예강지탕(銳降脂湯)이 고지혈증 SHR 및 항산화에 미치는 영향

백경민,Baek, Kyung-Min 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4

Objective : Yegangji-tang (YJT) is noted in China as effective medicine for hyperlipidemia. This experiment was performed to determine the effects of Yegangji-tang (銳降脂湯: YJT) on antioxidant activity and hyperlipidemia induced by hypercholesterolemic diet in mice. Methods : We observed three experimental groups: normal, control, and treatment. Rats were provided a normal diet in the normal group, and the other groups were provided a hypercholesterolemic diet to induce hyperlipidemia. After 2 weeks, YJT was treated to the treatment group. We observed the change of body and liver weight, change of serum total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides, lipid peroxidation and antioxidant activity of liver tissue, cholesterol gene revelation control efficiency, and histologic change of liver and abdominal aorta. Results : Total cholesterol, LDL cholesterol and triglycerides decreased significantly with YJT, whereas HDL cholesterol increased significantly. Lipid peroxidation decreased and antioxidant activity of the liver increased significantly. Gene revelation of ACAT and HMG-CoA reductase in hepatic tissue decreased significantly with YJT. We also found that tissue defects of the liver and abdominal aorta were controlled by YJT on histologic study. Conclusion : These results suggest that YJT might be effective in treatment and prevention of hyperlipidemia.

나노 입자의 군집밀도를 이용한 고분자 나노복합재의 기계적 거동 예측에 대한 멀티스케일 연구

백경민,신현성,한진규,조맹효,Baek, Kyungmin,Shin, Hyunseong,Han, Jin-Gyu,Cho, Maenghyo 한국복합재료학회 2017 Composites research Vol.30 No.5

본 연구에서는 폴리프로필렌 내에 투입된 탄화규소 나노 입자들의 군집현상이 나노복합재의 역학적 거동에 미치는 영향을 고찰하기 위해 분자동역학 전산모사를 통해 얻은 정보를 연속체 역학 수준에 적용시키는 멀티스케일 해석을 수행하였다. 입자 간의 거리에 따른 계면 물성의 하락을 반영하는 모델을 이용하여, 다양한 군집 상황에 따른 고분자 나노복합재의 탄성거동 변화를 관찰하였다. 또한, 나노복합재의 기계적 거동에 영향을 미치는 주요 요인을 파악하여 군집밀도라는 새로운 지표를 정의하였다. 나노 입자의 군집밀도와 나노복합재의 탄성거동 간의 상관관계를 파악한 결과, 군집밀도의 값이 증가할수록 계면효과가 저하되어 최종적으로 나노복합재의 기계적 물성 상승이 억제되었다. 나노 입자의 랜덤분포를 고려한 해석을 통해, 동일한 군집밀도의 수치에 대해 나노복합재가 가질 수 있는 탄성계수의 범위를 파악할 수 있었다. 상관관계는 지수 함수형태로 표현될 수 있었으며, 이를 통해 나노 입자의 군집밀도를 이용하여 고분자 나노복합재의 기계적 거동을 효과적으로 예측 가능하다. In this study, multiscale analysis in which the information obtained from molecular dynamics simulation is applied to the continuum mechanics level is conducted to investigate the effects of clustering of silicon carbide nanoparticles reinforced into polypropylene matrix on mechanical behavior of nanocomposites. The elastic behavior of polymer nanocomposites is observed for various states of nanoparticulate agglomeration according to the model reflecting the degradation of interphase properties. In addition, factors which mainly affect the mechanical behavior of the nanocomposites are identified, and new index 'clustering density' is defined. The correlation between the clustering density and the elastic modulus of nanocomposites is understood. As the clustering density increases, the interfacial effect decreased and finally the improvement of mechanical properties is suppressed. By considering the random distribution of the nanoparticles, the range of elastic modulus of nanocomposites for same value of clustering density can be investigated. The correlation can be expressed in the form of exponential function, and the mechanical behavior of the polymer nanocomposites can be effectively predicted by using the nanoparticulate clustering density.

