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El-Brashy, Amina Mohamed,Metwally, Mohamed El-Sayed,El-Sepai, Fawzi Abdallah Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.3
Two simple, rapid and sensitive spectrophotometric methods for the determination of three fluoroquinolones, namely levofloxacin, norfloxacin and ciprofloxacin have been performed either in pure form or in their tablets. In the first method, levofloxacin and norfloxacin are directly treated with bromocresol green (BCG) in dichloromethane while ciprofloxacin is allowed to react with the same dye in aqueous acidic buffer. Highly yellow colored complex species were formed instantaneously in case of levofloxacin and norfloxacin or after extraction into dichloromethane for ciprofloxacin. The formed complexes are quantified spectrophotometrically at their absorption maxima at 411 nm for levofloxacin and 412 nm for norfloxacin and ciprofloxacin. The second method involves the reaction of levofloxacin with ${\rho}$-chloranilic acid ( ${\rho}$-CA) and norfloxacin with tetracyanoethylene (TCNE) in acetonitrile to give complexes with maximum absorbance at 521 and 333 nm for the two drugs, respectively. Adopting the first procedure, calibration graphs were linear over the range 1- 20 ${\mu}g\;mL^{-1}$ with mean percentage recoveries of 100.41 ${\pm}$ 0.72, 99.99 ${\pm}$ 0.54 and 100.23 ${\pm}$ 0.91 for the theree drugs, respectively. For the second procedure, the concentration ranges were 15-250 ${\mu}g\;mL^{-1}$ for levofloxacin using ${\rho}$-CA and 0.8-16 ${\mu}g\;mL^{-1}$ for norfloxacin using TCNE with mean percentage recoveries of 99.88 ${\pm}$ 0.45 and 100.26 ${\pm}$ 0.68 for the two drugs, respectively. The proposed methods were successfully applied to determine these drugs in their tablet formulations and the results compared favorably to that of reference methods. The proposed methods are recommended for quality control and routine analysis.
Metwally, M.A.,Bondock, S.A.,El-Desouky, S.I.,Abdou, M.M. Korean Chemical Society 2012 대한화학회지 Vol.56 No.1
Novel azopyrazolin-5-one dyes 4a-f were synthesized by the regioselective reaction of phenylhydrazine with 2,3,4-chromantrione-3-arylhydrazones 2a-f. The acid dissociation constants $pK_a$ for the series prepared were determined and correlated by the Hammett equation. The results of such correlation together with the spectral data indicated that the studied compounds exist predominantly in the hydrazone keto structure, (D) as the Z-configuration. The dyes were applied to polyester fabrics, affording orange-yellow shades and assessments of their dyeing performance are considered. Further, the compounds 4a-f were screened for their antimicrobial activity against various microorganisms.
Metwally, M.A.,Bondock, S.,El-Desouky, S.I.,Abdou, M.M. Korean Chemical Society 2012 대한화학회지 Vol.56 No.3
In an attempt to find a new class of bisazo disperse dyes with better dyeing properties, a series of novel bisazo dyestuffs based on 4-arylhydrazono-3-(2'-hydroxyphenyl)-1-phenyl-2-pyrazolin-5-ones $\mathbf{3a-f}$ were prepared by diazocoupling of p-nitrophenyl diazonium chloride with 4-arylhydrazono-3-(2'-hydroxyphenyl)-1-phenyl-2-pyrazolin-5-ones $\mathbf{2a-f}$. Compounds $\mathbf{3a-f}$ were subsequently reacted with acetic anhydride in the presence of p-toluenesulfonic acid afford the corresponding O-acetyl derivatives $\mathbf{4a-f}$. The latter products as well as spectral data indicated that compounds $\mathbf{3a-f}$ exist predominantly in the azo-hydrazone tautomeric form (H) as the ZE-configuration. Additionally, two series of the synthesized dyes $\mathbf{3a-f}$ and $\mathbf{4a-f}$ were applied as disperse dyes for dyeing polyester fabrics and their fastness properties were evaluated. Also the position of color in CIELAB coordinates ($L^*$, $a^*$, $b^*$, $H^*$, $C^*$*) was assessed.
