韓牛의 後産停滯 除去에 關한 實驗的 硏究 (直腸 Massage)

徐斗錫,金五南,林貞澤,韓邦根 제주대학교 1976 논문집 Vol.8 No.-

In this study on the elimination of fetal membrane using the rectal massage in retention of placenta occurred to 25 heads of korean Native cattle, I could get the following results. 1. The placental elimination using the rectal massage in rotention of placenta, was much better in sanifation I could eliminate the fetal membrane within short time, and find no disturbamces in breeding after the manipulation. 2. Through this experiment I could remove the fetal membrane completely in 80%, Partially left in 8% and in 12% I removed the fetal membrane was so thin that I couldn't seperate it from the maternal placenta. 3. It was better to the rectal massage about 63 hours after the parturition. 4. In this experiment I couldn't expect a good result in breasing the body temperature and mulnutrition of mother cow.

Effects of Step-up Training on Walking Ability of Stroke Patients by Different Support Surface Characteristics

( Geun-sik Oh ),( Yu-ran Choi ),( Dae-hyouk Bang ),( Yong-jun Cha ) 대한물리의학회 2017 대한물리의학회지 Vol.12 No.3

PURPOSE: Gait disturbances in patients with hemiplegic stroke involve asymmetry of stance time. Step box training is used to supplement the limitations of stair walking training and increasing the torque value of the paralyzed lower leg`s strength. This study aimed to investigate whether step-up training on unstable support could change walking ability in patients with chronic stroke. METHODS: Thirty stroke patients were randomly assigned to the step-up training group (experimental group), that performed training on an unstable surface, and the control group, that performed training on a stable surface. Walking speed, step length, and cadence were measured before and after training. Paired t-tests were used to compare pre- and post-intervention data, while the independent samples t-test was used to determine intergroup differences. Values of p < .05 were considered statistically significant. RESULTS: There was a significant difference in walking ability before versus after the intervention in both groups, although the experimental group showed greater differences than the control group (walking velocity by 8.1%; step length of the non-paralyzed side by 6.9%, respectively; p<.05). CONCLUSION: Step-up training might be more effective on an unstable surface than on a stable surface for increasing walking speed and step length of the non-paralyzed side.

Survey results from the participants of the Asian Young Endoscopist Award and International Young Endoscopist Award as part of the International Digestive Endoscopy Network

Tae-Geun Gweon,Sang Hoon Kim,Ki Bae Bang,Seung Wook Hong,Won Jae Yoon,Sung Noh Hong,Jae Jun Park,Jimin Han,Ja Seol Koo,Oh Young Lee 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5

BRIEF REPORT

영상을 다항식 함수로 표현하기 위한 통계적 분할 및 합병 알고리즘

박근흠(Geun-Heum Park),방병조(Byung-Jo Bang),오승준(Seoung-Jun Oh) 한국정보과학회 1994 한국정보과학회 학술발표논문집 Vol.21 No.2A

최근 몇년동안 영상데이타 압축기술은 영역 또는 모델에 기반을 두고 발전되고 있다. 이 방법에서는 영상을 객체단위로 분할하여 각각의 특성에 맞게 부호화하기 때문에 보다 높은 압축률을 얻을 수 있다. 그러나 이 방법은 영상을 얼마나 정확하게 분할하는가에 크게 좌우되기 때문에 정확한 분할을 위한 알고리즘이 필요하다. Kunt와 그의 동료들이 제안한 분할 및 합병 알고리즘은 각영역을 분할하고 표현하기 위하여 다항식 근사함수를 사용하기 때문에 많은 계산시간을 요구하므로 본고에서는 영역분할 과정에서 통계적인 방법 특히 평균 분포에 기반을 둔 ShortCut 방법을 도입함으로써 계산시간을 줄이고 보다 HVS(human visual system)에 가까운 특성을 갖는 방법을 제안한다.

Direct modification of spermatogonial stem cells using lentivirus vectors <i>in vivo</i> leads to efficient generation of transgenic rats

Kim, Bang-Jin,Kim, Yong-Hee,Oh, Myeong-Geun,Kim, Ki-Jung,Jung, Sang-Eun,Jin, Ju-Hee,Kim, Sun-Uk,Min, Kwan-Sik,Ryu, Buom-Yong SCIENCE PRESS 2019 ASIAN JOURNAL OF ANDROLOGY Vol.21 No.2

