입자크기와 중합온도 제어를 통한 폴리다이아세틸렌의 센싱감도 향상

이길선 ( Gil Sun Lee ),오재호 ( Jae Ho Oh ),안동준 ( Dong June Ahn ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.4

Many studies on polydiacetylene(PDA) have been investigated to apply to chemical and biological sensors due to their unique optical properties of color change from blue to red and fluorescence change from non-fluorescence to red fluorescence. Especially, high sensitivity against specific molecules is very important to apply polydiacetylenes to various sensors. In this study, we examined the effect of sensitivity enhancement of 10, 12-pentacosadynoic acid(PCDA) vesicles in detection α-cyclodextrin(CD) according to control of vesicle size by filters with different pore sizes and polymerization temperature. Colorimetric response(CR) was calculated using visible spectrometer. In order to investigate the effect of vesicle size on sensitivity of PDA vesicles, two PCDA vesicles were filtered without filtration and with 0.22 μm filter. The two PCDA vesicles were polymerized at 25℃ and were incubated with α-CD(5 mM) for 30 mm. The CRs of the former and latter vesicles were 31.4% and 74.0%, respectively. Then, two PCDA vesicles filtered with 0.22 μm filter were polymerized at 25℃ and 5℃ and were reacted with α-CD(5 mM) for 30 min to examine the effect of polymerization temperature. The CRs of the former and latter vesicles were 74.0 and 99.2%, respectively. This suggests that vesicle sizes and polymerization temperature are key factors in enhancing the sensitivity of PDA vesicles. In addition, these results are expected to be useful to apply the PDA vesicles as biosensors to detect DNA, protein, and cells.

종례 : 위장관을 관통하여 췌장까지 침범한 생선가시 2예

이길선 ( Gil Sun Lee ),이은영 ( Eun Young Lee ),박은정 ( Eun Jung Park ),박하나 ( Ha Na Park ),허진석 ( Jin Seok Heo ),이종균 ( Jong Kyun Lee ) 대한내과학회 2012 대한내과학회지 Vol.82 No.6

이물질을 섭취하게 되면 대부분은 1주 이내에 별다른 문제없이 위장관을 통과한다. 이물질이 위장관을 관통하여 이차적으로 췌장까지 침범하는 경우는 매우 드물다. 저자들은 이물질이 위장관을 관통하여 췌장까지 침범한 2예를 경험하여 이를 보고하고자 한다. 위장관을 관통한 이물이 흔치 않게 장기를 침범할 수 있으며, 임상적으로 비전형적으로 나타날 수 있으므로 복부증상을 주소로 내원한 환자에서 이물섭취의 가능성을 염두에 둔 세심한 진료가 필요하다. Most ingested foreign bodies pass through the gastrointestinal tract uneventfully within 1 week of ingestion, and so gastrointestinal tract perforation is rare, occurring in less than 1% of patients. The occurrence of a pancreas penetration secondary to foreign-body perforation is even rarer. Here we report two cases of foreign-body penetration of the gastrointestinal tract extending into the pancreas and retroperitoneum. The findings of these cases serve to remind all clinicians that the diagnosis of a foreign-body perforation should always be kept in mind in a patient with abdominal symptoms, and physicians should endeavor to determine the history of ingestion and be aware of foreign bodies in CT scans.

인공생체막을 이용한 이온추출

현진영,이길선,안동준 ( Jin Young Hyun,Gil Sun Lee,Dong June Ahn ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

Churg-Strauss 증후군 환자에서 저용량 경구 Cyclophosphamide 사용 중 발생한 출혈성 방광염

박은정 ( Eun Jung Park ),이길선 ( Gil Sun Lee ),박하나 ( Ha Na Park ),이은영 ( Eun Young Lee ),이병재 ( Byung Jae Lee ),최동철 ( Dong Chull Choi ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.1

Background: Cyclophosphamide (CYC) has been used in patients with Churg-Strauss syndrome with a major organ involvement or peripheral neuropathy in order to reduce mortality and disability. We report a patient who developed hemorrhagic cystitis after receiving low-dose oral CYC over a 6-year period (a total cumulative dose of 137 g), to treat Churg-Strauss syndrome with peripheral neuropathy. Case History: The patient developed left foot drop 18 months after he was diagnosed with Churg-Strauss syndrome. Despite 2 cycles of CYC pulse therapy, he complained of newly developed drop of the wrist and right foot. The neurologic manifestations had gradually improved with oral CYC therapy, which was given 1.5 mg/kg/day initially and was maintained at 0.3∼1.0 mg/kg/day in consideration of CYC pulse therapy-refractory peripheral neuropathy. Gross hematuria developed suddenly after 6 years. Results: The patient was diagnosed with hemorrhagic cystitis related to oral CYC after ruling out other causes of hematuria. Hemorrhagic cystitis improved 1 week after the discontinuation of oral CYC. Conclusion: The maintenance of oral CYC can be efficacious when puls therapies have failed. Hemorrhagic cystitis might occur at low dose of oral CYC. Routine urinalysis and history-taking are crucial for patients receiving oral CYC for a long period even in the absence of side effects. The use of uroprotective measure should be considered during oral CYC therapy. (Korean J Asthma Allergy Clin Immunol 2012;32:56-60)

신규 미니어레이어에 의한 폴리다이아세틸렌 패턴상의 생체유도결정화

안동준 ( Dong June Ahn ),이길선 ( Gil Sun Lee ),이원덕 ( Won Eoc Lee ) 한국화학공학회 2010 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.48 No.3