Metwally Mohamed Ali,El-Zawahry El-Yamani Ibrahim,Ali Maher Amer,Ibrahim Diaa Farrag,Sabry Shereen Ahmed,Sarhan Omnia Mohamed 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.3
Worldwide, cardiovascular disease is the main cause of death, which accordingly increased by hyperlipidemia. Hyperlipidemia therapy can include lifestyle changes and medications to control cholesterol levels. Statins are the medications of the first choice for dealing with lipid abnormalities. Rosuvastatin founds to control high lipid levels by hindering liver production of cholesterol and to achieve the targeted levels of low-density lipoprotein cholesterol, another lipid lowering agents named ezetimibe may be used as an added therapy. Both rosuvastatin and ezetimibe have low bioavailability which will stand as barrier to decrease cholesterol levels, because of such depictions, formulations of this combined therapy in nanotechnology will be of a great assistance. Our study demonstrated preparations of nanoparticles of this combined therapy, showing their physical characterizations, and examined their behavior in laboratory conditions and vivo habitation. The mean particle size was uniform, polydispersity index and zeta potential of formulations were found to be in the ranges of (0.181–0.72) and (–13.4 to –6.24), respectively. Acceptable limits of entrapment efficiency were affirmed with appearance of spherical and uniform nanoparticles. In vitro testing showed a sustained release of drug exceeded 90% over 24 h. In vivo study revealed an enhanced dissolution and bioavailability from loaded nanoparticles, which was evidenced by calculated pharmacokinetic parameters using triton for hyperlipidemia induction. Stability studies were performed and assured that the formulations are kept the same up to one month. Therefore, nano formulations is a suitable transporter for combined therapy of rosuvastatin and ezetimibe with improvement in their dissolution and bioavailability.
Synthesis of 2,5Bis(2'-piperidymethyl)piperidine and Related Compounds
Hammouda, Metwally,Kandeel, Ex-el-Din,Hamama, Wafaa,Afsah, Elsayed The Pharmaceutical Society of Korea 1993 Archives of Pharmacal Research Vol.16 No.1
The triketones 3-6 were obtained by alkylation of cyclopentanone or cyclohexanone with the appropriate cycloalkanone bis-mannich base (1) or (2). Schmidt reaction of the tricketones 3-6 afforded the corresponding trcyclic lactames 7-10 respectively. reduction of 7 and 9 gave compounds 11 and 12 respectively.
Screening thirty soybean genotypes under solid and intercropping plantings in Egypt
Abd El-Alim A. Metwally,Sayed A. Safina,Eman I. Abdel-Wahab,Sherif I. Abdel-Wahab,Tamer I. Abdel-Wahab 한국작물학회 2021 Journal of crop science and biotechnology Vol.24 No.2
Cropping systems are relatively more important for testing soybean genotypes under Egyptian conditions. A field experiment was carried out at the Agricultural Experiments and Research Station, Faculty of Agriculture, Cairo University, Giza, Egypt, during the 2016 and 2017 seasons to evaluate the productivity of thirty soybean genotypes collected from four countries in intercropping with corn. Intercropping two soybean ridges alternating with another two of corn (2:2) was used in a split plot distributed in randomized complete block design. Intercropping and solid systems were randomly assigned to the main plots, and the soybean genotypes were allocated in sub-plots. All over the genotypes, intercropping caused significant increases in maturity date, root length, and plant height; meanwhile, the reverse was true for each of total leaf chlorophyll content, numbers of branches and pods, as well as seed yield per plant. Soybean genotypes Giza 111, C1, Woodworth, C34, Hill, Hutcheson, and Holladay gave higher seed yield than the others. Allover cropping systems, soybean genotypes Giza 111, Woodworth, Hutcheson, and C1 had higher seed yield than the others under intercropping. A significant positive correlation was detected between pod number and seed yield under cropping systems. Early maturing genotypes under intercropping were correlated positively with a higher yield of plants, as well as relative values. Determinate soybean variety Woodworth was matured under intercropping and solid planting at the same time. Soybean genotypes Woodworth, C1, C34, Giza 35, Giza 82, and Giza 111 were tolerant than the others to intercropping. The six soybean genotypes off er useful genetic materials for soybean breeding programs to improve yield under intercropping.
