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Mechanisms of Type-I Interferon Signal Transduction
Uddin, Shahab,Platanias, Leonidas C. 한국생화학분자생물학회 (구 한국생화학회) 2004 BMB Reports Vol.37 No.6
Interferons regulate a number of biological functions including control of cell proliferation, generation of antiviral activities and immumodulation in human cells. Studies by several investigators have identified a number of cellular signaling cascades that are activated during engagement of interferon receptors. The activation of multiple signaling cascades by the interferon receptors appears to be critical for the generation of interferon-mediated biological functions and immune surveillance. The present review summarizes the existing knowledge on the multiple signaling cascades activated by Type I interferons. Recent developments in this research area are emphasized and the implications of these new discoveries on our understanding of interferon actions are discussed.
Mechanisms of Type-I Interferon Signal Transduction
Uddin, Shahab,Platanias, Leonidas C. Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.6
Interferons regulate a number of biological functions including control of cell proliferation, generation of antiviral activities and immumodulation in human cells. Studies by several investigators have identified a number of cellular signaling cascades that are activated during engagement of interferon receptors. The activation of multiple signaling cascades by the interferon receptors appears to be critical for the generation of interferon mediated biological functions and immune surveillance. The present review summarizes the existing knowledge on the multiple signaling cascades activated by Type I interferons. Recent developments in this research area are emphasized and the implications of these new discoveries on our understanding of interferon actions are discussed.
Coronatine Induces Stomatal Reopening by Inhibiting Hormone Signaling Pathways
Uddin Shahab,Bae Dongryeoul,차준영,안경익,김외연,김민갑 한국식물학회 2022 Journal of Plant Biology Vol.65 No.5
Coronatine (COR), a phytotoxin, aids Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) invasion by suppressing stomatal immunity, thus promoting bacterial replication. COR also promotes disease development, increases disease resistance in non-infected plant parts, suppresses cell wall defenses, and delays the hypersensitive response. Moreover, COR inhibits stomatal closure by influencing reactive oxygen species (ROS) synthesis, by NADPH oxidases RBOHD/F, which highlights the role of NADPH oxidases in guard cell signaling. Plant resistance to Pst DC3000 is dependent on guard cell-specific mitogen-activated protein kinases (MAPKs) that function downstream of ROS in salicylic acid (SA) and abscisic acid (ABA)-mediated stomatal closure. COR inhibits the ABA signal transduction pathway in guard cells, which is linked to pathogen-associated molecular pattern (PAMP)-induced stomatal closure. Furthermore, COR uses the plant jasmonate (JA) receptor coronatine-insensitive 1 (COI1) to activate multiple NAC transcription factors, which then regulate SA metabolic genes, preventing the accumulation of SA. In this review, we highlight the negative impact of COR on ROS production, SA and ABA signaling transduction, and consequently stomatal immunity. We believe that the inhibitory effects of COR on SA and ABA-induced stomatal closure require substantially more research to fully understand the stress adaptation mechanisms of plants.
Uddin A F M Shahab(우딘 에이에프엠 사합),TaeChoong Chung(정태충),Sung-Ho Bae(배성호) 한국방송·미디어공학회 2020 한국방송공학회 학술발표대회 논문집 Vol.2020 No.11
Due to the lack of improper image acquisition process, noise induction is an inevitable step. As a result, objective image quality assessment (IQA) plays an important role in estimating the visual quality of noisy image. Plenty of IQA methods have been proposed including traditional signal processing based methods as well as current deep learning based methods where the later one shows promising performance due to their complex representation ability. The deep learning based methods consists of several convolution layers and down sampling layers for feature extraction and fully connected layers for regression. Usually, the down sampling is performed by using max-pooling layer after each convolutional block. We reveal that this max-pooling causes information loss despite of knowing their importance. Consequently, we propose a better IQA method that replaces the max-pooling layers with strided convolutions to down sample the feature space and since the strided convolution layers have learnable parameters, they preserve optimal features and discard redundant information, thereby improve the prediction accuracy. The experimental results verify the effectiveness of the proposed method.
