블랙베리(Rubus fruticosus) 추출물을 이용한 모발의 염색특성

신화남 ( Hwa Nam Shin ),박철호 ( Chul Ho Park ) 한국미용학회 2014 한국미용학회지 Vol.20 No.1

The purpose of this study is to examine the possibility of anthocyanin pigments of Rubus fruticosus. In order to achieve this purpose, anthocyanin concentration was analyzed by measuring absorbency from anthocyanin 520nm of Rubus fruticosus. Hair dyeing was increased in dye intake(K/S) with increased dyeing temperature(20oC~60oC) and hair color was changed from red to purple. With increased pH, a* value proceeded from +(red) to -(green) or a color meter was reacted to yellow of original bleached hair and In thealkalic status, red brown or red green or a yellow green was shown because of reddish brown deposits and discolored original color ofanthocyanin mordant. It brought about poor dye intake and dyeing or mordanting effects were lost. It suggested that anthocyaninmordants were specially sensitive to pH and dye intake was rapidly decreased with increased pH. For hair dyeing, mordant concentrations should be selected in consideration of the characteristics of mordants(dye intake, lightless, chroma and color). While acidmordants(FeSO4, AlK(SO4)2·12H2O, CuSO4) could make bright color such as green, blue, dark blue, and purple based on red, carbonic(CaCO3, Na2CO3) alkalic mordants made white or brown. For hair dyeing, mordanting methods (pre-mordanting, simultaneous mordanting, or post-mordanting) should be selected in consideration of the characteristics of mordants(dye intake, lightless, chroma and color). Based only dye intake(K/S), while post-mordanting was effective for AlK(SO4)2·12H2O and CuSO4, simultaneous mordanting was effective for FeSO4. Pre-mordanting was effective for CaCO3, and Na2CO3.

연구논문 : 철계 형상기억 합금에서의 변형에 따른 회복률의 변화

남원종,박신화,윤만순,강신왕 ( Won Jong Nam,Shin Wha Park,Man Soon Yoon,Shin Wang Kang ) 대한금속재료학회 ( 구 대한금속학회 ) 1991 재료.물성 심포지엄 Vol.- No.-

원발성 침윤성 외음부암의 임상적 고찰

이신화 ( Shin Wha Lee ),정민형 ( Min Hyung Jung ),김규래 ( Kue Rye Kim ),유항조 ( Hang Jo Yoo ),김대연 ( Dae Yeon Kim ),김종혁 ( Jong Hyeok Kim ),김용만 ( Yong Man Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ),목정은 ( Ju 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3

목적: 외음부암은 여성에 있어 드문 질환이다. 이러한 드문 유병률로 인해 임상적 연구가 충분히 이루어지지 않았다. 그러나 고령 인구의 증가로 인해 외음부암의 유병률은 증가할 것이다. 이 연구의 목적은 외음부암 환자들의 임상적 특성을 분석하고, 치료에 대한 결과 및 예후를 알아보는 것이다. 연구 방법: 1989년 5월부터 2003년 12월까지 서울아산병원에서 원발성 침윤성 외음부암으로 진단된 23명의 환자를 대상으로 한 후향성 연구로서 환자들의 임상적 특 Objective: The vulvar cancer is an uncommon disease among female population. Because of its rare incidence, sufficient clinical studies have not been accomplished. However, the prevelance of vulvar cancer will continue to increase because of rapid growth

유두상 장액성 자궁내막암의 임상적 고찰: 자궁내막 선암과의 비교분석

이신화 ( Shin Wha Lee ),지용일 ( Yong Il Ji ),서미원 ( Mee Won Seo ),김대연 ( Dae Yeon Kim ),서대식 ( Dae Sik Seo ),김종혁 ( Jong Hyeok Kim ),김용만 ( Yong Man Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.8

