Effect of abdominal acupuncture combined with routine rehabilitation training on shoulder-hand syndrome after stroke: A randomized controlled trial

Zhan Jie,Ai Yirang,Zhan Lechang,Pan Ruihuan,Wang Yiqiao,Dong Cong,Wang Qiuchun,Chen Hongxia,Lu Liming,Li Mei 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.2

Background: Post-stroke shoulder-hand syndrome (SHS) is a common complication after stroke. To date, there is still a lack of consistently effective and good patient compliance methods for SHS. Methods: Fifty patients with SHS were included in this study. Patients in the control group received rehabilitation training (RT) for 2 weeks; each session was 30 min, 1 time per day, and 5 times per week. Patients in the observation group were additionally given Bo’s abdominal acupuncture (BAA) with the same frequency and duration. The primary outcome was the change value in the VAS score from baseline to 2 weeks. The secondary outcomes measured were motor function of the upper limb, shoulder range of motion, ADL, and swelling volume. Results: Compared with baseline values, the mean VAS score at 2 weeks was reduced by 3.68 in the observation group and by 1.92 in the control group, with a difference between the two groups of 1.84 (P < 0.001); the mean MBI score at 2 weeks increased by 10.44 in the observation group and by 4.79 in the control group, with a difference between the two groups of 5.84 (P = 0.032); the mean swelling volume at 2 weeks decreased by 9.64 in the observation group and by 3.29 in the control group, with a difference between the two groups of 6.48 (P < 0.001). BAA-related adverse events were not found during the study. Conclusions: BAA combined with RT is superior to RT alone in improving shoulder pain, swelling, and ADL in post-stroke SHS patients. Trial Registration: ChiCTR2100045464 (www.chictr.org.cn).

Adaptive Bipartite Output Containment Control of Heterogeneous Multi-agent Systems Based on Output Regulation Approach

Jie Cheng,Xisheng Zhan,Jie Wu,Huaicheng Yan 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.1

In this paper, the adaptive bipartite output containment problem is investigated, for a signed graph of heterogeneous multi-agent systems (HMASs). An adaptive state feedback algorithm and an output feedback algorithm are designed to ensure that cooperative and antagonistic agents enter different convex hull. A novel protocol is proposed for heterogeneous systems to deal with the bipartite output containment problem, where only the leader’s neighbours can learn the leader’s system matrix without all followers. Then, based on output regulation approach, Lyapunov stability analysis and some other methods guarantee that the bipartite output containment control problem is implemented. Finally, the validity of our analytical results is verified by the numerical simulations provided.

Phenol Removal Performance and Mechanism Using Catalytic Ozonation with the Catalyst of Cobalt-doped α-MnO2

Jie Zhang,Ben Dong,Ying Han,Xiaocui Zhan,Sijie Ge,Shilong He 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.3

In this paper, Cobalt-doped α-MnO2 (i.e., Co-α-MnO2) were synthesized through hydrothermal method. Phenol was employed as targeted pollutants to investigate the catalytic ozonation performance of Co-α-MnO2. Results showed that Co-α-MnO2 significantly improved the phenol removal increased to 97.47 % after 40 min, which was 16.46 %, 38.92 % higher than that of α-MnO2 catalytic ozonation and single ozonation without catalyst. Additionally, the physicochemical properties of α-MnO2 and Co-α-MnO2 were analyzed using technologies such as XRD, TEM, BET and XPS. Compared to α-MnO2, Co-α-MnO2 has larger specific surface area (79.496 m2/g) and pore volume (0.0396 cm3/g), higher Mn3+ relative content (41.16 %) and adsorbed oxygen content (18.99 %). Also, the oxygen vacancy content, lattice defect content and surface hydroxyl content of Co-α-MnO2 are higher than that of α-MnO2, which could result in higher catalytic oxidation performance of Co-α-MnO2. The influence of masking agent showed that surface hydroxyl group, •OH and •O2− were involved in the catalytic ozonation of phenol. This study could help recognize the role of surface hydroxyl groups and active free radicals and demonstrate the contribution of reactive oxygen species on phenol removal in Co-α-MnO2 systems.

