열충격 단백질의 신경정신의학적 의의와 중요성

오동훈,양병환,최준호,Oh, Dong-Hoon,Yang, Byung-Hwan,Choi, Joonho 대한생물정신의학회 2007 생물정신의학 Vol.14 No.4

Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins(HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage to the proteome, initiating refolding of denatured proteins and regulating degradation after severe protein damage. HSPs also modulate multiple events within apoptotic pathways to help sustain cell survival following damaging stimuli. HSPs are induced by almost every type of stresses including physical and psychological stresses. Our nervous system in the brain are more vulnerable to stress and damage than any other tissues due to HSPs insufficiency. The normal function of HSPs is a key factor for endogenous stress adaptation of neural tissues. HSPs play an important role in the process of neurodevelopment, neurodegeneration, and neuroendocrine regulation. The altered function of HSPs would be associated with the development of several neuropsychiatric disorders. Therefore, an understanding of HSPs activities could help to improve autoprotective mechanism of our neural system. This paper will review the literature related to the significance of HSPs in neuropsychiatric field.

정신분열병의 시각자극 사건유발전위 P300에 대한 연구

오동훈,남정현,안동현,김석현,최준호,Oh, Dong-Hoon,Nam, Jung-Hyun,Ahn, Dong-Hyun,Kim, Seok-Hyun,Choi, Joon-Ho 대한생물정신의학회 2004 생물정신의학 Vol.11 No.1

Objective:Event-related potentials(ERPs) are electrical changes recorded at the surface of the scalp in response to stimulus presentation, and their latency and amplitude change according to cognitive processes. Through past studies of the auditory ERP in schizophrenia, the P300 has been reported to be statistically smaller and delayed in schizophrenia than comparison groups. However, studies of the visual ERP have not been systematically examined. The present study was designed to investigate the visual P300 in patients with schizophrenia and normal controls and to compare the pattern of P300 between them. Methods:The subjects were composed of patients(N=22) with schizophrenia by DSM-IV and normal controls(N=22). The visual ERPs were measured by the visual continuous performance test. P300 amplitude and latency measured on 5 scalp electrodes(Fz, Cz, Pz, $T_7$, $T_8$) were compared between patients and controls. Results:The P300 latencies measured on Fz, Cz, Pz, and $T_7$ electrodes were significantly longer in patients than controls(p<0.05). The P300 amplitudes in patients were smaller than controls. However, the difference between them was not statistically significant. Conclusion:Analysis of the visual ERPs showed that the P300 latency is significantly delayed and the P300 amplitude is slightly smaller in patients than controls. These results are similar to established studies of the auditory P300 in schizophrenia.

단일벽 탄소나노튜브 필름의 전기적 및 광학적 특성

오동훈,강영진,정혁,송혜진,조유석,김도진,Oh, Dong-Hoon,Kang, Young-Jin,Jung, Hyuck,Song, Hye-Jin,Cho, You-Suk,Kim, Do-Jin 한국재료학회 2009 한국재료학회지 Vol.19 No.9

Thin films of single-wall carbon nanotubes (SWNT) with various thicknesses were fabricated, and their optical and electrical properties were investigated. The SWNTs of various thicknesses were directly coated in the arc-discharge chamber during the synthesis and then thermally and chemically purified. The crystalline quality of the SWNTs was improved by the purification processes as determined by Raman spectroscopy measurements. The resistance of the film is the lowest for the chemically purified SWNTs. The resistance vs. thickness measurements reveal the percolation thickness of the SWNT film to be $\sim$50 nm. Optical absorption coefficient due to Beer-Lambert is estimated to be $7.1{\times}10^{-2}nm^{-1}$. The film thickness for 80% transparency is about 32 nm, and the sheet resistance is 242$\Omega$/sq. The authors also confirmed the relation between electrical conductance and optical conductance with very good reliability by measuring the resistance and transparency measurements.

