deposition (MOVCD) were observed by transmission electron microscope (TEM) to investigate the influence of cone-shaped PSS on the GaN layer. The GaN/sapphire interfaces were analyzed by using high-resolution TEM (HRTEM) and convergent beam electron diffraction (CBED), and the residual strain was evaluated by measuring the variation of the lattice parameters quantitatively. From the TEM images, a large number of threading dislocations were found above the flat region of the GaN/sapphire interface. In contrast, only a few threading dislocations were identified above the cone-shaped region. The HOLZ pattern analysis revealed that the lattice parameter of the GaN layer was lower above the flat region of the GaN/sapphire interface compared with the cone-shaped region, and the difference was estimated to be about 0.1 %. This may be attributed to the formation of a GaN layer by the lateral overgrowth above the cone-shaped region, resulting in less lattice mismatch and incoherency between the GaN layer and the sapphire substrate.
Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide
Eun Hui Bae,In Jin Kim,Hong Sang Choi,Ha Yeon Kim,Chang Seong Kim,Seong Kwon Ma,In S. Kim,Soo Wan Kim 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2
Tumor necrosis factor-α (TNFα) and the angiotensin system are involved in inflammatory diseases and may contribute to acute kidney injury. We investigated the mechanisms by which TNFα-converting enzyme (TACE) contributes to lipopolysaccharide (LPS)-induced renal inflammation and the effect of TACE inhibitor treatment on LPS-induced cellular injury in human renal proximal tubule epithelial (HK-2) cells. Mice were treated with LPS (10 mg/kg, i.p.) and HK-2 cells were cultured with or without LPS (10 μg/ml) in the presence or absence of a type 1 TACE inhibitor (1μM) or type 2 TACE inhibitor (10 μM). LPS treatment induced increased serum creatinine,TNFα, and urinary neutrophil gelatinase-associated lipocalin. Angiotensin II type 1 receptor, mitogen activated protein kinase (MAPK), and TACE increased, while angiotensin-converting enzyme-2 (ACE2) expression decreased in LPS-induced acute kidney injury and LPS-treated HK-2 cells. LPS induced reactive oxygen species and the down-regulation of ACE2, and these responses were prevented by TACE inhibitors in HK-2 cells. TACE inhibitors increased cell viability in LPS-treated HK-2 cells and attenuated oxidative stress and inflammatory cytokines. Our findings indicate that LPS activates renin angiotensin system components via the activation of TACE. Furthermore,inhibitors of TACE are potential therapeutic agents for kidney injury.
Chen, Chang-Hui,Ravenhill, Emma R.,Momotenko, Dmitry,Kim, Yang-Rae,Lai, Stanley C. S.,Unwin, Patrick R. American Chemical Society 2015 Langmuir Vol.31 No.43
<P>The electrochemical detection of a single nanoparticle (NP) at a support electrode can provide key information on surface chemistry and fundamental electron transfer (ET) properties at the nanoscale. This study employs scanning electrochemical cell microscopy (SECCM) as a fluidic device to both deliver individual citrate-capped gold nanoparticles (AuNPs) and study the interactions between them and a range of alkanethiol-modified Au electrodes with different terminal groups, namely, −COOH, −OH, and −CH<SUB>3</SUB>. Single NP collisions were detected through the AuNP-mediated ET reaction of Fe(CN)<SUB>6</SUB><SUP>4–/3–</SUP> in aqueous solution. The collision frequency, residence time, and current–time characteristics of AuNPs are greatly affected by the terminal groups of the alkanethiol. Methods to determine these parameters, including the effect of the instrument response function, and derive ET kinetics are outlined. To further understand the interactions of AuNPs with these surfaces, atomic force microscopy (AFM) force measurements were performed using citrate-modified Au-coated AFM tips and the same alkanethiol-modified Au substrates in aqueous solution at the same potential bias as for the AuNP collision experiments. Force curves on OH-terminated surfaces showed no repulsion and negligible adhesion force. In contrast, a clear repulsion (on approach) was seen for COOH-terminated surface and adhesion forces (on retract) were observed for both COOH- and CH<SUB>3</SUB>-terminated surfaces. These interactions help to explain the residence times and collision frequencies in AuNP collisions. More generally, as the interfacial properties probed by AFM appear to be amplified in NP collision experiments, and new features also become evident, it is suggested that such experiments provide a new means of probing surface chemistry at the nanoscale.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2015/langd5.2015.31.issue-43/acs.langmuir.5b03033/production/images/medium/la-2015-03033w_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la5b03033'>ACS Electronic Supporting Info</A></P>
Chiung-Hui Peng,Shang-Jen Chang,Stephen S. Yang 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.4
A 28-year-old female with a 1-year history of ketamine abuse developed ketamine-associated urinary symptoms that were refractory to conservative treatment after the complete cessation of ketamine use. Smooth voiding with increased bladder capacity and minimal postvoid residual urine volume were achieved by performing an augmentation enterocystoplasty. An uneventful pregnancy with the vaginal delivery of a healthy baby occurred postoperatively.
