옥탈리시스를 통해 메타버스 환경을 위한 참여형 브랜디드 연구 -글로벌 브랜드 중심으로-

웨이위한 ( Wei Yuhan ),이창욱 ( Lee Chang-wook ) 커뮤니케이션디자인학회 2022 커뮤니케이션 디자인학연구 Vol.78 No.-

코로나19 전파로 인해 기존의 오프라인 세상이 온라인 세상으로 빠르게 전환하고 있는 가운데 온라인 수업, 재택근무가 일상화되었으며 온라인을 통해 비대면으로 하고 있는 것이 점차 일상화되고 있다. 이런 변화를 타고 가상현실로 확장을 도모하는 메타보스에 대한 관심 또한 높아지고 있다. 또한 이런 사회 변화속에 브랜들과 기업들이 온라인 환경과 메타버스로 몰리고 있었다. 그리고 예전에 비해 기업들이나 브랜드들은 더 쉽게 자신들의 제품과 서비스를 그들에게 선보일 수 있는 것이다. 일반적인 단방향 소통방식대신 쌍방향의 참여형 브랜디드 방식을 적용하고 브랜디브하고 있었다. 본 연구에서 게이미피케이션이 흥미 유발하고 참여 유도 위주 글로벌 브랜드들이 메타버스 환경에서 게이미피케이션을 활용한 사례를 분석하여, 게임기법을 적용한 기업 및 브랜드가 온라인 및 모바일 콘텐츠 기획시 브랜드와 소비자 간 지속적인 상호작용과 자발적 참여를 이끌어내는 브랜디드 게이미피케이션 활용 방안을 제언하는 것을 목적으로 한다. 분석을 통해서 과거의 일반식 브랜디드 방식보다 현재 참여형 브랜디드는 어떻게 상대방과 소통하는지, 어떻게 참여하게 유도를 하는지 더 중요해지는 것으로 제시하였고, 참여형 브랜디드의 특징과 게이미피케이션 적용내용,그리고 주의해야 할점에 대해서 제시하고 앞으로 이런 디자인분야에 대해서 영감을 주고자 한다. While the existing offline world is rapidly shifting to the online world due to the spread of COVID-19, online classes and telecommuting have become commonplace, and non-face-to-face online is becoming increasingly commonplace. Interest in Metaboss, which seeks to expand into virtual reality through these changes, is also increasing. In addition, brands and companies are flocking to Metabus amid these social changes. Companies and brands can more easily introduce their products and services to them. Instead of a general one-way communication method, a two-way participatory brandy method was applied and branded. The purpose of this study is to analyze cases in which gamification induces interest and participation-oriented global brands use gamification in a metabus environment, suggesting ways to utilize branded gamification that attracts continuous interaction and voluntary participation between brands and consumers when planning online and brands. Through the analysis, it was suggested that the current participatory brandy becomes more important how to communicate with the other party and induce participation, and to present the characteristics of the participatory brandy, application of gamification, and to inspire these design fields in the future.

청소년의 태권도수련과 비행과의 관계

이병익,정위곤,이창호 龍仁大學校 武道硏究所 2002 武道硏究所誌 Vol.13 No.1

The purpose of this study is to analyze the The Influence of Participation in Taekwon-do Training on Juvenile Delinquency To accomplish the purpose of this study, the 321 subjects were selected using the systematic stratified cluster random sampling method from students who study in middle and high school in Seoul 2002. The Survey questionaries were used to collect data. The questionaries for Participation in Taekwon-do Training was Sport Participation and degree on Scale developed by Kenyon and Schuts(1970). And the questionaries for Juvenile Delinquency scale was Expansion developed by Jung(1988) and Lim(1986). The statistical methods utilized in this study for analyzing the collected data were reliability analysis, descriptive statistics, Chi-Square, t-test, One-way ANOVA, and standard multiple regression analysis. From the analysis of this study, the following conclusions were obtain:. Firstly, adolescent' Taedkwon-do Training participation and degree, juvenile delinquency are partially different by the socio-demographic characteristics. In detail, adolescent' Taekwon-do Training participation is different according to income, parent education level, parent job style. Secondly, adolescent' Taekwon-do Training participation are different according to juvenile delinquency. In detail, the Taekwon-do Training participation group are lower in the delinquency of family, school, and social life than the non-participation of Taekwon-do Training group Thirdly, Taekwon-do Training participation degree are partially influence on the juvenile delinquency. In detail, Taekwon-co Training participation frequence and strength effective adolescent' on the delinquency of family, school, and social life.

