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보험 및 장애평가 대상으로서 무증상 뇌경색과 뇌미세출혈의 의미
정재훈,Joung, Jae-hoon 한국생명보험의학회 2009 保險醫學會誌 Vol.28 No.1
It is common to find cerebral infarct and hemorrhage without definite neurologic signs but with lesions on neuroimaging. These lesions are called silent lacunar infarct and cerebral microbleed. Silent lacunar infarct are frequently seen in the elderly and are associated with clinically apparent stroke and vascular dementia. Known stroke risk factors, such as hypertension, diabetes mellitus, smoking, hypercholesterolemia and heart problems may increase the risk of silent lacunar infarct. Metabolic syndrome, homocysteinemia, renal failure and intima media thickness(IMT) are also other risk factors of the silent lacunar infarct. Cerebral microbleed, lacunar infarct and intracerebral hemorrhage(ICH) have similar pathology and pathogenesis. So, cerebral microbleed are coexisted with lacunar infarct, leukoaraiosis, hypertensive ICH and vascular dementia. Cerebral microbleed are associated with volume and recurrence of ICH. Also cerebral microbleed may reflect baseline status of blood brain barrior disruption. Silent lacunar infarct and cerebral microbleed are very important to clinical management, but in the aspect of insurance medicine and independent medical examiners, these lesions are not subject of evaluation for handicap.
CFPR 및 SNA 방법을 활용한 자동차 물류 연구동향 분석에 관한 연구
정재훈 ( Joung Jae-hoon ),박성훈 ( Park Sung-hoon ),최영서 ( Choi Young-seo ),이해찬 ( Lee Hae-chan ),여기태 ( Yeo Gi-tae ) 한국해운물류학회(구 한국해운학회) 2021 해운물류연구 Vol.37 No.2
자동차 물류에 대한 연구는 아웃소싱, 경쟁력 등의 매우 한정적인 분야에 진행되었으며, 자동차 물류에 대한 연구 동향을 종단적으로 분석한 연구는 미비한 것으로 나타났다. 이러한 측면에서 본 연구는 자동차 물류 관련 키워드 수집을 통해 자동차 물류 연구 동향에 대해 파악하고자 한다. 분석결과, SNA(Social Network Analysis) 분석에서는 Automobile Industry 키워드가 상위 키워드로 나타났으며, CFPR (Consistent Fuzzy Preference Relation) 분석결과에서는 SCM, 수출물류 통합시스템 구축, 물류 효율성, 비용 절감 등의 키워드가 상위 키워드로 나타났다. 또한, Hub Index 분석 결과에서는 SCM, Automobile Industry으로 나타났다. 즉 결과를 통하여 확인된바와 같이 SCM과 Automobile Industry가 향하고 있는 자동차 물류의 주된 연구 방향은 자동차 부품이었으며, 효율성 제고와 장애요인 제거 및 비용 절감 등의 실질적 목적을 달성하기 위한 연구들이 많이 이루어지고 있음을 알 수 있다. Studies on automobile logistics have been restricted to certain research areas relating to outsourcing and competitiveness. In particular, no previous study has examined the research trend of automobile logistics in a longitudinal manner. This study investigated the research trends in automobile logistics by compiling related keywords. The social network analysis (SNA) results showed that “Automobile industry” was a high-ranking keyword. In the analysis of the consistent fuzzy preference relation (CFPR), the high-ranking keywords included “SCM,” “establishment of integrated system for exports logistics,” “logistics efficiency,” and “cost reduction. The hub index analysis results showed that “SCM” and “automobile industry” were high-ranking keywords. As confirmed by the results of the analyses, the main direction of research on automobile logistics demonstrated by the SCM and automobile industry related to automobile components. Studies aimed at achieving practical goals, including improving efficiencies, removing obstacles, and reducing costs were being conducted.
