Analysis of disease-resistant markers with cross-combination for breeding of Korean native chicken

Boyeong Park(박보영),Anh Duc Truong,Cong Thanh Hoang,Jihye Ban,Yeojin Hong,Yeong Ho Hong 한국가금학회 2015 한국가금학회 정기총회 및 학술발표회 Vol.2015 No.11

Urbanization of Scrub Typhus Disease in South Korea

Park, Sang-Won,Ha, Na-Young,Ryu, Boyeong,Bang, Ji Hwan,Song, Hoyeon,Kim, Yuri,Kim, Gwanghun,Oh, Myoung-don,Cho, Nam-Hyuk,Lee, Jong-koo Public Library of Science 2015 PLoS neglected tropical diseases Vol.9 No.5

<▼1><P><B>Background</B></P><P>Scrub typhus is an endemic disease in Asia. It has been a rural disease, but indigenous urban cases have been observed in Seoul, South Korea. Urban scrub typhus may have a significant impact because of the large population.</P><P><B>Methods</B></P><P>Indigenous urban scrub typhus was epidemiologically identified in Seoul, the largest metropolitan city in South Korea, using national notifiable disease data from 2010 to 2013. For detailed analysis of clinical features, patients from one hospital that reported the majority of cases were selected and compared to a historic control group. Chigger mites were prospectively collected in the city using a direct chigger mite-collecting trap, and identified using both phenotypic and 18S rDNA sequencing analyses. Their infection with <I>Orientia tsutsugamushi</I> was confirmed by sequencing the 56-kDa antigen gene.</P><P><B>Results</B></P><P>Eighty-eight cases of urban scrub typhus were determined in Seoul. The possible sites of infection were mountainous areas (56.8%), city parks (20.5%), the vicinity of one’s own residence (17.0%), and riversides (5.7%). Eighty-seven chigger mites were collected in Gwanak mountain, one of the suspected infection sites in southern Seoul, and seventy-six (87.4%) of them were identified as <I>Helenicula miyagawai</I> and eight (9.2%) as <I>Leptotrombidium scutellare</I>. Pooled DNA extracted from <I>H</I>. <I>miyagawai</I> mites yielded <I>O</I>. <I>tsutsugamushi</I> Boryong strain. Twenty-six patients from one hospital showed low APACHE II score (3.4 ± 2.7), low complication rate (3.8%), and no hypokalemia.</P><P><B>Conclusions</B></P><P>We identified the presence of indigenous urban scrub typhus in Seoul, and a subgroup of them had mild clinical features. The chigger mite <I>H</I>. <I>miyagawai</I> infected with <I>O</I>. <I>tsutsugamushi</I> within the city was found. In endemic area, urban scrub typhus needs to be considered as one of the differential febrile diseases and a target for prevention.</P></▼1><▼2><P><B>Author Summary</B></P><P>Scrub typhus is one of the high burdened infectious diseases in endemic rural areas. Our study showed that the disease could be endemic in urban areas. Indigenous urban scrub typhus may also have significant impact in terms of a disease burden and differential diagnosis. A low rate of characteristic eschar and skin rash may make the clinical suspicion more troublesome. Scrub typhus is the 3<SUP>rd</SUP> most frequent notifiable infectious disease in South Korea. Seoul is a densely populated capital city located in northwestern South Korea. We epidemiologically identified indigenous urban cases. A subgroup of them showed mild clinical characteristics. Direct mite collection from a suspected infection site, Mt. Gwanak in Seoul, showed that <I>Helenicula miyagawai</I> (87.4%) and <I>Leptotrombidium scutellare</I> (9.2%) were the dominant species. In addition, <I>O</I>. <I>tsutsugamushi</I>-specific gene, <I>tsa56</I>, was identified in a fraction of the collected <I>H</I>. <I>miyagawai</I>. The 18S rDNA sequencing of the chigger mites was complementarily helpful for the differentiation of species. Our data are from one region, but urban scrub typhus is likely a scenario in endemic areas. Urban areas should be included as possible locations for scrub typhus.</P></▼2>

부산시 인구수 분석 및 예측

박보영(BoYeong Park) 한국정보과학회 2022 한국정보과학회 학술발표논문집 Vol.2022 No.06

텍스트마이닝을 활용한 이주 관련 연구동향 분석

서보영 ( Boyeong Seo ),박현재 ( Hyunchae Park ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.4

