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불규칙 렌즈 배열을 통과한 영상을 이용한 2차원 물체의 수치적 복원
홍성인,김남,박재형,Hong, Sung-In,Kim, Nam,Park, Jae-Hyeung 한국광학회 2013 한국광학회지 Vol.24 No.3
본 논문에서는 임의의 모양, 크기, 및 초점 거리를 가지는 렌즈들의 불규칙한 배열을 통과하여 저장되는 영상으로부터 원본 2차원 객체의 모양을 복원하는 방법을 제시한다. 제안된 방법에서는 먼저 단일 물체점의 위치를 바꾸어가며 불규칙 렌즈 배열을 통한 촬영을 수행하여 각 물체점 위치에 대한 불규칙 렌즈 배열 영상들을 확보한다. 이와 같은 각 물체점별 불규칙 렌즈 배열 영상들을 임의의 모양을 가지는 2차원 물체에 대한 불규칙 렌즈 배열 영상과 비교하여 유사도를 산출함으로써 임의의 모양을 가지는 2차원 물체를 복원한다. 실험 결과를 통하여 원본 물체를 인식할 수 있는 수준으로 물체의 복원이 가능함을 확인하였다. 추후 보다 높은 해상도의 복원과 3차원 물체로의 확장을 위한 추가 연구가 필요함도 확인하였다. We propose a method to reconstruct the two-dimensional object from an image captured through an array of random lenses each of which has random shape, size, and focal power. In the proposed method, the characteristics of the random lens array are estimated by capturing images for known elementary inputs, and then the object is reconstructed by measuring correlations between the random lens images of the object and the elementary inputs. The experimental results show that the original object can be recognized by the proposed reconstruction method. Nevertheless, further quality enhancement is required to increase feasibility and to extend to general three-dimensional object cases.
HepG2 cell에서 유리지방산 유발 지방독성에 대한 생간건비탕(生肝健脾湯)과 일부 조성 한약물의 효과
홍성인,Hong, Sung-In 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.1
Objectives : The aim of this study was to investigate whether the effects of extract from Saengkankunbi-tang and its composition that Artimisiae capillaris Herba, Crataegi Fructus, Alismatis Rhizoma, Hoelen and Raphani Semen could protect HepG2 cells from palmitic acid-induced lipotoxicity through lysosomal and mitochondrial pathways in an in vitro model. Methods : To examine the effects of the extracts from Saengkankunbi-tang and its composition that Artimisiae capillaris Herba, Crataegi Fructus, Alismatis Rhizoma, Hoelen and Raphani Semen on palmitic acid-induced lipotoxicity in HepG2 cells, we measured the contents of cell viability, cytotoxicity. Then to investigate the effects of the extract from Saengkankunbi-tang, Artimisiae capillaris Herba and Raphani Semen, we measured that triglyceride, reactive oxygen species, ATP levels, glutathione levels, cytochrome c and cathepsin B. Results : The extracts from Saengkankunbi-tang and its composition had a cell-protective function. The extracts from Saengkankunbi-tang, Artimisiae capillaris Herba and Raphani Semen controlled triglyceride over-accumulation in cells and reduced overproduction of reactive oxygen species. The extracts from Saengkankunbi-tang and Raphani Semen increased ATP and glutathione levels which had been decreased by lipotoxicity. The extracts from Saengkankunbi-tang, Artimisiae capillaris Herba and Raphani Semen reduced leakage of cytochrome c and the extracts from Saengkankunbi-tang and Raphani Semen reduced leakage of cathepsin B in lipotoxicity. Conclusions : These results show that the extracts from Saengkankunbi-tang and its composition that Artimisiae capillaris Herba and Raphani Semen have cell protective effects on palmitic acid-induced lipotoxicity through lysosomal and mitochondrial pathways.
LPG차량 흡기계통 Cleaning이 엔진 및 배출가스에 미치는 영향
홍성인(Hong, Sung-In),이승철(Lee, Seung-Chul) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.3
LPG차량의 공기 흡입 시스템에서 먼지 입자의 대부분은 공기 청정기를 통해 제거되지만, 아주 작은 입자는 제거되지 않고 흡기계통에 축적되게 된다. 이 축적된 카본은 공회전 속도 제어와 센서신호 그리고 배출가스에 영향을 주게 된다. 또한 엔진 채터링 현상이나 자동변속기의 변속시점 불량등을 야기시킨다. 이 연구는 세척액을 사용하여 흡기계통을 세척하는 것에 관한 것이다. 워밍업된 챠량에서 흡입호스를 제거하고 세척액을 사용하여 가속시에 세척액 을 흡입장치에 분사시켜 흡기계통을 세척하는 것이다. 세척액을 사용하여 스로틀 바디, ISC, 서지탱크, 흡입매니폴드, 흡기밸브, 연소실까지 세척함으로서 다음과 같은 실험결과를 얻을 수 있다. 스로틀 밸브가 정확하게 작동되어 TPS의 센서 신호 전압이 개선되었으며, 차량이 정지하는 경우 ISC 시스템은 공회전 속도 제어를 원활하게 작동하였다. 또한 일산화탄소는 약 0.15 %, 탄화수소는 약 20~100PPM으로 각각 감소되어 배기가스가 현저하게 개선되었다. At the LPG vehicle air intake system, most of dust particles in the air cleaner are removed. However very small particles are not removed and accumulated. The accumulation of carbon in air intake system is going to affect the idle speed control and sensor signal. It also causes engine chattering and transmission troubles of automatic transmission. This is study about cleaning up intake system using cleaning chemical. We can clean up the intake system by spraying cleaning liquid onto intake device when the engine is idling after intake hose is removed from warmed up vehicle. We can obtain the following experimental results by cleaning up ISC, surge tank, intake manifold, intake valves and combustion chamber. According to this results, the stroll valve works correctly and power rate of engine is up to the standard, it is smoothy to control the idling speed when a vehicle pulls up. After cleaning up CO grow down about 0.15%, HC does about 20~100 ppm.
홍성인(Sung In Hong),허영림(Young Lim Hur),오승열(Seaung Youl Oh) 한국약제학회 2000 Journal of Pharmaceutical Investigation Vol.30 No.3
The objective of this work is to investigate the effect of molecular weight of poly(ethylene oxide) (PEO) and release medium on the release of nifedipine (NP) from PEO tablets containing NP and to get some mechanistic insights into the release of NP. The tablets containing NP were prepared by direct compression, using a flat-faced punch and die. The molecular weights of PEOs used were 200K, 900K, 2000K and 7,000K. The release kinetics were studied for 24 hours in aqueous ethanol solution, using a dissolution tester at 36.5℃ and 100 rpm. Drug release rate increased, as the concentration of ethanol in the dissolution medium increased, due to the increased solubility of NP. As the molecular weight of PEO increased, release rate decreased, due to the slower swelling and dissolution of PEO. The power values obtained by fitting data to the power law expression (M_t/M_∞-ktⁿ) indicated that, at low ethanol concentration, the release of NP is governed by anomalous diffusion. However, as the ethanol concentration increases, diffusional release becomes to prevail over anomalous or zero-order release. Overall, these results provided some insights into the release of NP from PEO tablet.