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Lim, Byungho,Mun, Jihyeob,Kim, Yong Sung,Kim, Seon-Young American Association for Cancer Research 2017 Cancer Research Vol.77 No.11
<P>These findings increase our knowledge surrounding mutational processes and the identification of cancer type-specific mutations within the tissue-specific epigenomic landscape.</P><P>Dynamic chromatin structures result in differential chemical reactivity to mutational processes throughout the genome. To identify chromatin features responsible for mutagenesis, we compared chromatin architecture around single-nucleotide variants (SNV), insertion/deletions (indels), and their context-matched, nonmutated positions. We found epigenetic differences between genomic regions containing missense SNVs and those containing frameshift indels across multiple cancer types. Levels of active histone marks were higher around frameshift indels than around missense SNV, whereas repressive histone marks exhibited the reverse trend. Accumulation of repressive histone marks and nucleosomes distinguished mutated positions (both SNV and indels) from the context-matched, nonmutated positions, whereas active marks were associated with substitution- and cancer type–specific mutagenesis. We also explained mutagenesis based on genome maintenance mechanisms, including nucleotide excision repair (NER), mismatch repair (MMR), and DNA polymerase epsilon (POLE). Regional NER variation correlated strongly with chromatin features; NER machineries exhibited shifted or depleted binding around SNV, resulting in decreased NER at mutation positions, especially at sites of recurrent mutations. MMR-deficient tumors selectively acquired SNV in regions with high active histone marks, especially H3K36me3, whereas POLE-deficient tumors selectively acquired indels and SNV in regions with low active histone marks. These findings demonstrate the importance of fine-scaled chromatin structures and associated DNA repair mechanisms in mutagenesis. <I>Cancer Res; 77(11); 2822–33. ©2017 AACR</I>.</P>
Lim, Byungho,Jin, Jaewon,Yoo, Jin,Han, Seung Yong,Kim, Kyeongyeol,Kang, Sungah,Park, Nojin,Lee, Sang Moon,Kim, Hae Jin,Son, Seung Uk The Royal Society of Chemistry 2014 Chemical communications Vol.50 No.57
<P>Very thin microporous organic networks were formed on the surface of Fe<SUB>3</SUB>O<SUB>4</SUB> nanospheres by Sonogashira coupling of tetra(4-ethynylphenyl)methane and 1,4-diiodobenzene. The thickness was controlled by screening the number of building blocks. Through carbonization, Fe<SUB>3</SUB>O<SUB>4</SUB>@C composites were prepared. The Fe<SUB>3</SUB>O<SUB>4</SUB>@C composites with 4–6 nm carbon thickness showed promising reversible discharge capacities of up to 807 mA h g<SUP>−1</SUP> and enhanced electrochemical stability.</P> <P>Graphic Abstract</P><P>Fe<SUB>3</SUB>O<SUB>4</SUB>@C composites obtained <I>via</I> carbonization of microporous organic networks showed promising discharge capacities of up to 807 mA h g<SUP>−1</SUP> and electrochemical stability. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc02068e'> </P>
Lim, Byungho,Ju, Hyoungseok,Kim, Minjin,Kang, Changwon Wiley Subscription Services, Inc., A Wiley Company 2011 Cancer Vol.117 No.22
<P><B>Abstract</B></P><P><B>BACKGROUND:</B></P><P>The runt‐related transcription factor RUNX3 plays essential roles in various types of tumors, including gastric cancer. Epigenetic changes in the methylation of the <I>RUNX3</I> proximal promoter, but not common genetic changes in <I>RUNX3</I>, have been associated with both changes in the gene expression and development of the cancer.</P><P><B>METHODS:</B></P><P>A case‐control association study was conducted by genotyping 865 unrelated Korean subjects. Subsequent functional studies were performed to reveal functional implication of genetic association.</P><P><B>RESULTS:</B></P><P>Several single‐nucleotide polymorphisms (SNPs) in <I>RUNX3</I> were significantly associated with susceptibility to intestinal‐type gastric cancer (.0028 ≤ <I>P</I> ≤ .022) but not diffuse‐type gastric cancer (.70 ≤ <I>P</I> ≤ .96). The risk‐associated, minor variant of an intestinal‐type gastric cancer‐associated SNP in the <I>RUNX3</I> distal promoter (rs7528484) significantly increased promoter activity in a CREB1‐dependent manner. The distal promoter‐derived, 33 kDa isoform of RUNX3 increased the activity of transcription factor nuclear factor kappa B (NF‐κB), which had been activated by <I>Helicobacter pylori</I> infection, a risk factor for intestinal‐type gastric cancer, and the expression of the interleukin‐1β gene (<I>IL1B</I>), an NF‐κB target genetically and functionally associated with gastric cancer. In contrast, the proximal promoter‐derived, 44 kDa isoform of RUNX3 decreased both NF‐κB activity and <I>IL1B</I> expression.