목적: 유두상 장액성 자궁내막암은 자궁내막암 중 드문 암종에 속하지만 나쁜 예후를 보인다는 면에서 임상적으로 중요하다. 본 연구의 목적은 자궁내막 선암과 비교하여 유두상 장액성 자궁내막암 환자들의 임상적 특성을 분석하고, 치료에 대한 결과 및 예후를 알아보는 것이다. 연구 방법: 1989년 5월부터 2004년 12월까지 서울아산병원에서 수술로 진단된 21명의 유두상 장액성 자궁내막암 환자와 332명의 자궁내막 선암 환자를 대상으로 하였다. 각 환자들의 의무기록, 병리보고서를 통하여 임상적 특징, 조직학적 소견, 수술적 병기, 치료 양식, 예후 및 생존율에 대하여 조사하였다. 결과: 21명의 유두상 장액성 자궁내막암 환자들의 진단 당시 평균 나이는 60.9세였다. 폐경 후 여성이 18명이었으며(85.7%), 대부분의 환자가 비정상 질출혈을 나타냈다 (75%). 자궁내막암의 위험요인으로 알려진 비만, 당뇨, 고혈압, 호르몬 대체 요법의 경험 등은 대체로 보이지 않았다. 병기 1기가 10명 (47.6%), 2기가 2명 (9.5%), 3기가 5명 (23.8%), 4기가 4명 (19.1%)이었다. 병기에 관계없이 전체 3년 생존율은 자궁내막 선암에서 97.4%이었고, 유두상 장액성 자궁내막암에서 43.1%로 나타났다. 수술을 시행 받은 21명의 유두상 장액성 자궁내막암 환자 가운데, 3명의 환자가 수술만 시행하고 보조요법을 받지 않았으며, 9명의 환자가 수술 후 방사선 치료를, 6명의 환자가 수술 후 항암 화학요법을, 그리고 3명의 환자가 수술 후 항암 화학요법과 방사선 요법을 함께 시행 받았다. 결론: 유두상 장액성 자궁내막암 환자들은 자궁내막 선암에 비해 나쁜 예후를 보였다. 따라서, 난소암의 경우와 같은 철저한 수술적 병기결정이 예후를 결정하는데 필수적이며, 충분한 수술 후 보조요법이 필요하다. Objective: Uterine papillary serous carcinoma (UPSC) is uncommon endometrial cancer, but clinically significant because of its poor prognosis. The aim of this study was to identify clinical and pathologic characteristics of patients with uterine papillary serous carcinoma and to evaluate the overall survival compared with endometrioid adenocarcinoma of uterus. Methods: Twenty one patients with uterine papillary serous carcinoma and 332 patients with endometrioid adenocarcinoma who were surgically staged at the Asan medical Center between 1989 and 2004 were analyzed with review of clinical characteristics; pathologic findings, surgical stages, treatment modalities, prognosis and survival time from medical records and pathologic reports. Results: In 21 patients with uterine papillary serous carcinoma, the median age at the time of diagnosis was 60.9 years (range, 38-81 years), which occurred in 18 postmenopausal women (85.7%) and usually presented with abnormal vaginal bleeding (75%). Obesity, diabetes, hypertension, or a history of hormone replace therapy, known as risk factors of endometrial cancer, were not so frequently associated. In 21 patients with uterine papillary serous carcinoma, there were 10 patients (47.6%) with stage I disease, 2 (9.5%) with stage Ⅱ, 5 (23.8%) with stage Ⅲ, and 4 (19.1%) with stage Ⅳ. The 3-year survival rate was 97.4% in endometrioid adenocarcinoma and 43.1% in uterine papillary serous carcinoma in all stages. Among 21 patients with uterine papillary serous carcinoma who had surgical staging, 3 patients received only operation and 9 patients received radiation therapy after surgery, 6 patients received chemotherapy and 3 patients eceived concurrent chemotherapy and radiation therapy. Conclusion: Patients with uterine papillary serous carcinoma showed a higher rate of abdominal metastasis and poor prognosis compared to patients of endometrioid adenocarcinoma. Therefore, complete surgical staging like in cases of ovarian cancer is vital in determining disease prognosis and vigorous adjuvant therapies are required.

피부미용 전공 학생의 진로 방향 모색에 대한 연구

김명기(Kim Myung-Gi),신화남(Shin Hwa-Nam) 한국인체예술학회 2007 한국인체미용예술학회지 Vol.8 No.1

This study aimed at consideration of the groping for the position after the graduation on students of the cosmetology as a major. The inventory was administered to 139 college students and 47 professors for cosmetology as a major. Data was gathered from a questionnaire. The results can be summarized as follows: 1. The problems that students after the graduation of the cosmetology as a major in getting a job are salary, paltry on working place, insufficiency on training on industrial market place. In aspects on professors, the problems are allocation on human resource, salary, paltry on working place. 2. The problems that on students after the graduation of the cosmetology as a major in course, the difference on college education program, lacking in establishment on professionalism, excess on working time, lacking on reeducation on aspects in industry. In aspects on college the problems were not reflection the request on industry, rationality on educational course. In aspects on person, the problems were the lacking on educational basis, misunderstanding on request on industry, the lacking on belief for their major, apprehensions for future value. 3. On extension on sphere, the professors recommended hotel, silver town, resort.

