컴퓨터와 냉각 기술

서민환,Seo, Min-Hwan 대한기계학회 2007 기계저널 Vol.47 No.5

Colistin 점안액을 사용하여 성공적으로 치료한 다약제내성 녹농균에 의한 각막궤양 1예

서민환(Min Hwan Seo),나윤협(Yun Hyup Na),이도형(Do Hyung Lee),김진형(Jin Hyoung Kim) 대한안과학회 2016 대한안과학회지 Vol.57 No.8

목적: 장기입원하고 있던 환자에서 다약제내성 녹농균에 의한 각막궤양이 발생하여 Colistin 점안액을 이용해 성공적으로 치료한 1예를 보고하고자 한다. 증례요약: 타 병원에서 뇌동맥류출혈로 장기 입원 중이던 와병상태 58세 여자 환자가 좌안 충혈 및 분비물로 치료 중 증상이 호전되지 않아 본원으로 의뢰되었다. 내원 당시 의사소통이 되지 않고 안과적 검사에 협조가 되지 않았으나, 휴대용 세극등검사상 각막부종, 각막침윤, 각막혼탁, 결막충혈, 결막부종 및 앞방축농이 관찰되어, 각막 및 결막에서 배양검사를 시행하였고, 항생제 감수성 검사 결과 colistin을 제외한 모든 약제에서 내성을 보이는 다약제내성 녹농균으로 보고되었다. 즉시 한 시간마다 국소 colistin 0.19% 점안을 시작하였으며, colistin 치료 28일째, 각막혼탁만을 남긴 후 각막궤양은 관해되었고 일 년 후의 경과관찰에서도 재발소견은 나타나지 않았다. 결론: 와병상태로 자칫 적절한 검사 및 치료시기를 놓칠 뻔한 다약제내성 녹농균에 의한 각막궤양 환자를 colistin 점안액을 사용해 각막천공 등의 심각한 합병증 없이 성공적으로 치료하여 보고하는 바이다. Purpose: To report a successful case of corneal ulcer caused by multidrug-resistant Pseudomonas aeruginosa using topical colistin in an immobilized patient who was hospitalized for a long period. Case summary: An immobilized 58-year-old female who was admitted for a long stay due to cerebral aneurysm hemorrhage presented with left ocular discharge and hyperemia, and was referred to our clinic. The patient was treated at a local clinic with topical antibiotics, but showed no improvement. At initial visit, she had difficulty communicating with the medical team and taking ophthalmic examination, and she had severe chemosis and corneal infiltration, corneal opacity, and hypopyon on her left eye with a portable slit lamp. Gram staining, bacterial and fungal cultures, and an antibiotic sensitivity test were performed from a corneal scrape. The cultures revealed growth of Pseudomonas aeruginosa, which is resistant to all antibiotics except colistin. As soon as we were aware of the results of the antibiotic sensitivity test, she was treated with topical colistin 0.19% every 1 hour on her left eye, starting immediately. After 28 days of treatment, the infection was resolved except for the remaining corneal opacity. She had a persisted stable corneal lesion at 1-year-follow up after colistin treatment, which indicated no recurrence. Conclusions: Due to gait disturbance, the patient almost missed appropriate ophthalmic examination or treatment. However, as we started immediate topical colistin treatment, we report a successful therapy of corneal ulcer induced by multidrug-resistant Pseudomonas aeruginosa without severe complications, such as perforation.

건성안증후군 환자의 주관적 증상 중증도와 관련있는 객관적 지표들

서민환(Min Hwan Seo),신주연(Joo Youn Shin),이도형(Do Hyung Lee),김진형(Jin Hyoung Kim) 대한안과학회 2017 대한안과학회지 Vol.58 No.3