</P><P><B>CONCLUSIONS:</B></P><P>In addition to epigenetic changes in the <I>RUNX3</I> proximal promoter, genetic changes in the distal promoter may be associated with susceptibility to intestinal‐type gastric cancer by increasing promoter activity. Functionally, 2 RUNX3 isoforms may contribute differentially to intestinal‐type gastric cancer susceptibility, at least in part through regulating NF‐κB activity and <I>IL1B</I> expression Cancer 2011;. © 2011 American Cancer Society.</P>
Lim Daesung,Park Song Yi,Choi Byungho,Kim Sun Hyu,류지호,Kim Yong Hwan,Sung Ae Jin,Bae Byung Kwan,Kim Han Byeol 대한의학회 2021 Journal of Korean medical science Vol.36 No.36
Background: Since the declaration of the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 has affected the responses of emergency medical service (EMS) systems to cases of out-of-hospital cardiac arrest (OHCA). The purpose of this study was to identify the impact of the COVID-19 pandemic on EMS responses to and outcomes of adult OHCA in an area of South Korea. Methods: This was a retrospective observational study of adult OHCA patients attended by EMS providers comparing the EMS responses to and outcomes of adult OHCA during the COVID-19 pandemic to those during the pre-COVID-19 period. Propensity score matching was used to compare the survival rates, and logistic regression analysis was used to assess the impact of the COVID-19 pandemic on the survival of OHCA patients. Results: A total of 891 patients in the pre-COVID-19 group and 1,063 patients in the COVID-19 group were included in the final analysis. During the COVID-19 period, the EMS call time was shifted to a later time period (16:00–24:00, P < 0.001), and the presence of an initial shockable rhythm was increased (pre-COVID-19 vs. COVID-19, 7.97% vs. 11.95%, P = 0.004). The number of tracheal intubations decreased (5.27% vs. 1.22%, P < 0.001), and the use of mechanical chest compression devices (30.53% vs. 44.59%, P < 0.001) and EMS response time (median [quartile 1-quartile 3], 7 [5–10] vs. 8 [6–11], P < 0.001) increased. After propensity score matching, the survival at admission rate (22.52% vs. 18.24%, P = 0.025), survival to discharge rate (7.77% vs. 5.52%, P = 0.056), and favorable neurological outcome (5.97% vs. 3.49%, P < 0.001) decreased. In the propensity score matching analysis of the impact of COVID-19, odds ratios of 0.768 (95% confidence interval [CI], 0.592–0.995) for survival at admission and 0.693 (95% CI, 0.446–1.077) for survival to discharge were found. Conclusion: During the COVID-19 period, there were significant changes in the EMS responses to OHCA. These changes are considered to be partly due to social distancing measures. As a result, the proportion of patients with an initial shockable rhythm in the COVID-19 period was greater than that in the pre-COVID-19 period, but the final survival rate and favorable neurological outcome were lower.
임해영(Lim, Hae Young),이병호(Lee, Byungho),윤현준(Yoon, Hyunjun) 서강대학교 생명문화연구소 2021 생명연구 Vol.61 No.-
본 연구는 마약류 중독자에 관한 사회적 인식이 어떻게 표상되고 있는지를 파악하고, 이것에 대해 사회복지 실천 분야에서 어떠한 사회적 노력이 필요할 지에 대한 유용한 시사점을 도출하는 데 목적이 있다. 이를 위해 본 연구는 인터넷 뉴스기사에 대한 질적 내용분석을 중심으로 특정한 개념과 주제를 도출하는 사건단위 분석법을 실시하였다. 분석 결과, 마약류 중독자에 대한 ‘중독발생 원인에 대한 인식’, ‘중독자에 대한 사회적 인식’, ‘중독자에 대한 감정적 인식’, ‘중독자에 대한 차별적 인식’, ‘중독자에 대한 온정주의적 인식’이란 5가지 주제 영역에서 개념들과 하위 주제를 도출할 수 있었다. 위와 같은 연구 결과를 토대로 사회복지실천 분야에서 숙고될 수 있는 몇 가지 논의 점을 제시하였다. The purpose of this study is to understand how social perceptions about drug addicts are represented, and to draw useful implications for what kind of social effort is needed in the field of social welfare practice. To this end, this study conducted an event-based analysis method that derives specific concepts and topics with a focus on qualitative content analysis of Internet news articles. As a result of the analysis, perception of the causes of addiction , social perception of addicts , emotional perception of addicts , discriminatory perception of addicts , paternalistic perceptions of addicts 5 Concepts and sub-topics could be derived from several subject areas. Based on the above research results, some points of discussion that can be considered in the field of social welfare practice are presented.