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Hamid Aboutaleb Kadkhodaeian,Taki Tiraihi,Hamid Ahmadieh,Hossein Ziaei,Narsis Daftarian,Taher Taheri 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.3
BACKGROUND: Retinal degeneration causes blindness, and cell replacement is a potential therapy. The purpose of this study is to formation of pigmented neurospheres in a simple medium, low-cost, high-performance manner over a short period of time while expressing markers of RPE cells and the activation of specific genes of the pigment cells. Also, these neurospheres have the ability to produce a monolayer of retinal pigment epithelium-like cells (RPELC) with the ability of photoreceptor outer segment phagocytosis. METHODS: BMSC were isolated from pigmented hooded male rats and were immunoreactive to BMSC markers, then converted into neurospheres, differentiated into pigmented spheres (PS), and characterized using Retinal pigment epithelium-specific 65 kDa protein (RPE65), Retinaldehyde-binding protein 1 (CRALBP) and orthodenticle homeobox 2 (OTX2) markers by immunocytochemistry, RT-PCR and RT-qPCR. The PS were harvested into RPELC. The functionality of RPELC was evaluated by phagocytosis of fluorescein-labeled photoreceptor outer segment. RESULTS: The BMSC immunophenotype was confirmed by immunostained for fibronectin, CD90, CD166 and CD44. These cells differentiated into osteogenic and lipogenic cells. The generated neurospheres were immunoreactive to nestin and stemness genes. The PS after 7–14 days were positive for RPE65 (92.76–100%), CRALBP (95.21–100%) and OTX2 (94.88–100%), and after 30 days RT-PCR, qPCR revealed increasing in gene expression. The PS formed a single layer of RPELC after cultivation and phagocyte photoreceptor outer segments. CONCLUSION: Bone marrow stromal stem cells can differentiate into functional retinal pigmented epithelium cells in a simple, low-cost, high-performancemanner over a short period of time. These cells due to expressing theRPELCgenes andmarkers can be used in cell replacement therapy for degenerative diseases including age-relatedmacular degeneration as well as retinitis pigmentosa.
Hamid Khademhosseini Beheshti,Hamid Lankarani 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.5
This paper obtains a Mathematical Dynamic Model (MADYMO) for occupant lumbar load evaluation under CFR Part 23 and 25 at extreme ranges of temperature. The validation of results is performed by full scale sled test results. Aircraft industries are using viscoelastic polyurethane foams as seat cushion. Visco-elastic foams bring not only more comfort to the passengers in long term sitting but it also maintains more safety during unpredicted crashes and hard landings. Aircraft seat cushions are exposed to varying temperature ranges during their life time. This fact has motivated aircraft industries to evaluate the seat cushion dynamic behavior at extreme ranges of temperatures in addition to what is mentioned in Federal Aviation Administration (FAA) Regulations at room temperature. This research provides a methodology based on simulation and modeling to eliminate, or at least, minimize the number of full scale dynamic sled tests defined by regulations for aircraft seats at extreme ranges of temperature.
The Impact of Supply Chain Management on Organizational Performance and Customer Satisfaction
Hamid Babaei Meybodi,Seyed Hamid Emadi,Tina Roostapisheh,Haniyeh Ghiyasvand Mohammadkha 대한산업공학회 2018 Industrial Engineeering & Management Systems Vol.17 No.3
The present study has been conducted with the purpose of investigating the impact of supply chain management (SCM) on organizational performance and customer satisfaction in two factories in Shiraz Industrial Estate. Therefore, according to the research subject, the variables of supply chain management, organizational performance and also customer satisfaction have been defined. In terms of objective, this is an applied study and in terms of nature and method, this is a descriptive-correlational study. The statistical population consists of 100 people and the sample consists of 80 people. The reliability and validity of research have firstly been examined and then the results were analyzed using SPSS and LISREL. The obtained results indicate the impact of supply chain management on organizational performance and customer satisfaction.