목적: 건성안증후군 환자의 증상 중증도 질문지 중 하나인 ocular surface disease index (OSDI) 점수와 객관적인 지표 사이의 상관관계를 알아보고, OSDI 중증군에 영향을 주는 생활환경요소 위험인자에 대해 알아보고자 한다. 대상과 방법: 본원에서 처음으로 건성안증후군 진단을 받은 총 30명(30안)을 대상으로 후향적 연구를 하였다. 쉬르머검사, 각막 및 결막염색검사, 눈물막파괴시간검사, 마이봄의 질(Quality of Meibum)검사와 OSDI 설문조사를 하였다. 또한 결막측정장치인 Lipiview?潁? 사용하여 눈물지질층두께, 부분눈깜빡임횟수를 측정하였으며, 하안검판 마이봄샘촬영 후 Image J?? 프로그램을 이용하여 하안검판에서 마이봄샘이 차지하는 백분율을 측정하였다. 각각의 안구지표들과 OSDI 점수 사이에 Pearson 상관분석, 다중선형회귀분석을 하였다. OSDI 중증군의 생활환경요소 위험인자에 대해 알아보고자, 성별과 함께 환자의 생활환경요소인 불면증, 컴퓨터사용력, 각막 관련수술, 냉난방환경노출 유무에 대해 로지스틱회귀분석을 하였다. 결과: Pearson 상관분석 결과, 마이봄의 질과 나이, 결막염색점수, 부분눈깜빡임횟수, 각막염색점수 순으로 OSDI와 높은 상관관계를 보였으며, 다중선형회귀분석 결과, 마이봄의 질과 나이가 OSDI에 영향을 주는 인자로 나타났다. 로지스틱회귀분석 결과, 4시간 이상 컴퓨터 사용군(교차비 7.43, p-value=0.02)이 유의한 생활환경요소 위험인자로 작용하였다. 결론: 중증 건성안증후군 환자 치료 시 마이봄샘기능부전, 나이 요소가 주관적 안구불편함의 중증도와 관련이 크다는 점과 증상이 심한 군에서는 장기간의 컴퓨터사용과 같은 생활환경인자 교정이 중요하다는 점에 대한 인지가 필요하다. Purpose: To evaluate the correlation between the ocular surface disease index (OSDI score) and objectively quantifiable parameters in dry eye syndrome patients, and to assess environmental and lifestyle risk factors in severe OSDI patients. Methods: The present study was retrograde and included 30 patients (30 eyes) diagnosed with dry eye syndrome at Ilsan Paik Hospital for the first time. Shirmer’s test, corneal staining, and conjunctiva staining were assessed, and tear break-up time, meibum quality, and OSDI questionnaires were performed. We measured the lipid layer thickness in tear meniscus and counted the amount of partial eyelid blinking using Lipiview??. Moreover, we modified images of the lower lid meibography and calculated the percentage of meibomian glands outside the lower tarsal plate using the ImageJ?? software. We analyzed the Pearson’s correlation and performed a multiple linear regression analysis between the test values and OSDI. In addition, logistic regression analysis was used to determine the risk factors of the severe OSDI group, such as insomnia, level of computer use, and exposure to fully air-conditioned indoor environments. Results: According to the Pearson’s correlation analysis, quality of the meibum showed the highest statistically significant correlation with OSDI, followed by age, conjunctiva staining score, counts of partial blinking, and corneal staining score. The multiple linear regression analysis revealed that quality of the meibum and age were statistically significant factors affecting the OSDI score. Based on the logistic regression analysis, using a computer for more than 4 hours at a time exhibited a 7.43-fold odds ratio for severe OSDI (p-value = 0.029). Conclusions: Meibomian gland dysfunction and age should be considered to be important factors, especially in treating dry eye syndrome patients who complain severely. Moreover, we should also consider environmental factors such as long-term computer use for the treatment of dry eye syndrome patients with severe symptoms.

조각난 경관에서 멸종위기종 붉은점모시나비의 서식지 패치 네트워크 분석과 보전

김도성,박성준,조영호,김기동,도재화,서형수,신영규,서민환,오길종,Kim, Do-Sung,Park, Seong-Joon,Cho, Young-Ho,Kim, Ki-Dong,Tho, Jae-Wha,Seo, Hyung-Soo,Shin, Young-Kyu,Suh, Min-Hwan,Oh, Gil-Jong 한국응용곤충학회 2012 한국응용곤충학회지 Vol.51 No.1

