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Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia
Narin, Piseth,Hamajima, Nobuyuki,Kouy, Samnang,Hirosawa, Tomoya,Eav, Sokha Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Background: Hepatocellular carcinoma (HCC) is one of the most frequent cancers in South East Asian countries including Cambodia, where prevalence of chronic carriers of hepatitis B and C virus (HBV and HCV) is reported to be very high. We reviewed HCC cases admitted to a cancer hospital in Phnom Penh, which is the only one hospital for cancer treatment and care in Cambodia during the study period. Materials and Methods: Information was collected from medical records of 281 cases (210 males and 71 females) diagnosed as primary HCC from 2006 to 2011. Results: The subjects were 7-81 years old with a median age of 53 years. Hypochondriac pain was the most common complained symptom (74%). One third of the cases presented with jaundice. Nearly half had ascites at their first visit. One third had liver cirrhosis. Nearly three fourths of the cases presented with tumor sized more than 50 mm in diameter, and in almost all cases (97.4%) the size was more than 20 mm. Among 209 subjects tested, hepatitis virus carriers were 75.6%; 46.4% for HBV only, 21.5% for HCV only, and 7.7% for both viral infections. Median age of patients with HBV was about ten years younger than those with HCV. Conclusions: This study revealed the characteristics of HCC cases in Cambodia, although there were several limitations. Most HCC cases were infected with HBV and/or HCV, and diagnosed at late stages with complications. This implicated that public health intervention to prevent HBV and HCV infection is of high priority.
Sui Kiat Chang,Hiroshi Hamajima,Amin Ismail,Teruyoshi Yanagita,Norhaizan Mohd. Esa,Mohamad Taufik Hidayat Baharuldin 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.4
This study aimed to determine the lipid-loweringproperties, antioxidant capacity (AC) and angiotensin-Iconverting enzyme (ACE)-inhibitory activity of oil palmkernel protein hydrolysates (OPKHs) that were producedusing protease and pepsin-pancreatin hydrolysis. Theeffects of the OPKHs on apolipoprotein B (apoB) secretionwas assessed using HepG2 cells as a model and the AC ofthe OPKHs was determined based on ABTS radicalscavenging activity and ferric reducing antioxidant power(FRAP). Both protease and pepsin-pancreatin hydrolysatesreduced apoB secretion significantly (p<0.05). The OPKHsscavenged ABTS radicals effectively and demonstrated ahigh reducing power even at a low concentration (1 mg/mL). The AC of the OPKHs was significantly correlatedwith the OPKHs protein content. However, the OPKHsdemonstrated very low ACE-inhibitory activity. The pepsinpancreatinhydrolysate demonstrated significant lipidloweringproperties, favourable AC and ACE inhibitoryactivity in compared to protease hydrolysate. Therefore,OPKH demonstrate the potential as a nutraceutical forfunctional foods.
No Association between the CDX2 G543C Polymorphism and Risk of Gastric Atrophy and Cancer
Goto, Yasuyuki,Kato, Tsuyoshi,Ando, Takafumi,Goto, Hidemi,Hamajima, Nobuyuki Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Ectopic expression of CDX2 in the stomach is closely associated with chronic Helicobacter pylori (H. pylori) infection and intestinal metaplasia. Whether CDX2 has tumor suppression or tumorigenesis potential remains to be elucidated. In this study, we investigated the association between the CDX2 G543C polymorphism (silent mutation) and the risk for H. pylori-induced gastric atrophy and cancer as well as H. pylori infection, using 454 Japanese subjects undergoing a health checkup and 202 gastric cancer patients. The frequency of the minor allele was the same as previously reported in China, but different from that reported in England. CDX2 G543C was not associated with risk of H. pylori infection, gastric atrophy, or gastric cancer, although the point estimate for non-cardiac differentiated gastric cancer as compared to controls with gastric atrophy was 2.22 (95%CI=0.17-29.4). In conclusion, our results indicate that the CDX2 G543C polymorphism is unlikely to affect the H. pylori infection-gastric atrophy-gastric cancer sequence.