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한국인에서 Neuregulin 3(NRG3) 유전자와 조현병의 연합 연구
신수진,최종택,김지원,노양호,박병래,배준설,신형두,최인근,한상우,황재욱,우성일,Shin, Su-Jin,Choi, Jong-Taek,Kim, Ji-Won,Roh, Yang-Ho,Park, Byung-Lae,Bae, Joon-Seol,Shin, Hyoung-Doo,Choi, Ihn-Geun,Han, Sang-Woo,Hwang, Jae-Uk,Woo, Sung-I 대한생물정신의학회 2012 생물정신의학 Vol.19 No.3
Objectives : Located on chromosome 10q22-q23, the human neuregulin 3 (NRG3) is suggested as a strong positional and functional candidate gene involved in the pathogenesis of schizophrenia. Several case-control studies examining the association between polymorphisms on NRG3 gene with schizophrenia and/or its traits (such as delusion) have been reported recently in cohorts of Han Chinese, Ashkenazi Jews, Australians, white Americans of Western European ancestry and Koreans. Thus, this study aimed to investigate the association of one SNP in exon 9 (rs2295933) of NRG3 gene with the risk of schizophrenia in a Korean population. Methods : Using TaqMan assay, rs2295933 in the exon 9 of NRG3 was genotyped in 435 patients with schizophrenia as cases and 393 unrelated healthy individuals as controls. Differences in frequency distributions were analyzed using logistic regression models following various modes of genetic inheritance and controlling for age and sex as covariates. Results : Subsequent analysis revealed that the frequency distribution of rs2295933 of NRG3 was not different between schizophrenia patients and healthy controls of Korean ethnicity. Conclusions : This study does not support the role of NRG3 in schizophrenia in a Korean population.
윤덕로,강대희,이승준,주영수,박진구,황호영,황필규,황은주,황예원,성주헌,홍순범,황승식,황재욱,조수헌 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1
Industrialization has introduced various working systems into the modern society. Shift work is a good representative among those. So far various adverse health effects, possibly caused by this shift work, have mainly been reported in the fields of manufacturing industry by many other researchers ; sleep disorders, gastrointestinal disorders and cardiovascular disorders and so on, These health effects were thought to be caused by the changes of circadian rhythm on shift working. This study was especially planned to evaluate effects of shift work on sleep disorders among shift-working medical manpower like hospital nurses, important persons dealings with lives, and ultimately to provide them with basic evidence for improving work environment. The study subjects were arbitrarily selected among shift-working female nurses and day-working female pharmacists in one university hospital in Seoul, and finally 79 nurses and 58 pharmacists were enrolled. The research was conducted by using self-administered questionnaire, consisting of items about socio-behavioral factors including demographic factors which can affect sleep patterns and questions which make it possible to evaluate sleep disorders(e.g. sleeping duration, sleep latency, re-sleep latency, days of insomnia per week, drug use for sleep, and subjective symptoms). The result showed that the shift workers had significantly longer sleep and re-sleep latency, more days of insomnia, and a stronger likelihood of using drugs when they had sleep difficulty than day-working pharmacists. And the number of night shift duties per month was discovered as the only significant predictor of sleep latency. Additionally, the subjective symptoms related to sleep disorders when awake and at work, showed negligible differences between the shift workers and dayworkers. In conclusion, we found shift-work was risk factor for sleep disorders.