연하장애를 동반한 중풍환자 3례에서의 두침 및 전침의 효과

백경민,김민지,이현의,임승민,안정조,유호룡,조현경,김윤식,설인찬,Baek, Kyung-Min,Kim, Min-Ji,Lee, Hyon-Ui,Lim, Seung-Min,Ahn, Jung-Jo,Yoo, Ho-Ryong,Jo, Hyun-Kyung,Kim, Yoon-Sik,Seol, In-Chan 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.3

Objectives : Although dysphagia is a common complication in stroke patients, there are few studies or reports about its treatment in oriental medicine. This study was to report the effects of scalp-acupuncture and electro-acupuncture in stroke patients with dysphagia. Methods : Three stroke patients with dysphagia hospitalized in our hospital were treated by scalp-acupuncture and electro-acupuncture simultaneously every day, 5 times a week for 4 weeks. Results : All of them showed constant improvement during the four weeks. Not only did their objective measures improve, but also their subjective symptoms such as throat discomfort, sputum, swallowing disturbance etc. Conclusions : This suggests that scalp-acupuncture and electro-acupuncture are quite effective when treating stroke patients with dysphagia. More clinical data and studies are to be done for efficient application.

실시간 탄성초음파를 이용한 만성 뇌졸중 후 편마비 환자의 상지 강직에 대한 사암침 효과 연구

백경민,권동락,박기영,Baek, Kyung-Min,Kwon, Dong-Rak,Park, Gi-Young 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.1

Objectives : To investigate the effects of Sa-am acupuncture on muscle architecture and elastic properties of the spastic elbow flexor and to evaluate the correlation between clinical findings and parameters of real-time sonoelastography (RTS) in patients with chronic post-stroke hemiparesis. Materials and Methods : Seven patients (five males, two females) with chronic post-stroke hemiparesis were included. Sa-am acupuncture of Ganseunggyeok (肝勝格: LU8 LR4 補, HT8 LR2 瀉) was applied to the unaffected side 3 times a week for 4 weeks. During each acupuncture treatment period, patients were requested to exercise their affected arm, and spasticity and functional recovery outcomes of the affected arm were evaluated before and after Sa-am acupuncture treatment. Clinical outcomes were assessed using motricity index (MI), modified Ashworth scale (MAS), Fugl-Meyer assessment scale (FMA) and modified Barthel index (MBI) for elbow flexor spasticity. RTS images indicate the relative hardness of the examined muscles ranged from red (hard) to purple (soft) for color-scale, and from black (hard) to white (soft) for hue scale. Color and hue histograms of the biceps brachii and brachialis were analyzed using Image J software, and median red, blue, and hue pixel intensity were obtained. Results : MI and FMA score significantly increased and MAS score significantly decreased (p<0.05). F-wave maximal amplitude of affected abductor pollicis brevis significantly decreased (p<0.05). Muscle thickness of affected brachialis significantly increased (p<0.05). Red and green pixel intensity of affected brachialis significantly decreased (p<0.05). Conclusions : Our study revealed that Sa-am acupuncture is effective as a useful and safe treatment for spasticity in chronic post-stroke hemiparesis.

가미자음강화탕(加味滋陰降火湯)이 SHR의 혈압에 미치는 영향

백경민,조현경,유호룡,김윤식,설인찬,Baek, Kyung-Min,Jo, Hyun-Kyung,Yoo, Ho-Rhyong,Kim, Yoon-Sik,Seol, In-Chan 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1

Objective : This study was done to investigate the effect of KJT on hypertension. Methods : Spontaneous Hypertensive Rats were sensitized and challenged with Kamijaeumganghwatang(KJT) for 5 weeks. Experimental group was treated with $200mg/day/2m{\ell}$ of KJT orally and control group was treated with $2m{\ell}/day$ of normal saline instead. Results : 1. KJT significantly showed significant protection against cytotoxicity and toxicity in the liver and the kidney. 2. KJT significantly decreased the blood pressure in SHR. 3. KJT significantly decreased the levels of aldosterone in SHR. 4. KJT significantly decreased the levels of dopamine, norepinephrine and epinephrine in SHR. 5. KJT significantly decreased the levels of sodium and potassium in SHR, but it did not decrease the levels of chloride in SHR. Levels of calcium in SHR increased, but only insignificantly. 6. KJT significantly decreased the levels of IL-6 in SHR, and significantly increased the levels of IL-10 in SHR. 7. For histological effects, KJT dillated capillary vessels in the kidney, significantly decreased eosinophilic changes in heart cells, and significantly decreased endothelial damage in the aorta. Conclusion: These results suggest that KJT is useful in treatment of hypertension.