A Case Report of Efficacy of Growth Height and Peak-Luteinizing Hormone Level Suppression on Idiopathic Gonadotropin-Dependent Precocious Puberty Patient Using Herbal Remedy, Aesopjiyoun-tang

남세현,Chong-hai Lee1,Yu-wei Tang,Yuan-sheng Liu,Ki-chul Kim,Sang-yeol Chun,염유림,Hyung chang Kim,Myoung-deok Lee 대한한의학회 2015 대한한의학회지 Vol.36 No.4

The purpose of this report is to evaluate effect of Korean medical treatment on idiopathic gonadotropin-dependent precocious puberty (G-DPP) patient received herbal medicine. We administered Aesopjiyoun-tang remedy to idiopathic G-DPP and analyzed the delay effect by hormonal value and radiographs; the height growth effect by measurement of height. After Korean medical treatment, suppression effect to peak- Luteinizing Hormone level (LHL) is 14.39IU/L to 10.9IU/L for 13month, growth effect to height value is 11cm/13month; and change of mean growth velocity (MGV) is 6.08cm/year to 10.06cm/year. The gain in height by treatment is 3.98cm/year. The result suggests Aesopjiyoun-tang can be an effective treatment for G-DPP. Herbal medicine can be used as an alternative treatment in place of the GnRH treatment.

Synergistic Improvement in Insulin Resistance with a Combination of Fenofibrate and Rosiglitazone in Obese Type 2 Diabetic Mice

Choi, Woon-Seok,Lee, Jung-Jin,Kim, Yo-Han,Kim, In-Su,Zhang, Wei-Yun,Myung, Chang-Seon 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4

Peroxisome proliferator-activated receptor (PPAR) ${\alpha}$, which is abundant in the liver, increases lipoprotein lipase activity, resulting in a decrease of triglyceride (TG) levels. $PPAR{\gamma}$, which is abundant in adipose tissue, stimulates adipocyte differentiation and adipogenesis, and results in an increase in insulin sensitivity. Fenofibrate, a $PPAR{\alpha}$ agonist, is commonly used to treat dyslipidemia, and rosiglitazone, a $PPAR{\gamma}$ agonist, is effective in improving glycemic control. To examine the synergistic effects of rosiglitazone in combination with fenofibrate, an obese type 2 diabetes mellitus (DM) mouse model was established by the combined administration of streptozotocin and nicotinamide and fed on a high-fat diet (35% of energy as fat) for 3 weeks. The mice had significantly higher plasma glucose concentrations and insulin resistance, as examined by an oral glucose tolerance test and insulin challenge test compared with normal mice. After establishing a dose-response curve for each drug, the drugs were orally administered for 3 weeks either alone or in combination. After individual administration of fenofibrate, HDL cholesterol levels significantly increased, and plasma glucose and TG levels decreased in obese type 2 DM mice. The individual administration of rosiglitazone showed increased insulin resistance (QUICKI). However, HDL cholesterol and TG levels were not significantly changed. In a combination of fenofibrate at 25 mg/kg and rosiglitazone at 1.25 mg/kg there was a decrease in plasma glucose and TG levels, and a combination of fenofibrate at 50 mg/kg and rosiglitazone at 2.5 mg/kg showed an increase in plasma HDL cholesterol levels. Moreover, parameters related to insulin resistance (HOMA-IR) and insulin sensitivity (QUICKI) were improved significantly. Thus, our results show that combination therapy with lower doses of fenofibrate and rosiglitazone ameliorates the type 2 DM condition to a greater extent than high doses of either individual monotherapy.

Maskless lithography 응용을 위한 마이크로렌즈 어레이 개발

남민우,오해관,김근영,서현우,위창현,송요탁,양상식,이기근,Nam, Min-Woo,Oh, Hae-Kwan,Kim, Geun-Young,Seo, Hyun-Woo,Wei, Chang-Hyun,Song, Yo-Tak,Yang, Sang-Sik,Lee, Kee-Keun 한국마이크로전자및패키징학회 2009 마이크로전자 및 패키징학회지 Vol.16 No.4

