Zipeprol(레스피렌$^{(R)}$)을 탐닉하던 노인의 급성 중독 사망례

이두환,최상천,안정환,조영신,김기운,민영기,정윤석,Lee, Doo-Hwan,Choi, Sang-Cheon,Ahn, Jung-Hwan,Cho, Young-Shin,Kim, Gi-Woon,Min, Young-Gi,Jung, Yoon-Seok 대한임상독성학회 2009 대한임상독성학회지 Vol.7 No.2

Zipeprol dihydrochloride is a non-opioid mucolytic, antitussive agent and it is frequently prescribed for respiratory symptoms such as cough and sputum. The main pharmacologic mechanisms of zipeprol are inhibition of superior laryngeal nerve stimulation and direct antagonism for stimulation of the bronchial receptors, which might have an effect for the drug's mucolytic action. Many cases of drug abuse with zipeprol have occurred world-wide due to the hallucinogenic effect of the drug. In Korea, zipeprol was reported to be the most commonly abused drug among young people for the 1990s. Zipeprol associated death was first reported since 1991 and 69 cases of death related to zipeprol abuse were further reported during 8 years (between 1991 and 1998). In addition to the hallucinogenic effect, dyspnea, extrapyramidal symptoms, seizure, cerebral edema have been reported as the signs and symptoms of toxic zipeprol overdose. However, zipeprol abuse is not common for old age people and non drug abusers. We report here on a fatal case of acute zipeprol poisoning in an eighty five year old drug addicted woman.

Predictors of Long-Term Survival in Acute Coronary Syndrome Patients With Left Ventricular Dysfunction After Percutaneous Coronary Intervention

이두환,정명호,Jung Ae Rhee,Jin Su Choi,Ki Hong Lee,Min Goo Lee,심두선,Keun Ho Park,윤남식,윤현주,김계훈,박형욱,홍영준,김주한,안영근,조정관,박종춘,강정채 대한심장학회 2012 Korean Circulation Journal Vol.42 No.10

Background and Objectives: Predictive factors of mortality in acute coronary syndrome (ACS) patients with left ventricular dysfunction were analyzed during 5-year clinical follow-up after percutaneous coronary intervention (PCI). Subjects and Methods: A total of 329 ACS consecutive patients (64.6±11.3 years, 227 males) who underwent PCI from January 2001 to March 2006 were followed for 5 years. All patients had lower than 40% of left ventricular ejection fraction (LVEF). Patients were divided into Group I (survived longer than 5-years: n=130, 101 males) and Group II (survived shorter than 5 years: n=199, 126 males). Results: The cumulative survival rate was 88.0% at 1 month, 78.0% at 6 months, 75.0% at 1 year, 67.0% at 2 years, 62.0% at 3 years,57.0% at 4 years and 40% at 5-years. Group II was older (61.6±11.2 years vs. 66.4±11.4 years, p<0.001), and showed higher prevalence of female gender (28.4% vs. 36.7%, p=0.006) and lower LVEF (35.3±5.2 vs. 33.6±5.6) than Group I. The independent predictors for mortality were LVEF <30% {odds ratio (OR)=1.793, 95% confidence interval (CI): 1.234-2.452, p=0.002 }, serum creatinine >3.0 mg/dL (OR=2.455,95% CI: 1.306-4.614, p=0.005), older than 65 years (OR=1.594, 95% CI: 1.152-2.206, p=0.005), and female gender (OR=1.524, 95% CI:1.090-2.130, p=0.014). Conclusion: Five-year survival rate was 40% in ACS patients with left ventricular dysfunction, and the predictors for mortality were low LVEF, high serum creatinine, old age, and female gender.

