Prognostic Factors in Transitional Cell Carcinoma of the Upper Urinary Tract after Radical Nephroureterectomy

조대성,홍석영,김영균,김선일,김세중 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.5

Purpose: The aim of this study was to evaluate the prognostic factors for survival in patients treated surgically for transitional cell carcinoma of the upper urinary tract (UUT-TCC). Materials and Methods: We retrospectively reviewed the medical records of 87 patients (64 men and 23 women, mean age of 62.2 years) with UUT-TCC who had undergone radical nephroureterectomy at our institution between June 1994 and June 2009. The median follow-up period was 32 months. The prognostic significance of various clinicopathological variables for recurrence-free and cancer-specific survival was analyzed by using univariate and multivariate analysis. Results: Of the total 87 patients, 21 patients (24.1%) developed local recurrence or distant metastasis and 16 patients (18.4%) died of disease during the follow-up period. The 5-year recurrence-free and cancer-specific survival rates were 74.6% and 75.2%, respectively. In the univariate analysis, hydronephrosis, T stage, N stage, and lymphovascular invasion (LVI) were significant prognostic factors for recurrence-free and cancer-specific survival. In the multivariate analysis, T stage and LVI were independent prognostic factors for recurrence-free and cancer-specific survival. Conclusions: The T stage and LVI are independent prognostic factors for recurrence- free and cancer-specific survival in patients with UUT-TCC treated by radical nephroureterectomy. These findings would be helpful for guiding decisions about adjuvant therapies and the surveillance interval. Purpose: The aim of this study was to evaluate the prognostic factors for survival in patients treated surgically for transitional cell carcinoma of the upper urinary tract (UUT-TCC). Materials and Methods: We retrospectively reviewed the medical records of 87 patients (64 men and 23 women, mean age of 62.2 years) with UUT-TCC who had undergone radical nephroureterectomy at our institution between June 1994 and June 2009. The median follow-up period was 32 months. The prognostic significance of various clinicopathological variables for recurrence-free and cancer-specific survival was analyzed by using univariate and multivariate analysis. Results: Of the total 87 patients, 21 patients (24.1%) developed local recurrence or distant metastasis and 16 patients (18.4%) died of disease during the follow-up period. The 5-year recurrence-free and cancer-specific survival rates were 74.6% and 75.2%, respectively. In the univariate analysis, hydronephrosis, T stage, N stage, and lymphovascular invasion (LVI) were significant prognostic factors for recurrence-free and cancer-specific survival. In the multivariate analysis, T stage and LVI were independent prognostic factors for recurrence-free and cancer-specific survival. Conclusions: The T stage and LVI are independent prognostic factors for recurrence- free and cancer-specific survival in patients with UUT-TCC treated by radical nephroureterectomy. These findings would be helpful for guiding decisions about adjuvant therapies and the surveillance interval.

Experimental Investigation of Convective Heat Transfer in a Narrow Rectangular Channel for Upward and Downward Flows

조대성,OMAR S. AL-YAHIA,RAGA’I M. ALTAMIMI,박종학,채희택 한국원자력학회 2014 Nuclear Engineering and Technology Vol.46 No.2

Heat transfer characteristics in a narrow rectangular channel are experimentally investigated for upward and downwardflows. The experimental data obtained are compared with existing data and predictions by many correlations. Based on theobservations, there are differences from others: (1) there are no different heat transfer characteristics between upward anddownward flows, (2) most of the existing correlations under-estimate heat transfer characteristics, and (3) existing correlationsdo not predict the high heat transfer in the entrance region for a wide range of Re. In addition, there are a few heat transfercorrelations applicable to narrow rectangular channels. Therefore, a new set of correlations is proposed with and withoutconsideration of the entrance region. Without consideration of the entrance region, heat transfer characteristics are expressedas a function of Re and Pr for turbulent flows, and as a function of Gz for laminar flows. The correlation proposed forturbulent and laminar flows has errors of ±18.25 and ±13.62%, respectively. With consideration of the entrance region, theheat transfer characteristics are expressed as a function of Re, Pr, and z* for both laminar and turbulent flows. The correlationfor turbulent and laminar flows has errors of ±19.5 and ±22.0%, respectively.

