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전해수 ( Hae-soo Jeon ),김희규 ( Hee-kyoo Kim ),최길순 ( Gil-soon Choi ) 대한내과학회 2020 대한내과학회지 Vol.95 No.2
Background/Aims: Although the number of domestic adverse drug reactions (ADRs) reported in Korea is rapidly increasing, the analysis of ADRs in cancer patients remains limited. We sought to investigate the clinical features of ADRs in cancer patients. Methods: ADR data were collected from a spontaneous reporting system at single university hospital, between July 2010 and June 2015. ADR cases assessed to be “unlikely” or “unclassifiable” as per the criteria of the World Health Organization-Uppsala Monitoring Center were excluded. Additional medical information was retrospectively collected from chart reviews, and clinical features of ADRs were analyzed. Results: In total, 1,455 cases were reported. Of these, 822 ADRs (52.1%) were observed in cancer patients. The mean age of cancer patients was 60.8 years (range, 17-90 years), and 45.9% were male. The most prevalent clinical features were gastrointestinal abnormalities (32.6%), such as nausea and vomiting, followed by skin (28.5%) and neurologic manifestations (26.0%). Fifty-one (6.2%) and 296 cases (36.0%) were classified as severe and moderate, respectively. The most common causative agents were parenteral nutrition (PN) supplements (40.4%), followed by antibiotics (17.8%), analgesics (16.7%), iodinated contrast media (ICM, 10.6%), and vitamins (3.9%). Antineoplastic agents were responsible for 2.9% of cases. PN supplements were commonly associated with severe reactions. Conclusion: Although it is well known that antibiotics, ICM, and analgesics induce ADRs, PN supplements, vitamins, and antineoplastic agents should also be considered as common causes of ADRs in cancer patients. Further investigation and monitoring to determine the causality associated with these agents is required. (Korean J Med 2020;95:104-113)
장정국,신용섭,최용준,이제근,전해수 ( Jeong Gook Jang,Yong Seop Shin,Yong Jun Choi,Jea Keun Lee,Hai Soo Chun ) 한국화학공학회 1996 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.34 No.3
상온 2단 선회류 유동층에서 하단 유동층으로 공급된 연료 입자 중 하단 가스공탑속도 변화에 따른 상단으로의 입자 유입속도를 파악하였다. 하단 가스공탑속도 증가에 따라 단위시간당 입자의 상단 유입량은 증가하는 경향을 보였으며, 본 연구의 하단 가스공탑속도 범위(U_(o1)=0.9-1.3m/s) 내에서 상단으로의 입자 유입량은 하단 유동층으로 공급되는 전체 입자량의 약 35-48% 범위에 해당되었다. 입경별 상단으로의 입자 유입속도를 측정한 결과, 입자의 종말속도가 하단 가스공탑 속도보다 큰 입자들은 거의 강단으로 유입되지 못하였다. 그러나 입자의 종말속도가 하단 가스공탑속도보다 작은 입자들의 경우에는 하단으로 공급된 시료입자 중 상단으로 유입된 입자의 분율은 하단 가스공탑속도가 증가하고 입경이 감소할수록 증가하였으며, 무차원 slip velocity가 1에 접근하게 되면 하단으로 공급된 연료입자 중 거의 대부분이 상단으로 유입되는 경향을 보였다. 또한 하단으로 공급된 연료입자 중 상단으로 유입되는 입자의 분율은 아래 식과 같이 무차원 slip velocity에 대하여 지수함수적인 상관관계를 가졌으며, 이 때 상관계수는 0.89이었다. (수식) The rate of particles entrained from the lower stage to the upper stage according to the primary superficial air velocity are investigated in a cold model two-stage swirl-flow fluidized bed combustor. The total entrainment rate increases with the primary superficial air velocity and ranges from 35 percent to 48 percent of particles fed into the lower bed under the operating conditions(U_(o1)=0.9-1.3 m/s). The particles whose terminal velocity is higher than the primary superficial air velocity may not be entrained from lower stage to the upper stage. However, in the case of particles whose terminal velocity is lower than the primary superficial air velocity, the entrainment rate of particles increases as the particle size becomes smaller and/or the primary superficial air velocity increases. Further, the particles whose dimensionless slip velocity approaches to unity are almost entrained. The entrainment rate can be correlated with the dimensionless slip velocity as follows: (수식)