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Hongyu Cen,Zhishun Zhu,Meng Chen,Xingpeng Guo,Zhenyu Chen 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.12
Dodecylamine, quinoline, allylthiourea, and thiourea, whose dipole moments were calculated by quantum chemistry and ingradient rise, were used to study the influence of magnetic field on inhibition effect through weight loss experiments, electrochemicalmeasurements, and surface characterizations. Results confirmed that the inhibition efficiency can be improvedto varying extents with the application of the magnetic field. In addition, maximum impedance increased three times morethan that in controlled trial when the magnetic field increased to 12 mT. Furthermore, the inhibition efficiency of inhibitorswith larger dipole moment will be affected more obviously, which was also positively related to the magnetic field strength. The mechanism of variation in polarizability of molecules was proposed to explain the effect of the magnetic field.
Study on constitutive model of 05Cr17Ni4Cu4Nb stainless steel based on quasi-static tensile test
Linlin Zhu,Xiongrong Huang,Hongyu Liu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.6
In order to obtain a constitutive model that can accurately describe the stress flow law of 05Cr17Ni4Cu4Nb stainless steel in extrusion forming process of spherical plain bearings, the quasi-static tensile tests of this material were carried out at room temperature in this paper, the engineering stress-strain curves of the material were obtained. Six constitutive equations were obtained by fitting the stress-strain data between the yield point and the necking point, the errors of the six models with the experimental data were analyzed. The results indicate that the Swift-Voce constitutive model had the highest correlation coefficient, the smallest mean square deviation with the experimental data and the best prediction accuracy at pre-necking and post-necking stage. Therefore, the Swift-Voce constitutive model was selected as the constitutive model of 05Cr17Ni4Cu4Nb stainless steel with large deformation at room temperature, and the finite element simulation technology was used to verify the Swift-Voce constitutive model. Once again, the simulation results show that, the stress-strain curve at prenecking stage of the material is in good agreement with the test data. This constitutive model established in this paper can accurately describe the stress flow behavior of the material at room temperature.
Zhanmeng Zhu,Yin Cao,Lingyun Liu,Zhiyi Zhao,Hongyu Yin,Hongliang Wang 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.3
Purpose: Our purpose was to verify the effects of atorvastatin (ATO) on prostate cancer (PCa) proliferation, apoptosis, invasion, and metastasis and to further explore the drug’s mechanism of action. Materials and Methods: We used cell counting kit-8 (CCK8) and clone formation experiments to study the effect of ATO on the proliferation of PC3 cells. Flow cytometry and Hoechst 33342 staining were used to detect cell apoptosis. Cell migration and invasion were detected through wound healing experiments and transwell experiments. Western blotting was applied to detect apoptosis-related proteins (BAX, Bcl-2, PARP, and Caspase-3), epithelial-mesenchymal transformation (EMT) proteins, and matrix metalloproteinase (MMP) expression. A mouse xenograft tumor model was established, and tumor volume and weight were determined. The expression levels of the above-mentioned proteins were determined through western blot. Results: ATO inhibited PC-3 cell proliferation and promoted cell apoptosis in a dose-dependent manner. ATO significantly up-regulated the expression of BAX, PARP, and Caspase-3 and inhibited the expression of Bcl-2. Wound healing and transwell experiments showed that ATO inhibited invasion and metastasis in PC-3 cells, possibly because ATO could inhibit the EMT and the expression of MMPs in PC-3 cells. Studies in nude mice showed that ATO significantly reduced tumor volume and weight; the expression levels of related proteins were consistent with the in vitro results. Conclusions: ATO inhibits the occurrence and development of PCa and regulates the migration and invasion of PCa cells by inhibiting the EMT and MMPs.
Huamei Zhu,Zhihang Li,Mengqi Huang,Pengxuan Ji,Hongyu Huang,Qianbing Zhang 국제구조공학회 2023 Smart Structures and Systems, An International Jou Vol.31 No.4
Post-earthquake building condition assessment is crucial for subsequent rescue and remediation and can be automated by emerging computer vision and deep learning technologies. This study is based on an endeavour for the 2nd International Competition of Structural Health Monitoring (IC-SHM 2021). The task package includes five image segmentation objectives - defects (crack/spall/rebar exposure), structural component, and damage state. The structural component and damage state tasks are identified as the priority that can form actionable decisions. A multi-task Convolutional Neural Network (CNN) is proposed to conduct the two major tasks simultaneously. The rest 3 sub-tasks (spall/crack/rebar exposure) were incorporated as auxiliary tasks. By synchronously learning defect information (spall/crack/rebar exposure), the multi-task CNN model outperforms the counterpart single-task models in recognizing structural components and estimating damage states. Particularly, the pixel-level damage state estimation witnesses a mIoU (mean intersection over union) improvement from 0.5855 to 0.6374. For the defect detection tasks, rebar exposure is omitted due to the extremely biased sample distribution. The segmentations of crack and spall are automated by single-task U-Net but with extra efforts to resample the provided data. The segmentation of small objects (spall and crack) benefits from the resampling method, with a substantial IoU increment of nearly 10%.