성행위 중 사용된 기구에 의해 발생한 요도 및 방광 내 이물

조대성,김세중,최종보 대한비뇨의학회 2003 Investigative and Clinical Urology Vol.44 No.11

초고층아파트 주거자의 주거환경의식에 관한 연구

조대성,신성영 대한건축학회 1992 大韓建築學會論文集 Vol.8 No.8

폐 페트와 탄소섬유를 혼합한 새로운 건설재료 개발에 관한 연구

조대성,김유성 한국지반신소재학회 2017 한국지반신소재학회지 Vol.16 No.2

신세포암에서 종양 혈관형성 및 미세혈관침범의 예후적 가치

조대성,임현이,오동근,강지훈,김영수,김세중 대한비뇨의학회 2006 Investigative and Clinical Urology Vol.47 No.2

Prognostic Significance of Preoperative C-Reactive Protein Elevation and Thrombocytosis in Patients with Non-Metastatic Renal Cell Carcinoma

조대성,김세중,이수형,안현수,김영수,김선일 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.2

Purpose: The aim of this study was to investigate the association of preoperative C-reactive protein (CRP) elevation and thrombocytosis with the prognosis of patients with non-metastatic renal cell carcinoma (RCC). Materials and Methods: This was a retrospective review of the medical records of 177 patients (130 men and 47 women) with non-metastatic RCC who underwent a radical nephrectomy between March 2000 and May 2008 and for whom preoperative CRP and platelet data were available for analysis. Preoperative CRP elevation and thrombocytosis were compared with clinical and pathological variables. Results: There were 38 patients with CRP elevation and 11 patients with thrombocytosis. The mean follow-up time was 48.3 months (median, 48.0; range, 13-111 months). Twenty-three patients (13.0%) developed metastases and six patients died during the follow-up period. CRP elevation was significantly correlated with anemia (p=0.001), T stage (p=0.004), grade (p=0.025), and metastasis (p<0.001). Thrombocytosis was significantly correlated with anemia (p=0.003), T stage (p=0.002), and metastasis (p=0.001). The univariate analysis identified anemia, CRP elevation, thrombocytosis, tumor histology subtype, tumor size, T stage, and grade as significant prognostic factors associated with recurrence-free survival, whereas the multivariate analyses showed that CRP elevation (p=0.033) and tumor size (p=0.007) were independent prognostic factors. Conclusions: Preoperative CRP elevation and thrombocytosis were associated with a poorer prognosis and a higher recurrence rate in patients with non-metastatic RCC. Moreover, preoperative CRP elevation appeared to be an independent predictor of tumor recurrence and prognosis. Preoperative thrombocytosis, however, was not an independent prognostic factor for tumor recurrence and prognosis. Purpose: The aim of this study was to investigate the association of preoperative C-reactive protein (CRP) elevation and thrombocytosis with the prognosis of patients with non-metastatic renal cell carcinoma (RCC). Materials and Methods: This was a retrospective review of the medical records of 177 patients (130 men and 47 women) with non-metastatic RCC who underwent a radical nephrectomy between March 2000 and May 2008 and for whom preoperative CRP and platelet data were available for analysis. Preoperative CRP elevation and thrombocytosis were compared with clinical and pathological variables. Results: There were 38 patients with CRP elevation and 11 patients with thrombocytosis. The mean follow-up time was 48.3 months (median, 48.0; range, 13-111 months). Twenty-three patients (13.0%) developed metastases and six patients died during the follow-up period. CRP elevation was significantly correlated with anemia (p=0.001), T stage (p=0.004), grade (p=0.025), and metastasis (p<0.001). Thrombocytosis was significantly correlated with anemia (p=0.003), T stage (p=0.002), and metastasis (p=0.001). The univariate analysis identified anemia, CRP elevation, thrombocytosis, tumor histology subtype, tumor size, T stage, and grade as significant prognostic factors associated with recurrence-free survival, whereas the multivariate analyses showed that CRP elevation (p=0.033) and tumor size (p=0.007) were independent prognostic factors. Conclusions: Preoperative CRP elevation and thrombocytosis were associated with a poorer prognosis and a higher recurrence rate in patients with non-metastatic RCC. Moreover, preoperative CRP elevation appeared to be an independent predictor of tumor recurrence and prognosis. Preoperative thrombocytosis, however, was not an independent prognostic factor for tumor recurrence and prognosis.

