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손소희,강지만,김종민,성세인,김이슬,이해정,김빛아름,이연경,고선영,신손문,김예진,Son, Sohee,Kang, Ji-Man,Kim, Jong Min,Sung, Sein,Kim, Yi-Seoul,Lee, Haejeong,Kim, BitA Reum,Lee, Yeon Kyoung,Ko, Sun Young,Shin, Son Moon,Kim, Yae-Jean The Korean Society of Pediatric Infectious Disease 2017 Pediatric Infection and Vaccine Vol.24 No.3
Purpose: Severe combined immunodeficiency (SCID) is the most serious form of primary immunodeficiency. Infants with SCID are susceptible to life-threatening infections. To establish newborn screening for SCID in Korea, we performed a screening test for T-cell receptor excision circle (TREC) and ${\kappa}$-deleting recombination excision circle (KREC) in neonates and investigated the awareness of SCID among their parents. Methods: Collections of dried blood spots from neonates and parent surveys were performed at the Samsung Medical Center and Cheil General Hospital & Women's Healthcare Center in Korea. The amplification crossing point (Cp) value <37.0 was defined as TREC/KRECpositive based on cutoff values from measuring multiplex real-time polymerase chain reaction. A Cp value >39.0 was defined as negative. Results: For TREC/KREC screening, 141 neonates were enrolled; 63 (44.7%) were male. One hundred forty neonates (99.3%) had positive TREC/KREC results at the time of the initial test; 82.3% and 75.9% were positive and 17.0% and 23.4% were weakly positive for TREC and KREC, respectively. In one neonate (0.7%), the initial TREC/KREC test result was negative. However, repeated tests obtained and confirmed a positive result. For an awareness survey, 168 parents were engaged. Only 2% of parents (3/168) knew that the newborn screening test for SCID had been introduced and performed in other countries. Eighty-four percent of parents (141/168) replied that nationwide newborn SCID screening should be performed in Korean newborns. Conclusions: In this study, newborn SCID screening was performed along with assessment of public awareness of the SCID test in Korea. The study results showed that newborn SCID screening can be readily applied for clinical use at a relatively low cost in Korea.
Feature Pyramid Network 기반 원거리 드론 검출 방법
권정인(Jeongin Kwon),손소희(Sohee Son),전진우(Jinwoo Jeon),이인재(Injae Lee),차지훈(Jihun Cha),최해철(Haechul Choi) Korean Institute of Information Scientists and Eng 2021 정보과학회논문지 Vol.48 No.3
With the rapid development in the field of drones, the need for a surveillance system to prevent accidents caused by drones has increased. Considering the high speed of drones, they must be detected from a distance. In long-distance images, the target size is very small and the background can be complex. Even if a deep learning technique is used for object detection the false detection rate remains very high. This paper introduces a multi-frame based post-processing method that can effectively reduce the false detection rate of feature pyramid network (FPN), which works well for tiny-object detection. The proposed post-processing method indexes detected objects and compares the distance and size difference concerning the corresponding objects of the previous frame to determine whether it is a false positive (FP) or not. FPN is trained on 44,986 images with annotations from 360 image sequences taken by hand. Experimental results show that the proposed method reduces the FP rate overall evaluation sequences by more than 80% and also increases the F-measure.
Preparation and characterization of chitosan-cholesterol nanoparticle
Son, Sohee,Chae, Su Young,Jang, Mi-kyeong,Nah, Jae-Woon 한국공업화학회 2004 응용화학 Vol.8 No.1
Low molecular weight oligo-chitosans were chemically modified by hydrophobic group of cholesterol. The particle size and critical aggregation concentration (cac) of the hydrophobized chitosan nanoparticles were investigated by using dynamic light scattering and fluorescence spectroscopy, respectively. The MW of chitosan and DS were played a critical roles for the physicochemical characteristics of hydrophobized chitosan nanoparticles.