본고는 이주, 이민, 유학생, 다문화 등 13개의 관련 중요 키워드를 선택하여, 검색을 통해 수집된 총 14,302건의 논문을 대상으로 텍스트마이닝 분석을 통해 이주 관련 연구 동향을 분석하고자 하였다. 연구의 결과, 첫째, 이주 관련 논문은 2010년 이후 매우 활발하게 연구되고 있다. 둘째, 이주 관련 주요 연구기관은 지방 거점국립대를 제외하고, 수도권에 집중되어 있다. 셋째, 학문 주제분야별로 살펴보면, 교육학과 문학 분야에서 이주 관련 연구를 많이 하고 있다. 넷째, 텍스트마이닝 분석 결과 최근 20년 동안 다문화, 교육, 이주, 결혼, 여성에 관한 연구가 가장 활발하게 진행되고 있다. 다섯째, 과거 10년 대비 2011년부터 2020년까지 최근 10년간의 연구 동향을 비교 분석한 결과, 유학생, 청소년, 인식, 사례, 난민 연구가 활성화되고 있음을 확인하였다. 본고는 이주관련 연구의 학술적 동향을 심층 분석함으로써, 연구자들의 향후 후속 연구에 많은 도움을 줄 수 있을 것으로 기대한다. In order to analyze the research trends related to migration, this paper selects 13 important related keywords and collects all the papers through a search in the KCI (Korean journal citation index). Total 14,302 papers were finally collected for text mining methodology. The main results of the analysis are as follows. First, the research related to migration is actively started since 2010. Second, major research institutes related to migration are located in capital regions. Third, as per academic subject areas, many studies related to migration were conducted in the fields of pedagogy and literature. Fourth, as a result of text mining analysis, main keywords of the study are multi-culturalism, education, migration, marriage, and women. Fifth, during recent 10 years, the studies related to international students, adolescents, perceptions, case studies and refugee have become more active. This study is analyzed current academic trends so it will be really helpful for researchers to consider future research topics.

Characterization of morphological changes of B16 melanoma cells under natural killer cell attack

Kim, Ji Sung,Kim, Boyeong,Lee, Hong Kyung,Kim, Hyung Sook,Park, Eun Jae,Choi, Yeo Jin,Ahn, Gi Beom,Yun, Jieun,Hong, Jin Tae,Kim, Youngsoo,Han, Sang-Bae Elsevier 2019 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.67 No.-

<P><B>Abstract</B></P> <P>Natural killer (NK) cell killing of melanoma cells involves perforin-mediated delivery of granzymes from NK cells to cancer cells; however, how melanoma cells die remains poorly characterized. Here, we examined the dying process of melanoma cells by using time-lapse imaging. Upon contact with NK cells, B16-F10 cells rounded and most of them showed membrane rupture (98 min); however, B16 parent cells showed writhing and delayed membrane rupture (235 min). This morphological difference depended on the expression levels of myosin regulatory light chain 9 (MYL9) but not activating ligands (CD112, CD155, Rae-1, and MULT-1), SPI, FasL, or PD-L1. Taken together, our data show that melanoma cells show two distinct types of morphological changes upon contact with NK cells and suggest that a strategy to decrease MYL9 expression by melanoma cells may improve the efficacy of NK cell–based immunotherapy.</P>

포스터 전시회 : Modal Data 분석을 통한 실제도로 주행 배출가스 특성 평가

윤시훈 ( Sihoon Yune ),김보영 ( Boyeong Kim ),박준홍 ( Junhong Park ),차준표 ( Junpyo Cha ),전문수 ( Munsoo Chon ) 한국액체미립화학회 2015 한국액체미립화학회 학술강연회 논문집 Vol.2015 No.-

Recently, an emission test procedure with PEMS(Portable Emissions Measurement Systems) has been received a lot of attention as an effective means of controlling real-driving emissions from light-duty diesel vehicles. In the present study, on-road NOx emissions were measured for 1 kinds of Euro 6 Korean light-duty diesel vehicle for real driving conditions including urban, rural and motorway test routes. Real driving emission characteristics were evaluated with both MAW(Moving Averaging Window) and Modal Data.

Prediction of Dynamic Compaction Crater Depths by Artificial Intelligence Method

Ewusi-Wilson Rodney,Junghee Park,Boyeong Yoon,Woojin Lee,Changho Lee 대한토목학회 2021 대한토목학회 학술대회 Vol.2021 No.10

The novel chicken interleukin 26 protein is overexpressed in T cells and induces proinflammatory cytokines

Truong, Anh Duc,Park, Boyeong,Ban, Jihye,Hong, Yeong Ho BioMed 2016 VETERINARY RESEARCH Vol.47 No.-

