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Diagnostic Imaging for Lung Lobe Torsion in a Miniature Pinscher
Jihye Choi,Hyunwook Kim,Jaeyoung Jang,Hyunjung Ban,Hyejin Kim,Jinkyung Kim,윤정희 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.3
and ultrasonography revealed the consolidation of left cranial lung lobe surrounded by pleural effusion and the extractionof left lung lobe was performed through thoracotomy. This case has the clinical significance because lung lobe torsionwas diagnosed by non-cardiac ultrasonographic examination, therefore surgical correction was performed without delayand led good outcome. Moreover, the authors believe the present case was the first report on lung lobe torsion inMiniature Pinscher dog.
반가운(Ban, Gaun),권소진(Kwon, Sojin),이지혜(Sojin․,Lee, Jihye),홍지아(Hong, Jia),김지영(Kim, Jiyoung) 충북대학교 생활과학연구소 2016 생활과학연구논총 Vol.20 No.2
This study is to develop the creative fashion designs with remarkable moulding sense that were inspired from modern architect s works that showed the rhythmic expression of geometrical forms. The method of this study based on literature analysis was to find out the expression characteristic of the representative contemporary architects, Danel Libeskind, Jean Nouvel, Peter Eisenman who were excellent at geometrical expression in the rhythmic ways. Design concepts and 3 pieces of real works were developed on the basis of analysis on architect s works. Daniel Libeskind expressed straight line and sharp stretched geometrical shapes dynamically by multiple line cross, overlapping and irregular variations of direction. Jean Nouvel showed machine aesthetics of external space and modern images as geometric shapes, so he tried to drag the latent human sense with continuity and individuality by connecting the geometrical panels. Peter Eisenman signified as the architectural space through the variation and mixture of basic units. On the basis of architect s analysis, Beyond the line was established as the design concept and design works were developed. We expressed geometric forms by strips weaving or linkage of motives focused on rhythmic flow. Through the integrated access with architectural fields, this study could give a chance to find the possibility of fashion creation with breaking up the boundary of design.
데이벤드란렝가라즈,Anh Duc Truong,Jihye Ban,Hyun S. Lillehoj,홍영호 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.7
Objective: Despite an increasing number of investigations into the pathophysiology of necrotic enteritis (NE) disease, etiology of NE-associated diseases, and gene expression profiling of NE-affected tissues, the microRNA (miRNA) profiles of NE-affected poultry have been poorly studied. The aim of this study was to induce NE disease in the genetically disparate Fayoumi chicken lines, and to perform non-coding RNA sequencing in the intestinal mucosal layer. Methods: NE disease was induced in the Fayoumi chicken lines (M5.1 and M15.2), and non-coding RNA sequencing was performed in the intestinal mucosal layer of both NE-affected and uninfected chickens to examine the differential expression of miRNAs. Next, quantitative real-time polymerase chain reaction (real-time qPCR) was performed to further examine four miRNAs that showed the highest fold differences. Finally, bioinformatics analyses were performed to examine the four miRNAs target genes involvement in the signaling pathways, and to examine their interaction. Results: According to non-coding RNA sequencing, total 50 upregulated miRNAs and 26 downregulated miRNAs were detected in the NE-induced M5.1 chickens. While 32 upregulated miRNAs and 11 downregulated miRNAs were detected in the NE-induced M15.2 chickens. Results of real-time qPCR analysis on the four miRNAs (gga-miR-9-5p, gga-miR-20b-5p, gga-miR-196-5p, and gga-let-7d) were mostly correlated with the results of RNAseq. Overall, gga-miR-20b-5p was significantly downregulated in the NE-induced M5.1 chickens and this was associated with the upregulation of its top-ranking target gene, mitogen-activated protein kinase, kinase 2. Further bioinformatics analyses revealed that 45 of the gene targets of gga-miR-20b-5p were involved in signal transduction and immune system-related pathways, and 35 of these targets were predicted to interact with each other. Conclusion: Our study is a novel report of miRNA expression in Fayoumi chickens, and could be very useful in understanding the role of differentially expressed miRNAs in a NE disease model.
AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation
Park, Hyojin,Lee, Sungwoon,Shrestha, Pravesh,Kim, Jihye,Park, Jeong Ae,Ko, Yeongrim,Ban, Young Ho,Park, Dae-Young,Ha, Sang-Jun,Koh, Gou Young,Hong, Victor Sukbong,Mochizuki, Naoki,Kim, Young-Myeong,Le The Rockefeller University Press 2015 The Journal of experimental medicine Vol.212 No.12
Truong, Anh Duc,Park, Boyeong,Ban, Jihye,Hong, Yeong Ho BioMed 2016 VETERINARY RESEARCH Vol.47 No.-
<P>In the present study, we describe the cloning and functional characterization of chicken interleukin 26 (ChIL-26). ChIL-26, a member of the IL-10 cytokine family, induces the production of proinflammatory cytokines by T cells. The ChIL-26 cDNA encodes an 82-amino-acid protein whose amino acid sequence has 22.63, 46.31 and 43.15% homology with human IL-26, pig IL-26 and canary IL-26, respectively. ChIL-26 signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains, which are expressed primarily in the CU91 T cell line as well as CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T cells. Recombinant ChIL-26 protein induced Th1 cytokines (IL-16 and IFN-γ), Th2 cytokines (IL-4, IL-6 and IL-10), Th17 cytokines (IL-17A, IL-17D, and IL-17F), and chemokine transcripts (mainly CCL3, CCL4, CCL5, CCL20 and CXCL13) in the CU91 T cell line and in CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T cells, however IL-18 was not expressed in the CU91 T cell line. Taken together, the data demonstrates that T cells express the functional ChIL-26 receptor complex and that ChIL-26 modulates T cell proliferation and proinflammatory gene expression. To the best of our knowledge, this is the first report of cloned ChIL-26. We evaluated its functional roles, particularly in the pathogenic costimulation of T cells, which may be significantly associated with the induction of cytokines.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s13567-016-0342-0) contains supplementary material, which is available to authorized users.</P>
AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation
Park, Hyojin,Lee, Sungwoon,Shrestha, Pravesh,Kim, Jihye,Park, Jeong Ae,Ko, Yeongrim,Ban, Young Ho,Park, Dae-Young,Ha, Sang-Jun,Koh, Gou Young,Hong, Victor Sukbong,Mochizuki, Naoki,Kim, Young-Myeong,Le The Rockefeller University Press 2015 The Journal of cell biology Vol.211 No.3
<▼1><P>AMIGO2 is a novel scaffold protein that regulates PDK1 membrane localization and Akt activation in endothelial cells, and inhibition of the interaction between PDK1–AMIGO2 results in impaired neovascularization, pathological angiogenesis, and tumor angiogenesis.</P></▼1><▼2><P>The phosphoinositide 3-kinase–Akt signaling pathway is essential to many biological processes, including cell proliferation, survival, metabolism, and angiogenesis, under pathophysiological conditions. Although 3-phosphoinositide–dependent kinase 1 (PDK1) is a primary activator of Akt at the plasma membrane, the optimal activation mechanism remains unclear. We report that adhesion molecule with IgG-like domain 2 (AMIGO2) is a novel scaffold protein that regulates PDK1 membrane localization and Akt activation. Loss of AMIGO2 in endothelial cells (ECs) led to apoptosis and inhibition of angiogenesis with Akt inactivation. Amino acid residues 465–474 in AMIGO2 directly bind to the PDK1 pleckstrin homology domain. A synthetic peptide containing the AMIGO2 465–474 residues abrogated the AMIGO2–PDK1 interaction and Akt activation. Moreover, it effectively suppressed pathological angiogenesis in murine tumor and oxygen-induced retinopathy models. These results demonstrate that AMIGO2 is an important regulator of the PDK1–Akt pathway in ECs and suggest that interference of the PDK1–AMIGO2 interaction might be a novel pharmaceutical target for designing an Akt pathway inhibitor.</P></▼2>
최지혜,김현욱,반현정,김진경,장재영,김혜진,서지민,이민정,윤정희,Choi, Jihye,Kim, Hyunwook,Ban, Hyunjung,Kim, Jinkyung,Jang, Jaeyoung,Kim, Hyejin,Seo, Jeemin,Lee, Minjung,Yoon, Junghee 대한수의학회 2007 大韓獸醫學會誌 Vol.47 No.1
In 3 dogs with gallbladder mucocele, rupture of gallbladder was diagnosed and treated. Althoughthe diagnosis of gallbladder is challenging due to non-specific clinical signs and physical examinationfindings, mucoceles are ultrasonographically characterized by the appearance of the stellate or finely striatedbile paterns and difer from biliary sludge by the absence of gravity dependent bile movement. In thiscase, gallbladder rupture caused by mucocele can be diagnosed based on not only above characteristicsbut secondary lesion such as ascites around gallbladder and swollen hyperechoic mesentery.