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Fan, Yong-Qiang,Liu, Hong-Jian,Li, Chang,Luan, Yu-Shi,Yang, Jun-Mo,Wang, Yu-Long Humana Press 2013 Applied biochemistry and biotechnology Vol.169 No.1
<P>In this study, we quantitatively examined the effects of the macromolecular crowding agents, polyethylene glycol 2000 (PEG 2000) and dextran 70, on guanidine hydrochloride (GdnHCl)-induced denaturation of recombinant human brain-type creatine kinase (rHBCK). Our results showed that both PEG 2000 and dextran 70 had a protective effect on the inactivation of rHBCK induced by 0.5 M GdnHCl at 25 C. The presence of 200 g/L PEG 2000 resulted in the retention of 35.33 % of rHBCK activity after 4 h of inactivation, while no rHBCK activity was observed after denaturation in the absence of macromolecular crowding agents. The presence of PEG 2000 and dextran 70 at a concentration of 100 g/L could decelerate the k (2) value of the slow track to 21 and 33 %, respectively, in comparison to values obtained in the absence of crowding agents. Interestingly, inactivation of rHBCK in the presence of 200 g/L PEG 2000 followed first-order monophasic kinetics, with an apparent rate constant of 8??10(-5)?s(-1). The intrinsic fluorescence results showed that PEG 2000 was better than dextran 70 at stabilizing rHBCK conformation. In addition, the results of the phase diagram indicate that more intermediates may be captured when rHBCK is denatured in a macromolecular crowding system. Mixed crowding agents did not produce better results than single crowding agents, but the protective effects of PEG 2000 on the inactivation and unfolding of rHBCK tended to increase as the ratio of PEG 2000 increased in the mixed crowding agent solution. Though it is not clear which crowding agents more accurately simulated the intracellular environment, this study could lead to a better understanding of protein unfolding in the intracellular environment.</P>
Upregulation of Fas in epithelial ovarian cancer reverses the development of resistance to Cisplatin
( Fan Yang ),( Wang Long ),( Han Xuechuan ),( Liu Xueqin ),( Ma Hongyun ),( Ding Yonghui ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.1
This study was to investigate the role of Fas in the developmentof Cisplatin-resistant ovarian cancer. On the cellularlevel, Fas expression was significantly reduced in Cisplatinresistant A2780 (A2780/CP) cells compared with A2780 cells. Fas silence with siRNA would promote tumor cell linesproliferation, facilitate tumor cell cycle transition of G1/S,prevent cell apoptosis, and promote cell migration. Expressionof drug resistance gene was negatively correlated to Fas. Innude mice metastasis model of human ovarian carcinoma bysubcutaneous transplantation, after Ad-Fas injected intratumorly,we found that upregulation of Fas could inhibit transplantationtumor tissue growth and reduce the expression of drugresistance gene. Our results indicated that upregulation of Fasin epithelial ovarian cancer reversed the development ofresistance to Cisplatin. In conclusion, our findings suggestedthat Fas might act as a promising therapeutic target for improvementof the sensibility to Cisplatin in ovarian cancer.
Fan-Long Jin,Chun-Liu Ma,Bao-Tian Guo,박수진 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.10
The surface of graphene (GE) was modified with a silane coupling agent, and its surface characteristics were investigated. Epoxy resin/GE nanocomposites were prepared via solution blending. The effect of the GE content on the thermal stability, flexural properties, impact strength, and morphology of the nanocomposites was studied. The thermal stability of the epoxy resin increased with the addition of pristine GE and surface-modified GE. The flexural strength, elastic modulus, and impact strength of the nanocomposites with surface-modified GE increased significantly with increasing GE content. Scanning electron microscopy images of the nanocomposites with surface-modified GE show a ductile deformation morphology, which is consistent with their high impact strength.
Synthesis and thermal properties of urethane-containing epoxy resin
Fan-Long Jin,Heng-Chang Liu,Baoqing Yang,박수진 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.24 No.-
A urethane-containing epoxy resin was successfully synthesized by reacting bisphenol A with 1,6- hexamethylene diisocyanate and epichlorohydrin. The chemical structure of urethane-containing epoxy resin was confirmed using FT-IR, 1HNMR, and elemental analysis. DSC results indicated that the initial curing and maximum exothermic peak temperatures of urethane-containing epoxy resin cured with 4,40-diaminodiphenylmethane were 60 8C and 135 8C, respectively; these values were lower than those of a bisphenol A-based epoxy resin. The thermal stability of epoxy resins was studied using TGA, and it was found that the degradation temperature of urethane-containing epoxy resin was lower than that of bisphenol A-based epoxy resin under the same conditions.