헤어미용 서비스품질에 대한 헤어미용종사자의 경력별 인식 차이

류은주(Ryu, Eun Ju),신화남(Shin, Hwa Nam) 한국디자인문화학회 2017 한국디자인문화학회지 Vol.23 No.2

본 연구는 헤어미용종사자가 헤어컬러디자인, 헤어펌디자인, 헤어커트디자인에 대한 서비스품질(기술서비스와 설명서비스)을 경력에 따라서 중요도를 다르게 인식하는지 확인하려는 목적에서 수행되었다. 연구대상자는 서울, 인천⋅경기, 충청도, 전라도에 위치한미용실 근무자를 표본으로 추출하였다. 2016년 12월 15일부터 2017년 1월 15일까지 1차 설문조사를 실시하였으며, 2차 설문조사는 2017년 1월 20일부터 2017년 2월 15일까지 실시하였다. 배포된 380부의 설문지중 376부가 회수되었고 그 중 유효한 352부를 활용하여 자료분석을 실시하였다. 자료분석은 SPSS 21.0 통계패키지 프로그램을 사용하여 빈도분석, 탐색적 요인분석, 신뢰도분석, 분산분석을 실시하였다. 연구결과 헤어미용종사자의 경력에 따라서 헤어컬러디자인 설명서비스품질과 기술서비스품질의 중요도 인식에 차이가 있는 것으로 확인되었다. 설명서비스품질과 기술서비스품질 모두 경력이 많은 집단이 적은 집단보다 더 중요하게 인식하고 있었다. 그러나 헤어펌디자인 서비스품질은 경력별로 중요도 인식에 차이가 확인되지 않았다. 헤어커트디자인 서비스품질은 경력별로 중요도 인식에 차이가 있는 것으로 확인되었다. 설명서비스품질은 경력이 많은 집단이 경력이 적은 집단보다 더 중요하다고 인식하고 있었고, 반대로 기술서비스품질은 경력이 적은 집단이 많은 집단보다더 중요하게 인식하고 있었다. 본 연구는 고객이 아니라 헤어미용종사자를 대상으로 어떠한 서비스를 중요하게 인식하고 있는가를 밝혔다는 점에서 실무적인 의의를 가진다. 향후에는 헤어미용종사자들이 이러한 인식에 차이가 생기는 원인에 대해서 더욱 심도 있는 연구를 수행할 필요가 있다. This study was intended to determine whether the quality of service (technical service and description service) of hair color design, perm design, haircut was recognized differently depending on the experience of hair salon workers. To achieve the objectives, it conducted a survey of workers of beauty salons in Seoul, Incheon, Kyinggi, Chungcheong-do and Jeolla-do. From December 15, 2016 to January 15, 2017, the first survey was conducted. And the second survey was conducted from January 20, 2017 to Feb. 15, 2017. Distribute 380 questionnaires, and 376 questionnaires returned. A total of valid 352 questionnaires were analyzed using SPSS 21.0 statistical package program. And frequency analysis, exploratory factor analysis, reliability analysis, and one-way ANOVA analysis were conducted. Research has shown that the hair color designs differs significantly from description service and technical services depending on experience of hair salon workers. A highly experience groups with both description services and technical services were more aware of the importance. However, the perm did not confirm the difference in importance of the services. Haircut has been found to have differing perceptions of importance services in terms of experience. The description service recognizes that highly experience groups are more important than less experienced groups. On the contrary, technology services were important to recognize that less experienced groups was more important than highly experienced group. This research has practical significance in the sense that it is important to recognize what services are important to the hair salon workers, not the customers. In the future, it is necessary to conduct further research on the causes of such differences in the perceptions.