Sherif Hamdy El-Gohary,Mohamed Kilany Metwally,Seyoung Eom,전승현,변경민,김태성 대한의용생체공학회 2014 Biomedical Engineering Letters (BMEL) Vol.4 No.3
Purpose In this work, we propose an alternative photoacousticprobe based on transurethral laser illumination to a conventionaltransrectal photoacoustic imaging system suffering from ahigh optical absorption at a rectal wall and its surroundingtissues. Methods We validate improved performance of the proposedscheme using 3-dimensional prostate model and analyticalcalculations such as Monte Carlo simulation and finiteelement method (FEM). Monte Carlo simulation and FEMare used to find the absorption profiles of photons and theaccompanying temperature elevation and pressure signalgeneration. Results It is found that light source inside the urethra andultrasound transducer on the rectal wall is an optimalcombination to produce a high amplitude in pressure signaland a high signal-to-noise ratio in the reconstructed image. Design study on light source geometry such as beam shape,beam size and gap distance between two light sources is alsoperformed to improve an absorption efficiency at the prostatecancer. Conclusions Our study will be helpful in determining anoptimized probe design of photoacoustic imaging system foradvancing the detection of prostate cancer.
M.M. El-Nahass,H.S. Metwally,H.E.A. El-Sayed,A.M. Hassanien 한국물리학회 2014 Current Applied Physics Vol.14 No.2
The JeV characteristics of the Au/5,10,15, 20-tetraphenyl-21H, 23H-porphine iron (III) chloride (FeTPPCl)/ ITO device exhibits rectifying behavior in the dark which can be explained due to the formation of Schottky barrier at ITO/FeTPPCl junction and the typical junction parameters were estimated in temperatures from 302 to 368 K. The temperature dependence of DC electrical conductivity showed that FeTPPCl films behave as semiconducting materials. These results indicate that the DC electrical conduction is through an activated process having three conduction mechanisms in the investigated range of temperatures. A variable range hopping model, a polaron model and band to band transitions have been used to explain the conduction mechanisms for FeTPPCl films.
( Ammal Mokhtar Metwally ),( Amany T Abdel Hameed ),( Dalia M Elmosalami ),( Amira Mohsen ),( Sherif El Deeb ),( Walaa A Fouad ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Scientifi c research clearly showed that personal health behaviors played a major role in endemicity of Hepatitis, mainly Hepatitis C (HCV) in Egypt. The study was a national survey that focused on identifying the level of behavioral development concerning different aspects of HCV and assessing the dominance of risk practices associated with infection by HCV for deciding which practices can be altered and targeted. Methods: This study was conducted through a project that was supported fi nancially by the Science and Technology Development Fund (STDF), Egypt, Grant No1774, during a period of one year started from November 2012 till November 2013. The national survey was directed to 1200 sampled families with 3780 individuals. The sample was selected from six governorates as representative to the six major subdivisions of Egypt; Urban Governorates, rural and urban Lower Egypt, urban and rural Upper Egypt and the Frontier Governorates Results: Only one fourth of the surveyed groups irrespective to their age group and sex could identify why HCV is considered dangerous reporting that it is a cause of Liver cirrhosis and liver failure. Generally speaking, participants who personally feel at risk were those who developed positive attitudes, those who tried and adopted the recommended safe practices that can prevent HCV infection (50 %), indicating that around half of individuals could participate in behaviors that increase the spread of HCV. Awareness was high (= 75%) as regard to only using previously used syringes, sharing shaving equipment, nail cutter or through needle stick injury as responsible methods for transmission of HCV. Conclusions: finding of the survey will put the corner stone for the development of appropriate and culture sensitive educational and multimedia materials to limit the endemicity of HCV in Egypt.