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임신 제 1삼분기에 소파수술후 50여일 이후에 발견된 감입태반
문형(Hyung Moon),황윤영(Youn Yeung Hwang),이용태(Yong Tae Lee),이문휘(Moon Hwi Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.7
During 1st and 2nd trimester, placenta accreta is rarely found and is not easy to diagnosis during these trimester. From time to time placenta accreta is found after induced abortion or spontaneous abortion. We had experienced a case of placenta increta which was found about 50 days after D&C due to missed abortion at local clinic. So we presented it with a brief case history and brief review of the concerned literatures.
난소암 세포주와 cisplatin 내성주에서의 MDR 관련 유전자의 발현에 관한 연구
문영진(Young Jin Moon),황윤영(Youn Yeung Hwang),이재규(Jai Kyu Lee),나영정(Young Jeong Na),이영미(Young Mi Lee),장성렬(Sung Yeoul Chang),조삼현(Sam Hyun Cho),김경태(Kyung Tai Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : Expressions of P-glycoprotein, the multidrug resistance-associated protein (MRP) and the lung resistance protein (LRP) with the MDR phenotype widely divergent in human cancer cell lines. This study focused on the altered gene expression related drug transport. Methods : To examine correlations between MDR-associated genes and PKC isozyme with cisplatin resistance on the level of the mRNA expression, we analyzed MDR-associated gene (LRP, MDR1/P-gp and MRP) expression and PKC isozyme, topoisomerase II alpha and beta in cisplatin-sensitive ovarian cancer cell line A2780 and cisplatin - resistant cell line A2780cp using cDNA-PCR approach. Results : LRP mRNA levels were significantly increased in A2780cp compared to the drug sensitive variant. In contrast, MRP mRNA levels were not significantly correlated with drug sensitivity. A modest increase in PKCη and MDR1/P-gp mRNA expression activity was also observed in ovarian cancer A2780cp cell lines that were resistant to CDDP. The level of topoisomerase II alpha and beta were not affected. Conclusion : These results showed that MDR1/P-gp expression may be an important determinant of the MDR phenotype in cell lines intrinsically resistant to cancer chemotherapeutic agents and a multifactorial emergence of MDR phenotype of tumor with a possible involvement of the PKC isozymes may be associated with CDDP resistant ovarian cancer cell line.
자궁 내막에서의 저 용량 아스피린과 클로미펜이 신경세포유착물질 ( NCAM )의 발현에 미치는 영향
이정한(Jung Han Lee),황정혜(Jung Hye Hwang),김승룡(Seung Ryong Kim),문영진(Young Jin Moon),박문일(Moon Il Park),정성로(Sung Ro Chung),문형(Hyung Moon),황윤영(Youn Yeung Hwang),장세진(Se Jin Jang),박일규(Il Kyu Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : The treatment with low-dose aspirin in the patients with unexplained infertility has been reported to improve the pregnancy rate and implantation rate via increasing the blood flow in the endometrium. But there are little known about the relationships between low-dose aspirin and cell adhesion molecules, NCAM. The aim of this study was to evaluate the effect of low-dose aspirin and clomiphene citrate treatment on the expression of NCAM in the endometrium. Methods : The patients with unexplained infertility (N=37) were grouped into 3 groups: clomiphene citrate and low-dose aspirin treated group (N=8), clomiphene citrate treated group (N=10), and natural cycle group (N=10, no treatment). As control group, the proliferative and menopausal endometrium was used. Each endometium was obtained by endometrial biopsy performed in late luteal phase and immunohistochemical staining with NCAM was performed. Results : In the stromal cells, the staining intensity of NCAM expression and the number of vessels were significantly increased in the endomterium treated with clomiphene citrate and low-dose aspirin compared with other groups (p<0.05). And the expression of NCAM in the prolifertive and menopausal endometrium showed very weak staining. Conclusion : The expression of NCAM in the stromal cells and the number of vessels were increased in the endometrium of unexplained infertility patients treated with clomiphene citrate and low-dose aspirin. These findings may suggest low-dose aspirin has an important role during the secretory phase of endometrium to improve the implantation via increasing the expression of cell adhesion molecules, especially NCAM and increasing the number of vessels.
