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      • KCI등재

        A successive ‘‘conversion-deposition” mechanism achieved by micro-crystalline Cu2O modified current collector for composite lithium anode

        Yifei Cai,Bin Qin,Chun Li,Xiaoqing Si,Jian Cao,Xiaohang Zheng,LIANG QIAO,Junlei Qi 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-

        Lithium (Li) metal is a promising material for high-energy–density batteries, but it is still plagued byobvious capacity degradation and low average Coulombic efficiency resulting from dendrite Li propagation. One main reason is the electro-mechanic coupled failure of plated Li on the current collector, whichcontributes to non-dense Li deposition on the anode. Transition metal oxides (TMOs) with a conversiontypemechanism have been used directly as the anode materials for lithium ion batteries, which demonstratedbetter electro-mechanical stability than metal Li. Herein, a successive ’’conversion-deposition’’mechanism is ingeniously developed to restrain the generation of dendritic Li. Specifically, a microcrystallineCu2O modified current collector was prepared, in which Li+ are sequentially inserted intoCu2O and deposited in the form of Li metal at successive low potential. A Li-Cu half-cell based on thehybrid mechanism sustains a high Coulombic efficiency of over 99.3 % in up to 800 cycles. This work ingeniouslyinhibits the generation of dendrite Li by incorporating conversion-type materials withdeposition-dissolution type metal Li, which contributes to a novel concept for the design of functionalcurrent collectors for composite Li anodes.

      • KCI등재

        Investigation of the Phenomenon of Propagated Sensation along the Channels in the Upper Limb Following Administration of Acupuncture and Mock Laser

        Shohreh Razavy,Marcus Gadau,Shi Ping Zhang,Fu Chun Wang,Sergio Bangrazi,Christine Berle,Mahrita Harahap,Tie Li,Wei Hong Li,Christopher Zaslawski 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.5

        Background: Similar to De Qi psychophysical responses, propagated sensation along the channels (PSC) is considered an important phenomenon in traditional Chinese acupuncture. In acupuncture clinical trials, different acupuncture manipulation techniques are used to enhance the propagation of sensation along the channels to facilitate an optimum therapeutic result. Aim: To examine and compare the PSC reported by participants in a clinical trial following the administration of acupuncture and inactive mock laser. Methods: The study was embedded in a two-arm parallel design multicenter, randomized clinical trial, the Tennis Elbow AcupuncturedInternational StudydChina, Hong Kong, Australia, Italy (TEA IS CHAI). Needle sensations were measured using a validated instrument, the Massachusetts General Hospital Acupuncture Sensation Spreading Scale. Ninety-six participants with lateral elbow pain were randomly allocated into two groups in a 1:1 ratio; the acupuncture treatment group (n Z 47) and the mock laser control group (n Z 49). Participants in both groups received the intervention at two acupoints, LI10 and LI11, consisting of 2 minutes of either standardized needle manipulation or mock laser at each acupoint with a rest period between each intervention period. Data were collected immediately following the interventions at the first and the ninth session within the clinical trial. Results: Although participants in both groups perceived PSC radiating to similar sites along the upper limb, the frequency of the reported radiation sites among the two intervention groups for both radiation up the limb (p < 0.05) and radiation down the limb (p < 0.001) were statistically significantly different. Among the radiating sensation sites recorded within the two study groups, the sensations were reported as radiating a greater distance down the forearm to the wrist compared to up the arm. Evaluation of PSC across the four study sites revealed a statistically significant difference in frequency of the reported radiation down the limb sites in each study group and radiation up the limb sites only in control group only (p < 0.001). Conclusion: The findings of the study demonstrated that the PSC phenomenon is not just associated with needling but can be perceived when using a mock laser. Trial registration: Australian and New Zealand Clinical Trial Registry reference: ACTRN12613001138774 on 11th of October 2013.

      • KCI등재

        Current state of research about acupuncture for the treatment of COVID-19: A scoping review

        Chen Chen,Jie Zhan,Hao Wen,Xiaojing Wei,Lu Ding,Chenyang Tao,Cui Li,Peiming Zhang,Yuyuan Tang,Jing-chun Zeng,Li-ming Lu 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.-