Sun Yan,Zhu Hongyu,Esmaeili Elham,Tang Xue,Wu Zhilin 대한마취통증의학회 2023 Korean Journal of Anesthesiology Vol.76 No.2
Responses to sedatives, analgesics and muscle relaxants vary among patients under general anesthesia, which could be ascribed to the disparities of clinical characteristics and genetic factors of individuals. Accumulating researches have indicated that gene polymorphisms of the receptors, transporters and metabolizing enzymes associated with anesthetics play a considerable role in their efficacy. However, a systematically summarized study on the mechanisms of gene polymorphisms on pharmacodynamics and pharmacokinetics of anesthetics is still lacking. In this paper, the recent researches on pharmacogenomics of sedatives, analgesics and muscle relaxants are comprehensively reviewed, and the contributions and mechanisms of polymorphisms to the differences of individual efficacy of these drugs are discussed, so as to provide guidance for the formulation of a rational anesthesia regimen for patients with various genotypes.
Yang Liu,Changkun Zhu,Hongyu Xie,Yaxia Chen,Weiguo Lv,Xing Xie,Xinyu Wang 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.2
Background: The use of molecular categorisation is shifting paradigm towards the use of molecular information to refine risk stratification in endometrial cancer (EC). To date, evidence to support molecular-guided therapies is limited to retrospective studies and secondary molecular analyses of patients receiving standard treatment. The PROBEAT study is the first randomized phase III trial to evaluate tailored adjuvant treatment based on WHO-endorsed molecular classification in Chinese EC patients. It is expected to provide a clinical decision-making tool for adjuvant treatment of patients with high-intermediate risk (HIR) or intermediate risk (IR) EC to better optimise and personalise patient care and increase relapse-free survival. Methods: The PROBEAT trial is a prospective, multicentre study led by Women’s Hospital of Zhejiang University Gynaecologic Oncology Group. Recruitment started on January 24, 2022, and 590 patients with HIR or IR endometrioid EC are expected to be recruited from 13 clinical centres in China. All tumor tissues will be classified into four molecular subtypes (POLEmut, MMRd, p53abn, or NSMP) based on WHO-endorsed molecular classification. Patients will be randomly assigned at a 2:1 ratio to either experimental arm and will receive molecular profile-based adjuvant treatment (observation in the POLEmut subgroup, vaginal brachytherapy in the MMRd or NSMP subgroup, or chemoradiotherapy in the p53abn subgroup) or to standard arm and will receive preferred adjuvant radiotherapy as recommended by the recent National Comprehensive Cancer Network guidelines version 1 (2022). The primary outcome is 3-year rates of recurrence. Secondary outcomes are relapse-free survival, overall survival, adverse events and health-related cancer-specific quality of life.
Aerobic Denitrification: A Review of Important Advances of the Last 30 Years
Bin Ji,Kai Yang,Lei Zhu,Yu Jiang,Hongyu Wang,Jun Zhou,Huining Zhang 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.4
Understanding aerobic denitrification has become an important focus of environmental microbiology. Aerobic denitrification can be performed by various genera of microorganisms and describes the use of nitrate (NO3 −) as oxidizing agents under an aerobic atmosphere. Isolation of aerobic denitrifiers, enzymes involved in aerobic denitrifiers, phylogenetic distribution of aerobic denitrifiers, factors affecting the performance of aerobic denitrifiers, attempts of applications and possible future trends are depicted. The periplasmic nitrate reductase is vital for aerobic denitrifiers and NapA gene may be the proof of aerobic denitrification. Phylogenetic analysis revealed that aerobic denitrifiers mainly belong to α-, β- and γ-Proteobacteria. Aerobic denitrifiers tend to work efficiently at 25 ~ 37°C and pH 7 ~ 8, when dissolved oxygen concentration is 3 ~ 5 mg/L and C/N load ratio is 5 ~ 10. In addition, recent progresses and applications on aerobic denitrifiers are described, including single aerobic reactors, sequencing batch reactor and biofilm reactors. The review attempts to shed light on the fundamental understanding in aerobic denitrification.
Preparation and Effect Analysis of {10–12} Extension Twins at the Edge of AZ31 Magnesium Alloy Plate
Zhiquan Huang,Chuanlu Qi,Yanchun Zhu,Guowei Yang,Hongyu Lai,Jinchao Zou 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.11
The edge samples of AZ31 magnesium alloy plate after hot rolling and annealing were compressed along the rolling direction(RD) under different deformation conditions. Then, the optimal conditions for the generation of {10–12} extension twinsand the microtexture evolution of edge samples were studied by using EBSD. The results show that the texture strength ofthe hot-rolled AZ31 magnesium alloy plate was significantly greater than that of the middle part. When the compressivestrain along the RD was small at the edge of the rolled piece at room temperature, a large number of extension twin layerswere generated. Grain matrix and twins coexisted. As the strain increased to 8.19%, the grains completely transformed intoextension twins. Along with the generation of extension twins, hard-oriented grains were consumed in large quantities andthe weakening effect of the basal texture was proportional to the volume fraction of the extension twins, while at high temperature(250 °C), the slip dominated the plastic deformation process.