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      • 80세 이상 급성기 뇌졸중 환자에게 시행하는 정맥내 혈전용해치료: 단일 기관 예비연구

        조아현,이익성,한수정,손영민,김범생 대한뇌졸중학회 2010 Journal of stroke Vol.12 No.3

        Background: Although the number of the elderly stroke patients increases, treatment with intravenous recombinant tissue plasminogen activator (rt-PA) is currently not recommended in the elderly. We investigated the safety and clinical outcome of the intravenous thrombolysis in the elderly. Methods: We consecutively enrolled patients who underwent intravenous rt-PA thrombolysis according to the treatment protocol based on the American heart association guidelines. The demographic data, initial national institutes of health stroke scale score and stroke subtype were assessed. The clinical outcomes were modified Rankin Scale (mRS) at 3 months. Symptomatic intracranial hemorrhage causing any neurological decline was evaluated. All clinical data were compared between patients who were 80 years or older and those less than 80 years. Results: Of the total 46 patients, 7 (15.2%) patients were 80 years or older. The baseline characteristics were comparable between both groups. Symptomatic hemorrhagic transformation was not different between both groups [0/7 (0%) vs. 3/39 (7.7%), P>0.999]. There was no difference in favorable outcome (mRS 0-2) and mortality between both groups [2/7 (28.6%) vs. 25/37 (67.6%), P=0.089, 1/7 (14.3%) vs. 4/37 (10.8%), P>0.999, respectively]. Conclusion: Symptomatic intracranial hemorrhage was not higher in the elderly and the favorable clinical outcome was comparable between the two groups. (Korean J Stroke 2010;12:102-105)

      • KCI등재

        청감실험방식에 따른 음풍경 평가결과 비교분석

        조아현,한찬훈,Jo, A-Hyeon,Haan, Chan-Hoon 한국음향학회 2022 韓國音響學會誌 Vol.41 No.3

        The present study aims to investigate the difference of soundscape evaluation results from on-site field test and laboratory test which are commonly used for soundscape surveys. In order to do this, both field and lab tests were carried out at four different areas in Cheongju city. On-site questionnaire surveys were undertaken to 65 people at 13 points. Laboratory listening tests were carried out to 48 adults using recorded sounds and video. Laboratory tests were undertaken to two different groups who had experience of field survey or not. Also, two different sound reproduction tools, headphones and speakers, were used in laboratory tests. As a result, it was found that there is a very close correlation between sound loudness and annoyance in both field and laboratory tests. However, it was concluded that there must be a difference in recognizing the figure sounds between field and laboratory tests since it is hard to apprehend on-site situation only using visual and aural information provided in laboratory tests. In laboratory tests, it was shown that there is a some difference in perceived most loud figure sounds in two groups using headphones and speakers. Also, it was analyzed that there is a tendency that field experienced people recognize the figure sounds using their experienced memory while non-experienced people can not perceive the figure sounds.