        Background Since the outbreak of coronavirus disease (COVID-19), acupuncture has been widely used in the treatment of COVID-19. The research community has responded rapidly and has already published many research articles about this topic. Methods We searched PubMed, Embase, Cochrane Library as well as CNKI, Wanfang and VIP from January 1, 2020 to July 31, 2021. The dates of publication, language of publication, methodological characteristics and the key findings were analyzed separately. The data are presented as bar graphs, structured tables and figures. Results In this scoping review, 16 research articles were included: 7 case reports, 6 observational studies, 1 review, 1 RCT and 1 nonrandomized clinical trial. The majority of the articles (81.3%) were published by Chinese scholars, 12.5% articles were by scholars in the United States, and 6.3% articles were by scholars in Iran. The included studies reported that acupuncture could alleviate the symptoms of COVID-19 patients, shorten their hospitalization days, and is effective for the elderly. There were no side effects reported. The most frequent acupoints used were LI4, PC6, ST36 and KI3. They reported many obstacles in implementing acupuncture therapy for treating COVID-19 patients. Conclusion Acupuncture has a good effect for the treatment of COVID-19, but high-quality evidence support is still lacking. Coupled with the difficulties that acupuncturists experienced during the process of treatment, the promotion of acupuncture treatment for COVID-19 faces many obstacles. Background Since the outbreak of coronavirus disease (COVID-19), acupuncture has been widely used in the treatment of COVID-19. The research community has responded rapidly and has already published many research articles about this topic. Methods We searched PubMed, Embase, Cochrane Library as well as CNKI, Wanfang and VIP from January 1, 2020 to July 31, 2021. The dates of publication, language of publication, methodological characteristics and the key findings were analyzed separately. The data are presented as bar graphs, structured tables and figures. Results In this scoping review, 16 research articles were included: 7 case reports, 6 observational studies, 1 review, 1 RCT and 1 nonrandomized clinical trial. The majority of the articles (81.3%) were published by Chinese scholars, 12.5% articles were by scholars in the United States, and 6.3% articles were by scholars in Iran. The included studies reported that acupuncture could alleviate the symptoms of COVID-19 patients, shorten their hospitalization days, and is effective for the elderly. There were no side effects reported. The most frequent acupoints used were LI4, PC6, ST36 and KI3. They reported many obstacles in implementing acupuncture therapy for treating COVID-19 patients. Conclusion Acupuncture has a good effect for the treatment of COVID-19, but high-quality evidence support is still lacking. Coupled with the difficulties that acupuncturists experienced during the process of treatment, the promotion of acupuncture treatment for COVID-19 faces many obstacles.

      • 각형강관 가새부재의 폭두께비에 따른 거동 평가

        천성욱,한상환,이리형 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

        Braced frames are a popular framing system for resisting to seismic loads in buildings because braced frame can provide large lateral stiffness and strength than moment frames. Hollow Square Section(HSS) members are one of the most efficient sections of compression members and bracing members. In this experimental study. Specimens were designed according to the AISC LRFD manual. The major parameter of these specimens is a width-thickness ratio. In this study three specimens were made for each test parameters to account for the variability of test results. The nine full-scale test specimens were tested using a quasi-static cyclic loading. This study modified the standard loading history in SAC to make it adequate for a bracing member test.

      • 대전·충남지역 학교보건실태 및 양호교사의 업무자신감에 관한 조사연구

        홍춘실,김현리 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

        The purpose of this study was to find out the status of school health, school health teacher' s performance for school health works and school health teacher's self-confidence to performance for school works for the 147 school health teachers in Taejon city and chungnam province. Data collection was conducted by means of questionairs made by Community Health Nursing Academis Affairs from July 10 1991 to July 25 1991. The results of this study were as follows; 1. In research subject school, The distribution of pupils was that the below 2.000group was above 85%, the distribution of teachers was that the below 60 group was about 75%, the distribution of classes was that the below 60 group was about 95%. the school health budget showed the most highest score in the below three hundreds of thousands won group (48.5%). Only 18.5% all subject schools had organization for school health. Above 70% of health clinics was located in 1st floor and the size of health clinics was less than 33m about 73.9%. The monthly average of clinic visitors was distributed that the 101-200 group was 46 school(31.7%), most high. The average of literal message was 9 times for 1 year. 2. The school health teacher's performance of schoolhealth nursing activities was that ; 1) The dimension of program planning aand evaluation was highly scored in plan ning(.0952). 2) The dimension of management of health clinic was highly scored in clinic management (.973) 3) The dimension of health education was highly scored in content assessing (.898). 4) The dimension of management of school environment was highly scored in management of water supply system(.878). 5) The dimension of operating of school health organization was highly scored in operating of community welfare organization(.286). 6) The dimension of health care services was highly scored in headache (.966), emergency management(.966),and most lowest scored in wound suturing(.012). 3. There was statistically significant difference in the comparison of performance of school health works according to major variables only the performance of environment manage ment(T=5.0366, P-0.263, Table 6). 4. The school health teacher's self-confidence of performance for school health works was that ; 1) The dimension of program planning and evaluation sshowed high scores in plan ning(2.865). 2) The dimension of health clinic management showed high score in clinic management(3.132), and the lowest score in participation of budget planning (2.340). 3) The dimension of health education showed the most highest score in education performance(2.912)). 4) The dimension of management of school environment showed the most highest score in toilet management(2.766), and the most lowest score in sewage management (2.528). 5) The dimension of operating of school health organization showed relatively low level, average 2.141. 6) The dimension of health care services showed the most highest score in immunization (3.000), the most lowest score in wound suturing (2.032). 5. As the school health teacher's self-confidence, there were no statistically significant difference according to number of pupils, school health budget, school health organization. Thus researcher suggested that for development of school health nursing was supported through arrangement of work conditions,the school health teachers must develop the performing ability of school health work for themselves, and also search variables for self-confidence.