혈관내 영양막 세포에서의 Neural cell adhesion molecule ( NCAM ) 의 발현 : 정상 임신과 습관성 유산에서의 비교
박문일(M . I . Park),문영진(Young Jin Moon),황윤영(Youn Yeung Hwang),황정혜(Jung Hye Hwang),김승룡(Seung Ryong Kim),김경태(Kyung Tai Kim),장세진(Se Jin Jang),박용욱(Yong Wook Park) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3
N/A Objective: Recently, investigations performed with human tissues have revealed that reduced trophoblast invasion of spiral arteries is closely correlated with the recurrent abortion. During placental development in normal pregnancy, trophoblast cells invade uterine arteries, where they migrate on the surface of endothelium, against the flow of blood. Migration of trophoblast cells depends upon binding the cell surface to endothelial cells or to extracellular matrix, and NCAM may play an important role in these migration of tropboblast. And NCAM may poteatially bind a variety of ligands that are likely to be encountered by trophoblast cells during their remodelmg of uterine arteries. We compared the expression of NCAM in normal pregnancies to that of recurrent abortions, especially in arterial invasion by trophoblast cells. Methods: Placental tissues fiom normal pegnancies and recurrent abortions were fixed and embedded in paraffin. Standard immunohistochemical staining were used to identify NCAM. Results: NCAM expression on endovascular trophoblast of recurrent abortion are lower than that of narmal pregnancy. There are no expression on syncytiotrophoblasts and villous cytotrophoblast in the both poup. In the decidua, NCAM was expressed in mild degree and there were no differences between in the normal pregnancy and recurrent abortion. Conclusion: NCAM expression on endovascular trophoblast of recunent abortion are lower than that of normal pregnancy. In normal pregnancy, NCAM may contribute to binding trophoblast cells to the surfaces of arterial endothelium and to maintaining cohesiveness of the plug, The failure of trophoblast to invade the maternal artery and to maintain the cohesiveness of endothelium could lead to early pregnancy failu.
신동열(Dong Yul Shin),김경태(Kyung Tai Kim),황윤영(Youn Yeung Hwang),홍은경(Eun Kyung Hong),김동훈(Dong Hun Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2
Patau syndrome, or Trisomy 13 is one of the most common autosomal aberration associtated with multiple congenital abnormalities. We report a case with trisomy 13 mosacism which was found during an amniocentesis performed due to the age of the mother and abnormal nuchal translucency. The clinical features of fetus included cleft lip and palate, low set ears, polydactily, small micro penis, and Rocker-bottom feet. After termination of the pregnancy, the fetus was sent for an autopsy. The autopsy report was compatible with the gross findings and pulmonary hypoplasia, microophthalmia, hypoplasia of left ventricle of heart were found.
상피성 난소암 환자에서 복수 내 p53 자가 항체의 임상적 의의
구미경(Mi Kyung Koo),김경태(Kyung Tai Kim),황윤영(Youn Yeung Hwang),구인상(In Sang Ku),강정권(Jung Kweon Kang),이영미(Young Me Lee),조삼현(Sam Hyun Cho) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3
N/A Objectives: A study was to assess the prognostic significance of ascitic anti-p53 autoantibodies in patients with advanced ovarian carcinoma. Methods: Retrospective study was peformed in 43 ovarian carcinoma patients who presented with a significant amount of ascites at the Department of Obstetrics and Gynecology in Hanyang University Hospital between 1991 to 2000. p53 autoantibodies were determined by highly specific enzyme-linked immunosorbant assay (p53-Autoantibody ELISA plus , CAT#QI A53, A CN Bioscience Company , Boston). The 'positive' and 'egative' group were categorized on the basis of the presence of anti-p53 autoantibodies. The clinicopathologic characteristics, disease free survival and overall survival rate in each groups were compared. Statistical analysis was performed by χ2 and independent sample t-test Result: Ascitic anti-p53 autoantibodies were found in 16%(7/43)of the study patients. The positive rates were revealed as follows: serous 15%(2/13), mucinous 11%(2/17),undifferentiated,42%(3/7)in histologic type ;stage I/II5%(1/21), III/IV/IV27%(6/16); grade I/II 12%(3/26), III 24%(4/17).There was no correlation between clinicopathologic characteristics and the presence of ascitic anti-p53 autoantibodies except the stage of disease. The overall survival rate revealed no significant statistical meaning (20.0 vs 35.7 months,p=0.492).In contrast, disease free survival rate was decreased in positive group.(10.0 vs 24.7 months, p=0.032).A significance association was observed between presence of ascitic anti-p53 autoantibody and response to chemotherapy. Ascitic anti-p53 autoantibodies were detected in only 3 (16%)of 18 patients who achieved pathological partial and complete response, but it was detected in 3 (75%)of 4 patients who did not respond to chemotherapy (p=0.046). Conclusion: The presence of p53 autoantibodies in ascites is tend to be associated with advanced stage and poorly differentiated group. A significant correlation was observed between presence of ascitic p53 autoantibodies and decrease in disease free survival rate suggesting that it is related to poor prognosis. Moreover, presence of ascitic p53 autoantibodies was also related to chemoresistance. But since this study is retrospective and based on very limited case, further study is warranted to be performed prospectively and based on larger number of study group.
