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안구적출에 따른 위둔덕의 칼슘결합단백질의 재구축 및 상호 연관성
안병수,고길석,안명수,김경주,권안성,정명섭,박춘매,조병옥,김진우,Samudra Acharya,Parmeshwar Narayan Amatya,장인엽 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1
Background: Superior colliculus is a part of midbrain, and participates in the visual reflexes, It receives afferent fibers from optic nerve, visual cortex, and spinotectal tract. After optic deprivation, the microscopic structure of the superior colliculus changed. Calcium-binding proteins (CBPs) Play an important role in the neuronal protection, differentiation and reorganization of the central nervous system, Objectives and Methods: The effects of neonatal retinal deafferentation on a CBPs, calbindm D-28k (CB), Parvalbumin (PB) and calretimn (CR), and the existence of colocalization between the CBPs were examined immunohistochemically in the rat superior colliculus. Results: On the experimental (contralateral to enucleation) side of superior colliculus, the number of CB-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. The number of PB-IR neurons and fibers was also reduced on the experimental side (88.5% compared to control), In the other hand, the CR-IR cells were dramatically increased (642% compared to control), but CR-IR fibers were markedly decreased on the experimental side. The colocalization between CB-CR and PV-CR was rarely observed in the superior colliculus Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of CBPs in different manners; relatively stable in CB- and PV-IR neurons and plastic in CR-IR neurons.
Lee, Bo An,Kim, Bong Seok,Ko, Min Seok,Kim, Kyung Youn,Kim, Sin Korean Nuclear Society 2014 Nuclear Engineering and Technology Vol.46 No.1
An electrical resistance tomography (ERT) technique combining the particle swarm optimization (PSO) algorithm with the Gauss-Newton method is applied to the visualization of two-phase flows. In the ERT, the electrical conductivity distribution, namely the conductivity values of pixels (numerical meshes) comprising the domain in the context of a numerical image reconstruction algorithm, is estimated with the known injected currents through the electrodes attached on the domain boundary and the measured potentials on those electrodes. In spite of many favorable characteristics of ERT such as no radiation, low cost, and high temporal resolution compared to other tomography techniques, one of the major drawbacks of ERT is low spatial resolution due to the inherent ill-posedness of conventional image reconstruction algorithms. In fact, the number of known data is much less than that of the unknowns (meshes). Recalling that binary mixtures like two-phase flows consist of only two substances with distinct electrical conductivities, this work adopts the PSO algorithm for mesh grouping to reduce the number of unknowns. In order to verify the enhanced performance of the proposed method, several numerical tests are performed. The comparison between the proposed algorithm and conventional Gauss-Newton method shows significant improvements in the quality of reconstructed images.
An electrical impedance sensor for water level measurements in air–water two-phase stratified flows
Ko, Min Seok,Lee, Sung Yong,Lee, Bo An,Yun, Byong Jo,Kim, Kyung Youn,Kim, Sin IOP Pub 2013 Measurement Science and Technology Vol.24 No.9
<P>We report a design of an optimized ring-type impedance sensor for water level measurements in air–water stratified flows through horizontal pipes. The ring-type sensor is optimized in view of the sensor linearity. In order to determine an optimal electrode and gap size of a ring-type sensor which generates a linear relationship between the impedance (resistance and/or reactance) and the water level, systematic numerical calculations are performed, and a ring-type impedance sensor of electrode width-to-diameter ratio 0.25 and gap-to-diameter ratio 0.2 has been selected as optimal. Lab-scale static experiments have been conducted to verify the sensor performance in terms of the linearity. Finally, this proposed sensor is installed in a horizontal loop 40 mm in diameter and roughly 5200 mm in length and measures water levels for various stratified flow conditions. The comparisons of water level measurements between the proposed sensor and the high-speed camera images post-processed by the edge detection scheme show that the maximum deviation in dimensionless water level is roughly 0.037, which corresponds to 1.5 mm over the range 40 mm.</P>
Study on quench detection of the KSTAR CS coil with CDA+MIK compensation of inductive voltages
An, Seok Chan,Kim, Jinsub,Ko, Tae Kuk,Chu, Yong The Korea Institute of Applied Superconductivity a 2016 한국초전도저온공학회논문지 Vol.18 No.1
Quench Detection System (QDS) is essential to guarantee the stable operation of the Korea Superconducting Tokamak Advanced Research (KSTAR) Poloidal Field (PF) magnet system because the stored energy in the magnet system is very large. For the fast response, voltage-based QDS has been used. Co-wound voltage sensors and balanced bridge circuits were applied to eliminate the inductive voltages generated during the plasma operation. However, as the inductive voltages are hundreds times higher than the quench detection voltage during the pulse-current operation, Central Difference Averaging (CDA) and MIK, where I and K stand for mutual coupling indexes of different circuits, which is an active cancellation of mutually generated voltages have been suggested and studied. In this paper, the CDA and MIK technique were applied to the KSTAR magnet for PF magnet quench detection. The calculated inductive voltages from the MIK and measured voltages from the CDA circuits were compared to eliminate the inductive voltages at result signals.
