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전대준(Dae Joon Cheon),강은희(Eun Hee Kang),추형식(Hyung Sik Chu),채희동(Hee Dong Chae),김정훈(Chung Hoon Kim),강병문(Byung Moon Kang),장윤석(Yoon Seok Chang),목정은(Jung Eun Mok) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
N/A Objective: To compare the pregnancy outcomes of transvaginal multifetal pregnancy reduction (MFPR) according to the gestational period when the procedure was performed Methods: From January l995 to February 1998, total 27 patients with multiple pregnancy were included in this study. The patients were grouped to early MFPR group (<8 weeks, n=16) and delayed MFPR group (>8 weeks, n=ll) according to the gestational age that MFPRs were performed. All MFPRs were performed by transvaginal sonography-guided fetal aspiration or mechanical trauma. The complete pregnancy loss rate before 24 weeks of gestation, spontaneous loss of embryo, procedure-related complication, gestational age at delivery, and pregnancy complication were compared between the two groups. Statistical analysis of data was performed using Students t-test and Fishers exact test as appropriate. Statistical significance was defined as p<0.05. Results: There was no significant difference in the complete pregnancy loss rate between the early MFPR group (6.3%) and the delayed MFPR group (27.3%). The incidence of partial spontaneous loss of embryo in the two groups were not differed significantly (6.3% vs. 18.2%). The procedure-related complication of the delayed MFPR group (36.4%) seemed to be higher than that of the early MFPR group (6.3%), however there was no statistical difference (p=0,07). Especially, all 3 patients in whom the MFPR was performed after 10 weeks suffered from the procedure-related complication. The mean gestational age at delivery of the two groups were not differed significantly (36.3+2.8 weeks vs. 37.0+1.3 weeks). There was also no significant difference in the mean birth weights of the two groups (2378.8+563.7 gm vs. 2427.1+436.2 gm). Conclusion: Although there was no statistically significant difference, the early transvaginal MFPR might be a safe and useful method without significant adverse complications compared to the delayed MFPR.
장미윤(Mi Yoon Chang),전대준(Dae Joon Cheon),오동렬(Dong Yul Oh),이용성(Yong Sung Lee),이상훈(Sang Hun Lee) 대한약학회 1999 약학회지 Vol.43 No.6
Human and bovine dopamine transporters (DAT) demonstrate discrete functional differences in the dopamine (DA) transport and cocaine binding. The functional analyses on the chimeras of human and bovine DAT have revealed that the region from the 133rd to 186th residue (encompassing the 3rd transmembrane domain(TM)) is responsible for the substrate transport and cocaine binding. The present studies have been done to find out the specific amino acid(s) which is essential for the binding of cocaine to DAT by interchanging the amino acids in that region between human and bovine DAT. When isoleucine, the 152nd residue of chimera B3 (bovine DAT sequence), was transformed back to valine, the human DAT residue at the identical position, the cocaine binding was remarkably recovered to 98% of the human DAT values. In addition, the cocaine binding of the human DAT was decreased by 57% by substituting isoleucine for valine at position 152. When isoleucine at position 152. When isoleucine at position 152 of the chimera B3 was converted to the other amino acids to provide an possible molecular basis for the functional role of the 152nd residue, only the conversion to alanine among the amino acids tested significantly increased the cocaine binding by 34%, but these effects were not as much as those by the conversion to valine. In conclusion, valine at position 152 is a crucial amino acid for the interaction of cocaine to the DAT.
설치류 자궁 세포주를 통한 에스트로젠과 프로게스테론에 의한 COX-2 조절 기전에 관한 연구
강병문(Byung Moon Kang),박은주(Eun Ju Park),김성훈(Sung Hoon Kim),전대준(Dae Joon Cheon),채희동(Hee Dong Chae),김정훈(Chung Hoon Kim),박견(Kyun Park),장윤석(Yoon Seok Chang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
N/A Objective : To evaluate the regulatory mechanism of cyclooxygenase(COX)-2 by estrogen and progesterone in uterine cell lines of rodents. Materials and Methods : CUE-P cells, originated from the uterine endometrial epithelial cells, and CUE-V2 cells, originated from the uterine endometrial stromal cells, were incubated in the Dulbecco's modified Eagle's medium(DMEM) and F12 medium. The cellular proliferation were evaluated every 24 hours. The expression of COX-2 was measured after estrogen and progesterone supplementation by western blot. Results : CUE-P cells have cuboidal morphology and CUS-V2 cells resemble fibroblast and exhibit a spindle-like morphology. When CUE-P and CUS-V2 cells were co-cultured with estrogen and progesterone supplementation, the expression of COX-2 was decreased after 24 hours of estrogen supplementation. The decreased expression of COX-2 was observed only when estrogen was supplemented after 9 hours of initial progesterone supplementation. Conclusion : The sex steroid, such as estrogen and progesterone could regulate COX-2 expression in uterine cell lines.
