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항결핵 치료 전 발견된 폐결핵과 동반된 폐동맥 혈전색전증 1예
윤창용 ( Chang Yong Yun ),유창민 ( Chang Min Yu ),오유미 ( Yu Mi Oh ),안수민 ( Soo Min Ahn ),심형훈 ( Hyoung Hun Sim ),김은실 ( Eun Sil Kim ),유지원 ( Ji Won Yu ) 전북대학교 의과학연구소 2013 全北醫大論文集 Vol.37 No.1
Venous thrombosis and pulmonary thromboembolism results from a distortion in Virchow`s triad by venostasis, hypercoagulability, or vessel wall inflammation. There have been reported very low prevalence of venous thrombosis combined with mycobacterium tuberculosis infection. The pathogenesis may be associated with rifampin and the hypercoagulable state induced by acute infection. We report a case of pulmonary thromboembolism associated with pulmonary tuberculosis before antituberculosis treatment. A 21-year old young man who presented with cough and dyspnea didn`t have any risk factors for venous thrombosis but contrast-enhanced chest computed tomography and perfusion scan showed pulmonary thromboembolism. Even before antituberculosis treatment, pulmonary thromboembolism can be combined with pulmonary tuberculosis.
윤창용(Chang-Yong Yun),배영철(Young-Chul Bae) 한국지능시스템학회 2021 한국지능시스템학회논문지 Vol.31 No.2
우리나라는 많은 교통사고로 인하여 큰 사회적 부담을 가지고 있다. 이러한 사회적 부담을 줄여주기 위한 방안을 마련하기 위해서는 정확한 교통사고 횟수에 대한 예측이 필요하다. 본 논문은 교통사고의 횟수를 줄이기 위한 교통사고 건수를 예측하기 위해, 교통사고에 주요한 영향을 미치는 상황을 확인하여 변수 데이터를 선정한 후 MLP 알고리즘을 적용한다. 또한 선정된 변수들을 지정하고 각각 다른 단위의 값을 통일하기 위해 정규화를 사용하였다. 또한 특정구간 데이터 학습을 위해 ReLU 활성화 함수를 사용하였고 계절적 패턴(강수량, 적설량, 가시성)과 예측 성능을 높이기 위해 1년 전의 교통사고 발생건수를 변수로 사용하였다. MLP(Multi-layer perceptron) 알고리즘을 적용한 모델을 구성하여 2006~2018년의 교통사고 발생건수를 예측하였고 알고리즘의 예측 성능을 평가하기 위해서 MAPE(Mean absolute percentage error)를 사용하였다. 예측 결과 MAPE가 평균 5.79으로 측정되었으며 예측값이 관측 데이터와의 오차가 7월사이에 가장 크게 발생하였고 12~3월 오차가 가장 적게 발생하였다. Our country has a large social burden due to many traffic accident. In order to reduce and prepare social burden with its solution, we need prediction for number of exact traffic accident. This paper identifies the situation which is affecting main influence by selecting the variable data and we apply MLP(multi-layer perceptron) algorithm to predict number of traffic accident to reduce the traffic accident. We also designate choosing variables and we use normalization in order to unify values for each different unit. Then we use ReLU as an activation function to learn data for certain interval. We also use the number of traffic accident in one year ago and seasonal pattern(Rainfall, Snow, Visibility) as a variable to improve seasonal pattern prediction performance. We organize the model which is applying MLP algorithm, and we predict the number of traffic accident from 2006 to 2018. To evaluate the prediction performance, we use MAPE (mean absolute percentage error). As a result of prediction, MAPE have an average 5.79. We recognize that error between prediction and observation data was large in March through July, while error between prediction and observation data was small in December through March.
크론병 환자에서 Azathioprine 치료 중 발생한 다형성 지방육종
안수민 ( Soo Min Ahn ),서승오 ( Seong O Suh ),오유미 ( Yu Mi Oh ),윤창용 ( Chang Yong Yun ),심형훈 ( Hyoung Hun Sim ),박채아 ( Chae A Park ),송철민 ( Cheol Min Song ),배지윤 ( Ji Yoon Bae ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.4
Azathioprine is frequently used for the treatment of inflammatory bowel diseases (IBD) such as Crohn`s disease and ulcerative colitis. Lymphomas, squamous cell carcinomas, and undifferentiated pleomorphic sarcomas have been reported among patients receiving azathioprine therapy. Herein, we report a case of pleomorphic liposarcoma of chest wall which occurred in a 44-year-old man with Crohn`s disease taking azathioprine. He was diagnosed with Crohn`s disease 3 years ago after suffering from abdominal pain and hematochezia for 12 years. He had been taking 50 mg of azathioprine per day for 23 months when he visited the thoracic and cardiovascular surgery clinic due to right chest palpable mass that had rapidly grown during the past 2 months. Excisional biopsy was performed and the mass was diagnosed as pleomorphic liposarcoma. Therefore, he underwent radical excision of the right chest wall mass, which measured 11.0×6.5 cm in size. He is scheduled to receive radiation therapy and chemotherapy. (Korean J Gastroenterol 2013;62:248-252)
혈소판 감소증으로 발견된 사람면역결핍 바이러스 감염증 1예
오유미 ( Yu Mi Oh ),조재현 ( Jae Hyun Cho ),안수민 ( Soo Min Ahn ),윤창용 ( Chang Yong Yun ),심형훈 ( Hyoung Hun Sim ),김소연 ( Soyon Kim ),김윤권 ( Youn Kwon Kim ),유창민 ( Chang Min Yu ),이세한 ( Se Han Lee ) 전북대학교 의과학연구소 2013 全北醫大論文集 Vol.37 No.1
Although hematologic abnormalities are common in patients with HIV infection, there are few reports of HIV infected patients who first presented with severe thrombocytopenia (<25,000 / μL). We experienced a case of HIV-infected patient presenting only severe thrombocytopenia. There was no other cause that can cause thrombocytopenia. He was treated with antiretroviral therapy. And thrombocytopenia improved after 7 months..
