상악동 병변의 인지시 파노라마 방사선사진의 유용성

이은숙,박창서,Lee Eun-Sook,Park Chang-Seo 대한영상치의학회 1999 Imaging Science in Dentistry Vol.29 No.1

Purpose: to evaluate the usefulness of the panoramic radiography, generally used in dental clinic, for the detection of the maxillary sinus pathosis due to the inflammation and tumor, through the comparison with CT findings as the absolute standard. Materials & Methods: 150 maxillary sinuses of 75 patients with or without particular signs and symptoms and showing soft tissue lesions or destruction of maxillary sinus walls in at least one sinus in CT, were selected as subject samples, and the panoramic radiography of the same patients were interpretated by 3 dental radiologists and 3 non dental radiologist given no previous informations. Using the CT findings as the absolute standard, the diagnostic ability of panoraimc radiography in the mucosal thickening, maxillary sinus haziness, inferior wall destruction, medial wall destruction, posterolateral wall destruction and the superior wall destruction was evaluated using the ROC curve and the difference between dental radiologist group and non dental radiologist group was also evaluated. Results: 1. When dental radiologist group interpretated the destruction of inferior wall and posterolateral wall, the kappa value which shows interobserver's coincidence was above 0.75. 2. The diagnostic ability according to site of interpretation was the highest when the inferior wall was interpretated in both observer groups and there was a statistically significant difference between the dental radiologist group and non dental radiologist group in interpretating the mucosal thickening, haziness, destruction of the inferior and medial wall(p<0.05). 3. The diagnostic ability in detecting the destruction of the sinus walls was better than in soft tissue lesions in both groups and between the groups there was a statistically significant difference(p<0.05). Conclusion: When detecting the destruction of inferior and posterolateral wall of the maxillary sinus there was coincident with that of CT findings, and so it is considered that diagnostic ability of panoramic radiography is high in this point. But in interpretating the destruction of medial wall and soft tissue lesions, diagnostic ability of the panoramic radiography was relatively low and there was a significant difference between the dental radiologist group and non dental radiologist group. Therefore CT or other auxiliary diagnostic method will be necessary when evaluating thorough pathosis of maxillary sinus objectively.

국민학생의 현존 치아우식 및 구강 환경상태와 Snyder검사 결과간의 상관관계에 관한 연구

이은숙,이백현,신승철 ( Eun Sook Lee,Baik Hyun Lee,Seung Chul Shin ) 대한예방치과·구강보건학회 1992 大韓口腔保健學會誌 Vol.16 No.2

기묘한 매력이 있는 나라, 터키

이은숙,Lee, Eun-Suk 한국주택협회 2006 주택과 사람들 Vol.193 No.-

터키의 매력은 소소한 일상이 드러나는 도시의 뒷골목에 있다. 나라 전체가 하나의 역사 박물관이라고 해도 손색없는 터키. 거리 곳곳에 숨어 있는 기독교 문화유산과 이슬람 문화유산을 번갈아 바라보면 저절로 묘한 매력에 빠지게 된다.

다양한 치은 연하 수복물에 대한 치은 섬유아 세포 부착 연구

이은숙,송인택,임정수,김형섭,Lee, Eun-Suk,Song, In-Taeck,Lim, Jeong-Su,Kim, Hyung-Seop 대한치주과학회 1999 Journal of Periodontal & Implant Science Vol.29 No.3

