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백서에서 분리된 췌도의 인슐린 분비에 미치는 Morphine과 Naloxone의 효과
전기엽,최호,박명철,유재성,정윤신,김환규,최영숙,이학송 대한내과학회 1990 대한내과학회지 Vol.38 No.4
This study evaluated the effect of morphine and naloxone on the biphasic insulin secretion of the perifused isolated rat pancreatic islets. The peirfusate was Krebs-Ringer solution, which contained 10m㏖/L glucose and 1.145m㏖/L calcium, and the flow rate was 1.5㎖/min. The results were as fallows: 1. The infusion of 1㎍/㎖ morphine caused a significant decrease in the first-phase and total insulin secretion of the diabetic rat islets only. It caused no significant change in the insulin secretion of the normal pancreatic islets. This suggests the possibility that 1㎍/㎖ morphine causes a greater increase in the outward potassium conductance of the diabetic pancreatic islets than that of the normal pancreatic islets. 2. The infusion of 1㎍/㎖ naloxone caused a significant decrease in total insulin secretion, both of the normal and diabetic pancreatic islets. Therefore, it suggests that the opioid system has some control function over the release of insuline by the pancreatic islets. But a small controversy exists concerning the regulatory function of the opioid system upon the insulin release of the pancreatic islets, so further study must be conducted to fully evaluate its function.
전기엽,홍복희,강성귀 전북대학교 의과학연구소 1983 全北醫大論文集 Vol.7 No.1
Authors reported a case of myasthenia gravis associated with thymoma, 41 years old woman. By the modified Osserman's classification, it is group lll, and obtained complete remission with prednisolon and thymectomy.
해당화 뿌리의 가수분해형 탄닌(Rosanin)이 실험용 백서의 혈당, 중성지방 및 제4 당수송체 mRNA의 발현에 미치는 영향
전기엽(Ki Youp Jeon),문성필(Sung Phil Mun) 대한내과학회 2000 대한내과학회지 Vol.58 No.2
N/A Background : The root of the plant Rosa rugosa has been reported to have an anti- hyperglycemic and anti-hyperlipidemic effect in experimental animals. But its definite anti-hyperglycemic and anti-hyperlipidemic substance has not yet been identified. In this study, we found the hydrolysable tannins of the hot water extract of the Rosa rugosa root had those effects, and named it as Rosanin. And its mode of actions were evaluated. Methods : Three groups of streptozotocin-injected rats and two groups of buffer-injected control rats were given 10 mg/Kg/ml of Rosanin, or glibenclamide, or water by nasogastric tubes for three weeks. Blood sugar, insulin, triglyceride and GLUT4 mRNA levels were checked in the fasting state. Liver, kidney and pancreatic specimens were observed by light microscopy. Results : All the water-treated, glibenclamide-treated and Rosanin-treated diabetic rats had significantly higher blood sugar levels compared to that of normal control rats (p<0.001, p<0.001 and p<0.05, respectively); but Rosanin-treated diabetic rats had significantly lower blood sugar level compared to those of glibenclamide-treated and water-treated diabetic rats (p<0.05 and p<0.001, respectively). In the Northern blot analysis from the experimental rats' hind limb skeletal muscle RNA, all the diabetic rats showed variously decreased levels of GLUT4 mRNA compared to those of normal control rats. The water-treated diabetic group showed a 66% decline (p<0.001); the glibenclamide-treated diabetic group led with a 2% decline; and the Rosanin-treated diabetic group revealed a 23% decline (p<0.05). All three groups of diabetic rats had significantly lower insulin levels compared to that of normal control rats (p<0.01), but glibenclamide-treated diabetic rats and Rosanin-treated diabetic rats had significantly higher insulin level compared to that of water-treated diabetic rats (p<0.05, each). Furthermore, Rosanin treatment significantly decreased plasma blood triglyceride levels of streptozotocin-injected diabetic rats compared to water-treated and glibenclamide-treated, streptozotocin-injected diabetic rats (p<0.05 and p<0.01, respectively). The light microscopic observation of pancreatic specimens of the Rosanin-treated diabetic group showed more intact islet cells than the water-treated diabetic groups. Liver specimens of the Rosanin-treated diabetic group showed a normal appearance, but those of the water-treated diabetic groups showed severe spotty hepatic necrosis and many regenerating hepatic cells. Conclusion : Rosanin has an anti-hyperglycemic effect. This effect is due, in part, through the enhancement of the GLUT4 mRNA expression, the stimulation of insulin secretion in hyperglycemia, and through the preservation of pancreatic beta cells from the destructory damages of the streptozotocin. Further, it has anti-hypertriglyceridemic and hepatotoxicity-relieving effects in streptozotocin-injected diabetic animals. Abbreviations : Rosanin, the high molecular weight hydrolysable tannins of the hot water extract of the Rosa rugosa root; has an average molecular weight of about 830,000; it mainly consists of D-glucose units linked by the 1→4 gulcoside bonds and phenolic acids, such as ellagic and gallic acid1).(Korean J Med 58:180-188, 2000)