자궁 경부암의 임상 조직학적 요인들과 T 조절 림프구 분포와의 상관 분석

권용순 ( Yong Soon Kwon ),김용만 ( Yong Man Kim ),이하영 ( Ha Young Lee ),이신화 ( Shin Wha Lee ),이정남 ( Jung Nam Lee ),김종혁 ( Jong Hyeok Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.12

목적: 자궁 경부암과 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3과의 상관 분석을 통해 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3의 임상적 의의를 찾고자 한다. 방법: 17명의 자궁 경부암 환자의 말초 혈액을 항 CD4, CD25 mAb 그리고 항 Foxp3 mAb와 결합하는 림프구 세포를 획득하여, flow cytometry을 이용한 Foxp3를 정량화 한다. 이후 자궁 경부암의 임상적, 인구 통계학적 특성과의 상관 분석을 실시한다. 분석된 특성들은 연령, 신장, 체중, 비만도, 최대 종양 직경, 자궁 방 침범 유무, 임파절 침범 유무, 그리고 림프관 종양 침범 유무 등으로 이루어진다. 결과: 여러 자궁경부암의 임상적, 인구 통계학적 특성들 중 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3는 최대 종양 직경과 통계적 유의한 상관성을 갖는다 (p value = 0.012, Spearman`s rho 상관 계수 = 0.593). 결론: 진행된 자궁 경부암의 초기 종양의 크기와 말초 혈액의 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3사이에는 통계적 유의한 상관관계를 나타내며, 이는 종양 크기와 항 종양 면역 체계와의 유의한 상관성을 지님을 시사한다. Objective: The aim of this study is to determine which clinicopathological factors have the significance in proportion of regulatory T lymphocytes in patients with cervical cancers. Methods: Blood samples were collected preoperatively from 17 patients with uterine cervical cancers (stage: IB, IIA) diagnosed at Asan medical center from May 2006 to October 2006. Patients were limited to who never been treated after diagnosis. We analyzed phenotypes of lymphocytes through flow cytometry by using anti CD3 antibodies, anti CD4 antibodies, anti CD25 antibodies and anti Transcription Factor Foekhead Box P3 (FoxP3) antibodies. Following analysis by flow cytometry, it was determined the relation between the proportion of regulatory T lymphocytes and clinicopathological factors of patients, including age, height, weight, BMI, maximum tumor diameter, lymphovascular tumor emboli, parametrial invasion, and lymph node metastasis. Results: Among many clinicopathological factors in patients with cervical cancer, only maximum tumor diameter was significantly correlated with the proportion of CD4+CD25+highFoxP3+ regulatory T lymphocytes (p=0.012, Spearman`s rho Correlation Coefficient=0.593). Conclusion: This is the first report to document the relation between uterine cervical cancer and the proportion of regulatory T lymphocytes in peripheral blood. In terms of positive correlation between the primary tumor size and the proportion of regulatory T lymphocytes in peripheral blood, we suggest that the spread mechanism of uterine cervical caner, especially direct invasion, will be related with the anti-tumor immune tolerance state. Further studies are necessary to explain the specific spread mechanisms and systemic antitumor immunity in cervical cancer.

재발성 상피성 난소암 및 원발성 복막 암종증 환자에서의 Topotecan/Platinum 복합요법의 효용성과 독성

유항조 ( Hang Jo You ),김용만 ( Yong Man Kim ),이신화 ( Shin Wha Lee ),이정남 ( Jung Nam Lee ),김대연 ( Dae Yeon Kim ),서대식 ( Dae Shik Suh ),김종혁 ( Jong Hyeok Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ),목정은 ( Jun 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.1