마스크리스 리소그래피(maskless lithography)에 응용하기 위한 마이크로렌즈 어레이(microlens array, MLA)가 석영의 습식 식각과 UV 접착제(UV adhesive)의 코팅을 바탕으로 개발되었다. 제작된 MLA의 초점거리는 ${\sim}45\;{\mu}m$ 정도였으며, 집광되는 광선의 초점은 ${\sim}1\;{\mu}m$로 측정되었다. MLA를 통과하며 초점을 맺은 빔(beam)의 크기 및 세기가 charge coupled device (CCD) 카메라와 빔 프로파일러(beam profiler)를 이용하여 각각 측정되었으며, 일정한 세기의 점들이 초점면에서 고르게 관찰되었다. 초점거리는 코팅된 UV 접착제의 두께에 따라 변화하였으며, UV 접착제의 두께가 두꺼울수록 짧아지는 경향을 보였다. 일반적인 마스크 얼라이너(mask aligner)를 이용한 MLA의 UV 포커싱(UV focusing)이 감광막(photoresist, PR) 상에서 실시되었으며, MLA를 통과한 빛이 감광막 위에 일정하게 집광되었다. 마스크 얼라이너와 MLA 사이의 거리 변화에 따라 감광막에 구현된 패턴 사이즈가 조절 되었다. 고온에서 오랜 시간이 지난 후에도 소자의 특성은 전혀 변함이 없었다. A microlens array (MLA) was developed based on the wet-etched quartz substrate and coating of UV adhesive on the substrate for maskless lithography application. The developed MLA has the focal length of ${\sim}45\;{\mu}m$ and the spot size of ${\sim}1\;{\mu}m$. The spot size of the focused beam passing through the MLA was detected by CCD camera, and its intensity was monitored by beam profiler. Uniform spots with nearly identical intensities were observed on the focal plane when a beam passes through the fabricated MLA. The focal length was varied depending on thickness of the coated UV adhesive. The thicker the thickness of the UV adhesive was, the shorter the focal length of the MLA was. With a general mask aligner, UV beam focusing was tested onto photoresist (PR). The beams were well focused onto PR when UV passes through the MLA. Depending on the variable distances from the MLA, beam sizes onto PR were controlled. Even at high temperature for a long time, the performances of the MLA were not changed.

Aerosol Effects on Instability, Circulations, Clouds, and Precipitation

Lee, Seoung-Soo,Tao, Wei-Kuo,Jung, Chang-Hoon Hindawi Limited 2014 Advances in meteorology Vol.2014 No.-

<P>It is well known that increasing aerosol and associated changes in aerosol-cloud interactions and precipitation since industrialization have been playing an important role in climate change, but this role has not been well understood. This prevents us from predicting future climate with a good confidence. This review paper presents recent studies on the changes in the aerosol-cloud interactions and precipitation particularly in deep convective clouds. In addition, this review paper discusses how to improve our understanding of these changes by considering feedbacks among aerosol, cloud dynamics, cloud and its embedded circulations, and microphysics. Environmental instability basically determines the dynamic intensity of clouds and thus acts as one of the most important controls on these feedbacks. As a first step to the improvement of the understanding, this paper specifically elaborates on how to link the instability to the feedbacks.</P>

Drug Synergism of Antihypertensive Action in Combination of Telmisartan with Lercanidipine in Spontaneous Hypertensive Rats

Lee, Jung-Jin,Shin, Chang-Yong,Park, Hong-Joon,Zhang, Wei-Yun,Kim, Yo-Han,Kim, In-Su,Lee, Kyu-Hyun,Myung, Chang-Seon 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.9

To examine drug synergism between angiotensin II AT1-receptor blocker and Ca2+ channel blocker for lowering blood pressure (BP), telmisartan and lercanidipine were orally injected into to telemetered-spontaneous hypertensive rats and BP was monitored. The highest doses of both drugs (7.66 mg/kg of telmisartan and 1.92 mg/kg of lercanidipine) were clinically relevant at 80 and 20 mg human equivalent doses, respectively, and denoted as dose 1. After constructing the dose-response curve using 0 (vehicle-treated control), 1/16, 1/8, 1/4, 1/2 and 1 doses, all possible combinations of both drugs were tested. Drug synergism in combination therapy of telmisartan with lercanidipine was assessed by calculating the interaction index (${\gamma}$) as evaluated by ${\gamma}$ < 1. We found statistically significant drug synergism in the investigated (telmisartan: lercandipine) combinations of (1/8:1/4), (1/4:1) and (1/8:1). Our results suggest that the combination therapy of telmisartan and lercanidipine at lower doses are effective in lowering BP, and also reduce side effects caused by maximal doses of each drug. Therefore, drug combination of AT1-receptor blocker with $Ca^{2+}$ channel blocker is a clinically important tool for the management of hypertension and hypertension-related cardiovascular risks.