안구운동 민감 소실 및 재처리 요법(Eye Movement Desensitization and Reprocessing) 치료 후 국소 뇌 혈류 변화:두 증례의 SPECT 연구

오동훈,최준호,Oh, Dong-Hoon,Choi, Joonho 대한생물정신의학회 2004 생물정신의학 Vol.11 No.2

Over the last decade, EMDR(Eye Movement Desensitization and Reprocessing) has emerged as a promising new treatment for trauma and other anxiety-based disorders. However, neurobiological mechanism of EMDR has not been well understood. Authors report SPECT findings of two patients of PTSD before and after EMDR. Brain 99mTc-ECD-SPECT was performed before and after EMDR treatment. To evaluate the significance of changes in the regional cerebral perfusion, t-test was conducted on the resulting images using SPM99. In addition, clinical scales(CAPS, CGI, STAI) were employed to asses the changes in the clinical symptoms of the patients. After EMDR treatment, each showed significant improvement in clinical symptoms. The cerebral perfusion increased in bilateral dorsolateral prefrontal cortex, and decreased in the temporal association cortex. The differences in the cerebral perfusion between patients after treatment and normal controls decreased. These changes appeared mainly in the limbic area the and the prefrontal cortex. These results suggest that EMDR may show the therapeutic effect through 1) improvement in the emotional control by increased activity in the prefrontal cortex, 2) inhibited hyperstimuli on amygdala by deactivation of the association cortex, 3) inhibition on past trauma related memory, and 4) keeping the functional balance between the limbic area and the prefrontal cortex. This case report needs further replication from studies with larger sample.

부산북항 재개발에 따른 유동장 및 해수교환 변화 모의

오동훈,이중우,금동호,전성환,김강민,Oh, Dong-Hoon,Lee, Joong-Woo,Keum, Dong-Ho,Jun, Sung-Hwan,Kim, Kang-Min 한국항해항만학회 2006 한국항해항만학회지 Vol.30 No.10

부산항(북항) 재개발사업은 노후화된 북항 일반부두를 해양관광의 중심지역 그리고 부산시민을 위한 친수공간으로 개발하기 위해 그동안 많은 연구와 노력이 진행되어 왔으며, 현재 구체적인 방안이 모색되는 실행단계로 진입하였다. 한편, 재개발로 인한 유동장 및 해수교환의 변화는 환경적인 측면에서 중요한 검토사항 중 하나이다. 본 연구에서는 북항 재개발에 따른 일반적인 자료를 수집 분석하고, 이를 바탕으로 하여 재개발에 따른 유동장의 변화와 만 내 해수교환을 수치실험으로 검토하였다. 실험결과, 조류속 변화는 북항 및 내항에서 감소가 나타나고 주수로상에서 증가가 나타나고 있다. 해수교환 변화는 15일이 지난 준 정상상태에서 재개발 전후 공히 약 77% 내외에 달하는 것으로 나타났다. In connection with redevelopment of Busan North Port, there has been lots of studies and efforts for the development of superannuated North general piers into a center of marine tourism and waterfront for the citizens of Busan. Recently it has moved to the stage of execution, after several trials to find concrete solutions. On the other hand, the change of flow field and tidal exchange cuased by redevelopment is one of the important investigation subjects. This study deals with the change of flow field and water exchange after redevelopment using numerical simulation technique, based on the general data which were collected and analyzed. As a result of simulation, the speed of tidal currents are tended to decrease near the North and inner-port and increase at the main waterway. Furthermore, the tidal exchange had a tendency to be small both before and after redevelopment by about 77% in a quasi steady state, which is about 15 days after.

노인주거시설 공급을 위한 도시지역 내 중·소 병원 리모델링 방안 연구

오동훈(Oh, Dong-Hoon),박주형(Park, Ju-Hyeung) 한국지역개발학회 2006 韓國地域開發學會誌 Vol.18 No.4

This study aims to show a model which is designed to serve(supply) more proper houses for the elderly, by remodeling small and medium-sized hospitals that have become needed to change it’s own use on the cause of the declining profitability. The two facilities - small and medium-sized hospitals and retirement houses for the elderly - have various similarities in the aspects like location, physical shape, space structure, and so on. This paper analyzed the profitability of the business by focusing on remodeling case study and then examined the technical and institutional plan for the transformation, searching for a supply method of changing hospitals with financial difficulties into houses for the elderly. In conclusion, this study found that small and medium-sized hospitals have strong potentials which may lead the hospitals to transform it’ s own use into retirement houses and that the project has the feasibility when it gets started.