개선된 계면 모델을 이용한 고분자 나노복합재 기계적 거동에 영향 미치는 나노 입자 군집 현상에 대한 멀티스케일 연구

백경민(Kyungmin Baek),신현성(Hyunseong Shin),조맹효(Maenghyo Cho) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11

Absorbed layer region called as interphase, which is a unique characteristic of polymer nanocomposites, results from interaction between polymer matrix and reinforced nano-fillers such as carbon nanotube, ultrafine alumina, and, etc. In order to obtain improved thermo-mechanical properties by added nano-fillers, it is essential to guarantee well refined interphase zone formation. It is known that nanoparticle clustering phenomenon affects to interphase formation and ultimately composite’s properties. In this study, effect of nanoparticulate agglomeration on mechanical behavior of polymer nanocomposites was investigated with a multiscale approach. To improve drawbacks of conventional interphase model, we newly proposed a modified interphase model being able to contain physics of clustering phenomenon. With the new interphase model, we investigated the effect of nanoparticulate agglomeration on mechanical behaviors of the nanocomposites. At this time, Christensen’s failure criteria was applied to describe damage initiation in polymer region. Obtained simulation results are agree with reported experimental tendency.

고분자 나노복합재의 전기 전도성에 대한 순차적 다중스케일 모델링 연구

백경민(Kyung Min Baek),김형준(Hyung Jun Kim),김태겸(Tae Gyeom Kim),조맹효(Maeng Hyo Cho) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.8

GPS/Leveling 자료를 이용한 최신 전지구중력장 모델의 정밀도 검증

백경민(Baek, Kyeongmin),권재현(Kwon, Jay Hyoun),이지선(Lee, Jisun) 한국측량학회 2013 한국측량학회지 Vol.31 No.3

BOST 칩 내 4단 의사 차동 링 오실레이터를 이용한 2~5 ㎓ 클락 위상 동기화 회로

백경민(Kyungmin Baek),정덕균(Deog-Kyoon Jeong) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.6

연구논문 : 한국 기업 내 사회적 책임 전담 부서의 설치

백경민 ( Kyung Min Baek ) 한국조사연구학회 2013 조사연구 Vol.14 No.3

이 연구는 한국 사업장 내의 사회적 책임 전담 부서의 설치 이유를 전략적 접근 방식과 신제도주의 접근 방식으로 분석한다. 2007년 한국 사업체패널에 수록된 종업원300인 이상인 487개의 사업장 중 53%가 사회적 책임 전담 부서를 설치하고 있다. 전략적 접근 방식에서는 사회적 책임을 통한 시장 전략의 효율성을 증가시키기 위해 사회적 책임 전담 부서를 조직 내에 설치한다고 설명하는 반면, 신제도주의 접근 방식에서는 기업의 사회적 책임에 대한 사회적 요구가 점증하고 이에 대한 반응으로 사업장내 사회적 책임 전담 부서가 설치된다고 설명한다. 본 논문에서는 두 가지 접근 방식에 기반한 가설을 도출하여 이항로지스틱 회귀분석(logistic regression analysis)을 실시하였고, 그 결과 사회적 책임 전담 부서는 전략적 필요에서뿐만 아니라 제도적 압력에 대한 대응으로 설치되고 있음을 발견하였다. 이 결과는 또한 한국 내 기업의 사회적 책임 논의가 전환하고 있음을 암시한다. This study examines the presence of a corporate social responsibility(CSR) department in Korean organizations. I derive hypotheses from strategic and institutional approaches. I have used a representative sample of 487 Korean organizations. A logistic regression model is employed to identify the predictors of the presence of a CSR department. The findings suggest that Korean business organizations that have a CSR department are responding to both market demands and institutional pressures for CSR. Also, these results imply that institutional pressures for CSR have recently changed in Korea.