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자궁경부 편평상피암의 유세포측정법을 이용한 DNA 함량분석 및 c-myc 종양단백 발현양상에 관한 연구
윤상애,김인선 고려대학교 의과대학 1993 고려대 의대 잡지 Vol.30 No.1
To evaluate the possible role of abnormal DNA content and c-myc oncoprotein overexpression as a prognostic indicator, 65 uterine cervical squamous cell carcinomas and 8 nonneoplastic cervices were retrived from the surgical materials. For DNA analysis, the nuclear suspension was stained with propidium iodide and analyzed by flow cytometry. Detection of c-myc oncoprotein was done by fluorimetrically using flow cytometry and immunohistochemically by labeled streptavidin (LSAB) method. DNA ploidy, cell proliferative activity and c-myc oncoprotein expression were evaluated with histologic malignancy grade, clinical stage, status of lymph node metastasis and recurrence. The obtained results are summarized as follows ; 1. DNA aneuploidy was found in 26 cases of 65 (40%) cervical cancers. There was no correlation between DNA ploidy and clinical stage, however, G_(2)M fraction and proliferative index were significantly higher in invasive carcinoma than in microinvasive carcinoma. 2. The proportions of the c-myc positive cells were higher in cervical carcinomas than in nonneoplastic cervices, however, there was no difference between clinical stages. The intensity of oncoprotein immunostaining was higher in invasive carcinomas than in microinvasive carcinomas. 3. There was no correlation of histologic malignancy grade with DNA ploidy and proliferative activity, however, the tumors in higher grade malignancy showed more intense immunostaining and positive nuclear area for c-myc oncoprotein than in lower grade. The histologic malignancy grade of tumor was positively correlated with clinical stages. 4. DNA aneuploidy and high proliferative activity were related with neither lymph node metastasis nor recurrence. Only the intensity and positive nuclear area for c-myc oncoprotein immunostaining were higher in the cases of lymph node metastasis.
조영도,조준,문창택,장상근,윤상애 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-
This case report deals with a 75-year-old female. The patient was admitted for headache due to passenger traffic accident. Plain radiographs of the skull showed the finding of dense calcified lesion in the right parietal bone. In the Brain CT scan, this lesion showed uniformly hyperdense and non-enhancing mass. The clinical examination showed no gross abnormalities. In the operation field, this lesion attached to the inner surface of the dura by the dense fibrous band and protruded into the cerebral cortex. One fragment was about 1cm×1.4cm×1.6cm and the other about 3mm×2mm×3mm. Histologic examination of the surgical specimen(H/E stain) showed a benign osteoma.
윤상애,전혜정,함희원,박형석 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-
Small cell carcinoma originates from APUD cell of any part of the body. Usually the cases are discovered in the lung, and have poor prognosis. Primary small cell carcinoma of the stomach has been recognized recently, and only three cases have been reported in the Korea. This tumor is morphologically analogous to small cell carcinoma of the lung, and characterized by very aggressive clinical course. We report a case of primary small cell carcinoma of the stomach which had hepatic metastasis. The lesion of the stomach, located in the upper body and cardia, is ulcerated with irregular margin and dirty surface covered with exudates.
김수녕,이성기,손인숙,이원욱,윤상애,김영문 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.6
저자들은 7일간 간헐적인 우측 하복부 동통을 주소로 내원한 22세 여성에서 우측 난소난관 절제술을 시행한 후 병리조직 검사에서 거대 난소부종으로 확인된 1예를 치험하였기에 문헌 고찰과 함께 보고하는 바이다. Massive ovarian edema was very rare disease in young women and tumor-like condition that marked enlargement of one or both ovaries by an accumulation of edema fluid in the stroma, separating normal follicular structures. The cause and pathogenesis of massive ovarian edema still remains unclear. The most likely mechanism for the development of such a condition is interference with lymphatic drainage and venous return, probably caused by partial torsion of the mesovarium. A 22-year-old woman who has suffered from right lower abdominal pain during seven days was performed right salpingooophorectomy under the impression of right ovarian tumor with torsion. Histopathological study demonstrated the 19×13×8.5 cm sized huge solid mass to be massive ovarian mass. Hereby we report this case with the brief review of literature.