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올메살탄 메독시밀 제제의 생물학적 동등성과 용량 비례성에 관한 연구
조성권,김춘옥,유수현,오은실,장성복,박융식,조경희,정재용,Cho, Sung Kweon,Kim, Choon Ok,Yu, Su Hyun,Oh, Eun Sil,Jang, Seong Bok,Park, Yoong Sik,Cho, Kyunghee,Chung, Jae-Yong 대한임상약리학회 2012 臨床藥理學會誌 Vol.20 No.2
Background: Olmesartan medoxomil is an angiotensin II receptor blocker commonly used in hypertension. First objective of this study was to evaluate the bioequivalence of two olmesartan formulations, Olmesartan 20 mg and 40 mg tablet (Yuhan, Pharmaceutical Corp. Seoul, Korea) as test drugs and $Olmetec^{(R)}$ 20 mg and 40 mg tablet (Daewoong, Pharmaceutical Corp. Seoul, Korea) as reference drugs. Second objective of this study was to evaluate the dose-proportionality of two formulations. Methods: Two studies (20 mg, 40 mg) were conducted as a randomized, open-label, 2-period, crossover design. Each subject received one 20 mg or 40 mg tablet of the reference or test formulation of olmesartan medoxomil in each study. Blood samples were obtained during the 48-hour period after the dose in each treatment period. Wash-out period was 1 week in each study. Concentrations of olmesartan medoxomil in plasma were analyzed using a liquid chromatography system with tandem mass-spectrometric detection (LC/MS/MS). The primary pharmacokinetic parameters were $C_{max}$ (maximum concentration) and $AUC_t$ (area under the concentration-time curve from time 0 to the last sampling time). Results: A total number of 40 healthy male volunteers participated in the study and 37 volunteers completed both treatment periods in 20 mg trial. All 40 participants completed both treatment periods in 40 mg trial. The 90 % CIs for the geometric mean ratios of the pharmacokinetic parameters (test:reference drug) were 0.93 ~ 1.04 for $AUC_t$ and 0.97 ~ 1.08 for $C_{max}$ in 20 mg trial. The 90 CIs were 0.94 ~ 1.02 for $AUC_t$ and 1.00 ~ 1.11 for $C_{max}$ in 40 mg trial. All parameters of two studies satisfy the range of bioequivalence criterion. Conclusion: The obtained results indicated that pharmacokinetic exposure to Olmesartan 20 mg and 40 mg tablet was bioequivalent to that of $Olmetec^{(R)}$ 20 mg and 40 mg tablet, respectively.
헬리컬 기본교란과 축대칭 분수조화교란을 이용한 원형제트에서의 보텍스 병합 및 제트확산
조성권,유정열,최해천,Cho, Sung Kwon,Yoo, Jung Yul,Choi, Haecheon 대한기계학회 1998 大韓機械學會論文集B Vol.22 No.11
An axisymmetric jet is forced with two helical fundamental waves of identical frequency spinning in opposite directions and an additional axisymmetric sub harmonic wave. The subharmonic component rapidly grows downstream from subharmonic resonance with the fundamental, significantly depending on the initial phase difference. The variations of the subharmonic amplitude with the initial phase difference show cusp-like shapes. The amplification of the sub harmonic results in 'vortex pairing of helical modes'. Furthermore, azimuthal variation of the amplification induces an asymmetric jet cross-section. When the initial subharmonics is imposed with an initial phase difference close to a critical value, the jet-cross section evolves into a three-lobed shape. One lobe is generated by the enhanced vortex pairing and the other two lobes are generated by the delayed vortex pairing. Thus, it is confirmed that the initial phase difference between the fundamental and the subharmonic plays an important role in controlling the jet cross-section.
조성권 ( Sung-kwon Cho ),임진욱 ( Jin-wook Lim ),임주영 ( Ju-yeong Lim ),전혜인 ( Hye-in Jun ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.2
1인 가구의 증가와 고령화에 따라 반려동물시장 또한 크게 성장하며 반려동물로써 관상어를 선택하는 경우 역시 늘어나고 있다. 하지만 그 수요의 증가에 비해 관상어 관리에서 중요한 요소인 온도, 탁도, 수위를 관리 지원하는 제품이나 시스템은 부족한 상황이다. 이에 따라 본 논문은 IoT 플랫폼을 기반으로 각종 센싱 데이터를 수집하여 이를 바탕으로 수온, 탁도, 수위를 자동 모니터링 및 제어해주는 스마트 수조 시스템을 개발해 보다 효과적인 관상어 원격 관리를 기대한다.
조성권(SungKwon Cho) 한국라틴아메리카학회 2009 라틴아메리카연구 Vol.22 No.3
Latin America did not become a primary concern of the US foreign policy during the Bush administration (20012008). Traditionally the issue of drug trafficking, however, has become one of main concerns of US foreign policy toward Latin America. Before taking office as President, in particular, Barack Obama met with Mexican President Calderon and their summit talks was to discuss with drug trafficking and immigration issues as a main agenda of both countries. In this context, this paper is to address searching for a new relationship between US and Mexico about drug trafficking under the Obama administration. For this, this paper, first, will suggest a theoretical framework with a comprehensive human security perspective. Second, this thesis will describe some current situations and problems about drug trafficking as a key issue of both countries. Third, this paper will offer not traditional national security, but a longterm perspective to drug issue. In other words, this will try a synthetic analysis in a comprehensive human security concerning neoliberalism, democracy, corruption, US drug policies to Mexico, arms trafficking from the US, etc. For this, this paper will provide some alternative opportunities for a new relationship between the US and Mexico.