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Takashi Watanabe,Shin Ishiguro,Akiko Aoki,Mikito Ueda,Yuki Hayashi,Kazufumi Akiyama,Kazuko Kato,Kazutaka Shimoda1 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1
Objective-Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population. Methods-In this age-and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD. Results-No significant differences were evident in the allele frequencies or genotype distributions of the COMT (rs4680), 5-HTTLPR polymorphisms or the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients and controls. Although there were no significant associations of these polymorphisms with in subgroups of PD patients differentiated by gender or in subgroup comorbid with agoraphobia (AP), significant difference was observed in genotype distributions of the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients without AP and controls (p=0.047). Conclusion-In this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population.
Takashi Watanabe,Mikito Ueda,Shin Ishiguro,Yuki Hayashi,Akiko Aoki,Masataka Shinozaki,Kazuko Kato,Kazufumi Akiyama,Kazutaka Shimoda 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.4
Objective: In this study, we investigated the determinants of remission and discontinuation of paroxetine pharmacotherapy in outpatients with panic disorder (PD). Methods: Subjects were 79 outpatients diagnosed with PD who took 10-40 mg/day of paroxetine for 12 months. The candidate therapeutic determinants included the serotonin transporter gene-linked polymorphic region and the −1019C/G promoter polymorphism of the serotonin receptor 1A as genetic factors, educational background and marital status as environmental factors, and early improvement (EI) at 2 weeks as a clinical factor were assessed. The Clinical Global Impression scale was used to assess the therapeutic effects of the pharmacotherapy. Results: Cox proportional hazards regression was performed to investigate the significant predictive factors of remission and discontinuation. EI was only a significant predictive factor of remission. EI was a significant predictive factor of remission (hazard ratio [HR], 2.709; 95% confidence interval [CI], 1.177-6.235). Otherwise, EI and marital status were significant predictive factors of the discontinuation. EI (HR, 0.266; 95% CI, 0.115-0.617) and being married (HR, 0.437; 95% CI, 0.204-0.939) were considered to reduce the risk of treatment discontinuation. In married subjects, EI was a significant predictive factor of the discontinuation (HR, 0.160; 95% CI, 0.045-0.565). However, in unmarried subjects, EI was not a significantly predictive factor for the discontinuation. Conclusion: EI achievement appears to be a determinant of PD remission in paroxetine treatment. In married PD patients, EI achievement also appears to reduce a risk of discontinuation of paroxetine treatment
( Junya Yano ),( Tatsuki Aoki ),( Kazuo Nakamura ),( Kazuo Yamada ),( Shin-ichi Sakai ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 3RINCs초록집 Vol.2015 No.-
Hydrogenated biodiesel (HBD) is envisaged as a new type of diesel. Some byproducts of the HBD production process could also replace fossil fuels; therefore, increasing these substitution amounts could contribute to reducing the burden on the environment. The purpose of this study was to clarify the reduction of the environmental burden brought about by combining the HBD production from waste cooking oil with the anaerobic digestion (AD) of food waste. A life cycle assessment (LCA) was conducted, in which a combined functional unit was established, which included “the treatment of the household waste and the waste cooking oil annually generated in Kyoto city” and “running a diesel vehicle for household waste collection.” The base scenario was that all household waste and waste cooking oil were incinerated. The results indicated that compared with the base scenario, utilizing the combined HBD production system and the AD of food waste could bring about a reduction of 41.8% in the integrated environmental effects (global warming, fossil fuel consumption, acidification, and urban air pollution). The reduction of greenhouse gases compared with the base scenario was 18,100 t-CO<sub>2</sub>eq/yr. Substitutions with the byproducts of the HBD production process could reduce greenhouse gas emissions by 1,070 t-CO<sub>2</sub>eq/yr.