복합발전 풍력-디젤 하이브리드 시스템 설치 지역의 전력품질 분석
안해준(An, Hae-Joon),김현구(Kim, Hyun-Goo),김석우(Kim, Seok-Woo),고석환(Ko, Seok-Whan),장길수(Jang, Gil-Soo) 한국신재생에너지학회 2009 한국신재생에너지학회 학술대회논문집 Vol.2009 No.06
A severely cold weather condition of King Sejong Station, Antarctica becomes a very severe condition for an installation/operation of wind generation system. When the existing wind generation system works, it may cause a damage and destruction of wind generation system and can bring about big problems in terms of the power quality. Accordingly, it is essential to obtain technologies for the installation and operation of small wind generation system for the polar region's wind generation, and to assess and demonstrate the performance in the severely-cold environment and the polar wind generation system's development, supplementation, alteration. Also, as the available power of King Sejong Station, Antarctica, the diesel generator has been mainly used, and the wind generator has been used in the hybrid form. Wind generation and diesel generation has the different load following control each other. In the wind generation, the generated power very rapidly changes according to the change of the velocity of the wind. On the other hand, the diesel generation shows very gentle change in the velocity of output. Therefore, the study is intended to analyze the 10kw small wind generator-diesel generator's power quality of King Sejong Station, Antarctica, which is the hybrid system installation area.
( Sae Hwan Lee ),( Il Han Song ),( Ran Noh ),( Ha Yan Kang ),( Soon Young Ko ),( Eom Seok Lee ),( Seok Hyun Kim ),( An Na Kim ),( Byung Seok Lee ),( Hee Bok Chae ),( Hong Soo Kim ),( Young Woo Kang ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Backgroud/Aims: Sorafenib, an oral multikinase inhibitor with antiangiogenic and antiproliferative properties, showed significant benefits in terms of time to progression and survival in patients with advanced hepatocellular carcinoma (HCC) in large clinical trials. The aim of this study was to investigate treatment outcomes of sorafenib in real clinical fields. Methods: From August 2007 to March 2012, patients with advanced HCC who received sorafenib in seven referral hospitals in Daejeon-Chungcheong province were retrospectively enrolled for the evaluation of tolerability, treatment response and survival following sorafenib administration. Treatment response was radiologically assessed by RECIST 1.1. Results: Among a total of 123 patients enrolled, sixty-eight (55%) patients received prior treatment and 74 (60%) patients had Child-Pugh A cirrhosis. One hundred-three (84%) patients were BCLC stage C; Ninety-three (76%) patients were modified UICC IV. The median duration of sorafenib treatment was 67 (14-452) days. Seventy-three (60%) patients have experienced adverse events, resulting in transient dose reduction or cessation. Treatment interruption was brought by disease progression (36%), adverse events (21%), hepatic failure (10%), and financial burden (7%). Complete response, partial response and stable disease were seen in none, 1% and 18%, respectively, and disease control rate was 29%. Median time to progression was 84 days and overall median survival was 139 days. Patients with decompensated cirrhosis showed a shorter median time to progression (61 vs. 104 days, p=0.036) and overall survival (63 vs. 168 days, p<0.001) compared to those with compensated cirrhosis. Child-Pugh class B/C (p=0.027) and prior treatment (p=0.015) were independent risk factors for survival. Conclusions: Clinical outcomes of sorafenib treatment in patients with advanced HCC were comparable to those of previous studies. The function of hepatic reserve and history of previous treatment were independent factors affecting survival.
디지털 패션쇼 사례분석 및 3D 디지털 패션쇼 제작에 관한 연구
우세희 ( Se Hee Wu ),강연경 ( Yeon Kyung Kang ),고영아 ( Young A Ko ),김안나 ( An Na Kim ),김나은 ( Na Eun Kim ),고형석 ( Hyeong Seok Ko ) 한국패션비즈니스학회 2013 패션 비즈니스 Vol.17 No.1
A new technology of fashion show is opening the digital era and an imaginary fashion show is now arising as a new form of fashion show which allows one to enjoy a collection through the monitor without holding a real fashion show. Digital fashion show allows designer to create infinite ideas by articulating the designer`s concept through not only garments but also other factors. In this research, We will analyze cases which are mixtures of digital technology and fashion show and will suggest a new paradigm of fashion show by producing an imaginary fashion show which cannot be easily articulated in an ordinary real fashion show, articulated by garments created by digital technology and graphic effects. The program used for this study is ``DC Suite 2.0`` developed by Physan and Digital Clothing Center of Seoul National University, available for 2D pattern production and 3D simulation. In addition, in order to enhance representation of the visual effects. Maya`s Qualoth and V-ray program which could be compatible with ``DC Suite`` were used to make 3D digital fashion show.