상피성 난소암에서 Wnt 1과 β-catenin의 발현에 관한 연구
임경란 ( Kyoung Ran Yim ),이찬 ( Chan Lee ),김용민 ( Yong Min Kim ),김광일 ( Kwang Il Kim ),김승조 ( Seung Jo Kim ),황윤영 ( Youn Yeung Hwang ),이선영 ( Seon Yeong Lee ),나영정 ( Young Jeong Na ),정상근 ( Sang Geun Jeong ),오예은 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.9
목적: 난소종양과 정상난소상피조직을 이용한 면역조직화학염색법을 통하여 난소종양의 상피세포에서 Wnt 1과 β-catenin의 발현 양상을 알아보고자 한다. 방법: 포천중문의과대학교 분당차병원 부인암센터에서 2000년 1월부터 2005년 12월까지 얻어진 난소종양과 정상난소상피조직의 포르말린 고정조직과 파라핀 포매조직을 이용하여 면역조직화학염색을 시행하였다. 실험 결과들은 SPSS 10.1을 이용하여 통계 분석하였으며, P<0.05인 경우 통계학적으로 의미 있는 것으로 판정하였다. 결과: 전체 난소상피조직 114예를 면역조직화학염색하였으며, 이 중 악성 종양은 54예였으며, 경계성 종양은 40예 그리고 양성 종양 12예, 정상난소상피조직이 8예였다. Wnt 1은 악성 종양의 51.9%, 경계성 종양의 32.5%, 양성 종양의 18.2%에서 면역조직화학염색에 양성 소견을 보였고, 모든 정상난소상피에서는 음성 소견을 보였다 (P<0.05). 상피성 난소암 중 투명세포 암 상피조직에서만 양성 소견을 보였다. β-catenin은 자궁내막모양 암의 28.6%에서 양성 소견을 보였다 (P<0.05). 결론: 난소상피조직을 이용한 본 연구 결과, Wnt 1의 과발현이 직접적으로 핵 세포질 내 β-catenin의 과발현을 유발시키지는 않는 것으로 생각되었다. 그러나 자궁내막모양암이나 투명세포암 등의 상피성 난소암의 발암 과정에 Wnt 1과 β-catenin이 관여하는 것으로 사료된다. 향후 보다 큰 규모의 연구를 통해 Wnt 신호의 다른 요소들에 대한 분석이 이루어진다면 상피성 난소암의 발암 과정에서의 역할이 규명될 수 있을 것이며, 이를 기초로 하여 난소암의 조기 진단, 치료 및 새로운 생물표지자의 개발에 유용한 정보를 제공해 줄 수 있을 것이다. Objective: We were trying to identify the expression of Wnt 1 and β-catenin in normal ovarian epithelium and epithelial ovarian tumor. Methods: We used archival formalin-fixed and paraffin-embedded tissues from Comprehensive Gynecologic Cancer Center and the Department of Pathology at Bundang CHA Hospital from 2000 to 2005. Immunohistochemical staining for Wnt 1 and β-catenin was performed on the ovarian epithelial tissues. Statistical analyses were performed with SPSS 10.1 for Windows and significance was defined as P<0.05. Results: Of 114 cases, the cases were composed of 54 carcinomas, 40 borderline tumors, 12 benign tumors and 8 normal control ovarian tissues. Abnormal nucleocytoplasmic expression of β-catenin was found in 4 endometrioid carcinomas. The nuclear expression of β-catenin was found especially in the components of the endometrioid carcinoma (28.6%, P<0.05). Wnt 1 was overexpressed in all 9 clear cell carcinomas, but not frequent in the other types of malignant tumors (P<0.05). We found a statistically significant correlation between β-catenin nuclear localization and endometrioid carcinomas. And we found a significant correlation between Wnt 1 expression and clear cell carcinomas. Conclusion: It does not seem that Wnt 1 over expression directly provoke the nuclear localization of β-catenin. But, deregulation of β-catenin and Wnt 1 may play a role in the pathogenesis of ovarian epithelial carcinogenesis of endometriod carcinoma and clear cell carcinoma. Evaluating this avenue of regulation of β-catenin and Wnt protein in ovarian epithelial carcinoma may provide a new direction for early diagnosis and treatment in ovarian epithelial carcinoma and provide opportunities for making a certain biomarkers.