목적: 이 연구의 목적은 camptothecin 유도체로서 DNA topoisomerase I 억제제인 topotecan을 platinum제제와 복합요법으로 사용하였을 때, 재발성 상피성 난소암과 원발성 복막 암종증 환자에서의 효용성과 독성을 평가하는 것이다. 연구방법: 2000년 1월부터 2007년 6월까지 서울아산병원에서 topotecan과 platinum의 복합 항암화학요법으로 치료받은 환자들을 대상으로 하였다. 51명의 재발성 상피성 난소암과 원발성 복막 암종증 환자가 있었으며 이들 각 환자들의 의무기록과 병리 및 진단 검사 보고서를 통하여 분석하였다. 치료에 대한 반응은 측정 가능한 재발성 종괴가 있는 경우에는 RECIST 기준을 적용하였고 측정 가능한 재발성 종괴가 없는 경우에는 CA-125 기준을 적용하였다. 부작용은 미국 NCI Common Toxicity Criteria version 3.0 기준에 따라 평가하였다. 결과: 환자군의 진단 당시 평균 나이는 53.4세였다. RECIST 기준으로 평가한 44명의 환자군에서 전체 반응률을 22.8% (10/44)이었으며, 6명에서 완전관해를 보이고 4명에서 부분관해를 나타냈다. Platinum 반응군에서는 26.9%, platinum 저항군에서는 16.7%의 반응률을 보였으나 통계적으로 유의하지는 않았고 (p=0.425), 반응기간과 진행까지의 기간을 볼 때 platinum 반응군에서 의미있게 길게 나타났다 (p=0.022, p=0.042). 이전에 3회 이상의 다른 항암화학요법을 시행 받은 환자군에서는 그렇지 않은 환자군과 치료반응에 있어 의미있는 차이를 보이지 않았다. 골수억제가 가장 흔한 부작용으로서, 전체 265회 시행한 항암화학요법에서 Grade 3/4의 호중구 감소증이 30.6%, 빈혈이 42.7%, 혈소판 감소증이 8.7%로 나타났으나 모두 회복 가능한 정도였고 그 이외의 부작용은 모두 경미하거나 회복 가능한 정도였다. 결론: Topotecan과 platinum의 복합요법은 platinum 제제를 기본으로 한 일차 항암화학요법 후 재발한 상피성 난소암과 원발성 복막 암종증 환자에서 치료 효과를 기대할 수 있을 것으로 생각된다. 향후 기존의 항암화학요법과의 효과를 비교하는 무작위 대조군 연구를 통한 치료 효과의 확인이 필요할 것이다. Objective: The aim of this study was to evaluate the efficacy and toxicity of topotecan, camptothecin analogue topoisomerase I inhibitor, as the combination therapy with platinum in patients with recurrent epithelial ovarian carcinoma and primary peritoneal carcinomatosis. Method: In this study, patients who were treated with topotecan between January 2000 and June 2007 at Asan Medical Center, Seoul, Korea were reviewed. Fifty-one patients with recurrent ovarian carcinoma and peritoneal carcinomatosis were included. These patients` data were analyzed by review of medical records and pathologic and laboratory reports retrospectively. Response was assessed by Response Evaluation Criteria in Solid Tumors (RECIST) criteria for patients with measurable disease and CA-125 response criteria for patients with non-measurable disease. The toxicities were evaluated according to NCI CTC (Common Toxicity Criteria) version 3.0. Results: The mean age of patients was 53.4 years (ranged between 37 and 69). Forty-four patients had been evaluated by RECIST criteria. The overall response rate was 22.8% (10/44). Platinum-sensitive patients showed more favorable response rate (26.9%) than platinum-resistant patients (16.7%), however, it was not significant statistically (p=0.425). Platinum-sensitive group had significantly longer response duration (12.14 vs. 3.33 months, p=0.022) and time-to-progression (11.34 vs. 7.33 months, p=0.042) than platinum-resistant group. Heavily pretreated group, three or more prior regimens were used, had no significant differences from another group. The most common adverse effect of topotecan in combination with platinum was hematologic toxicity; grade 3/4 neutropenia was 30.6%, anemia was 42.7%, and thrombocytopenia was 8.37% in total 265 cycles of chemotherapy, however, it was tolerable. Conclusion: Topotecan in combination with platinum is considered as effective regimen with acceptable toxicity in treating recurrent epithelial ovarian carcinoma and primary peritoneal carcinomatosis who have failed previous treatment with platinum-containing chemotherapy.

Fe-Ni-Cr-Mn-Si 형상기억합금에 있어서 냉각 및 변형량이 마르텐사이트 변태에 미치는 영향

이도형,박신화,남원종,윤만순,강신왕 대한금속재료학회(대한금속학회) 1991 대한금속·재료학회지 Vol.29 No.8

In Fe-Ni-Cr-Mn-Si shape memory alloy, the effect of cooling methods and strain on the martensitic transformation was investigated. After the solution treatment at 900℃ for 30 minutes, the specimens were air cooled, water cooled and quenched in liquid nitrogen. For air cooled specimens only austenite phase was detected, whereas austenite and ε-martensite phases were detected for specimens water cooled or quenched in liquid nitrogen. The amount of ε-martensite was increased with the cooling rate and strain. But the increasing rate of the amount of ε-martensite was decreased at 5% strain in air cooling and at 3% strain in water cooling, respectively. The occurrence of α'-martensite was found at about 5% strain in air cooled specimens. For water cooled specimens it was found at about 3% strain. These strains almost coinceded with the strains at which the increasing rate of the amount of ε-martensite was changed. The occurrence of α'-martensite in specimens quenched in liquid nitrogen was found less than 0.5% strain.