<P>In the present study, we describe the cloning and functional characterization of chicken interleukin 26 (ChIL-26). ChIL-26, a member of the IL-10 cytokine family, induces the production of proinflammatory cytokines by T cells. The ChIL-26 cDNA encodes an 82-amino-acid protein whose amino acid sequence has 22.63, 46.31 and 43.15% homology with human IL-26, pig IL-26 and canary IL-26, respectively. ChIL-26 signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains, which are expressed primarily in the CU91 T cell line as well as CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T cells. Recombinant ChIL-26 protein induced Th1 cytokines (IL-16 and IFN-γ), Th2 cytokines (IL-4, IL-6 and IL-10), Th17 cytokines (IL-17A, IL-17D, and IL-17F), and chemokine transcripts (mainly CCL3, CCL4, CCL5, CCL20 and CXCL13) in the CU91 T cell line and in CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T cells, however IL-18 was not expressed in the CU91 T cell line. Taken together, the data demonstrates that T cells express the functional ChIL-26 receptor complex and that ChIL-26 modulates T cell proliferation and proinflammatory gene expression. To the best of our knowledge, this is the first report of cloned ChIL-26. We evaluated its functional roles, particularly in the pathogenic costimulation of T cells, which may be significantly associated with the induction of cytokines.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s13567-016-0342-0) contains supplementary material, which is available to authorized users.</P>

Children with COVID-19 after Reopening of Schools, South Korea

( Eun Young Kim ),( Boyeong Ryu ),( Eun Kyoung Kim ),( Young-joon Park ),( Young June Choe ),( Hye Kyung Park ),( Eun Kyeong Jeong ) 대한소아감염학회 2020 Pediatric Infection and Vaccine Vol.27 No.3

목적: 국내 초중고 학교 등교재개 이후 소아에서의 코로나바이러스감염증-2019 (코로나19) 사례의 감염경로를 파악하고자 하였다. 방법: 2020년 5월 1일부터 7월 12일까지 국가감염병감시체계에 신고된 3-18세 소아 청소년 코로나19 확진자의 사례조사서 및 역학조사서를 분석하였다. 결과: 2020년 5월 국내 초중고 학교 등교 재개 이후 7월 12일까지 총 127명의 소아 청소년 코로나19 확진자가 신고되었다. 그 중 59명(46%)은 가족 및 친지로부터 전파된 사례였으며 18명(14%)은 학원 및 개인교습 중 전파되었다. 8명(6%)은 다중이용 시설에서 전파되었으며 3명(2%)은 학교에서 전파된 사례였다. 결론: 코로나19 감염예방을 위한 관리체계가 사전에 마련되고 준비된 경우 학교 내 코로나19 전파는 드물게 나타났다. Purpose: To describe pediatric coronavirus disease 2019 (COVID-19) cases after the reopening of schools in the Republic of Korea and their transmission routes. Methods: All case report forms and epidemiologic investigation forms for children aged 3-18 years reported as COVID-19 cases to the National Notifiable Disease Surveillance System from May 1 to July 12, 2020, were reviewed. Results: After the schools were reopened in May 2020, a total of 127 pediatric COVID-19 cases were confirmed until July 12. Of these, 59 children (46%) were exposed to severe acute respiratory syndrome coronavirus 2 through family and relatives, followed by 18 children (14%) through cram schools or private lessons, 8 children (6%) through multi-use facilities, and 3 children (2%) through school. Conclusions: The present data do not suggest an increased risk of COVID-19 transmission in the context of stringent school-based infection prevention measures introduced across the country.

코로나19 판데믹 기간 여러 국가에서 발표한 확진자 및 사망자의 보고율에 대한 혈청역학적 비교 연구

이상원(Sangwon Lee),류보영(Boyeong Ryu),박신영(Shin Young Park) 서울대학교 보건환경연구소 2023 보건학논집 Vol.60 No.1

Objectives: The COVID-19 pandemic that began in 2020 is the largest pandemic since the 1918 influenza pandemic, causing significant loss of life worldwide. To accurately understand and prepare for future pandemics, it is important to have a detailed understanding of the number of COVID-19 cases worldwide, as well as an assessment of the reliability of the reported incidence and mortality data from each country. Methods: This study compared COVID-19 incidence, mortality, case fatality rates reported by 11 countries with the COVID-19 infection induced antibody seropositivity rates obtained from 15 surveys conducted in those countries. Results: Based on patient incidence statistics reported by various countries from the start of the pandemic in 2020 up to March 7, 2023, patient incidence and mortality rates are higher in high-income countries and lower in low- and middle-income countries. Conversely, the case fatality rate is lower in high-income countries and higher in low- and middle-income countries. However, it is important to note that these results may be due to different reporting rates in each country. The analysis found that the estimated reporting rates of COVID-19 in low- and middle-income countries were estimated to be between 0.4% and 1.3%, while the estimated reporting rates in high-income countries were estimated to be between 15.1% and 78.5%. Conclusion: Among the high-income countries, those with a high proportion of patients from 2020 to the end of 2021 who required hospitalization had higher case fatality rates.