<P>Spermatogonial stem cells (SSCs) transmit genetic information to the next progeny in males. Thus, SSCs are a potential target for germline modifications to generate transgenic animals. In this study, we report a technique for the generation of transgenic rats by <I>in vivo</I> manipulation of SSCs with a high success rate. SSCs in juvenile rats were transduced <I>in vivo</I> with high titers of lentivirus harboring enhanced green fluorescent protein and mated with wild-type females to create founder rats. These founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%. Subsequent generations of progeny from the founder rats both expressed and passed on the transgene. Thus, direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male germline. This technology could be adapted to larger animals, in which existing methods for gene modification are inadequate or inapplicable, resulting in the generation of transgenic animals in a variety of species.</P>

Validation of Group B Borderline Resectable Pancreatic Cancer: Retrospective Analysis

( Tak Geun Oh ),( Moon Jae Chung ),( Seungmin Bang ),( Seung Woo Park ),( Jae Bok Chung ),( Si Young Song ),( Jinsil Seong ),( Chang Moo Kang ),( Woo Jung Lee ),( Jeong Youp Park ) 대한소화기학회 2014 Gut and Liver Vol.8 No.5

Background/Aims: Among borderline resectable pancreatic cancer (BRPC), group B BRPC patients have findings that are suggestive but not diagnostic of metastasis. In this study, we attempted to validate whether group B could truly be categorized as a borderline resectable group. Methods: We placed the BRPC patients into group A or group B. The survival outcomes were compared between the groups. Results: A total of 53 patients with pancreatic adenocarcinoma was classified as either group A or B borderline resectable. In group A, 23 (60.5%) of 38 patients underwent pancreatectomy after concurrent chemoradiotherapy or chemotherapy, but in group B, only five (33.3%) of 15 patients underwent pancreatectomy, mainly because of the progression of suspected distant metastasis. There was a significant difference in overall survival (OS) between group A and B patients (median OS, 21.2 months vs 10.2 months, respectively; p=0.007). Of the patients who underwent pancreatectomy, group B had a higher recurrence rate compared to group A (recurrence rate: 11 of 23 patients [47.8%] vs five of five patients [100%], respectively; p=0.033). Conclusions: This report is the first to validate the definition of BPRC. Group B had much worse outcomes, and whether group B BRPC can be categorized as BRPC together with group A is questionable. (Gut Liver 2014;8:557-562)

Lipopolysaccharide 세포독성에 대한 SNP 효과에 관한 연구

황호근,허정무,방현주,김범영,손홍문,문연자,오재민,정연태,최민규 대한해부학회 2000 Anatomy & Cell Biology Vol.33 No.5

특집-급성 췌장염의 최신 지견 : 급성 췌장염의 병태생리

오탁근 ( Tak Geun Oh ),방승민 ( Seungmin Bang ) 대한내과학회 2013 대한내과학회지 Vol.85 No.2

여러 가지 원인이 급성 췌장염을 일으키나 각각의 요인들이 어떤 메커니즘으로 급성 췌장염을 유발하는지에 대한 이해는 급성 췌장염의 원인을 정확히 파악하고 치료하는 데 도움이 될 수 있다. 대표적인 원인 인자로는 만성 알코올 남용과 담석을 꼽을 수 있으며 그 밖에 CFTR mutation과 연관된 가족성 췌장염을 생각해 볼 수 있다. 심한 형태인 괴사성 췌장염에 관해서는 췌장효소의 활성화, 췌장 미세혈관의 손상, 염증인자의 분비가 췌장의 손상과 괴사를 악화시키며 심한 췌장 손상을 받은 일부 환자에서는 전신성 염증반응 증후군까지 진행될 수 있는데 이는 염증소견을 보이는 췌장에서 분비된 활성화된 췌장효소와 사이토카인이 전신으로 순환하면서 발생한다고 볼 수 있다. 일반적으로는 보상화된 항염증 반응이 전신성 염증반응과 균형을 이루면서 회복이 되지만 이와 같은 균형이 깨지면 심한 장기 부전으로 인해 사망으로까지 이를 수 있다. 또한, 급성 췌장염의 경과 중 장내 세균의 전좌(translocation)로 인하여 심한 급성 췌장염 환자의 30%에서 췌장과 췌장주위에 세균감염이 발생할 수 있는데, 이 경우 다발성 장기부전으로 이어질 수 있다. 췌장염의 초기 과정에서는 선방 세포 내의 trypsinogen의 활성화가 중요한 역할을 하나 사망에까지 이르게 하는 전신적 염증 반응의 경우는 독립적인 인자들이 작용하므로 이에 대한 메커니즘 연구 및 그에 맞는 치료법에 대한 연구가 필요한 실정이다. 이와 같이 급성 췌장염은 사망에까지 이르게 할 수 있는 질환으로서 정확한 진단과 치료의 기반이 될 수 있는 급성 췌장염의 병태생리에 대한 이해와 연구가 중요하다. Acute pancreatitis is an inflammatory disease that is caused by various etiologies including gallstone, alcohol or hypertriglyceridemia. Although most cases of acute pancreatitis show self-limiting course, severe cases are still associated with significant morbidity and mortality. The pathogenic mechanisms of acute pancreatitis are not fully understood. However, it is a central dogma that premature intracellular activation of trypsinogen is the earliest pathologic event. Even though it remains unknown how intracellular trypsinogen activation can be caused by such diverse etiologies, this initial insult in pancreatic acinar cells lead to local inflammatory complications and a systemic response or death. Pathophysiologic mechanisms related to the progression of acute pancreatitis include microcirculatory injury, chemoattraction of inflammatory cells, release of pro-inflammatory cytokines, and bacterial translocation to pancreas and systemic circulation. Recently, several interesting transgenic mice model experiments shed a light in trypsin independent mechanism of local and systemic inflammation for progression of acute pancreatitis.(Korean J Med 2013;85:111-115)

