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유양돌기절제술 후 발생한 가쪽반고리관 양성 돌발성 두위현훈 1예
안성기,전시영,박정제,조한규 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.11
Benign paroxysmal positional vertigo (BPPV) is one of the most common peripheral vestibular disorder characterized by short, often recurrent episodes of vertigo triggered by certain head movements. BPPV may be idiopathic or secondary to head injury, viral neurolabyrinthitis, Menieres disease etc. Ear operation is also considered one of the etiological factors in BPPV. However, a survey of the relevant literatures shows scarcity of publications on BPPV following mastoidectomy. We report a case of BPPV of horizontal semicircular canals following mastoidectomy with a review of the related literatures.
전정신경염 환자에서 Beck Anxiety Inventory 설문지를 이용한 불안감의 평가
안성기,김진용,권오진,조수연,허동구,전시영,김대우 대한평형의학회 2010 Research in Vestibular Science Vol.9 No.2
Background and Objectives The intimate relationship of vertigo and anxiety has been previously recognized. Anxiety may have an important influence on recovery of symptoms in vestibular neuritis (VN). The aim of study was to evaluate subjective anxiety of the pre-VN, at the time of onset of VN, and just after vestibular rehabilitation therapy (VRT) using Beck Anxiety Inventory (BAI)questionnaire, respectively. Materials and Methods Twenty-eight patients with VN were asked to complete the BAI and dizziness handicap inventory (DHI). Each of the BAI and DHI was scored. We also evaluated the relationship between the DHI and BAI scores. Results The VN patients at the time of attack had significantly more anxiety with vertigo and related symptoms (p<0.05). In most patients, anxiety level decreased following VRT. Conclusion These findings indicate that almost every VN patients can recovery from anxiety as vertigo regressed. However, the emotional support as well as physical and/or functional rehabilitation may be required to provide a more rapid and complete return to normal daily lives for these patients.
근간대와 간질발작을 동반한 조발형 가족성 알쯔하이머병 환자 1예
안성기,이재홍 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1
Early-onset familial Alzheimer's disease (EOFAD) is rare and autosomal-dominantly inherited disease by mutations in one of the following three known causative genes:amyloid precursor protein (APP) gene, presenilin-1 (PS1) and presenilin-2(PS2) genes. EOFAD tends to present clinically at a younger age (40-60 years) and myoclonus is recognized as a prominent and early clinical feature, particularly in chromosome 14-linked pedigrees with mutations in the PS1 gene, when myoclonus may be accompanied by seizures. We present a 44-year old man who developed progressive dementia and accompanied by myoclonus and recurrent seizure. His father and uncle had early-onset dementia at the fifth decade. He was pathologically confirmed as Alzheimer's disease. He had apolipoprotein E (ApoE) epsilon 3 allele and PS-1 mutation was not found.
Rat Model of Staphylococcal Enterotoxin B-Induced Rhinosinusitis
안성기,전시영,Roza Khalmuratova,김동주,김진평,허동구 대한이비인후과학회 2008 Clinical and Experimental Otorhinolaryngology Vol.1 No.1
Objectives. It has been proposed that microbial persistence, superantigen (SA) production, and host T-cell response may be involved in the development of chronic rhinosinusitis. According to the SA hypothesis, a single intranasal application of SA such as staphylococcal enterotoxin B (SEB) may induce chronic eosinophilic rhinosinusitis. This study aimed to develop a rat model of rhinosinusitis induced by intranasally applied SEB. Methods. Forty L of SEB (100 g/mL) or phosphate buffered saline was applied intranasally through each naris in 4 weekold Sprague-Dawley test rats (N=36) and controls (N=16), respectively. Following sacrifice at 1, 5, 14, and 28 days, the obtained nasal cavity and sinuses were prepared for histologic investigation. The histologic sections were examined in a blind manner for the ratio of the sinus spaces occupied by inflammatory cell clusters and the number of inflammatory cells in the lamina propria. Results. Infiltration of neutrophils in the lamina propria and appearance of neutrophil clusters in the sinus spaces were observed in the SEB-applied rats. The ratio of the sinus spaces occupied by neutrophil clusters and the number of neutrophils infiltrated in the lamina propria increased significantly at day 1 as compared with the control rats. Conclusion. Intranasally applied SEB induces acute neutrophilic rhinosinusitis in rats. Eosinophilic inflammation was not demonstrated. The mere presence of SA in the nose does not necessarily induce SA-induced inflammation, as suggested by the SA hypothesis. Objectives. It has been proposed that microbial persistence, superantigen (SA) production, and host T-cell response may be involved in the development of chronic rhinosinusitis. According to the SA hypothesis, a single intranasal application of SA such as staphylococcal enterotoxin B (SEB) may induce chronic eosinophilic rhinosinusitis. This study aimed to develop a rat model of rhinosinusitis induced by intranasally applied SEB. Methods. Forty L of SEB (100 g/mL) or phosphate buffered saline was applied intranasally through each naris in 4 weekold Sprague-Dawley test rats (N=36) and controls (N=16), respectively. Following sacrifice at 1, 5, 14, and 28 days, the obtained nasal cavity and sinuses were prepared for histologic investigation. The histologic sections were examined in a blind manner for the ratio of the sinus spaces occupied by inflammatory cell clusters and the number of inflammatory cells in the lamina propria. Results. Infiltration of neutrophils in the lamina propria and appearance of neutrophil clusters in the sinus spaces were observed in the SEB-applied rats. The ratio of the sinus spaces occupied by neutrophil clusters and the number of neutrophils infiltrated in the lamina propria increased significantly at day 1 as compared with the control rats. Conclusion. Intranasally applied SEB induces acute neutrophilic rhinosinusitis in rats. Eosinophilic inflammation was not demonstrated. The mere presence of SA in the nose does not necessarily induce SA-induced inflammation, as suggested by the SA hypothesis.