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Chronological Endoscopic and Pathological Observations in Russell Body Duodenitis
Atsushi Goto,Takeshi Okamoto,Masaharu Matsumoto,Hiroyuki Saito,Hideo Yanai,Hiroshi Itoh,Isao sakaida 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.4
A 64-year-old man was found to have a nodule in his right lung. He also complained of nausea and abdominal pain during the clinical course. Esophagogastroduodenoscopy revealed a duodenal ulcer associated with severe stenosis and a suspicion of malignancy. However, three subsequent biopsies revealed no evidence of malignancy. The fourth biopsy showed scattered large eosinophilic cells with an eccentric nucleus, leading to a diagnosis of Russell body duodenitis (RBD). RBD is an extremely rare disease, and little is known about its etiology and clinical course. The pathogenesis of RBD is discussed based on our experience with this case.
Atsushi Goto,Takeshi Okamoto,Ryo Ogawa,Kouichi Hamabe,Shinichi Hashimoto,Jun Nishikawa,Taro Takami 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.4
Background/Aims: Intralesional steroid injections have been administered as prophylaxis for stenosis after esophageal endoscopicsubmucosal dissection. However, this method carries a risk of potential complications such as perforation because a fine needle is usedto directly puncture the postoperative ulcer. We devised a new method of steroid intralesional infusion using a spray tube and evaluatedits efficacy and safety. Methods: Intralesional steroid infusion using a spray tube was performed on 27 patients who underwent endoscopic submucosal dissectionfor superficial esophageal cancer with three-quarters or more of the lumen circumference resected. The presence or absence ofstenosis, complications, and the number of endoscopic balloon dilations (EBDs) performed were evaluated after treatment. Results: Although stenosis was not observed in 22 of the 27 patients, five patients had stenosis and dysphagia requiring EBD. The stenosisin these five patients was relieved after four EBDs. No complications related to intralesional steroid infusion using the spray tubewere observed. Conclusions: Intralesional steroid infusion using a spray tube is a simple and safe technique that is adequately effective in preventingstenosis (clinical trial number, UMIN000037567).
A New Moving-magnet Type Linear Actuator utilizing Flux Concentration Permanent Magnet Arrangement
Goto, Akira,Okamoto, Takuya,Ikariga, Atsushi,Todaka, Takashi,Enokizono, Masato The Korean Institute of Electrical Engineers 2012 Journal of Electrical Engineering & Technology Vol.7 No.3
This paper presents a moving-magnet type linear actuator designed by using flux concentration type permanent magnet arrangement, which can generate higher magnetic flux density in air-gap. In this construction, detent force which is induced by both slot-effect and end-effect becomes larger due to strong attractive forces. To reduce cogging force we have employed a modular mover structure of two magnetic pole sections connected with a center yoke. The improved motor performance is demonstrated with the prototype machine.
Aerosol model evaluation using two geostationary satellites over East Asia in May 2016
Goto, Daisuke,Kikuchi, Maki,Suzuki, Kentaroh,Hayasaki, Masamitsu,Yoshida, Mayumi,Nagao, Takashi M.,Choi, Myungje,Kim, Jhoon,Sugimoto, Nobuo,Shimizu, Atsushi,Oikawa, Eiji,Nakajima, Teruyuki Elsevier 2019 Atmospheric research Vol.217 No.-
<P><B>Abstract</B></P> <P>This study newly applies measurements from two geostationary satellites, the Advanced Himawari Imager (AHI) onboard the geostationary satellite Himawari-8 and the Geostationary Ocean Color imager (GOCI) onboard the geostationary satellite COMS, to evaluate a unique regional aerosol-transport model coupled to a non-hydrostatic icosahedral atmospheric model (NICAM) at a high resolution without any nesting technique and boundary conditions of the aerosols. Taking advantage of the unique capability of these geostationary satellites to measure aerosols with unprecedentedly high temporal resolution, we focus on a target area (115°E-155°E, 20°N-50°N) in East Asia in May 2016, which featured the periodic transport of industrial aerosols and a very heavy aerosol plume from Siberian wildfires. The aerosol optical thickness (AOT) fields are compared among the AHI, GOCI, MODIS, AERONET and NICAM data. The results show that both AHI- and GOCI-retrieved AOTs were generally comparable to the AERONET-retrieved ones, with high correlation coefficients of approximately 0.7 in May 2016. They also show that NICAM successfully captured the detailed horizontal distribution of AOT transported from Siberia to Japan on the most polluted day (18 May 2016). The monthly statistical metrics, including correlation between the model and either AHI or GOCI, are estimated to be >0.4 in 42–49% of the target area. With the aid of sensitivity model experiments with and without Siberian wildfires, it was found that a long-range transport of aerosols from Siberian wildfires (from as far as 3000 km) to Japan influenced the monthly mean aerosol levels, accounting for 7–35% of the AOT, 26–49% of the surface PM2.5 concentrations, and 25–66% of the aerosol extinction above 3 km in height over Japan. Therefore, the air pollutants from Siberian wildfire cannot be ignored for the spring over Japan.