Radiotherapy for locally recurrent rectal cancer treated with surgery alone as the initial treatment

Hidekazu Tanaka,Takahiro Yamaguchi,Kae Hachiya,Sunaho Okada,Masashi Kitahara,Katsuya Matsuyama,Masayuki Matsuo 대한방사선종양학회 2017 Radiation Oncology Journal Vol.35 No.1

Purpose: Although the technical developments of radiotherapy have been remarkable, there are currently few reports on the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as initial treatment in this three-dimensional conformal radiotherapy era. Thus, we retrospectively evaluated the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as the initial treatment. Materials and Methods: Thirty-two patients who underwent radiotherapy were enrolled in this study. The dose per fraction was 2.0–3.5 Gy. Because the treatment schedule was variable, the biological effective dose (BED) was calculated. Results: Local control (LC) and overall survival (OS) rates from the completion of radiotherapy were calculated. The 1-, 2-, 3-, 4-, and 5-year LC rates were 51.5%, 24.5%, 19.6%, 19.6%, and 13.1%, respectively. LC rates were significantly higher for the high BED group (≥75 Gy10) than for the lower BED group (<75 Gy10). All patients who reported pain achieved pain relief. The duration of pain relief was significantly higher for the high BED group than for the lower BED group. The 1-, 2-, 3-, 4-, and 5-year OS rates were 82.6%, 56.5%, 45.2%, 38.7%, and 23.2%, respectively. There was a trend toward higher OS rates in with higher BED group compared to lower BED group. Conclusion: For patients with unresectable locally recurrent rectal cancer treated with surgery alone, radiotherapy is effective treatment. The prescribed BED should be more than 75 Gy10, if the dose to the organ at risk is within acceptable levels.

Radiotherapy for locally recurrent rectal cancer treated with surgery alone as the initial treatment

Tanaka, Hidekazu,Yamaguchi, Takahiro,Hachiya, Kae,Okada, Sunaho,Kitahara, Masashi,Matsuyama, Katsuya,Matsuo, Masayuki The Korean Society for Radiation Oncology 2017 Radiation Oncology Journal Vol.35 No.1

Purpose: Although the technical developments of radiotherapy have been remarkable, there are currently few reports on the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as initial treatment in this three-dimensional conformal radiotherapy era. Thus, we retrospectively evaluated the treatment results of radiotherapy for local recurrence of rectal cancer treated with surgery alone as the initial treatment. Materials and Methods: Thirty-two patients who underwent radiotherapy were enrolled in this study. The dose per fraction was 2.0-3.5 Gy. Because the treatment schedule was variable, the biological effective dose (BED) was calculated. Results: Local control (LC) and overall survival (OS) rates from the completion of radiotherapy were calculated. The 1-, 2-, 3-, 4-, and 5-year LC rates were 51.5%, 24.5%, 19.6%, 19.6%, and 13.1%, respectively. LC rates were significantly higher for the high BED group (${\geq}75Gy_{10}$) than for the lower BED group (<$75Gy_{10}$). All patients who reported pain achieved pain relief. The duration of pain relief was significantly higher for the high BED group than for the lower BED group. The 1-, 2-, 3-, 4-, and 5-year OS rates were 82.6%, 56.5%, 45.2%, 38.7%, and 23.2%, respectively. There was a trend toward higher OS rates in with higher BED group compared to lower BED group. Conclusion: For patients with unresectable locally recurrent rectal cancer treated with surgery alone, radiotherapy is effective treatment. The prescribed BED should be more than $75Gy_{10}$, if the dose to the organ at risk is within acceptable levels.

Thermoelectric Power in Single-crystalline CeRhSi3

Hidekazu A. Tanaka,Naofumi Aso,Masato Hedo,Takao Nakama,Yoshinao Takaesu,Hiroki Iida,Noriaki Kimura,Haruyoshi Aoki 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12

The thermoelectric power S of a heavy-fermion superconductor CeRhSi3 has been measured attemperatures from 2.0 K to 300 K under hydrostatic pressures up to 2.7 GPa in order to clarify theKondo effect in CeRhSi3. S exhibits a large value of up to 60 µV/K, which is characteristic of heavyfermionsystems. S shows a maximum in its temperature dependence mainly due to the Kondoeffect, and its maximum temperature TSmax gradually increases from 96 K at ambient pressure to127 K at 2.7 GPa when a pressure is applied.

