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Recent Advances in the Development of TGF-β Signaling Inhibitors for Anticancer Therapy
이호재 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.4
TGF-β is a multifunctional cytokine that plays an important role in both physiologic and pathologic processes, including cancer. Importantly, TGF-β has a dual role in tumorigenesis, acting as a tumor suppressor or a tumor promoter, depending on the stage of tumor development. The aberrantly upregulated production of TGF-β has been strongly implicated in tumor progression, angiogenesis, and metastasis, as well as immune evasion. Therefore, hyperactivated TGF-β signaling is considered a potential therapeutic target for cancer therapy. Numerous inhibitors of overactivated TGF-β signaling have been developed, and some of them are currently in clinical trials. This review focuses on the TGF-β signaling that contributes to tumor progression and immune evasion in the tumor microenvironment and presents recent achievements on TGF-β signaling inhibition as a single or combined therapeutic approach in cancer therapy. Key Words TGF-b, Tumor microenvironment, Tumor escape, Antineoplastic agents, Immune checkpoint inhibitors
원전구조물용 플라이애시 콘크리트의 시공이음 형태에 따른 투기특성 분석
이호재,김지현,최유진,서은아 한국산학기술학회 2023 한국산학기술학회논문지 Vol.24 No.11
In this study, the gas permeability coefficient of concrete structures in a nuclear power plant was evaluated by measuring the concrete permeation flow rate according to the construction joint type and pressure conditions. The pressure conditions for evaluating the concrete gas permeability characteristics were 0 to 300 psi, a total of 7 levels, and test specimen thicknesses of 30 mm and 50 mm. The average permeation flow rates at 300 psi for the OPC and FA20 specimens were 0.42 L/min and 0.59 L/min, showing similar air permeability performance. The permeation flow rate of the FA20-CJ(s) test specimen manufactured without any additional treatment at the joint was over 1 L/min, which was 1.7 to 2.4 times higher than that of the fully cast test specimen. The permeation flow rate of the FA20-CJ(r) test specimen with surface treatment applied to the construction joint was 60% lower compared to the FA20-CJ(s) test specimen. The most influential factor on the air permeability performance of sound concrete was the thickness of the test specimen, and in cases where there were construction joints, the method of processing the joints was significantly affected.
백서 치주인대세포의 분화에 대한 Bone morphogenetic protein-7의 영향
이호재,김영준,정현주,Lee, Ho-Jae,Kim, Young-Jun,Chung, Hyun-Ju 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.3
Periodontal therapy has dealt primarily with attempts at arresting progression of disease. however, more recent techniques have focused on regenerating the periodontal ligament having the capacity to regenerate the periodontium. Recombinant human bone morphogenetic protein-7(rhBMP-7) can differentiate the osteoprogenitor cells and induce bone formation. The purpose of this study was to evaluate the effect of BMP-7 on rat periodontal ligament cells differentiation, in vitro. In the control group, cells was cultured with DMEM media. In the experimental groups, cells were cultured with rhBMP-7 in concentration of 10, 25, 50 and 100 ng/ml. Each group was characterized by examining alkaline phosphatase activity at 3 and 5 days of culture and the ability to produce mineralized nodules of rat calvarial cells at 14 days of culture. Synthesis of type I collagen(COL-I), osteocalcin(OCN), and bone sialoprotein(BSP) was evaluated by RT-PCR at 7 days of culture. Activation of Smad proteins and p38 MAP kinase was determined by western blot analysis of the cell lysates. Alkaline phosphatase activity was significantly increased in the concentration of BMP-7 50 ng/ml and 100 ng/ml compared to the control(p<0.05). The mineralized bone nodule formation was greater with addition of 50 ng/ml and 100 ng/ml BMP-7 than the control(p<0.01). In 7 days' culture, the expressions of COL-I, BSP, and OCN was increased by BMP-7 in concentration of 10 $ng/ml{\sim}100$ ng/ml. In western blot analysis, BMP-7 treated culture cells expressed Smad 1,5,8 in dose-dependent manner, whereas BMP-7 did not activate phosphorylated form of p38 MAP kinase. These result suggested that BMP-7 stimulate rat periodontal ligament cells to differentiate toward osteoblast phenotype and increase bone matrix production by activation of BMP-Smad pathway.
이호재,김홍주,김재근,Lee, Ho-Jae,Kim, Hong-Ju,Kim, Jae-Geun 한국전자통신연구원 1992 전자통신 Vol.14 No.2
본고에서는 CCITT 표준에 기본을 둔 다양한 전송서비스 능력을 갖는 SDH 망요소들의 모듈화 구현기법을 제시하고, 나아가 이들 망요소들을 응용한 동기식 전송망의 구조를 전송서비스의 보호특성을 강조하여 제시한다.