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외상성 진성 환축추 탈구 1예에 대한 성공적 보존요법 및 경구적 환축추 고정술에 대하여
홍용길,박영섭,안명수,최창락 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.3
Atlanto axial(A-A) dislocation which may be either congenital or due to traumatic inflammatory causes or tumor etc are managed accordingly depending upon their causes. Generally conservative treatment or operative posterior fusion have been employed. A case of traumatic A-A transligamental dislocation has been encountered at St. paul's Hospital by our neurosurgical team. A transoral anterior fusion had been done and the result was successful and very encouraging. It is therefore with great pleasure that we share with you this experience, that management of A-A dislocation could wholly be by surgical technique.
척추 후부 요소들의 퇴행성 비후에 의한 흉추관 협착증 : An Analysis of 21 Surgical Cases
홍용길,박춘근,성기원,백민우,강준기,최창락 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.2
Twenty-two surgical cases of myelopathy due to narrow thoracic spinal canal associated with degenerative changes of the posterior spinal elements have ever been reported in the literature since Govoni presented the first cases in 1971. Authors have experienced five surgical cases and added them to the above twenty-two cases. And clinical analysis was made with twenty-one cases, which had proper data to be analysed and included our own five cases. Thirteen patients were male and the average age was around fifty-five years. Most of the lesions were found in the lower thoracic spines and involved single segment in each patient. The symptoms were so various and non-specific that pertinent treatments were delayed and the disease had been misdiagnosed in most of the patients. Intrathecal enhanced spine CT might be the most accurate diagnostic tool. Surgical decompression may produce good results, even when symptoms have been presented for years.
Molecular Approaches for Brain Tumor Therapy : Gene Transfer and Ant-sense Oligonucleotides
홍용길 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9
Despite advances in neurosurgery, radiation, and chemotherapy, the prognosis of patients with malignant brain tumors still remains grim. Considerable efforts have been made to develop new therapeutic strategies for malignant brain tumors. One of the promising new therapies for brain tumors is an intervention at molecular level and several molecular approaches have been shown to have in vitro and in vivo activities. These include the use of retroviral vectors, herpes simplex viruses, adenoviral vectors in gene transfer, and antisense vectors and oligonucleotides the clinical potential of these molecular therapies. Here, I discuss the current status of molecular therapy for brain tumors together with future directions for its development
뇌종양 면역학 : 제2부 : 악성뇌종양의 면역요법 Part Ⅱ : Immunotherapy of Malignant Brain Tumors
홍용길,나형균,정철구,이상원,조태훈,백민우,윤석훈,강준기,송진언,최창락 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.10-12
The prognosis of patients with malignant brain tumors has improved only slightly despite the combined use of surgery, radiation therapy, and chemotherapy. Immunotherapy offers some possibilities and hopes as a fourth modality for the treatment of cancers although it is still in the early stages of development. It is possible to classify immunotherapy within four generally accepted modalities : 1) restorative or nonspecific immunotherapy 2) adoptive immunotherapy 3) passive immunotherapy 4) active immunotherapy. The techniques of recombinant DNA, genetic engineering, cell fusion and hybridoma production, and molecular biology will make these therapeutic approaches more successful and as the clinical applications expand the skillful cancertherapist will become increasingly familiar with these treatments and the problems associated with their use.
기전대뇌동맥의 거대뇌동맥류 : 증례 보고 Case Report
홍용길,최승진,윤석훈,최창락,송진언 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.1
A case of large aneurysm of azygos anterior cerebral artery(Azygos ACA) is reported. This 52-year-old male patient became unconscious suddenly on working. The CT scan demonstrated small amount of hemorrhage in the interhemispheric fissure and basal cistern and huge intraventricular hematoma with marked dilatation of all ventricles. Emergency extraventricular drainage was done and his consciousness recovered to the level of possible spontaneous eye opening, 4-vessels angiography done a moth later revealed a large fusiform aneurysm at the bifurcation of distal end of azygos ACA. Authors preferred interhemispheric approach and clipped the aneurysmal neck uneventfully. Despite the successful clipping of the aneurysm confirmed by postoperative angiography, preoperative mutism, spastic weakness of lower extremities and urinary incontinence didn't recovered. This case suggests that preoperative neurological status is no less critical to the postoperative outcome than surgical technique. This is the first case of large aneurysm at this site so far as we know.
수막종의 에스트로젠 및 프로제스테론 수용체와 세포증식능
홍용길,조경근,조경석,백민우,강준기,최창락 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.2
It has been suggested that hormaonal manipulation may be proved to be an alternative mode of therapy, especially in cases of unresectable or recurrent meningiomas, and the effect of the endocrinological therapy may be influenced by the presence or absence of hormone receptors in meningiomas. The assessment of biological behavior of the tumors is important to plan postoperative adjuvant therapy and follow-up schedules, and the evaluation of cell proliferative activities has been known to be valuable in prediction of recurrence and aggressiveness of meningiomas. The purpose of this study was to investigate the status of hormone receptors and cell proliferative activities, and to determine the relationship between nucleolar organizer regions(AgNORs) and flow-cytometric methods in evaluating cell kinetics of meningiomas. Cytosolic estrogen receptors(ER) and progesterone receptors(PR) were studied in meningiomas removed from 43 patients. Cell proliferative index(PI) based on tumor cell-cycle stage(%S+%G_(2)M) was calculated by flow-cytometric studies of paraffin-embedded meningioma tissue blocks, and the mean number of AgNORs per cell was measured by silver-colloid staining techniques. Evaluable results of hormone receptors, PI, and AgNORs could be obtained in 40, 37, and 41 of original meningiomas, respectively. Significnat levels of ER(ER+) were found in 27.5% of the patients, while significant PR levels(PR+) were detected in 40%. PR+ were found in 14(40%) of 35 benign meningiomas but in all the one atypical and one malignant meningioma. It appeared that the tumors with the anaplastic histological features of necrosis or brain infiltration had higher incidence of PR+ than the tumors without them, and the higher the cell proliferative activities, the higher the incidence of PR+. PI of two atypical and one malignant meningiomas were rather higher but the number of AgNORs of them were significantly higher than those of thirty benign meningiomas(p<0.05). The tumors with the histological feature of mitotic figures had higher proliferative activities than those without mitotic figures(p<0.05). Thirty-three percent of the benign meningiomas had the PI value higher than 30%, and about twelve percent of the benign meningiomas had the AgNORs greater than 2.5 per cell. A linear correlation was demonstrated between PI and the number of AgNORs(r=0.71, p<0.001). These results suggest that antiprogesterone therapy may be of use in treatment of highly proliferative or aggressive meningiomas, and the number of AgNORs showing correlation with PI may reflect the cell kinetics well and be of value in predicting recurrence of meningiomas and in planning postoperative adjuvant therapy.