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엄정란,이정희,정미온 이화여자대학교 의과대학 1979 梨花醫學誌 Vol.- No.11
The authors attempted to isolate and identify bacteria from cooked rice samples immediately after cooking and more than 6 hours long-kept at room temperature. Several species of Genus bacillus and coccoid organisms were identified, but some of them could not be classified. It was confirmed that a lot of bacterial species were contained in cooked rice even immediately after cooking in addition to the possibility of later contamination, and therefore they could be propagated in cooked rice according to the temperature at which the cooked rice is keft.
엄정란,이정희,정미온 이화여자대학교 의학회 1979 梨花醫學會誌 Vol.- No.11
The authors attempted to isolate and identify bacteria from cooked rice samples immediately after cooking and more than 6 hours long-kept at room temperature. Several species of Genus bacillus and coccoid organisms were identified, but some of them could not be classified. It was confirmed that a lot of bacterial species were contained in cooked rice even immediately after cooking in addition to the possibility of later contamination, and therefore they could be propagated in cooked rice according to the temperature at which the cooked rice is keft.
최정란,남정모,강대룡,엄상미,이혜진,박찬미,임진우,장양수 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.4
Purpose: Recent studies using human and mice reported that apolipoprotein A-V (APOA5) gene plays an important role in controlling triglyceride (TG) concentrations. The purpose of the present study was to investigate the correlation between single nucleotide polymorphisms (SNPs) and haplotypes in the APOA5 gene and TG in subjects and to search for possible associations of the APOA5 gene variants and common haplotypes with hypertriglyceridemia (HTG). Materials and Methods: We examined the case-control subjects including 100 HTG patients and 243 unrelated healthy control. The genes were screened for SNPs by direct sequencing in 48 genetically unrelated individuals. Six SNPs (-1390C>T, -1020G>A, -3A>G, V150M, G182C and 1259T>C) were genotyped in case and control populations. Results: In this study, our results indicated a strong association between APOA5 SNP -3A>G and G182C and elevated TG levels (p <0.001). Analysis of the SNPs from APOA5 gene has identified major haplotype showing very strong association with HTG, CGGGTT (p<0.001). Likelihood ratio test (LRT) of these six SNPs revealed that haplotypes were strong independent predictors of HTG (p<0.001). Haplotype-trend logistic regression (HTR) analysis revealed a significant association between the CGGGGC (haplotype 2) and CGGGTT (haplotype 4) and HTG (OR=2.48, 95% CI=1.06-5.76 and OR=8.54, 95% CI=2.66-27.42, respectively). Conclusion: We confirm that the APOA5 variants are associated with triglyceride levels and the haplotype may be strong independent predictors of HTG among Koreans.
Alpha2B-아드레날린 수용체 Insertion/Deletion 유전자 다형성과 관동맥질환과의 연관성
최정란,박찬미,홍정애,배수진,엄상미,조은영,고영국,박현영,장양수 대한심장학회 2005 Korean Circulation Journal Vol.35 No.3
Background and Objectives :Cardiovascular disease (CVD) is a complex multigenic disorder, with significant inheritable elements having important roles relating to environmental factors. Recently, the alpha 2 adrenoceptor ( α2-AR) gene has -gate the relationships between an insertion/deletion (I/D) in α2B-AR and CAD in Korean subjects. Subjects and Methods :The α2B-AR I/D polymorphism, which was located in the third intracellular loop of the receptor polypeptide, was exami -ned in 292 patients (M :F=2 19:73) with CAD and 151 healthy control subjects (M :F=70 :81) who visited the Cardio -vascular Genome Center in Yonsei Cardiovascular Hospital. Results:In the patient group, 77 men (35. 1(35.6%) had the I/I genotype; 105 men (47.9%) and 39 women (53.4%) a heterozygous genotype and 37 ( 17.0%) and 8 ( 11.0%) the D/D genotype. In the controls, 23 men (32.8%) and 29 women (35.8%) had the I/I genotype; 38 (54.3%) and 39 (48. 1%) the I/D genotype and 9 ( 12.9%) and 13 (16.1%) the D/D genotype. There were no diferences in the genotype frequencies between the patient and control groups, either in men or women. From a logistical regression analysis, the α2B-AR ge -Conclusion :The α2B-AR I/D polymorphism is not a risk factor for CAD in the Korean population. 배경 및 목적:α2B-아드레날린 수용체(α2B-adreceptor)는 혈관수축과 관련된 세포표면 수용체로써 최근에는 α2B-AR 유전자의 삽입/결손(insertion/deletion) 단일염기다형성 변이가 서양인에서 관찰되었으며 관동맥질환과의 연관성이 보고되었다.18) 이에 α2B-AR 유전자의 삽입/결손 단일염기다형성 변이가 한국인 에서 관동맥질환에 미치는 영향과 위험인자와의 상관성에 대해 알아보고자 하였다. 방 법: 151명의 대조군과 292명의 관동맥질환 환자군을 대상으로 α2B-AR 유전자 삽입/결손 다형성의 유전형을 조사하여 양군에서 각각 삽입/결손 유전자형의 빈도를 비교하였고 각각의 유전형에 따른 기본적인 임상적인 자료들을 바탕으로 관상동맥질환과 위험인자와의 연관성을 비교 분석하였다. 결 과: 관동맥환자군 및 정상대조군에서 α2B-AR 유전자 삽입/결손 다형성의 유전형은 유의한 차이가 없었다. 유전형에 따른 관동맥질환 위험요인의 분포에도 유의한 차이가 없었으며, 환자군에서 각각의 유전형에 따라 성별, 흡연, 연령층 등 심혈관계질환의 여러 위험인자 별로 나누어 분석해도 통계학적으로 유의한 차이가 없었다. 결 론: α2B-AR 유전자의 삽입/결손 다형성의 결손 대립유전자 빈도가 서양인보다 높은 빈도로 관찰되었지만 한국인에서 관동맥질환 및 심근경색의 발생과 유의한 연관성은 없었다.