한국재래산양태아 및 신생아 뇌에서 별아교세포의 전자현미경적 연구

송치원,김무강,류시윤,이강이,박일권,이미영,권효정,박미선,이경열,이두환,신현국,최윤석,장규태,Song, Chi-Won,Kim, Moo-Kang,Ryu, Si-Yoon,Lee, Kang-Lee,Park, Il-Kwon,Lee, Mi-Young,Kwon, Hyo-Jung,Park, Mi-Sun,Lee, Kyoung-Youl,Lee, Doo-Hwan,Shin, 한국현미경학회 2001 Applied microscopy Vol.31 No.2

한국재래산양의 임신60, 90, 105, 120일령 태아 및 신생아의 뇌를 대상으로 면역조직화학적방법을 통하여 면역반응을 나타낸 방사아교세포를 투과전자현미경적 방법을 이용하여 그 미세구조를 연구한 결과 임신 60일령 태아의 방사아교면역반응세포는 소수의 사립체와 많은 당원질 및 과립형질내세망이 관찰되었으며 임신90일령 태아 이후에서도 소수의 사립체, 많은 당원질 그리고 소수의 형질내세망이 관찰되었으며 임신95일령 태아에서 골지체가 관찰되었다. 그리고 임신 120일령에서 혈관에 부착되어 종말발을 뻗고 있는 GFAP 면역반응세포를 관찰할 수 있었다. This study, the ultrastructure of radial glial cells in the fetuses (the 60th, 90th, 105th 120th of gestation) and neonate brains of korean native goat were investigated by immunohistochemical method and transmisson electron microscopy. 1. In the 60th day of gestation, mitochondria and many glycogen body were observed in the radial glial cells. 2. In the 90th day of gestation, mitochondria, many glycogen body and rough endoplasmic reticulum were observed. 3. In the 95th day of gestation, Golgi's apparatus was found. 4. In the 120th day of gestation, Endfeets of radial glial cell attached vessel wall were observed.

돼지 사료에 초활성점토광물을 첨가하여 사육한 효과

이두환 ( Doo Hwan Lee ),김태종 ( Tae Jong Kim ) 한국자연치유학회 2015 Journal of Naturopathy Vol.4 No.1

Domestic SAMs (super activated material series) were added by 0.8% to the feed of 24 pigs in order to study the component change of excretion, the reduction effect of malodorous substances, and the change of meatiness. P, Zn, Mn, and organic components out of excrement components were decreased. Valeraldehyde, a highly malodorous substance, and methyl isobutyl ketone were decreased by 58% and 39%, respectively. As for the characteristics of meatiness, in the group with addition of 0.8% SAMs, all of the brightness, red index, and yellow index tended to increase in comparison with those of control group. As for the dressed carcass, the effect of 0.8% SAMs addition on the growth (weight increase and feed conversion rate) was insignificant. The concentration of immunoglobulin G in the blood of growing piglets was increased from the range of 25 to 50% in the 11th week to the range of 40 to 60% in the 16th week, and the number of lymphocytes started to increase from the 5th week and increased by 18% in the 16th week. There existed preventive effects on respiratory disease and viral syndrome, which often generate in growing pigs. The results above indicate that the addition of SAMs to pig feeds is expected to decrease the amount of such an environmental pollutant excretion as P out of excrement and to have a positive influence on the immunity enhancement and growth rate.

미들웨어 기반 런타임 낸드 플래시 메모리 불량 블록 관리 기법

이두환(Doo Hwan Lee),이동훈(Dong Hun Lee),김준형(Jun Hyoung Kim),김정열(Jeong Yeol Kim),박상우(Sang Woo Park) 한국항공우주학회 2019 한국항공우주학회 학술발표회 논문집 Vol.2019 No.11

WELL Building Standard 적용 기존 건축물 그린리모델링의 건강성능 평가

이두환(Du Hwan Lee),김영일(Young Il Kim),김선혜(Sean Hay Kim) 대한설비공학회 2018 대한설비공학회 학술발표대회논문집 Vol.2018 No.11

In this study, the WELL Building Standard was used to derive the Features for the evaluation of health performance of existing buildings, and to examine changes in health performance before and after improvement of green remodeling. As a result, the total score of each Feature that reflects the weight was 17.75 points, the total score before improvement of green remodeling was 8.19 points, and the score after improvement of green remodeling was 11.13 points. Among the 23 Features that can be evaluated from the WELL Building Standard, 11 Features improved health improvement by 16.6% after improvement of green remodeling. Improvement of indoor ventilation(Feature 3), removal of asbestos(Feature 6), installation of automated shading(Feature 16, Feature 20), and replacement of energy efficient equipments for HVAC(Feature 24) have been shown to improve health performance.