      • KCI등재

        가래떡에 오염된 곰팡이와 효모의 분리 동정

        조아현,김중범 한국식품위생안전성학회 2022 한국식품위생안전성학회지 Vol.37 No.1

        The purpose of this study was to analyze the hazard of fungi in Garaetteok (Korean rice cake) byisolating and identifying of fungi contaminated with Garaetteok and investigating the possibility of mycotoxin production. Garaetteok used in this study were the ones that were returned back to the manufacturers in Jeollanam-dodue to the presence of foreign matters presumed to be fungi. The fungi foreign matter was collected and inoculatedon Potato dextrose agar, Malt extract agar, and Czapek yeast extract agar, and then cultured at 25oC for 7 days. Themicro-structure was observed under an optical microscope for the colonies in which pure isolation was confirmed. Thegene sequencing of the product of amplified PCR was analyzed using the ITS primer. Colony-1 and 2 maintained thesame properties in each tray, confirming that they were purely isolated. Budding cells were observed from the Colony-1, thus, it was determined to be yeast. Colony-2 was determined to be a fungus that belongs to Fusarium spp. as fusiformconidia were observed. As a result of gene sequencing, a total of 76 cases of fungi of Fusarium spp. were found,among which Fusarium solani was the most observed cases (53 cases). From the morphological and genetic identification,Colony-2 was identified as Fusarium spp., specifically, Fusarium solani. The fungi found in Fusarium spp. produce mycotoxins such as nivalenol, zearalenone, and fumonisin, which may cause vomiting, diarrhea, and cancer. Conclusively, the results confirm the possibility of mycotoxin production by Fusarium spp. isolated from Garaetteok. Consequently, when an unknown fungus was found, it is necessary to isolate and identify the fungus, determinewhether it is a mycotoxin producing species, and strengthen relative administrative measures, accordingly. 본 연구에서는 가래떡에 오염된 곰팡이를 분리 동정한후 곰팡이독소 생산 가능성을 조사하여 식품 이물 중 곰팡이에 대한 위험성을 분석하였다. 실험에 사용된 가래떡은 전라남도 소재 떡 제조업체에 곰팡이로 추정되는 이물이 발견되어 반품된 제품을 사용하였다. 곰팡이 이물을 채취한 후 Potato dextrose agar, Malt extract agar, Czapekyeast extract agar에 접종하고 25oC에서 7일간 배양하여순수 분리 결과를 판단하였다. 순수 분리가 확인된 집락에 대해 광학현미경으로 포자의 미세구조를 관찰하여 형태학적으로 동정하였다. 유전학적 동정은 ITS primer를 이용하여 증폭된 PCR 산물의 유전자 염기서열을 분석하였다. Colony-1과 2는 각각 배지에서 동일한 성상을 나타내어 순수분리 되었음을 확인하였다. Colony-1은 출아세포가 관찰되어 효모로 판정하였다. Colony-2는 방추형의 분생자가 관찰되어 Fusarium 속 곰팡이로 판정하였다. 유전자 염기서열 분석 결과 Fusarium 속 곰팡이가 총 76건으로 나타났으며, 그중 Fusarium solani가 53건으로 가장 높게 나타났다. 형태학적 동정 결과와 유전학적 동정 결과를 바탕으로 Colony-2는 Fusarium spp.로 동정되었고 그중 Fusarium solani로 추정되었다. Fusarium 속 곰팡이는Nivalenol, Zearalenone, Fumonisin 등의 곰팡이독소를 생산하여 구토, 설사, 암 등을 유발한다. 이러한 결과를 종합해 볼 때 가래떡에서 분리된 Fusarium 속 곰팡이에 의한 곰팡이독소 생산 가능성은 상존하는 것으로 판단되었다. 따라서 곰팡이 이물이 보고되면 곰팡이를 분리 동정하여 곰팡이독소를 생산할 수 있는 균종인지 판단하고, 그결과에 따라 행정조치를 강화하여야 할 것으로 판단된다.

      • KCI등재후보
      • KCI등재

        습도조건에 따른 PEG 처리 수침고목재의 PEG 용출량 및 압축강도 변화

        조아현,이광희,최태호,고인희,서정욱 한국문화재보존과학회 2020 보존과학회지 Vol.36 No.3

        The present study aimed to monitor changes in the amount of PEG free-flowing back from PEG-treated woods and compressive strength changes with change in relative humidity from 90% to 30%. The change in the relative humidity was done 3 times. For the current study, water-logged wood (Prinus group) was used and the wooden blocks cut out of it were subjected to 3 different impregnation methods combined with different drying conditions as follows: 1) impregnating with 80% PEG#4000 followed by drying in nature (hereafter PEG80), 2) impregnating with 40% PEG#4000 and then drying in vacuum freeze drying equipment (hereafter PEG40), and 3) impregnating with 40% PEG#4000 in t-butanol, followed by drying in the vacuum freeze drying equipment (hereafter TB40). It was verified that most of the PEG was free-flowing back from the PEG-treated woods; however, a small amount of left PEG was observed on the lumen surface. The amount of PEG free-flowing back from the PEG-treated woods increased whenever the relative humidity changes from 90% to 30%. The compressive strengths of PEG80 and TB40 were increased whenever the relative humidity changed from 90% to 30%, whereas PEG40 decreased. The current study showed how to control the relative humidity to effectively manage PEG-treated waterlogged woods. 본 연구는 PEG 함침처리한 수침고목재를 대상으로 고습도(RH 90%)에서 저습도(RH 30%)로습도변화를 주면서 목재 내부에 있는 PEG 및 약제 용출량과 압축강도 특성 변화를 관찰하기 위해 수행되었다. 고습도에서 저습도로의 변화는 3회 실시하였다. 시험에 사용된 수침목재는 졸참나무류(Prinus group)이며, 함침 및 건조 방법은 1) PEG 완료농도 80% 및 자연건조(이하 PEG80), 2) PEG 완료농도 40% 및 진공동결건조(이하 PEG40), 그리고 3) t-butanol을 이용한 PEG 완료농도 40% 및진공동결건조(이하 TB40) 이다. 목재 내부에 있는 PEG는 3차 습도변화 이후에 대부분 용출되어 제거되었으며, 내강 벽면에 남은 PEG의 결정이 편평하게 고착되었다. 약제의 용출량은 대부분의 경우 습도변화 횟수가 증가할수록 그 양이 증가하였다. 습도조건에 따른 압축강도의 변화는 PEG80 과 TB40의 경우 습도변화 횟수가 증가할수록 증가하였으나, PEG40은 감소하였다. 본 연구를 통해PEG 처리된 수침고목재 보존을 위한 습도조건에 대한 계획 마련에 필요한 기초자료가 마련되었다.

