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Lu-Lu Zhang,Yi-Yang Li,Jiang Hu,Guan-Qun Zhou,Lei Chen,Wen-Fei Li,Ai-Hua Lin,Jun Ma,Zhen-Yu Qi,Ying Sun 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4
Purpose Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT). Materials and Methods Retrospective study of 415 Chinese patients with non-metastatic T4 NPC treated with definitive IMRT with or without chemotherapy at our cancer center between October 2009 and September 2013. The nomogram for LRFS at 3 and 5 years was generated based on multivariate Cox proportional hazards regression, and validated using bootstrap resampling, assessing discriminative performance using the concordance index (C-index) and determining calibration ability via calibration curves. Results Five-year LRFS was 88.8%. We identified and incorporated four independent prognostic factors for LRFS: ethmoid sinus invasion, primary gross tumor volume, age, and pretreatment body mass index. The C-index of the nomogram for local recurrence was 0.732 (95% confidence interval, 0.726 to 0.738), indicating excellent predictive accuracy. The calibration curve revealed excellent agreement between nomogram-predicted and observed LRFS probabilities. Risk subgroups based on total point score cutoff values enabled effective discrimination of LRFS. Conclusion This pretreatment nomogram enables clinicians to accurately predict LRFS in T4 NPC after definitive IMRT, and could help to facilitate personalized patient counselling and treatment strategies.
Chen Lu,Zhiwei Yu,Shuiming Li,Dagang Lu,Jian Liu 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.4
This paper performs the research on failure mechanism of single-layer steel reticulated domes with the reinforced concrete substructure subjected to sever earthquakes. Based on ABAQUS, this paper built user-defined material subroutines of the steel and the reinforced concrete, which took material non-linearity and the material damage accumulation into consideration. The failure mechanism of reticulated domes with reinforced concrete substructures under severe earthquakes is studied by the nonlinear dynamic response analysis. Three different failure modes of single-layer reticular domes with different sizes of reinforced concrete substructure are illustrated. Failure criterion is put forward to discriminate the failure modes and to estimate the critical load strength for single-layer reticular domes based on the structural damage theory. It has been found that reinforced concrete substructure has significant impact on the failure behaviors and the critical load of reticulated domes under seismic loads. It is essential to consider the influence of the reinforced concrete substructure upon the failure behaviors in the structural analysis and design process of reticular domes.
Lu-xi Chen,Hang-kai Pan,Yu-tian Tao,Dang Yang,Hui-min Deng,Kai-jie Xu,Wen-bin Chen,Jun-min Li 한국식물병리학회 2022 Plant Pathology Journal Vol.38 No.5
Thunberg fritillary (Fritillaria thunbergii), a perennial used in traditional Chinese herbal medicine, is a members of the family Liliaceae. The degeneration of germplasm is a severe problem in the production of Fritillaria thunbergii var. chekiangensis. However, no information about viral infections of F. thunbergii var. chekiangensis has been reported. In this study, we sequenced the small RNAs of F. thunbergii var. chekiangensis from leaves and bulbs, and viruses were identified using a phylogenetic analysis and BLAST search for sequence. In addition, multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) was used to rapidly detect viruses in this variety. Our study first reported that five viruses infected F. thunbergii var. chekiangensis. Among them, fritillary virus Y (FVY), lily mottle virus (LMoV), Thunberg fritillary mosaic virus (TFMV), and hop yellow virus (HYV) had been reported in F. thunbergii, while apple stem grooving virus was first reported in the genus Fritillaria. A multiplex RT-PCR method was developed to rapidly test the four viruses FVY, LMoV, TFMV, and HYV in F. thunbergii var. chekiangensis. Our results provide a better understanding of the infection of F. thunbergii var. chekiangensis by viruses and a basic reference for the better design of suitable control measures.