( Fan Zhu ),( Jian Li ),( Wen Xin Li ),( Zhong Chun Liu ),( Xing Long ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.6
The expression and clinicopathological significance of Quox-1 gene was studied in oral squamous cell carcinoma (OSCC). Immunocytochemistry and western blot analysis were used to examine the different expressions of Quox-1 protein in 114 OSCC specimens, 34 oral epithelial dysplasia specimens, and 16 normal oral mucosa specimens. RT-PCR and virtual Northern Blot were also used to examine the expression of Quox-1 mRNA. It was found that Quox-1 was not expressed in normal epithelium. However, as dysplastic lesions progressed Quox-1 expression increased (p < 0.01), and Quox-1 expression was not significantly different between severe dysplasia and highly differentiated OSCCs (p > 0.05). As the degree of differentiation decreased, Quox-1 positivity increased in OSCC (p < 0.01), and the rate of Quox-1 (81.58%) positivity in OSCC was higher than that in normal oral mucosa (p < 0.01). Our findings imply that the positive expression of Quox-1 is correlated with the histological classification of OSCCs. Thus, the expression of Quox-1 in OSCC may serve as a significant predicting factor of proliferative status and malignant degree, and it may also be a biological detection marker of oral mucosas initial cancer and of OSCC.
Video-assisted Thoracoscopic Surgery for Treatment of Earlystage Non-small Cell Lung Cancer
Fan, Xing-Long,Liu, Yu-Xia,Tian, Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Objectives: To evaluate the safety, efficacy, and invasiveness of lobectomy by video-assisted thoracoscopic surgery (VATS) in the treatment of stage I/II non-small cell lung cancer (NSCLC). Methods: A total of 148 patients presenting with Stage I or II NSCLC were enrolled into our study, comprising 71 who underwent VATS and 77 patients undergoing conventional thoracotomic lobectomy, in combination with systematic lymph node resection. Results: It was found that VATS was superior to conventional thoracotomy in terms of the duration of surgery, intraoperative blood loss, frequency of the need to administer postoperative analgesia, thoracic intubation indwelling time, post-operative hospital stay, and survival rate (P<0.05). We saw no obvious difference in the number of resected lymph nodes with either approach. Conclusions: VATS lobectomy is a safe and reliable surgical approach for the treatment of Stage I/II NSCLC, characterized by significantly minimal invasiveness, rapid post-operative recovery, and markedly lower loss of blood.
Yue-Long Lyu,Xiao-Xin Liu,Peng-Yuan Wang,Erni, Daniel,Qun Wu,Cong Wang,Nam-Young Kim,Fan-Yi Meng Institute of Electrical and Electronics Engineers 2016 IEEE transactions on antennas and propagation Vol.64 No.6
<P>In this paper, we propose an approach to realize substrate integrated waveguide (SIW)-based leaky-wave antennas (LWAs) supporting continuous beam scanning from backward to forward above the cutoff frequency. First, through phase delay analysis, it was found that SIWs with straight transverse slots support backward and forward radiation of the -1-order mode with an open-stopband (OSB) in between. Subsequently, by introducing additional longitudinal slots as parallel components, the OSB can be suppressed, leading to continuous beam scanning at least from -40 degrees through broadside to 35 degrees. The proposed method only requires a planar structure and obtains less dispersive beam scanning compared with a composite right/left-handed (CRLH) LWA. Both simulations and measurements verify the intended beam scanning operation while verifying the underlying theory.</P>
A depth-based Multi-view Super-Resolution Method Using Image Fusion and Blind Deblurring
( Jun Fan ),( Xiangrong Zeng ),( Qizi Huangpeng ),( Yan Liu ),( Xin Long ),( Jing Feng ),( Jinglun Zhou ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.10
Multi-view super-resolution (MVSR) aims to estimate a high-resolution (HR) image from a set of low-resolution (LR) images that are captured from different viewpoints (typically by different cameras). MVSR is usually applied in camera array imaging. Given that MVSR is an ill-posed problem and is typically computationally costly, we super-resolve multi-view LR images of the original scene via image fusion (IF) and blind deblurring (BD). First, we reformulate the MVSR problem into two easier problems: an IF problem and a BD problem. We further solve the IF problem on the premise of calculating the depth map of the desired image ahead, and then solve the BD problem, in which the optimization problems with respect to the desired image and with respect to the unknown blur are efficiently addressed by the alternating direction method of multipliers (ADMM). Our approach bridges the gap between MVSR and BD, taking advantages of existing BD methods to address MVSR. Thus, this approach is appropriate for camera array imaging because the blur kernel is typically unknown in practice. Corresponding experimental results using real and synthetic images demonstrate the effectiveness of the proposed method.