개발마케팅 실패 사례 유형화에 관한 연구

오동훈(Oh, Dong-Hoon),오근상(Oh, Keun-Sang) 한국도시행정학회 2014 도시 행정 학보 Vol.27 No.3

본 연구는 국내외 개발마케팅의 실패 사례들을 유형화함으로써 향후 개발에서 요구되는 계획 및 마케팅방안의 수립에 시사점을 주는 데 목적이 있다. 실패 요인들은 지역 내부적 요소, 거시환경적 요소, 주체들의 역량적 요소 등에 기인할 수 있으며, 이러한 요인들은 마케팅 형성과정이나 추진 및 운영단계로 구분할 수 있다. 어떤 사업이 한 가지 이유만으로 실패했다고는 볼 수 없으나, 본 연구에서는 주요 실패 요인들을 중심으로 개발마케팅 실패 사례들을 분류하였다. 그 결과 6개의 개발마케팅 실패 사례 유형, 즉 ‘지역의 정체성 및 이미지와의 부조화’, ‘지역시장을 고려하지 않은 사업 추진’, ‘사업 관련 주체 간의 갈등’, ‘사업 추진 관련 주체의 의지 및 역량 부족’, ‘사업계획과 전략의 미숙’, ‘시장 및 환경 변화에 따른 사업 부진’을 제시하였다. 이와 관련하여 향후 개발마케팅에서는 도시 및 장소에 알맞은 비전이나 이미지를 정립하고, 이를 중심으로 지역시장에 수요를 고려하는 것이 필요하며, 적절한 전략을 마련해야 한다. 그리고 마케팅 활동을 이끌어가는 주체의 역량이 고려되어야 하며, 관련 주체들의 갈등을 최소화하기 위한 노력이 필요하다. 또한 사업 및 경제 환경 악화에 대한 시나리오를 준비하고 이에 대응할 수 있도록 하는 것도 중요할 것이다. The goal of this study is to suggest implications for establishing development marketing by categorizing its failure cases according to marketing failure causes. The failure causes can be related to regional elements, macro-environmental elements, and marketing-related entities" capability elements. And these elements can belong to the process of building marketing strategy or that of operating the strategy. This study divides failure cases into 6 development failure types on the basis of their main failure causes. They are Mismatch between Region and its Identity/Image, Business without Considering Regional Market, Conflicts among Marketing-related Entities, Lack of Will/Capability of Marketing-developing Entities, Inexperience in Strategy/Plan, and Business Depression due to Market/Environment Change. Therefore, we can say that successful development marketing needs vision/image well-matching for a place, consideration of demand of regional market, and appropriate marketing strategy. In addition, Capability of marketing-developing entities should be considered, and the effort to minimize conflicts among entities is necessary. A few alternatives for deterioration of market or economy situation should be included in the marketing strategy as well.

서울시 동시분양아파트 청약경쟁률 결정요인에 관한 실증연구

오동훈(Oh Dong-Hoon),강민철(Kang Min-Chul) 한국도시행정학회 2002 도시 행정 학보 Vol.15 No.3

The purpose of this paper is to find the determinative factors of new apartment subscription rate in Seoul Metropolitan Area. The new apartment market in Seoul is chosen for this study because Seoul where the housing diffusion rate is still relatively low compared to other cities in Korea still have active demand and takes large part in apartment supply. This study uses cross-sectional data with 603 observations from June, 1999 to October, 2001. Both the new apartment selling rate and the subscription rate to buy high-rise apartment which will be built within 2-3 years are used as dependant variables showing preference in housing purchase. Characteristics which new apartments have are divided by three sides, that is residential site, residential environment, and investment value related elements such as the brand value of construction company, selling price index and profit ratio. The Multiple regression method is used in order to make an appropriate model that can determine and affect new apartment subscription rate in each housing sub-market. Therefore we divided Seoul area into three housing submarkets. According to the analysis, proximity like distance to park, high ratio of green area to land within the complex, and low selling price index result in high competing rate subscribing to buy new high-rise apartment.

일본에서의 물리학 연구의 태동과 성장, 1880~1920

오동훈 ( Dong Hoon Oh ) 한국과학사학회 2003 한국과학사학회지 Vol.25 No.1

獨活(Aralia continentalis K.) 主産地 土壤特性과 施肥養分이 根莖收量에 미치는 影響

吳東勳(Dong-Hoon Oh),黃南悅(Nam-Yul Hwang),羅鍾城(Jong-Seong Na),朴建縞(Keon-Ho Park) 한국토양비료학회 1994 한국토양비료학회지 Vol.27 No.3