유철수 (劉哲秀) 교수 회갑기념호 - 화학공학 ; 인공생체막 표면에서의 이온 흡착 밍 교환

안동준(Dong June Ahn),현진영(Jin Young Hyun),이길선(Gil Sun Lee) 고려대학교 공학기술연구소 1997 공학논문집 Vol.34 No.1

N/A N/A

증례 : 위의 종괴 양상으로 재발한 골육종 1예

박하나 ( Ha Na Park ),박준영 ( Jun Young Park ),이은영 ( Eun Young Lee ),박은정 ( Eun Jung Park ),이길선 ( Gil Sun Lee ),김은정 ( Eun Jung Kim ),민병훈 ( Byung Hoon Min ) 대한내과학회 2012 대한내과학회지 Vol.83 No.1

골육종의 위장관 전이는 매우 드물다. 그러나 보조적 항암치료의 도입 이후 골육종의 위장관 전이가 보고되고 있는데 그 중에서도 위전이는 전 세계적으로 3예만 보고되었고 국내에서는 보고된 바가 없다. 또한 수술과 함께 보조적 항암치료를 받은 골육종 환자에서 치료 종료 후 오랜 기간이지난 후에 발생한 지연성 재발이 보고되고 있다. 따라서 오래 전에 항암치료를 포함한 골육종 치료를 받은 환자에서 혈변이나 흑변과 같은 위장관 증상이 새로이 발생했을 때, 치료 후 장기간 동안 재발이 없었다 하더라도 골육종의 위장관 전이 가능성을 고려해야 할 것이다. 저자들은 대퇴부 골육종을 진단받고 수술 및 항암치료 후 11년간 재발이 없었던 환자에서 발생한 위전이 재발의 증례를 문헌고찰과 함께 보고하는 바이다. Metastasis of osteosarcoma to the gastrointestinal tract is very rare. However, since the introduction of intensive adjuvant chemotherapy, the number of reported cases of gastrointestinal metastasis has been increasing in patients with osteosarcoma. Only three cases of gastric metastasis have been reported to date, and no case has been reported in Korea. Delayed metastasis long after successful treatment can also occur in osteosarcoma, particularly in patients who receive adjuvant chemotherapy and radical surgery. Hence, the possibility of gastrointestinal metastasis needs to be considered in the differential diagnosis when patients with osteosarcoma present with gastrointestinal symptoms, such as melena or hematochezia, long after successful treatment, including chemotherapy. Here, we report a recurrent osteosarcoma presenting as gastric metastasis in a patient who underwent a radical limb salvage operation followed by adjuvant chemotherapy and who had no evidence of recurrent disease for 11 years.

응급 개흉술시 발견된 외상성 기관지파열 환자의 수술 치험

이길선 최신의학사 1990 最新醫學 Vol.33 No.7

컴퓨터 보조학습(CAI)이 청각장애 중·고등학생의 수학 문장제 문제 해결능력에 미치는 효과

이길선,박은혜 이화여자대학교 특수교육연구소 2007 특수교육 Vol.6 No.2

청각장애 학생들의 교육에 있어서 가장 중요한 문제는 그들이 가진 교육 가능성에 비해 실제로 나타나는 교육 성취 수준이 상대적으로 낮은 데 있다.청력의 손실로 인한 기초학력 지체 및 특히 고차원적 사고 능력과 언어 능력이 필요한 수학 문장제 문제에 있어서 많은 어려움을 겪게 된다.컴퓨터 보조학습은 다양한 교육적 요구를 가진 학생들에게 효율적으로 개별화 된 교수를 제공할 수 있으며,전통적인 교수 자료의 단점을 극복하여 다감각적인 자료를 제공하는 것과 같이 학습과제를 학습자 개개인의 요구에 맞추어 제시할 수 있는 교수방법이다.본 연구에서는 서울 시내 A 청각장애 특수학교에 재학 중인 청각장애 중·고등부 학생들을 대상으로 방과 후에 청각장애학생들이 어려움을 보이는 수학 문장제 문제 지도를 위한 컴퓨터 보조학습 프로그램을 개발하여 시행하였다.연구 결과.청각장애 학생의 수학 문장제 문제 해결 정확도(맞은 문항의 수)는 전통적인 방식으로 수업을 한 통제 집단보다 컴퓨터 보조학습을 실시한 실험 집단에서 유의하게 향상되었으며,수학 문장제 문제해결 유창성(분당 맞은 문항의 수)에서도 실험 집단이 유의하게 향상되었다.이러한 연구 결과는 청각장애학생의 학습 특성을 반영하여 개발된 컴퓨터 보조학습이 청각장애 학생들의 수학 문장제 문제 해결능력을 향상시키기 위한 교수방법의 하나로서 적용할 수 있음을 시사한다고 볼 수 있다. The purpose of this study was to investigate the effects of the Computer Assisted Instruction(CAI) in the mathematical word problem solving instruction for students with hearing impairments. Specially developed tutorial type CAI was used to enhance math word problems solving ability of students with hearing impairment. Participants were twelve middle school and high school students with hearing impairments. They were divided into two group based on IQ test(Korean-WISC-Ⅲ), arithmetic test and reading test, pure-tone audiometry and selection test. CAI program was used for the experiment group and controlled group received traditional math instruction. Self-made mathematical word problems solving test was sued as pre and posttest. Mann-Whitney correlation test was used for the analysis of data about differences of mathematical word problems solving ability with accuracy and fluency between two groups. The results of this study showed that significant difference was found between experimental group and control group in mathematical word problem solving ability both on accuracy and fluency. The result from this study indicates that specifically developed math problems solving CAI program has a positive effect on accuracy and fluency of students with hearing impairment.