Effect of oxygen incorporation in<i>a</i>-plane GaN on p-type ohmic contact property
Jung, Ki-Chang,Lee, Inwoo,Park, Jaehyoung,Bae, Hyojung,Kim, Chung Yi,Shin, Hui-Youn,Kim, Hyung-Gu,Jeon, Jina,Jung, S.,Choi, Yoon-Ho,Lee, Jung-Soo,Ha, Jun-Seok IOP Publishing 2014 Japanese journal of applied physics Vol.53 No.9
Bae, Eun Hui,Kim, In Jin,Choi, Hong Sang,Kim, Ha Yeon,Kim, Chang Seong,Ma, Seong Kwon,Kim, In S.,Kim, Soo Wan The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2
Tumor necrosis $factor-{\alpha}$ ($TNF{\alpha}$) and the angiotensin system are involved in inflammatory diseases and may contribute to acute kidney injury. We investigated the mechanisms by which $TNF{\alpha}$-converting enzyme (TACE) contributes to lipopolysaccharide (LPS)-induced renal inflammation and the effect of TACE inhibitor treatment on LPS-induced cellular injury in human renal proximal tubule epithelial (HK-2) cells. Mice were treated with LPS (10 mg/kg, i.p.) and HK-2 cells were cultured with or without LPS ($10{\mu}g/ml$) in the presence or absence of a type 1 TACE inhibitor ($1{\mu}M$) or type 2 TACE inhibitor ($10{\mu}M$). LPS treatment induced increased serum creatinine, $TNF{\alpha}$, and urinary neutrophil gelatinase-associated lipocalin. Angiotensin II type 1 receptor, mitogen activated protein kinase (MAPK), and TACE increased, while angiotensin-converting enzyme-2 (ACE2) expression decreased in LPS-induced acute kidney injury and LPS-treated HK-2 cells. LPS induced reactive oxygen species and the down-regulation of ACE2, and these responses were prevented by TACE inhibitors in HK-2 cells. TACE inhibitors increased cell viability in LPS-treated HK-2 cells and attenuated oxidative stress and inflammatory cytokines. Our findings indicate that LPS activates renin angiotensin system components via the activation of TACE. Furthermore, inhibitors of TACE are potential therapeutic agents for kidney injury.
Boo, Sunjoo,Froelicher, Erika S.,Yun, Ju-Hui,Kim, Ye-Won,Jung, Ju-Yang,Suh, Chang-Hee Wolters Kluwer Health 2016 Medicine Vol.95 No.40
<P><B>Abstract</B></P><P>The purposes of this study were to compare the perceived and actual 10-year risk for cardiovascular disease (CVD) and to evaluate the influence of cardiovascular risk factors on perceived CVD risk in patients with rheumatoid arthritis (RA) in Korea. Additionally, the attainment of CVD prevention guideline goals by 3 levels of CVD risk (low, moderate, and high) was presented.</P><P>For this cross-sectional study, data were collected from 208 patients with RA. Actual CVD risk was estimated with the Systematic Coronary Risk Evaluation (SCORE), and goal attainment was assessed based on the European League Against Rheumatism guidelines. Actual CVD risk and perceived risk were compared with cross-tabulation. Chi-square tests were used to evaluate differences in cardiovascular risk factors by perceived risk. Levels of goal attainment were presented in percentages.</P><P>Among patients with RA, 13.9% were identified as being at high risk for CVD, whereas 39.9% were at moderate risk, and 46.2% were at low risk. The majority of those at high risk (96.6%) underestimated their risk for CVD. The use of antihypertensive or lipid-lowering medications and having a parental history of CVD significantly increased the likelihood that subjects with RA would perceive themselves as being at high risk for CVD. Diabetes, smoking, physical inactivity, and obesity did not affect perceived risk. A substantial proportion of the subjects with RA did not meet the prevention guideline goals.</P><P>Patients with RA who are at increased risk of developing CVD must be managed as soon as possible to attain the guideline goals and, accordingly, lower their risk of future CVD.</P>