SF?와 제조공기(I-Air)의 압력별 절연파괴특성 비교

이창욱(Chang-Wook Lee),김영수(Young-Su Kim),方亞偉(Ya-Wei Fang),이창훈(Chang-Hun Lee),김도석(Do-Seok Kim),常超(Chao Chang),최은혁(Eun-Hyuck Choi),임창호(Chang-Ho Lim),이광식(Kwang-Sik Lee) 한국조명·전기설비학회 2006 한국조명·전기설비학회 학술대회논문집 Vol.2006 No.11월

본 연구는 현재 전력설비에 사용되고 있는 SF?가스의 대체 절연가스로 제조공기(Ⅰ-Air)의 절연파괴특성 연구를 위하여 모의 GIS 챔버와 AC 300[㎸] 전원장치로 교류전압을 인가하여 연구를 수행하였다. 침 전극 대 평판전극을 이용하여 SF?가스와 I-Air의 절연내력을 비교하기 위해서 3, 4 및 5[atm]까지 가스의 압력변화를 주었고 각 압력별 전극간거리(d)에 따른 절연파괴전압(V<SUB>B</SUB>)을 연구하였다.

P008 Inhibition of collagen synthesis by a small molecule tankyrase inhibitor IWR in fibroblasts

( Ming-wei Zhou ),( Cho-ah Lim ),( Hae-eul Lee ),( Myung Im ),( Young Lee ),( Chang Deok Kim ),( Young-joon Seo ),( Jeung-hoon Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Keloid is a benign tumor that is characterized by the hyperproliferation of dermal fibroblasts and excessive deposition of extracellular matrix (ECM) especially the collagen. Aberrant activation of Wnt/β-catenin signaling is implicated in the pathogenesis of keloid. Objectives: We investigated the effects of IWR-1, a small molecule inhibitor for Wnt/β-catenin signaling via the inhibition of tankyrase, on production of collagen and matrix metalloproteinase (MMP) in dermal fibroblasts. Methods: We cultured human normal skin- and keloid-derived fibroblasts, then treated with IWR-1. The effects of IWR-1 on collagen and MMP production were determined by Western blot, ELISA and zymography. Results: IWR-1 significantly suppressed the proliferation and migration of both the normal and keloid fibroblasts. IWR-1 also inhibited the production and secretion of type I collagen from the fibroblasts. In addition, IWR-1 significantly increased the expression of MMPs, such as MMP-1, MMP-3 and MMP-13, along with the increase of gelatinase activity. These results suggest that inhibitory effect of IWR-1 on collagen production may be related with the increased MMP activity. Conclusion: These results provide evidence that IWR-1 can be a possible candidate to be developed as a therapeutics for keloid.

ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment

Po-Wei Lee,Tzu-Yun Wang,Yun-Hsuan Chang,Sheng-Yu Lee,Shiou-Lan Chen,Ze-Cheng Wang,Po See Chen,Chun-Hsien Chu,San-Yuan Huang,Nian-Sheng Tzeng,I Hui Lee,Kao Chin Chen,Yen Kuang Yang,Jau-Shyong Hong,Ru-B 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2 ) gene has been associated with OUD and ALDH2 gene polymorphisms may affect aldehyde metabolism and cognitive function in other substance use disorder. Therefore, we aimed to investigate whether ALDH2 genotypes have significant effects on neuropsychological functions in OUD patients undergoing methadone maintenance therapy (MMT). Methods: OUD patients undergoing MMT were investigated and followed-up for 12 weeks. ALDH2 gene polymorphisms were genotyped. Connors’ Continuous Performance Test (CPT) and the Wechsler Memory Scale-Revised (WMS-R) were administered at baseline and after 12 weeks of MMT. Multivariate linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the ALDH2 genotypes and performance on the CPTs and WMS-R. Results: We enrolled 86 patients at baseline; 61 patients completed the end-of-study assessments. The GEE analysis showed that, after the 12 weeks of MMT, OUD patients with the ALDH2 *1/*2+*2/*2 (ALDH2 inactive) genotypes had significantly higher commission error T-scores (p = 0.03), significantly lower hit reaction time T-scores (p = 0.04), and significantly lower WMS-R visual memory index scores (p = 0.03) than did patients with the ALDH2 1 */*1 (ALDH2 active) genotype. Conclusion: OUD patients with the ALDH2 inactive genotypes performed worse in cognitive domains of attention, impulse control, and memory than did those with the ALDH2 active genotype. We conclude that the ALDH2 gene is important in OUD and is associated with neuropsychological performance after MMT.