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FlambeauJoseph Kayihura,Gwi-Hee Koh,Won-Jong Lee,Seoung-Hoon Lee,Jungro Yoon 한국산업식품공학회 2017 학술대회 및 심포지엄 Vol.2017 No.04
Bourbon is the major coffee variety grown in Rwanda. Fully washed bourbon produced in Rwanda is a nascent specialty coffee and no investigation of its quality characteristics has been reported. Thus, this study aimed at providing information about intrinsic flavor characteristics and identifying the most discriminating aroma compounds of this coffee from the major growing areas in four provinces (considered by this study as geographical sub-regions) in comparison with Arabica coffee from Ethiopia and Brazil using electronic nose and electronic tongue. Samples were discriminated and characterized by performing a principal component analysis (PCA). A discriminant factorial analysis (DFA) model was also used to predict the geographic origin of coffee samples based on their flavor characteristics. A similarity was observed between flavor characteristics of coffee samples from western and southern sub-regions as well as between northern and eastern sub-regions of Rwanda. Twenty one most discriminating aroma compounds were found but the identified and confirmed ones are: Butan-2-one, Acetic acid, n-Butanol, 2, 3- Pentanedione, Ethyl-2-methybutyrate, Dimethylsulfide, 2-Prpanol, 2-Methylfuran, Ethylacetate, Ethyl propionate and Heptanal. A DFA model using e-nose was successful in predicting the geographic origin of coffee samples but not with e-tongue. This means that aroma can reliably be used to predict the geographic origin of coffee samples than their taste characteristics. Further investigation is required to test the possibility of origin recognition based on taste characteristics.
원발성 종격동 악성 기형종에 속발된 급성 골수성 백혈병 1 예
김병수,고은희,이선주,한지숙,김주항,서창옥,고윤웅,박시훈,김귀언 대한내과학회 1986 대한내과학회지 Vol.31 No.3
We had experienced a case of acute myelogenous leukemia following primary medistinal malignant teratoma. The patient received chmotherapy and radiotherapy, but chemotherapy or radiotherapy dose not appear to be causally associated with the development of the nematologic malig nancy. The germ cell tumor may be the site of origin of the myelogenous leukemia or may serve as a source of growth factors which promote the proliferation of a leukemic clone in a susceptible host. Although the precise pathogenosis of the relation between these rare two tumors is unclear, the totipotent nature of malignant germ cell tumors may be involved.
문성록,이형식,김귀언,안기정,서창옥,노준규,민진식,이경식,김병수,노재경,고은희,Moon, Sun-Rock,Lee, Hyung-Sik,Kim, Gwi-Eon,Ahn, Ki-Jung,Suh, Chang-Ok,Kyu, John-Juhn,Min, Jin-Sik,Lee, Kyung-Sik,Kim, Byung-Soo,Noh, Jae-Kyung,Koh, Eun-Hee The Korean Society for Radiation Oncology 1990 Radiation Oncology Journal Vol.8 No.1
유방암의 일차 치료후 흉벽이나 국소임파절에 국한된 재발은 비교적 흔하게 관찰된다. 방사선치료는 이러한 국소재발유암 환자에게 효과적인 치료법으로 사용되어 왔으나 국소병변의 관해에도 불구하고 많은 경우에서 이차개발 또는 원격전이로 인해 불량한 예후를 보이므로 최근에는 다방면 병용요법을 시도하여 환자의 수명을 연장시키고 관해율을 증가시켰다는 고들이 있다. 이에 저자들은 국소 재발유암 환자의 특성과 치료결과, 치료후 실패양상, 생존율에 영향을 미치는 예후인자를 분석하여 향후치료의 지침으로 삼고자, 1974년 부터 1986년까지 연세대학교 의과대학 치료방사선과에서 방사선치료를 받은 53명을 대상으로 후향적분석을 통해 다음과 같은 결과를 얻었다. 32예 ($60.4\%$)가 단일 병소에, 21예 ($39.4\%$)가 다발병소에 재발하였다. 방사선치료후 31예 ($58.4\%$)에서 완전관해를 보였으나 그 중 7예는 치료부위에 다시 재발하였다. 전체환자의 5년 생존율과 무병생존율은 각각 $27\%,\;15\%$였다. 