한국인의 비만형 인슐린비의존성 당뇨병 발생기전에 있어서 β₃아드레날린 수용체 유전자 다형성의 의의
고은미(Eun Mi Koh),안규정(Kyu Jeung Ahn),김경아(Kyoung Ah Kim),김연선(Yeun Sun Kim),정재훈(Jae Hoon Choung),민용기(Young Ki Min),이명식(Myung Shik Lee),이문규(Moon Kyu Lee),김종원(Joung Won Kim),김광원(Kwang Won Kim),김성운(Sung Woon 대한내과학회 1997 대한내과학회지 Vol.53 No.6
N/A Objectives : The β₃adrenergic receptor(β₃-AR) may play an important role in the regulation of energy expenditure and lipolysis. A mutation of the β₃- AR gene(Trp64Arg) has been reported to be associated with early onset of non-insulin dependent diabetes mellitus(NIDDM), obesity and syndrome X which are related with insulin resistance. It is well known that Korean NIDDM patients, in contrast to Caucasians, are mainly non-obese and have experienced severe weight loss during the course of disease. We studied the frequency of the mutation in Korean NIDDM patients and non-diabetics control and evaluated the clinical characteristics of Korean obese NIDDM patients. We investigated the frequency of the mutation in NIDDM patients and clinical characteristics of the patients with the mutation in order to elucidate the significance of the mutation in the pathogenesis of NIDDM in Koreans. Methods: We studied 401 NIDDM patients and 99 controls. The NIDDM patients were divided into two groups, non-obese group and obese group, according to their body mass index at diagnosis of the disease. The Trp64Arg mutation was detected by the PCR/RFLP method using restriction enzyme Mva I. Results: The Trp64Arg allele frequency(16M) of NIDDM did not differ from that(16%) of controls. Although the mutant allele frequency was not different between non-obese and obese group both in NIDDM patients and controls, the frequency of patient with the mutant allele was significantly higher in obese NIDDM patients than in non-obese NIDDM patients(38.5% vs. 26.9%, P=0.04). However, no significant differences were found in clinical and laboratory findings between the NIDDM patients with the mutant allele and those without the mutant allele. Conclusion: These data suggest that β³-AR mutation might be associated with Korean obese NIDDM, and other factors might also be associated with the development of obesity and insulin resistance in NIDDM patients.
분리 핵을 이용한 Trichoderma koningii의 형질전환
민경렴,박희문,하영칠,정재훈 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-
Trichoderma koningii의 영양요구성 돌연변이주인 CUT 121로부터 얻은 원형질체를 야생형인 ATCC 26113의 핵과 혼합하여 PEG 용액을 처리한 결과, 독립영양형의 형질전화체가 30% 이상의 빈도로 생성되었다. 이 독립영양형 군체로부터 얻은 분리체 중의 하나는 xylanase의 활성이 야생형보다 3배 가량 증진되었으며, 다른 세포외 다당류 분해효소능도 야생형과 유사한 수준을 나타내었다. 분리체의 DNA 함량, 인위적인 분리양상 및 동위효소 양상 등을 조사 분석한 결과, 독립영양형의 형질전환체는 실험에 사용된 두 핵간의 유전물질교환에 의하여 생성된 형질전환체로 판명되었다. 이상의 결과로부터 Trichoderma속 균류의 균주개량법으로, 핵전이법이 통상의 원형질체 융합법보다 효율적인 것으로 판명되었다. When protoplasts from auxotrophic mutant of Trichoderma koningii CUT121(Lys^-, Met^-) were mixed with isolated nuclei of wild type T. koningii ATCC 26113 and treated with PEG solution, protrophic colonies were produced with frequency of more than 30 percent. One of segregants from prototrophic colonies showed increased xylanase activity and other polysaccharide-hydrolyzing activities comparable to those of wild type strain. Through measurement of DNA contents, induced segregation, and analysis of isozyme patterns, it was revealed that the prototrophic colonies were transformants resulted from exchange of genetic materials between the two kinds of nuclei used. These results suggest that nuclei transfer technique is more efficient than conventional protoplast fusion technique for strain improvement of Trichoderma species.