When mucoperiosteal flaps are positioned and sutured to desirable position, the wound contains several interface between tissues which differ fundamentally in composition & biological reaction. Thus the C-T surface of the flap will, on one hand, oppose another vascularized surface, and on the other, the avascular dental material for example, when root resoptions, fractured root, endodontic perforation, deep root carious lesions were filled with amalgam, glass ionomer, resin etc. Recently, a number of case report described the successful treatment of a subgingival root lesion with restorative material & free gingival graft, open flap surgery, but more objective research was needed . Most of study on restorative materials were concerned for cytotoxicity not for actual healing event on that materials and its influencing factors such as biocompatibility, surface wettability, surface topography . The aim of this in vitro study was to evaluate the effect of amalgam, resin modified glass ionomer, composite resin per se, and their surface roughness on the growth of human gingival fibroblast. The cells were obtained and placed on culture flask and incubated for 3 days with the prepared test materials. Then count the attached cell number with hemocytometer,(n=12) and 2 samples were examined with SEM about attachment cell morphology . Another 4 samples were evaluated on their surface roughness with Talysurf and average surface roughness value(Ra) were obtained. Statistical difference in attached cell number, roughness value were analyzed using ANOVA. The number of attached cell was as follows, for root dentin specimen 16.7${\pm}$4.41, resin modified glass ionomer 14.0${\pm}$4.15, resin 8.13${\pm}$3.63, amalgam 0.72${\pm}$3.33(${\times}10^3$). Between root dentin and resin-modified glass ionomer, no significant difference was observed, but resin, amalgam showed a significant less cell numbers than for root dentin, resin modified glass ionomer cement. SEM examination expressed many cell surface attachment apparatus in root dentin and resin modified glass ionomer specimens. For resin specimen, cell attachment was observed but exposed less appratus. The average surface roughness value are following results. Dentin specimen 0.6972${\pm}$ 0.104, resin modified glass ionomer 0.0822${\pm}$0.009, resin 0.0875${\pm}$0.005, amalgam 4.2145${\pm}$0.985(${\mu}m$). Between root dentin, resin-modified glass ionomer, and resin, no significant difference was observed, but amalgam showed a significant more rough surface than other groups. When evlauated the interrelationship between cell attachment and surface roughness, therefore, there was weak reverse correlation.(pearson correlation : - 0.593) These results suggest that resin modified glass ionomer have the favorable healing potential when used for subgingival restoration. And for relationship between cell attachment and surface characteristics, further investigations were needed.

유아의 구강건강관리 실태와 유치우식에 관한 연구

이은숙,신승철 ( Eun Sook Lee,Seung Chul Shin ) 대한예방치과·구강보건학회 1996 大韓口腔保健學會誌 Vol.20 No.3

고객의 행복과 꿈을 짓는 기업, 화성산업

이은숙,Lee, Eun-Suk 한국주택협회 2006 주택과 사람들 Vol.191 No.-

고객의 꿈과 행복을 짓는 기업이 있다. 48년간 한결같은 고객 사랑의 정신을 바탕으로 일해온 화성산업이 바로 그곳. 좋은 기업이라는 이미지를 뛰어넘어 최근 위대한 기업으로의 도약을 꿈꾸는 화성산업을 방문했다.

상황버섯으로부터 분리한 고분자 다당류의 특성

이은숙,서부일,Lee Eun-Sook,Seo Bu-Il 대한한의학방제학회 2000 大韓韓醫學方劑學會誌 Vol.8 No.1

상황버섯 자실체의 열수 및 알카리 추출 다당류에 대한 성분 분석을 조사하여 다음과 같은 결과를 얻었다. 1. 상황버섯 자실체를 열수 및 알칼리 추출시 수율은 각각 1.1%와 4.4% 였으며, 당은 각각 81.1%와 37.4%를 함유하고 있었다. 2. 구성당은 glucose와 galactose가 주를 이루고, 아미노산은 열수 추출분획은 Tre와 Ser을 다량 함유하고 있었으며, 알칼리 추출분획은 Asp와 Ala가 주를 이루는 것으로 조사되었다. To examine the chemical properties of the polysaccharide from Phellinus linteus, we obtained the polysaccharide treated by the alkali and hot water. The carbohydrate and protein contents of each polysaccharide 81.1%, 37.4% and 6.2%, 21.8%, respectively. The carbohydrate consisted of six monosaccharides and the protein contained 16 amino acids.