즐례 : 심방 세동 환자에게 propafenone 투여 후 발현된 Brugada 심전도 패턴 1예
심형훈 ( Hyoung Hun Sim ),권낙현 ( Nak Hyun Kwon ),백주영 ( Joo Yeong Baeg ),윤창용 ( Chang Yong Yun ),안수민 ( Soo Min Ahn ),오유미 ( Yu Mi Oh ),김영중 ( Young Jung Kim ) 대한내과학회 2014 대한내과학회지 Vol.86 No.1
Brugada 증후군은 구조적 심질환이 없는 환자에게서 발생 하는 심실성 부정맥과 연관된 돌연사를 특징으로 한다. 저자 등은 실신을 주소로 내원한 환자의 심방 세동 치료를 위해 propafenone 투약 후 숨겨져 있던 Brugada 심전도 패턴이 드러난 증례를 경험하였다. 실신을 경험한 34세의 남자 환자가 급성 심방 세동으로 응급실로 내원하였으며 propafenone 300 mg 투여 후 Brugada type 1 심전도 패턴이 발현되어 이를 보 고하는 바이다. Brugada syndrome is characterized by sudden cardiac death associated with ventricular tachyarrhythmia in patients without structural heart disease. We recently observed a case of concealed Brugada ECG pattern, which appeared after oral propafenone administration for atrial fibrillation. A 34-year-old male patient who experienced syncope was admitted to the emergency department with acute atrial fibrillation (AF). Three hundred milligrams of propafenone that were administered to convert AF to sinus rhythm unmasked the Brugada ECG pattern that had remained concealed. The patient showed a type 1 Brugada ECG pattern after taking propafenone. (Korean J Med 2014;86:70-73)
윤기철 ( Kichul Yoon ),김나영 ( Nayoung Kim ),이주엽 ( Ju Yup Lee ),오동현 ( Dong Hyun Oh ),서아영 ( A Young Seo ),윤창용 ( Chang Yong Yun ),윤혁 ( Hyuk Yoon ),신철민 ( Cheol Min Shin ),박영수 ( Young Soo Park ),이동호 ( Dong Ho 대한소화기학회 2018 대한소화기학회지 Vol.72 No.3
Background/Aims: Abdominal bloating is a troublesome complaint due to insufficient understanding of the pathophysiology. The aim of this study was to evaluate the efficacy of rifaximin in reducing bloating associated with functional gastrointestinal disorders (FGIDs). Methods: A total of 63 patients were treated with rifaximin for FGIDs with bloating or gas-related symptoms between 2007 and 2013 at Seoul National University Bundang Hospital. Rifaximin was administered at a dose between 800 mg/day and 1,200 mg/day for 5 to 14 days. The proportion of patients who had adequate relief of global FGID symptoms and FGID-related bloating was retrospectively assessed. The response was recorded when the symptoms were reduced by at least 50% at the follow-up after treatment cessation. Results: The mean age was 56.8±14.2 years; 49.2% were females. According to Rome III criteria, 20.6% (13/63) had irritable bowel syndrome (IBS) with constipation, 9.5% (6/63) had IBS with diarrhea, 4.8% (3/63) had mixed IBS, 23.8% (15/63) had functional dyspepsia, and 12.7% (8/63) had functional bloating. Of the 51 subjects who were followed-up, 30 (58.8%) had adequate relief of global FGID symptoms and 26 (51.0%) experienced improvement of abdominal bloating after rifaximin treatment. The proportion of female was slightly higher in non-response group than in the response group (60.0% vs. 34.6%, p=0.069). Otherwise, there was no difference between the two groups. Conclusions: Despite the limitations of this retrospective study, our data confirms that rifaximin may be beneficial for abdominal bloating. Further prospective clinical trial with a larger cohort is needed. (Korean J Gastroenterol 2018;72:121-127)