      • 재가노인의 일상생활동작수행의 의존성과 생활만족에 관한 연구

        홍춘실,김현리,이상화 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

        This study was conducted to analyse the correlation between the ADL dependency and life satisfaction. Data were collected from the 102 home resident eldery who have no dementia by cognition test. The age distribution f subjects were 65 years and over The data were collected from January 16th to February 15th, 1997. The instruments used for this study were a survey of general characteristics(10 items), physical function(15 items), life satisfaction(20 items). The data were analysed by using an SPSS program and included percentage, t-test, ANOVA & Pearson correlation coefficient. The result of the study are summarized as follows: 1. The mean of ADL dependency score was 5..912 in a possible range of 15 to 60 when 15 indicates high dependency and 60 incicates low dependency. 2. The mean of life satisfaction score was 20.363 in a possible range of 0 to 40 when 0 indicates low life satisfaction and 50 indicates high life satisfaction. 3. The relationship between ADL dependency and life satisfaction for old people in home proved to be of statistically highly negative correlation(r=-.2553 P=.01). 5. General characteristics related to life satisfaction was educational status, household status, economic status, personality, perception of health(P<0.05). In conclusion, it was identified that ADL dependency is the important variable influencing the life satisfaction of the elderly. Therefore, more efforts are needed to decreased the ADL dependency of the elderly to enhance life satisfaction of the elderly.

      • 대전·충남지역 보건소 간호사의 보건사업 수행에 관한 조사연구

        홍춘실,김현리,신창례,한창옥 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

        This study was purposed to find out the health service performance of public health nurses in Taejon and Chungnam area. The study subjects was public health nurses,119 and data collection was performed from 3.Sep.1990 to 30.Nov. 1990. The research scale was made by Community Health Nursing Academic Affairs and revealed to health service dimension in health center. The result were as follows : 1. General characteristics of subjects. We can notice the most largest distributions in each characteristics: 1) Marrital status : the married(72.3) 2) Religion : the protestant(33.6) 3) The career in hospital : 1-4years group(37.8) 4) The possession of licence and qualification : double licenses or qualification possession. Only 2% of subjects had bachelor degree. The distribution of working part was that : family planning(31.1%),infant and child(29.4%), clinic(15.1%), TB management(9.2%), others(9.2%), immunization (4.2%) injection part(1.7%). 2. Work performance according to the dimension of health project was that : planning(2.771),other official affairs(2.501), infant and child care(2.442), others special project(2.424), prenatal care(2.303), postpartum care (2.296), family planning(2.267), disease control(1.933), delivery care(1.904), TB management(1.827), practice education(1.748), other health projects( 1.677), and there was a high performance score in guide and education items and record and report items relatively. . 3.Work performance according to general characteristics There was a statistically significant differences in work performance score of planning dimension according to age, marrital status, working place and working part, and in work performance score of disease control dimension according to religion, and in work performance score of other dimension according to marrital status,and in work performance score of planning,infant & child care, family planning, practice education, other official affairs and other health projects according to working places. There was a statistically significant differences in work performance score of planning, prenatal care, postpartum care, infant & child care, family planning, disease control and others dimension according to working part.