종에 대한 생태적 특성과 서식지에 대한 이해는 종의 보전에 매우 중요하다. 본 연구는 멸종위기에 처해있는 붉은점모시나비의 생태적 특성을 바탕으로 서식지 패치네트워크를 분석하였다. 그 결과 포획 개체수는 188개체, 재포획은 220회 되었다. 그리고 암수의 비율은 42:146개체로 암컷보다는 수컷이 약 4배 많은 것으로 나타났다. 또한 개체의 평균생존일수는 $3.93{\pm}3.93$일(수컷: $4.0{\pm}3.9$, 암컷: $2.5{\pm}1.0$), 암컷과 수컷의 최대 생존일수는 각각 13, 14일 나타났고, 수컷이 암컷에 비하여 오래 생존하는 개체가 많은 것으로 나타났다. 종의 평균이동거리는 377 m을 보였으며 최대 1550 m까지 이동하는 것으로 나타났다. 패치연결성과 개체생존이주율의 추정에서 패치간의 거리가 약 300 m 이내가 종의 이주에 적합하며 600 m 이상 떨어질 경우 개체생존이주율이 급격하게 감소하는 것으로 나타났다. 또한 종의 이주 빈도는 근접한 거리에서 다수의 패치가 있는 곳에서 활발하게 일어나고 있어 종의 보전을 위해서는 근접한 거리에 다수의 패치가 필요함을 알 수 있었다. 이번 연구 결과는 붉은점모시나비의 서식지 특성이 분석되어 종 보전을 위한 서식지 디자인 및 설계에 유용하게 사용될 수 있을 것으로 본다. Understanding the ecological complexity and habitat of a species are crucially important to conserve an endangered species. This study evaluated the patch network ecology of the endangered species $Parnassius$ $bremeri$. The results indicated that 188 individuals were captured and 220 were recaptured, respectively. The sex ratio of female: male was 42:146; males were four times more abundant than females. The average longevity of an adult was $3.93{\pm}3.93$ days (male, $4.0{\pm}3.9$; female, $2.5{\pm}1.0$ days); the maximum longevity was 14 days for males and 13 days for females, respectively. Therefore, the expected longevity of males was longer than that of females. The average emigration distance for the species was 377 m, and the maximum emigration distance was 1550 m. The analysis of patch connectivity and individual colonization revealed that the ideal distance between patches was about 300 m. Moreover, a >600 m patch distance decreased the colonization rate severely. We also observed higher immigration and emigration between patches that were clustered in close proximity. This leads us to conclude that a higher number of patches at a close distance is best suited for $P.bremeri$. We find these results to be crucial to determine a policy to protect and conserve this endangered species.

연구논문 : 종분포모형을 이용한 히어리 서식지의 분포 특성 연구

권혁수 ( Hyuk Soo Kwon ),류지은 ( Ji Eun Ryu ),서창완 ( Chang Wan Seo ),김지연 ( Ji Yeon Kim ),임동옥 ( Dong Ok Lim ),서민환 ( Min Hwan Suh ) 한국환경영향평가학회 2012 환경영향평가 Vol.21 No.5

Since the CBD(Conservation on Biological Diversity)`s 10th Conference of the Parties adopted the protocol on access to genetic resources and benefit sharing in Nagoya 2010, the importance of endangered species studies such as habitat distribution, protection and management have been more emerged. Corylopsis coreana, an endangered species in Korea, was isolated nationally and has been damaged by anthropogenic factors. In this paper, we identified the factors affecting C. coreana habitat at the national scale and regional scale using National Survey of Natural Environment and predicted the distribution of C. coreana. Annual precipitation, precipitation of wettest quarter, temperature seasonality and Digital Elevation Model(DEM) were derived as important factors at the national scale, and precipitation of wettest quarter, DEM and solar radiation on spring were identified as important factors at regional scale. Colylopsis distribution was affected by an effect of climate significantly at the national scale, and by additionally the microclimate and topography at regional scale. These findings will be used as the basis on habitat conservation and restoration plan and climate change.

硏究論文 : 국지적으로 분포하는 식물에 대한 기후 및 환경변수 영향

권혁수 ( Hyu Ksoo Kwon ),류지은 ( Ji Eun Ryu ),서창완 ( Chang Wan Seo ),김지연 ( Ji Yeon Kim ),도재화 ( Jae Hwa Tho ),서민환 ( Min Hwan Suh ),박종화 ( Chong Hwa Park ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2012 한국환경복원기술학회지 Vol.15 No.6

Climate is generally accepted as one of the major determinants of plants distribution. Plants are sensitive to bioclimates, and local variations of climate determine habitats of plants. The purpose of this paper is to identify the factors affecting the distribution of narrow-range plants in South Korea using National Survey of Natural Environment data. We developed species distribution models for 6 plant species using climate, topographic and soil factors. All 6 plants were most sensitive to climatic factors but less other factors at national scale. Meliosma myriantha, Stewartia koreana and Eurya japonica, distributed at southern and coast region in Korea, were most sensitive to precipitation and temperature. Meliosma myriantha was mostly effected by annual precipitation and precipitation of driest quarter, Stewartia koreana was effected by annual precipitation and elevation, and Eurya japonica was affected by temperature seasonality and precipitation of driest quarter. On the other hand, Spiraea salicifolia, Rhododendron micranthum and Acer tegmentosum, distributed at central and northern inland in Korea, were most sensitive to temperature and elevation. Spiraea salicifolia was affected by mean temperature of coldest quarter and annual mean temperature, Rhododendron micranthum and Acer tegmentosum were affected by mean temperature of warmest quarter and elevation. We can apply this result to future plant habitat distribution under climate change.