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A high resolution model generally produces an observed aerosol distribution. </LI> <LI> Next-generation geostationary satellites are applied for aerosol model evaluation. </LI> <LI> Multiple measurement helped to understand the 4-dimensional aerosol structure. </LI> <LI> Siberian wildfires strongly affected the aerosol levels over Japan in May 2016. </LI> </UL> </P>
A CONSIDERATION FOR DELTA-SIGMA MODULATOR IN MULTI-CHANNEL MEASUREMENT SYSTEMS
Atsushi ASADA,Satoshi HIRANO,Tomio GOTO,Masaru SAKURAI,Shogo MIURA,Daijyu ITAGAKI 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
In this papar, we have examined reproduction of waveform and stability that needs to be cleared in order to introduce the delta-sigma modulator into the multi-channel measurement systems. Our study has proved that the delta-sigma modulator can be applied to the multi-channel measurement system.
A New Moving-magnet Type Linear Actuator utilizing Flux Concentration Permanent Magnet Arrangement
Akira Goto,Takuya Okamoto,Atsushi Ikariga,Takashi Todaka,Masato Enokizono 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.3
This paper presents a moving-magnet type linear actuator designed by using flux concentration type permanent magnet arrangement, which can generate higher magnetic flux density in air-gap. In this construction, detent force which is induced by both slot-effect and end-effect becomes larger due to strong attractive forces. To reduce cogging force we have employed a modular mover structure of two magnetic pole sections connected with a center yoke. The improved motor performance is demonstrated with the prototype machine.
The CCR4-NOT Complex Is Implicated in the Viability of Aneuploid Yeasts
Tange, Yoshie,Kurabayashi, Atsushi,Goto, Bunshiro,Hoe, Kwang-Lae,Kim, Dong-Uk,Park, Han-Oh,Hayles, Jacqueline,Chikashige, Yuji,Tsutumi, Chihiro,Hiraoka, Yasushi,Yamao, Fumiaki,Nurse, Paul,Niwa, Osami Public Library of Science 2012 PLoS genetics Vol.8 No.6
<P>To identify the genes required to sustain aneuploid viability, we screened a deletion library of non-essential genes in the fission yeast <I>Schizosaccharomyces pombe</I>, in which most types of aneuploidy are eventually lethal to the cell. Aneuploids remain viable for a period of time and can form colonies by reducing the extent of the aneuploidy. We hypothesized that a reduction in colony formation efficiency could be used to screen for gene deletions that compromise aneuploid viability. Deletion mutants were used to measure the effects on the viability of spores derived from triploid meiosis and from a chromosome instability mutant. We found that the CCR4-NOT complex, an evolutionarily conserved general regulator of mRNA turnover, and other related factors, including poly(A)-specific nuclease for mRNA decay, are involved in aneuploid viability. Defective mutations in CCR4-NOT complex components in the distantly related yeast <I>Saccharomyces cerevisiae</I> also affected the viability of spores produced from triploid cells, suggesting that this complex has a conserved role in aneuploids. In addition, our findings suggest that the genes required for homologous recombination repair are important for aneuploid viability.</P><P><B>Author Summary</B></P> <P>Aneuploidy is a major cause of abortive development and is implicated in tumorigenesis in humans. Recent studies revealed that the increased need for protein degradation might account for the detrimental effects of aneuploidy on a cell. Here, we investigated the genetic systems responsible for aneuploid viability. Using a collection of gene deletions in fission yeast, we isolated mutants that affect aneuploid viability. We found that an evolutionarily conserved transcription regulator, the CCR4-NOT complex, and its related factors are required for aneuploid viability, suggesting that regulation of mRNA turnover is required to tolerate aneuploidy. In addition, homologous recombination repair is important for aneuploid viability.</P>