스텐트 재협착 병변에서 약물코팅 풍선카테터과 약물용출 스텐트의 예후 분석

이두환 ( Doo Hwan Lee ),송종남 ( Jong Nam Song ),박신의 ( Sin Eui Park ),최남길 ( Nam Gil Choi ),한재복 ( Jae Bok Han ),김인수 ( In Soo Kim ) 한국방사선학회 2019 한국방사선학회 논문지 Vol.13 No.3

약물용출 스텐트(drug-eluting stents, DES)는 일반 금속 스텐트에 비하여 재협착을 현저하게 줄였지만, 여전히 관상동맥 스텐트 재협착은 비율이 높다. 2012년 11월부터 2016년 12월까지의 일 대학교병원 심혈관센터에서 경피적 관상동맥 스텐트 삽입술 후 관상동맥 조영술에서 스텐트 재협착 환자 187명 그룹 I (약물코팅 풍선카테터 사용, n=127명), 그룹 II (약물용출 스텐트 사용, n=60명)로 분류하여 치료효과, 주요심장사건, 사망 발생률, 심근경색, 표적병변 재개통술 그리고 스텐트 혈전등을 2년 동안 추적 분석하였다. 임상적 특성는 두 그룹간 차이는 없었고(21.1 ± 5.3 vs. 25.3 ± 9.6 mm, p<0.002), 혈관조영검사에서 약물코팅 풍선카테터 사용 그룹에서 스텐트 재협착 길이가 짧았다. 주요심장사건은 8.7%vs.10.0%, p=0.789, 사망발생률0%vs.0%,p=1.000, 심근경색 1.6%vs.6.7%, p=0.085, 표적병변 재개통술 8.7% vs. 10.0%, p=0.789 그리고 스텐트 혈전증 0% vs. 0%, p=1000에서 양군 간에 차이를 보이지 않았다. 약물코팅 풍선카테터가 약물방출 스텐트와 비교하여 2년 추적 검사 결과 주요심장사건에서 차이가 없었고, 약물코팅 풍선카테터는 스텐트 재협착 병변에서 약물방출 스텐트와 함께 선택할 수 있는 좋은 치료방법이라고 사료된다. Although the development of Drug-eluting stent (DES) improved the ISR significantly more than the Bare metal stent (BMS), the coronary stent restenosis (ISR) treatment still has a high recurrence rate. This study is compared the efficacy of DEB with that of DES implantation in patients with ISR. Among 4,316 patients who underwent coronary stent implantation at the Chonnam National University Hospital between November 2012 and December 2016, 187 patients developed ISR on follow-up coronary angiography (66.3 ± 11.0 years, 123 males) were enrolled and divided into two groups according to revascularization method as group I (DEB group; n= 127) and group II (DES group; n= 60). Primary end point was defined as major adverse cardiac events (MACEs), composite of cardiac death (CD), myocardial infaction (MI), target lesion revascularization (TLR) and stent thrombosis (ST) during two-year follow-up between the two groups. There were no differences in the baseline characteristics and angiographic findings except that prevalence of device length was shorter (21.1 ± 5.3 vs. 25.3 ± 9.6 mm, p<0.002) in group I.Two-year MACE were not different in the two groups (8.7%vs.10.0%, p=0.789). The incidences of cardiac death (0%vs.0%, p=1.000), MI (1.6%vs.6.7%, p=0.085), TLR(8.7% vs. 10.0%, p=0.789) and ST (0% vs. 0%, p=1000). DEB demonstrated comparable risk reduction for MACEs compared with DES in patients with ISR during two-year follow-up. DEB might be good alternative for the treatment of ISR in patients with ISR