상황버섯으로부터 분리한 고분자 다당류의 약리활성

이은숙,서부일,Lee Eun-Sook,Seo Bu-Il 대한한의학방제학회 2000 大韓韓醫學方劑學會誌 Vol.8 No.1

상황버섯 자실체의 열수 및 알칼리 추출다당류에 대한 약리 효과는 다음과 같다. 1. 분자량은 10kD 부근에서 주를 이루고 있었으며, IR은 다당류의 전형적인 peak 흡수대를 나타냈다. 2. 항암 활성과 보체 활성에 있어서는 열수추출 다당류에서 높게 나타났으며, 지질 과산화 저해능은 알칼리 추출 및 열수 추출 분획에서 각각 71.3%와 55.8%의 저해율을 나타내었다. 상기와 같은 결과를 종합하여 볼 때 상황버섯 자실체의 열수 및 알칼리 추출물은 당과 단백질로 구성된 단백 다당류였으며, 열수 추출과 알칼리 추출에 의한 약리활성 정도는 유사한 것으로 조사되었다. To examine the pharmacological activity of the polysaccharide extracted from phellinus linteus, we obtained the polysaccharide treated by the alkali and hot water, molecular weights of hot water was 10kD and 225 kD. Anticomplementary activity were highly observed in hot water fraction than alkali fraction. The tumor inhibition ratio of the polysaccharide extracted by hot water and alkali of Phellinus linteus against sarcoma 180 were 72.5% and 67.6%, respectively. These results suggest that protein bound polysaccharides extracted by a hot water and alkali of Phellinus linteus were similar to the pharmacological activities and chemical properties.

배초향으로부터 Grb2-Shc domain 결합저해 물질의 분리

이은숙,안병태,이새봄,김혜경,복성해,정태숙,Lee, Eun-Sook,Ahn, Byung-Tae,Lee, Sae-Bom,Kim, Hyae-Kyeong,Bok, Song-Hae,Jeong, Tae-Sook 한국생약학회 1999 생약학회지 Vol.30 No.4

SH2 domains and their associated catalytic or noncatalytic proteins constitute critical signal transduction targets for drug discovery. Grb2 associates with phosphotyrosine sites of the activated receptors or Shc via their SH2 domain to link receptor tyrosine kinases to ras signalling. Blocking of the Grb2-Shc complex may be to intervene the oncogenic signal transduction pathways and to develop a new antitumor drug. In the search for blockers of Grb2 SH2-Shc interaction, Lutein, a family of carotenoids, was isolated from the extract of the leaf of Agastache rugosa O. Kuntze as SH2 domain antagonists. The $IC_{50}$ of Lutein against Grb2-Shc binding was $6.8\;{\mu}M$.

Locoregional Recurrence of Breast Conserving Surgery after Preoperative Chemotherapy in Korean Women with Locally Advanced Breast Cancer

이은숙,Seok Won Kim,김석기,Keun Seok Lee,Eun-A Kim,Youngmee Kwon,Kyung Hwan Shin,강한성,노정실,Eun Sook Lee 한국유방암학회 2011 Journal of breast cancer Vol.14 No.4

Purpose: Preoperative chemotherapy has been used to increase the rate of breast conserving surgery (BCS) in Caucasian women. However, whether it would also increase the rate of BCS in Korean women has not been verified. The aim of this study was to determine the effectiveness of preoperative chemotherapy to make BCS possible in Korean women who have locally advanced cancer without any increase of locoregional recurrence according to operation methods (BCS vs. mastectomy). Methods: From August 2002 to April 2005, 205 patients with stage II or III breast cancer were enrolled in a phase III randomized trial of preoperative chemotherapy. Surgeons decided on the type of surgery (mastectomy or BCS) at initial diagnosis. By randomization, patients received four cycles of either docetaxel/capecitabine or doxorubicin/cyclophosphamide followed by surgery and crossover to the other treatment as postoperative chemotherapy. Results: The mean tumor size was 3.29 cm and the mean breast volume was 489 cc at diagnosis. After preoperative chemotherapy, clinical response was shown in 76.0% of the patients. Of the 71 patients planned for a mastectomy at initial diagnosis, 27 patients underwent BCS (38.0%). Clinical T stage after preoperative chemotherapy, pathologic T size and lymphatic invasion were correlated with conversion to BCS. In multivariate analysis, only lymphatic invasion showed statistical significance. Locoregional disease-free survival did not statistically differ between the two operation methods for the patients who were planned for a mastectomy at the initial exam. Conclusion: This study showed that preoperative chemotherapy also increased the rate of BCS, while avoiding any increase of locoregional recurrence in Korean women with locally advanced breast cancer.