Guinea Pig 에 있어 Asorbic Acid 지속성 캅셀제제의 생체이용률에 관한 연구

안형수,박재길,한창훈 한국약제학회 1985 Journal of Pharmaceutical Investigation Vol.15 No.1

Bioavailability studies in guinea pigs and dissolution tests of sustained release capsules of ascorbic acid were investigated comparing with those of solution. The results were as follows; 1. In the dissolution test, sustained release capsules released 90% of ascorbic acid after 12 hours, and ascorbic acid in the chewable tablet was dissolved. completely within 10 minutes. 2. In the determination of total ascorbic acid concentration in serum, the area under the curve between 0 and 24 hours (AUC 0∼24h) and the maximum serum concentration (C_(max)) did not show any significant difference between solution and sustained release capsule. The time to the maximum concentration (T_(max)) and the time over 50㎍/㎖ cocentration showed significant difference. 3. The time reached to maximum excretion rate (T_(max)) in sustained release capsule was longer than that of solution.

Antiretroviral Effects of 2',3'-Dideoxycytidine and Recombinant $Interferon-{\alpha}-A$ on the Infection of Anemia-inducing Murine Friend Virus

안형수,안령미,김동섭,Ann, Hyung-Soo,Ahn, Ryoung-Me,Kim, Dong-Seop The Korean Society of Pharmacology 1995 대한약리학잡지 Vol.31 No.3

Anemia-inducing strain of Friend virus (FVA)는 적혈구 progenitor cell의 증식을 촉진하는 생쥐 retrovirus의 일종이다. FVA에 감염된 생쥐는 생성이 촉진된 progenitor cell이 분화되지 못하고 비장내에 축적되므로서 비장비대를 초래한다. 이에 본 실험에서는 FVA에 감염된 생쥐의 비장비대를 지표로 사용하여 2',3'-dideoxycytidine (ddC) 및 $interferon-{\alpha}-A\;(rIFN-{\alpha}-A)$의 항retrovirus효과를 측정하였다. 매일 ddC (100 mg/kg) 및 $rIFN-{\alpha}-A$ (10 KU/mouse)를 각각 단독 또는 병용하여 18일간 복강내 투여시 비장의 비대가 각각 15.1%, 52.7%, 61.6% 억제되었다. 또 다른 실험군으로 ddC를 식수중에 용해하여 (0.1 mg/ml) 경구로 18일간 투여시, 그리고 ddC의 경구투여와 병용하여 $rIFN-{\alpha}-A$을 위와 마찬가지 용량으로 복강내 투여시, 비장비대를 각각 38.4% 및 83.2% 억제하였다. 이 결과는 ddC의 투여시 복강내 주사보다는 경구투여가 더 유효하며, ddC와 $rIFN-{\alpha}-A$는 병용투여시 상가적인 효과가 있음을 제시한다. ddC 투여시 progenitor cell의 특성상 변화를 검토하기 위해, $Ca^{++}$ uptake $[^3H]cyclohexyladenosine$ (CHA) binding 실험을 실시하였다. CHA bindng 실험결과 성숙된 적혈구에서는 저친화성의 결합부위 하나뿐인데 반해, progenitor cell에서는 고친화성과 저친화성의 두가지 결합부위를 나타내었다. $Ca^{++}$ uptake 측정결과 성숙된 적혈구에 비해 대조군의 정상적인progenitor cell은 약 20배 증가를 나타내었으며, ddC를 연속투여한 군에서도 유사한 결과를나타내었다. 이때 CHA에 의한 $Ca^{++}$ uptake의 억제효과를 측정한 바, ddC 100 mg/kg 투여군의 경우 76%로 대조군의 86% 보다 억제효과가 크게 나타났으며, 이들 모두는 adenosine 길항약인 theophylline의 전처치시 대조군과 유사하게 회복되었다. The anemia-inducing strain of Friend virus (FVA) is a murine retrovirus which stimulates the proliferation of erythroid progenitor cells. The progenitor cells synthesized by FVA-stimulation are unable to proceed with differentiation and accumulate in the spleen resulting in splenomegaly in infected mice. Using FVA-inoculated mice as a model, we have investigated the antiretroviral effects of 2',3'-dideoxycytidine (ddC) and recombinant $interferon-{\alpha}-A\;(rIFN-{\alpha}-A)$ on FVA infection. The extent of the infection was determined by measuring the weights of the spleens. Daily intraperitoneal injection of ddC (100 mg/kg body weight), $rIFN-{\alpha}-A$ (10 KU/mose) and the combination of both drugs to FVA inoculated mice for 18 days resulted in suppression of the growth of spleens by 15.1%, 52.7% and 61.6%, respectively. When ddC was dissolved in drinking water (0.1 mg/ml) and administered to a group of FVA inoculated mice ad libitum, and $rIFN-{\alpha}-A$ (10 KU/mouse) was intraperitoneally injected daily to another group of ddC (0.1 mg/ml) drinking mice for 18days, the growth of spleens was suppressed by 38.4% and 83.2%, respectively. These results indicate that administration of ddC via drinking water is more effective in suppressing FVA infection than the daily injection of ddC, and that the combined effects ddC and $rIFN-{\alpha}-A$ are not synergistic but additive. In order to determine whether ddC treatment alters the characteristic of the progenitor cells with respect to $Ca^{++}$ uptake, $Ca^{++}$ uptake in erythroid cells and the effect of cyclohexyladenosine (CHA) on the $Ca^{++}$ uptake were studied. $Ca^{++}$ uptake in the erythroid progenitor cells was about 20-fold greater than in mouse erythrocytes and the inhibition of $Ca^{++}$ uptake by CHA was the greatest in the progenitor cells from FVA infected mice which were treated with ddC. The inhibition was obviated by theophylline. Results of CHA binding studies showed that the erythroid progenitor cells contain both high and low affinity CHA binding sites, whereas mose erythrocytes contain only the low affinity CHA binding sites.