      • KCI등재

        ‘불완전한 관용’: 한국 옴니보어의 시민성과 탈물질주의

        조아현 한국조사연구학회 2023 조사연구 Vol.24 No.3

        This study investigates how Korean’s cultural consumption patterns, measured by omnivorousness, are linked to social/political attitudes and related behaviors. In Korean society, cultural omnivorousness is associated with citizenship and post-materialism value orientation. More specifically, Omnivores are more trusting to their family, friends, and neighbors than other individuals. They also tend to participate broader volunteer and civil activities, and show greater acceptance towards immigrant workers. Furthermore, they hold post-materialistic values, which include more progressive gender role attitudes and concerns for the environment. However, the study also found that Korean omnivores do not necessarily display more tolerant attitudes towards refugees and sexual minorities, nor do they align with the most politically liberal group within society. Several factors contribute to the incomplete political tolerance of omnivores, including the differentiation of political ideology and religion within the omnivore group, the intermingling of cosmopolitan outlook with nationalism and collectivism, and patriarchal societal norms that exclude sexual minorities. The study concludes that cultural choices are not solely determined by socioeconomic status but also reflect a broader internalized value system among individuals. It also emphasizes the importance of considering the specific societal context when examining the connections between cultural repertoires and social/political attitudes. 이 연구는 옴니보어성으로 측정되는 한국인의 문화 소비 패턴이 사회정치적 태도와 행동에 어떻게 연계되는지 조사한다. 한국 사회에서 문화적 옴니보어성은 전반적으로 높은 수준의 시민성과 탈물질주의 가치 지향에 결부된다. 구체적으로, 옴니보어는 다른 개인들보다 가족, 친구, 이웃에 대한 신뢰가 높고, 자원봉사활동과 시민참여활동에 더 적극적이며, 이주 노동자에게 호의적이다. 또한 이들은 진보적인 성역할 태도를 지원하며 환경 의식이 높다는 점에서 탈물질주의 가치를 보여준다. 그러나 이들은 난민과 성 소수자에 대해서 유의하게 관용적인 태도를 보여주지는 않는다. 또한 한국의 옴니보어 집단은 정치적으로 가장 진보적인 집단도 아니다. 한국 옴니보어의 정치적 관용을 불완전하게 만드는 요소들에는 옴니보어 내부에서의 정치적 성향 및 종교의 분화, 민족주의 및 집단주의와 혼합된 코즈모폴리터니즘, 그리고 성 소수자를 배제하는 가부장적 사회 규범이 포함된다. 이 연구는 개인의 문화적 선택이 단순한 사회경제적 지위의 산물이 아니라, 개인에게 내면화된 광범위한 가치체계를 재현한다는 점을 보여준다. 또한, 그러한 문화적 레퍼토리와 사회정치적 태도 사이의 연관성들은 구체적인 사회적 맥락에 따라 달라진다.

      • KCI등재

        Estimation of penetration equation parameters by comparing numerical analysis and experimental results

        조아현,박강,김건인 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.12

        Penetration analyses are needed to improve the survivability of combat vehicles. The penetration analysis can be achieved by numerical analysis or experiments. Because excessive time is required to obtain results in both cases, it is needed to derive a penetration equation using numerical analysis. But, the constants for the penetration equation are hardly found in the literature. Therefore, in this paper, the penetration equation is derived using the following steps: (1) Setting up a numerical analysis model and proving it with experimental data, and (2) determining the constants of the penetration equations for various target materials and impact conditions using the numerical analysis model. This procedure can be used to predict penetration when there are no sufficient penetration experimental data for a given material and impact conditions. In this paper, ANSYS Explicit Dynamics was used for creating the simulated penetration data to estimate the parameters of the penetration equation. The penetration numerical analysis was performed for a high-velocity collision between a 7.62 mm AP (armor piercing) bullet and the targets, which include RHA (rolled homogeneous armor) steel and 7075 aluminum. As a result, the error rate between the results of the numerical analysis and penetration experiments is approximately 5 %, which verifies the accuracy of the numerical analysis. The constants of the penetration equation for RHA steel and 7075 aluminum were determined using the numerical analysis model. In vulnerability analyses, penetration equation with the constant that was identified using our methodology can replace the numerical penetration analysis, which requires excessive calculation time.

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