블러기반 움직임 벡터와 오차 영상 보상을 이용한 물체지향 부호화기

조대성,박래홍 대한전자공학회 1996 전자공학회논문지-B Vol.b33 No.3

In this paper, we propose an object-oriented coding method in low bit-rate channels using block-based motion vectors and residual image compensation. First, we use a 2-stage algorithm for estimating motion parameters. In the first stage, coarse motion parameters are estimated by fitting block-based motion vectors and in the second stage, the estimated motion parametes are refined by the gradient method using an image reconstructed by motion vectors detected in the first stage. Local error of a 6-parameter model is compensted by blockwise motion parameter correction using residual image. Finally, model failure (MF) region is reconstructed by a fractal mapping method. Computer simulation resutls show that the proposed method gives better performance than the conventional ones in terms of th epeak signal to noise ratio (PSNR) and compression ratio (CR).

Cyclooxygenase-2 and p53 Expression as Prognostic Indicators in Conventional Renal Cell Carcinoma

조대성,주희재,오동근,강지훈,김영수,이기범,김세중 연세대학교의과대학 2005 Yonsei medical journal Vol.46 No.1

The aim of this study was to investigate the relationship of cyclooxygenase (COX)-2 and p53 expression with prognosis in patients with conventional renal cell carcinoma (RCC). Formalin-fixed, paraffin-embedded tissue sections of conventional RCC from 92 patients, who had undergone radical nephrectomy, were examined for COX-2 and p53 expression by immunohistochemistry and compared with clinicopathological variables. The COX-2 expression significantly correlated only with tumor size (p=0.049), whereas the p53 expression profoundly correlated with the TNM stage (p=0.024), M stage (p=0.001), and metastasis (synchronous or metachronous; p= 0.004). The COX-2 overexpression did not significantly associate with p53 positivity (p=0.821). The survival rate of patients correlated with the p53 expression (p<0.0001) but not with the COX-2 expression (p=0.7506). Multivariate analyses indicated that tumor size, M stage, and p53 expression were independent prognostic factors for cancer-specific survival. The COX-2 expression was not an independent factor. These results show that the increased expression of p53 was associated with metastasis and a worse prognosis in conventional RCC, which suggests that p53 might have played an important role in the progression of conventional RCC. The increased expression of COX-2 was associated only with tumor size, but may not be an important prognostic factor in conventional RCC. No association was observed between COX-2 overexpression and p53 positivity in conventional RCC.

Hydrodynamic model of interfacial area for trickling flow in a packed bed

조대성 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.1

To predict local interfacial area in a packed bed under the trickling flow, a wavy annular flow model was developed by introducing theshape of waves in a thin liquid film. The trickling flowin a packed bed was approximated by an annular flow through a number ofequivalent channels in which the continuous gas and liquid were completely separated by a wavy interface. Film thicknesses were measuredby parallel wire probes to estimate the wave structure on the interface. By integrating the interfacial areas over a certain time period,the time-averaged local interfacial area was evaluated from a low to high interaction flow regime: 1) from trickling to bubbly flow and 2)from trickling to pulsing flow. The interfacial area predicted by the wavy annular flow model in the trickling flow was moderately higherthan those predicted with the empirical correlations developed by others. The results show that the interfacial area increases more significantlyas the flow regime changes from trickling to pulsing flow than that increases as the flow regime changes from trickling to bubblyflow. As a result, the wave structure on the interface should be considered to predict more accurate interfacial area in a packed bed.