RNAi and miRNA in Viral Infections and Cancers
Mollaie, Hamid Reza,Monavari, Seyed Hamid Reza,Arabzadeh, Seyed Ali Mohammad,Shamsi-Shahrabadi, Mahmoud,Fazlalipour, Mehdi,Afshar, Reza Malekpour Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Since the first report of RNA interference (RNAi) less than a decade ago, this type of molecular intervention has been introduced to repress gene expression in vitro and also for in vivo studies in mammals. Understanding the mechanisms of action of synthetic small interfering RNAs (siRNAs) underlies use as therapeutic agents in the areas of cancer and viral infection. Recent studies have also promoted different theories about cell-specific targeting of siRNAs. Design and delivery strategies for successful treatment of human diseases are becomingmore established and relationships between miRNA and RNAi pathways have been revealed as virus-host cell interactions. Although both are well conserved in plants, invertebrates and mammals, there is also variabilityand a more complete understanding of differences will be needed for optimal application. RNA interference (RNAi) is rapid, cheap and selective in complex biological systems and has created new insight sin fields of cancer research, genetic disorders, virology and drug design. Our knowledge about the role of miRNAs and siRNAs pathways in virus-host cell interactions in virus infected cells is incomplete. There are different viral diseases but few antiviral drugs are available. For example, acyclovir for herpes viruses, alpha-interferon for hepatitis C and B viruses and anti-retroviral for HIV are accessible. Also cancer is obviously an important target for siRNA-based therapies, but the main problem in cancer therapy is targeting metastatic cells which spread from the original tumor. There are also other possible reservations and problems that might delay or even hinder siRNA-based therapies for the treatment of certain conditions; however, this remains the most promising approach for a wide range of diseases. Clearly, more studies must be done to allow efficient delivery and better understanding of unwanted side effects of siRNA-based therapies. In this review miRNA and RNAi biology, experimental design, anti-viral and anti-cancer effects are discussed.
Reduction of nitrate in groundwater by hematite supported bimetallic catalyst
Hamid, Shanawar,Lee, Woojin Techno-Press 2016 Advances in environmental research Vol.5 No.1
In this study, nitrate reduction of real groundwater sample by 2.2%Cu-1.6%Pd-hematite catalyst was evaluated at different nitrate concentrations, catalyst concentrations, and recycling. Results show that the nitrate reduction is improved by increasing the catalyst concentration. Specific nitrate removal by 2.2%Cu-1.6%Pd-hematite increased linearly with the increase of nitrate concentration showing that the catalyst possesses significantly higher reduction capacity. More than 95% nitrate reduction was observed over five recycles by 2.2%Cu-1.6%Pd-hematite with ~56% nitrogen selectivity in all recycling batches. The results from this study indicate that stable reduction of nitrate in groundwater can be achieved by 2.2%Cu-1.6%Pd-hematite over the wide range of initial nitrate inputs.
Theoretical modeling and numerical solution of stratified condensation in inclined tubes
Hamid Saffari,Vahid Naziri 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.12
The heat transfer phenomenon occurring during stratified condensation inside an inclined tube is investigated theoretically and numerically. Differential equations governing the kinematic, dynamic, and thermal aspects for vapor condensation inside inclined tubes,which are derived from a thin film flow modeling, are solved simultaneously. These solutions are achieved by applying an explicit finite difference numerical method to predict the condensation heat transfer coefficient variations along the tangential and axial coordinates. The inclination angle is found to have a significant effect on condensation heat transfer coefficient inside inclined tubes. In addition, in accordance with the given physical and thermal condition of working fluids, there is a specific optimum inclination angle. In this study,the 30°–50° range from the horizontal position is found to be the range of the optimum inclination angle for achieving the maximum condensation heat transfer coefficient, with R134a, R141b, and R11 as the working fluids. The results of the present study are compared with experimental data, and a good agreement is observed between them.