각각의 예후인자에 대한 단일변량분석에서는 최초 수술당시의 액와임파절전이 숫자, 보조적 화학요법의 시행 유무, 경도의 유무 등이 통계적 유의성을 보였고, 다변량분석법을 통한 분석에서는 최초수술당시의 액와임파절전이의 수, 경도의 유무, 재발시 병변의 크기, 치료후 관해기간 등이 생존율에 통계적으로 유의한 영향을 끼치는 예후인자였다. Between January,1974 and December 1980, fifty eight patients with locoregional recurrent breast carcinoma who did not have evidence of distant metastasis after initial treatment of surgery with or without adjuvant chemotherapy were treated with radiation therapy. Among them, five patients were excluded from this study because of incomplete record or incomplete treatment. The 5-year overall survival and disease free survival from the time of locoregional recurrence was $27\%\;and\;15\%$ respectively. In univariate analysis of prognostic variables, the clinical stage at initial diagnosis, recur duration, number of recurrence sites, size of recurrences, response to the treatment, remission duration were all found to have no significant effect on survival or disease free survival. On the other hand, menopausal status at initial diagnosis, number of positive node at initial surgery, whether or not the use of adjuvant chemotherapy after initial mastectomy had definite prognositc significance. In multivariate analysis of prognostic variables, remission duration, menopausal status at diagnosis, number of axillary node at mastectomy had definite prognostic significance. On the other hand, remission duration more than 12 months, premenopaus at initial mastectomy, less than four positive axillary lymph nodes at mastectomy predicted a good prognosis.
권혁문(Hyuck Moon Kwon),정재복(Jae Bock Chung),김주항(Joo Hang Kim),전상일(Sang Il Chun),조준구(Jun Koo Cho),박용준(Yong Jun Park),고은희(Eun Hee Koh),노재경(Jae Kyung Roh),서창옥(Chang Ok Suh),김귀언(Gwi Eon Kim),노준규(J . K . Loh) 대한내과학회 1987 대한내과학회지 Vol.33 No.1
N/A There is no acceptable evidence, either in this presentation of in the literature, that the patterns of occurance of multiple primary maligant neoplasms of different organs of tissues are governed by anything more than conincidence. The freqency of occurance of specific types of second primary cancers is probably largely determined by the age of the patient at the time of diagnosis of initial cancer and the expected longevity after treatment of the initial lesion. The absolute number of reported cases of multiple primary malignant tumors has increased in recent years and the freqency of occurance of this phenomenon has increased. There is no factual basis for assuming that the existence of any one malignant neoplasm influence or that it implies any susceptibility of any other organ or organ system to future cancer. But it becomes apparent that existence of one malignant neoplasm implies increased susceptibility to the development of a second lesion but also a malignant lesion in one organ may imply increased susceptibility of another organ to malignant neoplasm, particularly another organ in the same or an associated system. This report deals with the clincal analysis of 42 cases of multiple primary malignant tumors from tumor registry of Severance hospital and yonsei cancer center during 7 years from Jan 1979 to Dec. 1985 and review of the literatures, The following results were abtained. 1) The incidence of multiple primary malignant tumor was 0.26% of tumor registry (42/25, 863) and the mean age of 26 male patients at first cancer was 58.8 years old and 54.9 years old in 16 female patients. 2) The mean time interval between first and second cancer was 34.1 months in 12 metachronous tumors. 3) In male patients, the stomach cancer was the most common first cancer followed by lung cancer. In female patients, the cancer of uterine cervix was the most common first cancer. 4) The ratio between synchronous and metachronous multiple primary was 2.5:1 (30:12).