S-8 : Comparison of Efficacy Between Full-dose GEM CCRT and 5FU CCRT in Locally Advanced Pancreatic Cancer

( Huapyong Kang ),( Tak Geun Oh ),( Moon Jae Chung ),( Jeong Youp Park ),( Seung Woo Park ),( Si Young Song ),( Jae Bok Chung ),( Seung Min Bang ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background: Concurrent chemoradiotherapy (CCRT) is a standard therapeutic option for managing locally advanced pancreatic cancer (LAPC). Although 5-Fluorouracil (5-FU) or gemcitabine are recommended as the reference chemotherapeutic agent for CCRT, the optimal dosage for CCRT is still controversial. Aim: To compare the therapeutic efficacy and tolerability of full-dose gemcitabine based CCRT (FG-CCRT) and low dose 5-FU based CCRT (5FU-CCRT) for LAPC. Methods & Materials: From January 2006 to March 2013, 110 patients with LAPC who received FG-CCRT (n=90) or 5FU-CCRT (n=20) were included for retrospective analysis. FG-CCRT included full-dose weekly gemcitabine monotherapy (1000 mg/m2) or combination therapy with cisplatin (70 mg/m2). 5FU-CCRT treated with radiosensitizing low dose of bolus 5-FU (500mg/m2, weekly) plus leucovorin (20mg/m2). Concurrent radiotherapy targeted the primary tumor with 5 to 10 mm margin without regional lymph node irradiation. One month after completion of CCRT, response evaluation was conducted by computed tomography scan. Results: FG-CCRT had more advanced T-stage at the time of diagnosis (T4-86.7% versus 60.0%; p=0.005). Objective response rate (ORR) and disease control rate (DCR) was significantly higher for FG-CCRT than 5FU-CCRT (ORR-32.6% versus 5%; p=0.013; DCR-79.8% versus 50.0%; p=0.006). Both groups showed similar loco-regional control rate (92.2% versus 85.0%; p=0.362) but distant metastasis rate was higher in 5FU-CCRT (17.8% versus 45.0%; p=0.017). Grade 3 or higher neutropenia (34.4% versus 10%; p=0.031) and thrombocytopenia (21.1% versus 0%; p=0.021) was more frequent in FG-CCRT. The subgroup of FG-CCRT patients who received gemcitabine monotherapy showed no significant differences in toxicity rate compared with 5FU-CCRT (all p>0.05). Conclusion: Full-dose gemcitabine based CCRT seems more effective on initial local and distant control of LAPC than bolus 5-FU based CCRT. With cautious monitoring on hematologic toxicities, FG-CCRT can be tolerably conducted. Considering that distant metastasis is one of treatment failure pattern in CCRT of LAPC, full-dose gemcitabine CCRT should be considered as the first line treatment.

Development and Characterization of a New Cell Line from Olive Flounder Paralichthys olivaceus

Kim, Ju-Won,Oh, Bang Geun,Kim, Julan,Kim, Dong-Gyun,Nam, Bo-Hye,Kim, Young-Ok,Park, Jung Youn,Cheong, JaeHun,Kong, Hee Jeong The Korean Society of Developmental Biology 2018 발생과 생식 Vol.22 No.3

A new embryonic cell line (OFEC-17FEN) derived from olive flounder Paralichthys olivaceus was developed. OFEC-17FEN cells were subcultured for <30 passages over ~200 days. OFEC-17FEN cells had a doubling time of 114.34 h and modal diploid chromosome number was 48. The pluripotency genes POU5f1 and NANOG were expressed in OFEC-17FEN cells. However, the lack of several pluripotency-related genes expression indicates that OFEC-17FEN cells are not stem cells. OFEC-17FEN cells transfected with plasmid pEGFP-c1 exhibited a strong green fluorescent signal at 48 h after transfection. Accordingly, OFEC-17FEN cells may be useful for both basic research and biotechnological application.