Yu-Hsuan Lu,Dan Chen,Sheng-Fu Hsiao,Ching-Jan Chen,Hung-Shou Nien 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
In recent years, the ripple-based constant on-time (RBCOT) control scheme for voltage regulators has been adopted in many applications because of its high efficiency feature under light-load conditions. However, a RBCOT control suffers from output-voltage offset problem. Therefore, an offset correction circuit (OC) is often added to the basic RBCOT scheme to correct the problem. In the OC circuit, there is a RC filter. The size of this RC filter not only affects the circuit stability and converter transient responses but also directly affects the controller chip size/cost. The main focus of the present paper is to investigate the relationship between the RC filter value and the feedback stability so that RC value can be minimized while avoiding circuit instability. A time-domain analysis approach is proposed to model OCRBCOT scheme for a buck converter configuration. Experimental and simulation results are given for verification.
Computed Tomography Manifestations of Histologic Subtypes of Retroperitoneal Liposarcoma
Lu, Jing,Qin, Qin,Zhan, Liang-Liang,Yang, Xi,Xu, Qing,Yu, Jing,Dou, Li-Na,Zhang, Hao,Yang, Yan,Chen, Xiao-Chen,Yang, Yue-Hua,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Objective: Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20% of all mesenchymal malignancies, often occurring in deep soft tissue of retroperitoneal space. Accurate preoperative diagnosis is therefore necessary. We explored whether computed tomography (CT) could be used to differentiate between the various types of retroperitoneal liposarcoma (RPLS). Method: Forty-seven cases of RPLS, diagnosed surgically and histologically, were analyzed retrospectively. CT features were correlated with postoperative pathological appearance. Results: The study radiologist identified 29, 11, 2, 2 and 3 RPLS as atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL), dedifferentiated liposarcoma (DDL), myxoid/round cell liposarcoma (ML/RCL), pleomorphic liposarcoma (PL) and mixed-type liposarcoma. Analysis of CT scans revealed the following typical findings of the different subtypes of RPLS: ALT/WDL was mainly visible as a well-delineated fatty hypodense tumor with uniform density and integrity margin; DDL was marked by the combination of focal nodular density and hypervascularity. ML/RCL, PL and mixed liposarcoma showed malignant biological behaviour and CT findings need further studies. Conclusions: CT scanning can reveal important details including internal components, margins and surrounding tissues. Based on CT findings, tumor type can be roughly evaluated and biopsy location and therapeutic scheme guided.
Performance Analysis of Permanent Magnet Brushless Motors for Mobility Scooters
Yu-Chuan Lu,Ming-Yang Cheng,Chun-Hsien Wu,Wei-Chih Chen,Cheng-Hu Chen 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
Most modern commercial electric scooters are still equipped with the DC brush motor. This type of motor has mechanical structures such as permanent magnet, brush, and commutator. Therefore, it has attractive features, e.g., large start-up torque and easy to control. However, this kind of mechanical commutation often leads to drawbacks such as low power density, low reliability, and poor heat dissipation. In contrast, the Permanent Magnet Brushless Motors (PMBLMs) have advantages such as high efficiency and maintenance free, etc. Hence, the PMBLMs have great potential in becoming the actuators for electric scooters. In this paper, the performance of the PMBLMs with trapezoidal and sinusoidal back-emf waveforms driven by square wave commutation and sinusoidal commutation is investigated. To reduce the cost, low-resolution Hall sensors are used to implement sinusoidal commutation.
Xia Chen,Tingjie Lu,Longfei Guo,Yu Shen,Chenguang Wang 보안공학연구지원센터 2014 International Journal of Smart Home Vol.8 No.6
Some studies have shown that the attitude and intention of using mobile LBS is strongly influenced by the privacy factor. Since LBS bears prominent privacy attribute, our study selects the aggregation form based on Microblog content in the LBS of SinaMicroblog, namely, LBS Microblog, asthe object of study, acquires an actual Microblog user data sample of over 30,000 items, with over 8.64 million Microblog postings and 20 million Microblog re-postings of these users, conducts a contrastive research on the adoption behavior in LBS of users at Hub nodes and common nodes in social network through relative analysis, and discusses the diffusion rule of LBS through BASS model. The study finds that the structure attribute of users in social network has strong influence on the adoption rule of LBS; the adoption of different types of LBS by users is obviously in consistency; LBS is remarkably influenced by emergencies related to privacy.