An Unstructured Kinetic Model to Study NaCl Effect on Volatile Ester Fermentation by Candida etchellsii for Soy Sauce Production

Jie Feng,Xiao-Bei Zhan,Dong Wang,Li-Min Zhang,Chi Chung Lin 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.2

Salt-tolerant aromatic yeast is an important microorganism arising from the solid state fermentation of soy sauce. The fermentation kinetics of volatile esters by Candida etchellsii was studied in a batch system. The data obtained from the fermentation were used for determining the kinetic parameters of the model. Batch experimental results at four NaCl levels (180, 200, 220, and 240 g/L) were used to formulate the parameter estimation model. The kinetic parameters of the model were optimized by specifically designed Runge-Kutta Genetic Algorithms (GA). The resulting mathematical model for volatile ester production, cell growth and glucose consumption simulates the experimental data well. The resulting new model was capable of explaining the behavior of volatile ester fermentation. The optimized parameters (μo, Xmax, Ki, α, β, YX/S, m, and YP/S) were characterized by a correlation of functions assuming salinity dependence. The kinetic models optimized by GA describe the batch fermentation process adequately, as demonstrated by our experimental results.

Clinical Study on Safety and Efficacy of Qinin^® (Cantharidin Sodium) Injection Combined with Chemotherapy in Treating Patients with Gastric Cancer

Zhan, Yi-Ping,Huang, Xin-En,Cao, Jie,Lu, Yan-Yan,Wu, Xue-Yan,Liu, Jin,Xu, Xia,Xu, Lin,Xiang, Jin,Ye, Li-Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objectives: To assess the efficacy, side effects, and the impact on quality of life with $Qinin^{(R)}$ (Cantharidin sodium) injection combined with chemotherapy for gastric cancer patients. Method: A consecutive cohort of 70 patients were divided into two groups: experimental group with cantharidin sodium injection combined with chemotherapy, while the control group received chemotherapy alone. After more than two courses of treatment, efficacy, quality of life and side effects were evaluated. Results: The response rate of experimental group was not significantly different from that of the control group (P>0.05), but differences were significant in clinical benefit response and KPS score. In addition, gastrointestinal reactions and the incidence of leukopenia were lower than in the control group (P<0.05). Conclusions: $Qinin^{(R)}$ (Cantharidin sodium) injection combined with chemotherapy enhances clinical benefit response, improving quality of life of gastric cancer patients and reducing side effects of chemotherapy. Thus $Qinin^{(R)}$ (Cantharidin sodium) injection deserves to be further investigated in randomized control clinical trails.

MiR-124 regulates apoptosis in hypoxia-induced human brain microvessel endothelial cells through targeting Bim

Jie Pu,Yuan Long,Jian Zhou,Yanqiang Zhan,Xiaoyong Qin 한국응용생명화학회 2018 Applied Biological Chemistry (Appl Biol Chem) Vol.61 No.6

Human brain microvessel endothelial cells (HBMECs) are crucial for brain vascular repair and maintenance. The high-expressed expressions of micro- RNA-124 (miR-124) in brain have been investigated and revealed in many researches. In this work, we aimed to investigate the role of miR-124 in apoptosis of HBMECs and the underlying mechanism. Here, we found the lowexpressed miR-124 in hypoxia-induced HBMECs using qRT-PCR analysis. MiR-124 targeting 30-untranslated region (30-UTR) of Bim mRNA was predicted by Targetscan database. Importantly, the decreased miR-124 expression and increased Bim expression, an opposite trend, were obtained in hypoxia-induced HBMECs. The further confirmation of the correlation between miR-124 and Bim was conducted by miR-124 overexpression and dual luciferase reporter assays. The inhibitory role of miR- 124 in Bim expression was evidenced by results obtained from miR-124 overexpression analysis. Luciferase reporter assay further proved that miR-124 directly targeted the two conserved seed sites in the Bim 30-UTR. The inhibited apoptosis of HBMECs was observed under both miR-124 overexpression and Bim knockdown condition in flow cytometry analysis. Collectively, these findings outline that miR-124 regulates apoptosis in hypoxia-induced HBMECs through targeting Bim, providing a better understanding of the role of miR-124 in apoptosis of HBMECs.