초활성점토광물 분말의 특성과 미생물 증식에 미치는 영향

이두환 ( Doo Hwan Lee ),김태종 ( Tae Jong Kim ) 한국자연치유학회 2015 Journal of Naturopathy Vol.4 No.1

This paper is to study the characteristics of super activated material series(SAMs) powders and their influence on the lethality and multiplication of microbes. SAMs are composed of lime powder up to 95.5%, most of which are minerals of 400 mesh. In them, CaO is 774.16 ppm, P2O5 374.25 ppm, SiO2 62.37% while Pb, Cd, Hg and As were not found. According to the observation with the scanning electron microscope(SEM), they had a sheet structure without air pores. They showed no smell, flavor and elution of color. Average radiation rate of far-infrared rays was 0.93 μm, and average radiation energy of far-infrared was 3.74×102 W/m2/μm. When A. niger was cultured on the SAMs culture medium, it showed 100% sterilizing power in a week and on. E. coli showed 86.1% reduction on the SAMs medium; P. aeruginous 82.7%. In the water tank medium to which SAMs were added by 5 g/L, the surviving population of Cochlodinium polykrikoides decreased from initial 53% to 20%; In the medium by 10 g/L, it reduced from 60% to 10%. In the medium for A. niger to which 0.05-0.3% SAMs were added, its pH was from 6.6 to 4.4 after 24-48 hours, showing that it became lower according to the concentration of SAMs. The multiplication of cells increased according to the concentration of SAMs. pH of L. acidophilus culture medium added with 0.25-0.3% SAMs decreased from initial 6.6 to 5-4.9 after cultivation of 24-48 hours. But, in the medium of 0-0.1% SAMs, pH increased after 24 hours. The number of cells increased according to the concentration of SAMs. In the 0.5% SAMs medium, pH of Agrobacterium sp. changed from initial 6.09 to 6.55. The measurement of cell mass O.D. increased to 18.65 at 0.5% SAMs medium when compared with that at 0% medium. When the concentration of SAMs was 0%, the dry cell weight was 2.55 g/L. But when the concentration was 0.5%, it increased to 6.80 g/L. The production of polymer curdian was not influenced by SAMs concentration.

연속지적도와 토지피복도를 이용한 불법개발지 추출

이두환(Dohuan Lee),장재원(Jaewon Jang),이주희(Juhee Lee),유석현(Seokhyeon You),박재국(Jaekook Park) 대한공간정보학회 2020 한국공간정보학회 학술대회 Vol.2020 No.11

국내 소규모 건축물의 하자 예방을 위한 시방서 개발방향에 관한 연구

이두환(Lee, Du-Hwan),김재문(Kim, Jae-Moon),전완표(Jeon, Wan-Pyo),남승훈(Nam, Seung-Hoon) 대한건축학회 2021 대한건축학회논문집 Vol.37 No.4

In this study, the development direction of specification specialized for small-sized buildings was proposed to develop measures to prevent defects and improve quality of small-sized buildings that are being built or remodeled. This is in accordance with the continuously increasing trend of small-sized buildings in the construction market. Canadian specifications used for large-sized buildings and small-sized building were chosen for comparative analysis, since its components are most similar to those in Korea. The features of small-sized building specifications were derived based on the construction classification and specification code contents. Additional improvement was proposed using the ‘General requirements for small-sized buildings (in Korea)’ as an outline. And the series of processes and results were synthesized and the ‘Application plan of domestic small-sized building specifications’ was prepared. In addition, the relevant literature was investigated and linked to reflect the visualization of specifications, and the ‘Development direction of small-sized building guide specification’ was established by compiling these results.