Molecular characterization of HEXOKINASE1 in plant innate immunity
Jing Wu,Uddin Shahab,Chakraborty Rupak,Van Anh Duong Thu,Macoy Donah Mary,Park Si On,Ryu Gyeong Ryul,Kim Young Hun,Cha Joon‑Yung,Kim Woe-Yeon,Kim Min Gab 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.6
Hexokinase1 (HXK1) is an Arabidopsis glucose sensor that has a variety of roles during plant growth and devlopment, including during germination, fowering, and senescence. HXK1 also acts as a positive regulator of plant immune responses. Previous research suggested that HXK1 might infuence plant immune responses via responses to glu‑ cose. Plant immune responses are governed by two main pathways: PAMP-triggered immunity (PTI) and efectortriggered immunity (ETI). PTI involves the recognition of Pathogen-Associated Molecular Patterns (PAMPs) and leads to increased callose formation and accumulation of pathogenesis response (PR) proteins. ETI acts in response to efectors secreted by Gram-negative bacteria. During ETI, the membrane-localized protein RPM1-interacting protein 4 (RIN4) becomes phosphorylated in reponse to interactions with efectors and mediates the downstream response. In this study, the efects of glucose on plant immune responses against infection with Pseudomonas syringae pv. tomato DC3000 and other P. syringae strains were investigated in the presence and absence of HXK1. Infltration of leaves with glucose prior to infection led to decreases in bacterial populations and reductions in disease symptoms in wild-type Arabidopsis plants, indicating that glucose plays a role in plant immunity. Both PTI and ETI responses were afected. However, these efects were not observed in a hxk1 mutant, indicating that the efects of glucose on plant immune responses were mediated by HXK1-related pathways.
Microfabricated Stretching Devices for Studying the Effects of Tensile Stress on Cells and Tissues
김재원,김세인,Shahab Uddin,이성식,박성수 한국바이오칩학회 2022 BioChip Journal Vol.16 No.4
Tensile stress is one of the most common mechanical stresses on the connective tissues of human organs. Cell stretching devices have been developed to study the effects of tensile stress on cells and tissues. In this study, we review how these devices function mechanically and apply them to biological research. To this end, we technically evaluate the four types of actuation processes used in cell stretching devices, including electric motor-driven and electromagnetic actuation, along with their pros and cons. For example, these cell stretching devices have shortcomings including large size, a complicated system, and generation of heat and shock, which hinder the real-time imaging of cells during stretching in high-resolution microscopes. We also describe the effects of tensile stress on cellular and tissue homeostasis. With this review, we seek to explore future directions for development of cell tensioning devices to understand mechanobiological responses to mechanical stress in vivo.
Macoy Donah Mary J.,Uddin Shahab,안경익,Peseth Son,Ryu Gyeong Ryul,차준영,Lee Jong-Yeol,Bae Dongryeoul,백승만,정혜진,Mackey David,이상열,김외연,김민갑 한국식물학회 2022 Journal of Plant Biology Vol.65 No.2
Coumaroyl tyramine (CT) and coumaroyl tryptamine (CTr) are neutral hydroxycinnamic acid amides (HCAAs) that accumulate in plants in response to pathogen infection. In this study, we showed that inoculation of Pseudomonas syringae pv. tomato DC3000 (Pto) and Erwinia carotovora carotovora (ECC) increased the accumulation of CT in Arabidopsis thaliana leaves at 24 h post-inoculation. Both CT and CTr increased the accumulation of PATHOGENESIS-RELATED 1 (PR1) protein. However, CT and CTr had no significant effect on resistance to biotrophic pathogens in both compatible and incompatible plant–pathogen interactions. Nonetheless, our results revealed that CTr plays a critical role in increasing plant susceptibility to the necrotrophic pathogen ECC. Exogenous application of CT and CTr increased the induction of callose deposition in both the absence and presence of ECC. Increased callose deposition was detected in salicylic acid induction-deficient Arabidopsis mutant sid2 but to a lesser extent in ethylene signaling mutants, ein2-1 and etr1. Overall, our results suggest that ethylene signaling is related to CT and CTr-induced callose deposition and contributes to plant defense against pathogens, whereas salicylic acid is not required for this response.