천식 치료약

안형수 약업신문사 1999 의약정보 Vol.1999 No.10

진통 소염제

안형수 약업신문사 1999 의약정보 Vol.1999 No.12

항 virus 약

안형수 약업신문사 2000 의약정보 Vol.2000 No.1

항부정맥약

안형수 약업신문사 2000 의약정보 Vol.2000 No.10

감마 금속정을 이용한 대퇴골 전자부 골절의 치료

안형수,박병철,인주철,김신윤 대한골절학회 1994 대한골절학회지 Vol.7 No.2

Surgical fixation, early weight bearing and bony union remain a challange in the treatment of intertrochanteric femur fractures, especially if the fractures are comminuted or unstable. We have experienced 18 cases of intertrochanteric femur fracture that were treated using Asian Gamma nails(Gamma AP ) in Kyungpook National University Hospital in period from Feb. 1993 to Oct. 1993. Early full weight bearing was encouraged and this seemed to be beneficial for old patients. All fractures were healed securely and many patients(15/18) could be painless ambulatory regardless of fracture configuration(9 fractures classified as unstablej. Major complications included screw cut-out(2 cases), lateral cortical fracture(1 cases) and delayed union(1 case). In this early experience, the Gamma nail appears to be useful internal fixator for intertrochanteric femur fractures and it allows early ambulation regardless of the fracture configuration with excellent clinical results.

고혈압 치료약

안형수 약업신문사 2001 의약정보 Vol.2001 No.4

흰쥐에 있어 Dopamine 길항약인 Veralipride의 심혈관에 대한 영향

안형수 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-

Cardiovascular effects of veralipride, dopamine antagonist, on blood pressure and vascular response were evaluated in rats. Veralipride did not directly changed on the blood pressure response and vascular tone in rats. But veralipride completely blocked the hypotensive response induced by bromocriptine, dopamine agonist, in consious rats. Veralipride did not affect on the bromocriptine induced vasorelaxation which was precontracted by norepinephrine in isolated rat thoracic aorta. These reaults suggested that mechanisms of action of veralipride on the menopausal hot flush would be related cental dopamine antagonistic action rather than peripheral vasomoter action or estrogen-like action.

악교정 수술을 받은 골격성 Ⅲ급 부정교합자의 치료전후 하악전치부 치조골 형태변화에 대한 연구

안형수,김성식,손우성 대한치과교정학회 2002 대한치과교정학회지 Vol.32 No.5

이번 연구의 목적은 골격성 Ⅲ급 부정교합자의 악교정 수술 전과 수술 후의 하악전치부 치조골의 형태 변화를 평가하는 것이다 : 하악지 시상골분할절단술만을 시행받은 30명의 성인 골격성 Ⅲ급 부정교합자를 대상으로 하였다. 초진시와 수술 전과 수술 후 3개월이 경과하였을 때의 측모두부규격방사선 사진을 비교하였다. 골격과 하악이부의 계측치를 비교하였으며 이들 사이의 상관성 분석을 시행하여서 다음과 같은 결과를 얻었다. 1. 술전교정후군과 악교정수술후군에서 치료전군에 비해 하악전치부의 순측과 설측의 치조골 높이가 감소하였다. 2. 치조골 기저부의 전후방적인 폭경은 두개안면골격의 수직계측항목과 역상관관계를, IMPA와는 순상관관계를 보였다(p<0.01). 3. 하악이부 계측항목중 하낙이부의 장경과 폭경은 두개안면골격과 상관관계를 보이지 않았다. 4. 순측의 치조골 높이와 설측의 치조골 높이는 순상관관계를 나타냈지만(p<0.001), 설측의 치조정의 폭경과는 역상관관계를 보였다(p<0.01). 순측과 설측의 치조정의 폭경은 역상관관계를 보였다(p<0.05). 하악이부의 장경과 폭경은 서로 순상관관계를 보였다(p<0.01). 5. IMPA와 LISA는 순,설측치조골의 장경과 설측의 치조골 폭경과는 역상관관계를 보였지만, 순측치조골폭경과는 순상관관계를 보였다. The purpose of this study was to evaluate the morphological changes of alveolar bone and mandibular symphysis of lower incisor by presurgical orthodontic treatment and orthognathic surgery in skeletal class Ⅲ malocclusion. the sample consisted of 30 adult class Ⅲ malocclusion patients who have received bilateral sagittal split mandibular osteotomy. Lateral cephalograms were taken before treatment, after presurgical orthodontic treatment and 3 months after orthognathic surgery. skeletal and symphyseal measurements were compared and the relationships between them were analysed. The results were as follow : 1. The labial and lingual alveolar bone height in presurgical and poetastrical group were decreased than that of pretreatment group. 2. The vertical measurements of the craniofacial skeleton showed reverse correlationship with anteroposterior width of basal alveolar bone, but IMPA showed correlationship(p<0.01). 3. The craniofacial skeleton and the change of symphyseal measurements(symphyseal length, symphyseal width) showed no correlationship. 4. The labial alveolar bone height showed correlationship with lingual alveolar bone height(p<0.001), and negative correlationship with lingual alveolar crestal width(p<.01). Labial and lingual alveolar crestal width has negative correlationship (p<0.05). Mandibular symphyseal length and width has positive correlationship(p<0.01). 5. IMPA, LISA showed negative correlationship with labiolingual alveolar bone height and lingual alveolar width and positive correlationship with labial alveolar base bone width.