혈액투석 환자에서 발생한 신장 혈종과 자발성 비장 파열의 1예
허소정 ( So Chong Hur ),김윤권 ( Youn Kwon Kim ),정준오 ( Jun Oh Jung ),이세한 ( Se Han Lee ),유서희 ( Seo Hee Ryu ),심형훈 ( Hyoung Hun Sim ),윤창용 ( Chang Yong Yun ) 전북대학교 의과학연구소 2012 全北醫大論文集 Vol.36 No.2
혈액 투석 중인 환자에서의 자발성 비장출혈은 요독성 출혈 경향과 항혈소판제, 투석중 헤파린 사용 등과 연관되어 발생할 수 있으며 매우 드물게 보고되고 있다. 저자들은 혈액 투석 중인 환자에서 최근 외상병력 없이 새로이 발생한 자발성 비장 출혈을 경험하였다. 말기 신부전으로 혈액 투석중인43세 남자가 투석 후 복부 전반의 찌르는듯한 통증을 주소로 내원하였다. 3개월전 발생한 자발성 우측 신장 혈종으로 보존적 치료 중이었으며 항응고제를 복용하고 있지 않았다. 혈압은 152/88 mmHg, 맥박 78 회/분이었고 결막은 창백하고 복부 전반에 걸친 압통과 반발통이 있었다. 복부 전산화 단층 촬영에서 비장 혈종과 다량의 복강 내출혈을 보여, 비장 절제술을 시행 받고 현재혈액투석하며 경과 관찰 중이다. Spontaneous splenic rupture is a rare disease. Dialysis patients with chronic renal failure can undergo spontaneous splenic hemorrhage caused by uremic coagulopathy, heparin used in hemodialysis, infection, amyloidosis. We report spontaneous splenic rupture in a 43year-old man undergoing hemodialysis for end-stage renal disease (ESRD). After hemodialysis he was admitted with complaints of pricking whole abdominal pain and anorexia. He had undergone renal hematoma 3months ago without recent trauma history and had been managed conservatively without using anticoagulant and anti platelet agents during hemodialysis. Blood pressure was 152/88 mmHg, heart rate was 78 bmp. White blood cell count was 8,600/μL, hemoglobin was 6.6 g/dL, platelet was 121,000/μL, PT INR was 1.37 and aPTT was 30.4sec. Abdominal CT scan showed splenic hematoma and large amount of hemoperitoneum. An emergent splenectomy was performed without immediate complications related to the surgical procedures. Pathology report demonstrated that spleen had normal tissue with hematoma. The postoperative course was uneventful. The patient has been undergoing hemodialysis till now. Spontaneous spleen rupture, a rare disease can cause life threatening situation and we should make early diagnosis and management of spontaneous spleen rupture when evaluating patients undergoing hemodialysis who present with abdominal pain and acute onset of anemia.
Yoon, Chang Yong,Hong, Choong Man,Cho, Yong Yeon,Song, Ji Young,Song, Hee Jong,Yun, Young Won,Yang, Ki Hwa,Choi, Kwang Sik,Kim, Cheul Kyu 한국수의공중보건학회 2001 예방수의학회지 Vol.25 No.2
Flow cytometry(FCM)를 이용하여 sperm chromatin structure assay(SCSA)를 실시하면 독성물질로 인한 정자세포 발달과정의 변화 양상을 용이하게 관찰할 수 있다. 이 방법은 정상적인 DNA를 가진 세포는 in situ의 인위적변성에 저항성을 갖지만 독성물질에 susceptibility를 가진 DNA는 인위적 자극에 의하여 DNA 구조에 변화가 일어나는 원리를 이용한다. 본 연구에서는 SD랫드에 여러 농도의 Ethylene glycol monoethyl ether(EGEE)를 4주간 강제 경구투여한 후 EGEE가 부고환 및 정관내 정자세포의 chromatin structure에 미치는 영향을 FCM을 이용하여 측정하였다. 실험결과, EGEE의 투여는 부고환 및 정관내에 변성 DNA를 가진 정자세포의 수를 유의하게 증가시켰다. 부고환의 정자세포의 경우, X축 channel의 중심이동 정도를 나타내는 Xt는 큰 변화를 보이지 않았지만 주 세포집단을 벗어난 세포들의 percentage를 나타내는 COMPt는 농도의존적으로 증가하였다(800 mg/kg B.W./day, p<0.01). 정관내 정자세포의 경우, Xt는 농도의존적으로 증가한(100 mg/kg B.W./day, p<0.05; 200∼800mg/kg B.W./day, p<0.01) 반면 COMPt는 200 mg/kg B.W./day에서 최대치를 보였다. 이러한 결과는 EGEE가 랫드정자세포의 유전자 수준에서도 독성을 일으킬 수 있음을 보여주며, 이를 구체적으로 규명하기 위해서는 향후 EGEE에 의 정자세포에 대한 유전독성학적 측면의 연구가 더 이루어져야 할 것으로 사료된다.