      • KCI등재

        이명박 정부의 대북정책 : 평가와 전망

        문정인,이춘복 연세대학교 통일연구원 2009 통일연구 Vol.13 No.2

        이명박 정부 들어 지난 1년간 남북관계는 경색, 악화 국면을 넘어 거의 단절 수준까지 이르렀다. 특히 서해안에서의 해상 충돌과 그에 따른 군사적 긴장의 고조는 역대 최악의 남북관계를 예고해 주고 있다. 이러한 상황전개는 북측의 일방적 태도와 이명박 정부의 경직된 대북정책이 빚어낸 결과라 할 수 있다. 특히 비핵·개방·3000』과 ABR(Anything But Roh Moo-hyun)이라는 이명박 정부의 대북정책 기조는 남북관계 개선에 커다란 걸림돌이 되고 있다. 대북관계에서 지나치게 지난 정권과의 차별화를 강조함으로 남북관계는 위기로 치닫고 있으며 과거 화해협력정책이 애써 이룩해 놓은 성과마저 점차 무력화되고 있다. 현재의 고착 상태를 극복하기 위해서는 남북간 신뢰 회복이 선행되어야 하며 이를 위해 역지사지의 대북정책이 모색되어야 할 것이다. 중도실용주의 원칙에 기초하여 이명박 대통령이 직접 「6.15선언」과 「10.4선언」의 존중의사를 밝히는 동시에 제 3차 남북정상회담의 개최를 통해 새로운 돌파구를 마련해야 할 것이다. Since the inauguration of the Lee Myung-bak (MB) government, inter-Korean relations have remained stalled. The Mt. Keumgang tourist project was shut down since July 2008, the Kaesung Industrial Complex is being jeopardized. And official contacts between two Koreas are virtually frozen. New hope formed through the resumption of reunion of separated families in October was again derailed by naval clash in West Sea in November. The stalemate can be attributed partly to North Korea's inertia-driven behavior and partly to the MB government's rigid stance on North Korea. The latter's blind obsession with the "De-nuke, Open 3,000" policy and the attitude of 'Anything But Roh Moo-hyun (ABR)' is likely to further strain inter-Korean relations, while heightening military tension. The most viable way to overcome the current dilemma is to engage with North Korea, to honor policy legacies of past governments such as the June 15 Joint Declaration and the October 4 North-South Summit Declaration, and to expedite the 3rd inter-Korean summit. In so doing, the MB government needs to adopt an inter-subjective approach to the understanding of North Korea because it can enhance inter-Korean trust-building, exchanges and cooperation, and eventually peaceful co-existence.

      • Cationic surface modification of cellulose nanocrystals: Toward tailoring dispersion and interface in carboxymethyl cellulose films

        Li, Mei-Chun,Mei, Changtong,Xu, Xinwu,Lee, Sunyoung,Wu, Qinglin Elsevier 2016 Polymer Vol.107 No.-

        <P><B>Abstract</B></P> <P>The present work describes the development of high performance cellulose nanocrystals/carboxymethyl cellulose (CNC/CMC) films through a rational design of CNC surface chemistry. Considering the anionic surface nature of CMC, surface cationization of CNCs was performed in order to build strong interfacial bonding by electrostatic attraction and form uniform dispersion state by electrostatic repulsion. Nanocomposite films were fabricated by dispersing the CNCs and cationically modified CNCs (mCNCs) in CMC matrix through solution casting. The resultant CNC/CMC and mCNC/CMC films were then evaluated in terms of processability, mechanical properties and fracture surface morphology. Results showed that the reinforcing capacity of mCNCs was greatly dependent on its substitution degree. High substitution degree was favorable for obtaining mCNC/CMC film with uniform dispersion and superior mechanical properties. The observed distinctive reinforcing phenomena from CNCs and mCNCs in CMC matrix were interpreted in terms of dispersion state and interfacial bonding based on the fracture surface morphology.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cationic cellulose nanocrystals (CNCs) are synthesized through etherification. </LI> <LI> Substitution degree (DS) is tuned by controlling water content in reaction system. </LI> <LI> Cationic CNCs are firstly used to reinforce carboxymethyl cellulose (CMC) films. </LI> <LI> The DS of cationic CNCs plays critical role on their dispersion in CMC films. </LI> <LI> Superior reinforcement of CMC films is achieved using cationic CNCs with higher DS. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells

        Chun, Jaemoo,Li, Rui-Juan,Cheng, Mao-Sheng,Kim, Yeong Shik Elsevier 2015 Cancer letters Vol.357 No.1

        <P><B>Abstract</B></P> <P>The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway. Alantolactone effectively suppressed both constitutive and inducible STAT3 activation at tyrosine 705. Alantolactone decreased STAT3 translocation to the nucleus, its DNA-binding, and STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs and on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases. Although SHP-1, SHP-2, and PTEN, which are protein tyrosine phosphatases (PTPs), were not affected by alantolactone, the treatment with a PTP inhibitor reversed the alantolactone-induced suppression of STAT3 activation, indicating that PTP plays an important role in the action of alantolactone. Finally, alantolactone treatment resulted in the inhibition of migration, invasion, adhesion, and colony formation. The <I>in vivo</I> administration of alantolactone inhibited the growth of human breast xenograft tumors. These results provide preclinical evidence to continue the development of alantolactone as a STAT3 inhibitor and as a potential therapeutic agent against breast cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> STAT3 is a transcription factor that is a potent regulator of tumorigenesis. </LI> <LI> Alantolactone suppresses constitutive and inducible STAT3 tyrosine phosphorylation. </LI> <LI> Alantolactone inhibits NF-κB translocation to the nucleus. </LI> <LI> Alantolactone inhibits cell migration, invasion, adhesion, and colony formation. </LI> <LI> Alantolactone inhibits the tumor growth of MDA-MB-231 xenografts in mice. </LI> </UL> </P>

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