A PWM Motor Speed Control System based on the Dual-Loop PLL

Hidekazu Machida,Michinobu Kambara,Kohta Tanaka,Taisuke Yamochi,Fuminori Kobayashi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

PLL motor speed control systems can completely reject speed error and steady-state phase error for constantspeed input signals. However, it is not usually applied to systems with inputs including acceleration, because they have poor tracking speed and strange pull-in behavior. In the field of radio communication, “dual-loop PLL” is very effective for such signals. It can not only enable high-speed tracking, but also cancel phase error. This article shows that the principle can be applied, with some devices, to motor speed control, and a prototype implementation using PWM is described. Two supplemental techniques, called “active feedforward” and “active limiter”, are also incorporated, to achieve faster tracking and speed limitation. The scheme was implemented by programming an FPGA, and satisfiable results were obtained.

Department of Neurosurgery, Dhaka Medical College Hospital, Dhaka, Bangladesh

Kenji Endo,Hidekazu Suzuki,Hirosuke Nishimura,Hidetoshi Tanaka,Takaaki Shishido,Kengo Yamamoto 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.6

Study Design: Normal cervical sagittal length patterns were measured by magnetic resonance imaging (MRI). Purpose: The aim of this study was to evaluate the relationship of sagittal length patterns between the cervical cord and the cervical canal in flexion-extension kinematics. Overview of Literature: Cervical dynamic factors sometimes cause a cervical spondylotic myelopathy in elderly subjects and an overstretching myelopathy in juvenile subjects. Previous studies showed the length changing of the cervical cord in flexion and extension. However, there is no detailed literature about the relationship between cervical vertebral motion and cord distortion yet. Methods: Sixty-two normal subjects (28 male and 34 female, 42.1±8.5 years old) without neck motion disturbances and abnormalities on cervical X-ray and MRI were enrolled in this study. Results: The cervical cord length was significantly longer in flexion and significantly shorter in extension in all cervical cord sagittal lines. The cervical canal length pattern was also the same as the cervical cord. The elongation of the cervical cord and canal was the largest at the site of the posterior cervical canal and the shortest at the anterior canal site. The positions of the cerebellar tonsils were verified at each neck position. Conclusions: The posterior elements of the cervical canal were most affected by neck motion. Movement directions of the upper cervical cord were verified among the various neck positions.

Characteristics of Sagittal Spino-Pelvic Alignment in Japanese Young Adults

Kenji Endo,Hidekazu Suzuki,Hirosuke Nishimura,Hidetoshi Tanaka,Takaaki Shishido,Kengo Yamamoto 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.5

Study Design: Radiological analysis of normal patterns of sagittal alignment of the spine. Purpose: This study aimed to clarify the characteristics of normal sagittal spino-pelvic alignment in Asian people. Overview of Literature: It is known that there are differences in these parameters based on age, gender, and race. In order to properly plan for surgical correction of the spine for Asian patients, it is necessary to understand the normal spino-pelvic alignment parameters for this population. Methods: This study analyzed 86 Japanese healthy young adult volunteers (48 men and 38 women; age 35.9±11.1 (mean±standard deviation [SD]). The following parameters were measured on lateral standing radiographs of the entire spine: sagittal vertical axis (SVA), horizontal distance between the C7 plumb line and the posterior superior corner of the superior margin of S1, thoracic kyphotic angle (TK), lumbar lordotic angle (LLA), sacral slope (SS), pelvic tilt (PT), and pelvic incidence (PI). Results: The values (mean±SD) of SVA, TK, LLA, SS, PT, and PI were 8.45±25.7 mm, 27.5±9.6°, 43.4±14.6°, 34.6±7.8°, 13.2±8.2°, and 46.7±8.9°, respectively. The Japanese young adults evaluated in this study tended to have a smaller PI, LLA, TK, and SVA than most Caucasian people. Regarding gender differences, SVA was significantly longer and TK was significantly smaller in men; however, there was no statistically significant difference in LLA, SS, PA, and PI. Conclusions: Japanese young adults apparently have smaller PI and LLA values than Caucasian people. When making decisions for optimal sagittal spinal alignment, racial differences should be considered.