Rhein lysinate decreases inflammation and adipose infiltration in KK/HlJ diabetic mice with non-alcoholic fatty liver disease

Jie Wei,Yong-Zhan Zhen,Ju Cui,Fa-Lin He,Tao Shen,Gang Hu,Xiao-Hong Ren,Yajun Lin 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7

The objective of this study was to investigate the protective effects of rhein lysinate (RHL) on the liver. Mice were divided into four groups: C57BL/J control, the KK/HlJ diabetic model, and 25 and 50 mg/kg/day RHLtreated KK/HlJ groups. The KK/HlJ diabetic mouse model was made by injecting STZ and feeding mice diabetic food. At 16 weeks, mice were sacrificed and their livers were harvested. The results indicated that compared with the C57BL/J control group, the body weights, liver weights and liver weight-to-body weight ratio were increased in KK/HlJ diabetic mice; however, these values were decreased following treatment with RHL. Compared with the C57BL/J control, KK/HlJ diabetic mice had a significantly lower level of SOD and GSH-px in their livers, but had a significantly higher level of MDA. However, these effects were ameliorated by RHL. Hepatic adipose infiltration was observed in KK/HlJ mice, but not in C57BL/J mice. RHL decreased the incidence of hepatic adipose infiltration and significantly decreased the expression of TNF-a, IL-6, NF-jB, SREBP-1c, and Fas, as well as the phosphorylation of NF-jB in the liver. In conclusion, RHL can improve hepatic function by decreasing hepatic adipose infiltration and the expression of inflammatory factors.

Silica Aerogel/Potassium Hexatitanate Whisker Composite Coated Fabric for Metallurgical Protective Clothing

Jie Wang,Mengling Wang,Liuxiang Zhan,Ni Wang 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1

Silica aerogel/potassium hexatitanate whisker composite coated fabric was successfully prepared by polyacrylate coating,which could further improve the thermal insulation property of the fabric and provide more efficient thermal protection. The results show that with the increase of the proportion of aerogel particles, the thermal insulation property of the coatedfabric first increases and then decreases. When the mass ratio of silica aerogel particles to potassium hexatitanate whisker is3:7, the composite coated fabric has the best thermal insulation performance with thermal conductivity of 0.232 W/(m·k). After the heat source irradiated the fabric, the temperature difference of the inner and outer of the coated fabric decreased by16.1 ℃ and 19.35 ℃, respectively, compared with the original fabric, and the composite coated fabric exhibited more than75% reflectivity in the near-infrared band. Also, in the test of resistance of the coated fabric to molten metal splash, afterthe coated fabric was poured with 250 g of molten aluminum, the surface of the coated fabric was not adhered by moltenaluminum, and the coated fabric was not burned through and remained intact in appearance, and the PVC film attached to theback of the coated fabric was not damaged, the surface texture of PVC film was clear, indicating that the composite coatedfabric has a good thermal protection effect.

Clinical Safety and Efficacy of Kanglaite^® (Coix Seed Oil) Injection Combined with Chemotherapy in Treating Patients with Gastric Cancer

Zhan, Yi-Ping,Huang, Xin-En,Cao, Jie,Lu, Yan-Yan,Wu, Xue-Yan,Liu, Jin,Xu, Xia,Xiang, Jin,Ye, Li-Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

Objective: To observe efficacy and side effects, as well as the impact on quality of life, of Kanglaite$^{(R)}$ (Coix Seed Oil) injections combined with chemotherapy in the treatment of advanced gastric cancer patients. Method: A consecutive cohort of 60 patients were divided into two groups: the experimental group receiving Kanglaite$^{(R)}$ Injection combined with chemotherapy and the control group with chemotherapy alone. After more than two courses of treatment, efficacy, quality of life and side effects were evaluated. Results: The response rate and KPS score of experimental group were significantly improved as compared with those of the control group (P<0.05). In addition, gastrointestinal reactions and bone marrow suppression were significantly lower than in the control group (P<0.05). Conclusions: Kanglaite$^{(R)}$ Injection enhanced efficacy and reduced the side effects of chemotherapy, improving quality of life of gastric cancer patients; use of Kanglaite$^{(R)}$ injections deserves to be further investigated in randomized control clinical trails.

Observer-based Adaptive Bipartite Time-varying Formation Tracking of Multi-agent System with Bounded Unknown Input

Xiaoyi Zhang,Jie Wu,Xisheng Zhan,Tao Han,Huaicheng Yan 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.12

In this paper, the bipartite time-varying formation tracking (BTVFT) problem is studied for multi-agent system (MAS) with the state of agents is unpredictable and a tracking leader of unknown bounded control input. Based on available states and unavailable states, a innovative kind of adaptive BTVFT protocols for MAS is respectively proposed in this article. Then by using Lyapunov stability theory, the result implies that under the appropriate assumptions, one group of followers will trace the leader agent and achieve given formation, while another group of followers will accomplish a given formation at the opposite to the origin. Furthermore, simulation example is represented to validate the performance and effectiveness of the design techniques.