체외수정시술 후 삼태 임신에서 다태 임신 감수술의 시행으로 성립된 쌍태 임신의 주산기 예후
이해림(Hae Rim Lee),이동선(Dong Sun Lee),박은주(Eun Ju Park),김성훈(Sung Hoon Kim),전대준(Dae Joon Cheon),채희동(Hee Dong Chae),김정훈(Chung Hoon Kim),강병문(Byung Moon Kang),박견(Kyun Park),장윤석(Yoon Seok Chang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
N/A Objective:To investigate the perinatal outcome and complications of reduced twin pregnancies from triplet by multifetal pregnancy reduction (MFPR) in patients who underwent in vitro fertilization and embryo transfer. Materials and methods:From January 1995 to December 1999, a total of 71 twin pregnancies were included in this study. The patients were grouped into the MFPR group (n = 19) and the non-MFPR group (n = 59). The pregnancies in the MFPR group were reduced to twin from triplet by the MFPR. MFPR was performed by transvaginal sonography-guided fetal aspiration or mechanical trauma. The obstetric and perinatal outcomes were compared between the two groups. Statistical analysis was performed using Student's t-test, Fisher's exact test, and χ2 test as appropriate. Statistical significance was defined as p < 0.05. Results:There were no significant differences in mean gestational age and distribution of gestational age between the two groups. However, the fetal loss rate before 24 weeks of gestation was significantly higher in the MFPR group than the non-MFPR group. We did not find any significant differences in mean birth weight and weight discordancy between the two groups. There were no differences in obstetric and perinatal outcomes between the MFPR and non MFPR groups as well. Conclusion:These data suggest that pregnancy outcome of reduced twin pregnancies from triplet by MFPR in patients underwent IVF-ET might be comparable to that of non-reduced twin pregnancies.
폐경기 여성에서 혈중 에스트라디올 농도 및 골밀도와 청력 기능과의 연관성
박은주 ( Eun Ju Park ),이동선 ( Dong Sun Lee ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ),전대준 ( Dae Joon Cheon ),박견 ( Kyun Park ),유항조 ( Hang Jo You ),음현진 ( Hy 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
N/A Objective: To clarify whether hearing sensitivity in postmenopausal women is associated with serum estradiol level or bone mineral density (BMD) Materials and Methods: From January 1999 to December 1999, serum concentration of estradiol, bone mineral densities of the lumbar vertebrae and femoral neck, and hearing sensitivity were measured in 1162 postmenopausal women. Serum concentration of estradiol was measured by radioimmunoassay. Dual energy X-ray absorptiometry (DEXA) was used to measure bone mineral densities of the lumbar vertebrae and femoral neck. Pure tone thresholds were evaluated by screening pure tone audiometry. All data were analyzed with Student`s t-test, multiple logistic regression analysis, and multiple linear regression analysis. Results: A total of 1155 patients were analyzed; 155 patients were in the hearing-loss group and 1000 patients were in the control group. On univariate analysis, significant differences were found in mean age, concentration of serum estradiol, and BMD of the fernoral neck between the two groups (mean±SD, 58.1±5.2 vs 56.0±4.3, 11.6±6.0 vs 13.1±12.0, 0.67±0.11 vs 0.70±0.11; p-value: 0.0001, 0.01, 0.02). On multiple logistic regression analysis and multiple linear regression analysis, significant association was found between age and hearing loss and between age and pure tone threshold (p-value: 0.0001, 0.0001, respectively). However, neither seum concentration of estradiol nor BMD was associated with hearing loss or pure tone threshold. Conclusion: This study suggests that hearing sensitivity in postmenopausal women is not directly associated with serum estradiol level or BMD.
박은주 ( Eun Ju Park ),김성훈 ( Sung Hoon Kim ),장윤석 ( Yoon Seok Chang ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ),전대준 ( Dae Joon Cheon ),박견 ( Kyun Park ),차지만 ( Ji Man Cha ),음현진 ( 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
N/A Objectives: To evaluate the causes of intrauterine adhesion (IUA) and the efficacy of hysteroscopic adhesiolysis in patients with IUA Methods: From January 1995 to June 1999, a total of 63 patients with IUA were underwent hysteroscopic adhesiolysis. The patients with IUA only were trying to be pegnant spontaneous whereas, intrauterine insemination (IUI) or in vitro fertilization and embryo transfer (IVF-ET) were performed in the patients who have other infertility factors and IUA as well. The data such as the changes of menstrual amount and pattern, fertility, and full-term live birth rate were analyzed. Results: The most common cause of IUA was curettage related problems; after incomplete abortion 20.6%, postpartum bleeding 9.5%, elective abortion 47.6%, missed abortion 11.1%, and for treatment of hydatidiform mole 1.6%. All patients with amenorrhea or oligomenorrhea had improvement of their menstrual patterns. Forty seven patients wanted pregnancy and 31 patients achieved pregnancy (68.4%). Full-term live birth rate 38.3% and there was one placenta accreta in full-term live birth case, which was resolved by postpartum curettage. Conclusion: Hysteroscopic adhesiolysis of IUA could be effective for restoring the normal menstrual pattern and fertility.
습관성 유산 산모의 태아에서 발견된 9 번 염색체 장완 중복다형성 1 예
박은주,이동선,김성훈,채희동,김정훈,강병문,이해림,최은녕,정주연,서을주,전대준 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
Habitual abortion or recurrent pregnancy loss has been defined as the occurrence of three or more clinically recognized pregnancy loss before 20 gestational weeks. A recognized cause of habitual abortion is a genetic abnormality, and karyotyping of couples will reveal that about 5% have some abnormality, most frequently a balanced translocation. However, it has been reported that duplication of chromosome is a rare condition associated with habitual abortion. We have experienced a case of chromosomal duplication 9q as polymorphism found in fetus of the patient with habitual abortion. Father of the fetus also has the same chromosomal duplication on 9q. This represents familial polymorphism and it is very rare variant. We presented with brief review of literatures.