Treatment for Osteoporotic Vertebral Fracture - A Short Review of Orthosis and Percutaneous Vertebroplasty and Balloon Kyphoplasty

Masahiro Kawanishi,Hidekazu Tanaka,Yutaka Ito,Makoto Yamada,Kunio Yokoyama,Akira Sugie,Naokado Ikeda 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

The management of osteoporotic vertebral fractures (OVFs) in the elderly includes nonoperative treatment and vertebroplasty, but has not been established due to the diversity of patient backgrounds. The purpose of this study was to compare the impact of 3 treatment modalities for the management of OVF: orthotic treatment, percutaneous vertebroplasty (PVP), and balloon kyphoplasty (BKP). The method was based on an analysis of the latest RCTs, meta-analyses, and systematic reviews on these topics. No study showed a benefit of bracing with high level of evidence. Trials were found that showed comparable outcomes without orthotic treatment. Only 1 randomized controlled trial (RCT) showed an improvement in pain relief up to 6 months compared with no orthosis. Rigid and nonrigid orthoses were equally effective. Four of 5 RCTs comparing vertebroplasty and sham surgery were equally effective, and one RCT showed superior pain relief with vertebroplasty within 3 weeks of onset. In open trials comparing vertebroplasty with nonoperative management, vertebroplasty was superior. PVP and BKP were comparable in terms of pain relief, improvement in quality of life, and adjacent vertebral fractures. BKP does not affect global sagittal alignment, although BKP may restore vertebral body height. An RCT was published showing that PVP was effective in chronic cases without pain relief. Vertebroplasty improved life expectancy by 22% at 10 years. The superiority of orthotic therapy for OVF was seen only in short-term pain relief. Soft orthoses proved to be a viable alternative to rigid orthoses. Vertebroplasty within 3 weeks may be useful. There is no significant difference in clinical efficacy between PVP and BKP. Vertebroplasty improves life expectancy.

Efficacy of Adenine in the Treatment of Leukopenia and Neutropenia Associated with an Overdose of Antipsychotics or Discontinuation of Lithium Carbonate Administration: Three Case Studies

Takashi Tomita,Hidekazu Goto,Kenji Sumiya,Tadashi Yoshida,Katsuya Tanaka,Yukinao Kohda 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.4

Because adenine is effective for managing cases of radiation-induced and drug-induced leukopenia, it may be effective in cases of antipsychotic-induced leukopenia and neutropenia. Here, we report our experience with patients with leukopenia and neutropenia caused by an antipsychotic overdose or discontinuation of lithium carbonate, in whom adenine administration ameliorated the white blood cell and neutrophil counts. The progress of patients suggests that adenine is effective in cases of leukopenia and neutropenia associated with lithium carbonate discontinuation and an antipsychotic overdose.

PARALLEL-RESONANT CONVERTER WITH ZVS-PWM CONTROL

Tamotsu NINOMIYA,Takayoshi HASHIMOTO,Hidekazu TANAKA,Masahito SYOYAMA,Richard P.TYMERSKI 전력전자학회 1998 ICPE(ISPE)논문집 Vol.- No.-

A parallel-resonant converter with zero-voltage-switching, pulse-width-modulation (ZVS-PWM) control is proposed Similar to the previously proposed series-resonant counterpart, it has a simple structure and can be controlled at a constant switching frequency using an active-clamp technique The nearly constant current output characteristic of the parallel-resonant converter lends itself beneficially to pre­cisely controlled constant current power supply applications. An experimental breadboard fea­tured an accuracy of ± 1% for an output current of 2A, with an efficiency of 75%.<br/>

Assist Force Control of Smart Suit for Horse Trainer Considering Motion Synchronization and Postural Stabilization

Takashi KUSAKA,Takayuki TANAKA,Shun’ichi KANEKO,Yoshihito SUZUKI,Munenobu SAITO,Shuji SEK,Naohisa SAKAMOTO,Hidekazu KAJIWARA 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

This paper describes the assist force control of semi-active assist system ”Smart Suit” for horse trainer. We developed a soft and flexible power assist device named ”Smart Suit” for reducing horse trainers’ physical fatigue in their horse training works in order to prevent their spine or legs injuries. The smart suit is a kind of semi-active and flexible power assist devices. In order to gain the suitable assist force for periodical horse trainers’ motion, the assist force control method based on the periodical input control was developed in this study. Also, for stabilizing their horse riding motion, we developed the assist force control method considering their dynamic stability by controlling their center of gravity on the zero moment point (ZMP)which is the dynamic stable point.