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함평만 갯벌에서 순복사에 의한 토양열 플럭스와 기온의 변동 분석
박호선 ( Ho-seon Park ),권병혁 ( Byung Hyuk Kwon ),김일규 ( Il-kyu Kim ),소윤환 ( Yoon Hwan So ),오세봉 ( Se Bong Oh ),강동환 ( Dong-hwan Kang ) 한국환경과학회 2017 한국환경과학회지 Vol.26 No.9
In this study, we analyze changes in soil heat flux and air temperature in August (summer) and January (winter) according to net radiation, at a mud flat in Hampyeong Bay. Net radiation was observed as -84.2~696.2 W/m<sup>2</sup> in August and -79.4~352.5 W/m<sup>2</sup> in January. Soil heat flux was observed as -80.7~139.5 Wm<sup>-2</sup> in August and -49.09~137 W/m<sup>2</sup> in January. Air temperature was observed as 24.2~32.9˚C in August and -1.5~11.1˚C in January. The rate of soil heat flux for net radiation (HG/RN) was 0.17 in August and 0.34 in January. Because the seasonal fluctuation in net radiation was bigger than the soil heat flux, net radiation in August was bigger than in January. We estimated a linear regression function to analyze variations in soil heat flux and air temperature by net radiation. The linear regression function and coefficient of determination for the soil heat flux by net radiation was y=0.19<sub>x</sub>, 0.51 in August, and y=0.39<sub>x</sub>-11.69, 0.81 in January. The time lag of the soil heat flux by net radiation was estimated to be within ten minutes in August 2012 and January 2013. The time lag of air temperature by net radiation was estimated at 160 minutes in August, and 190 minutes in January.
쥐에서 브롬산염 투여에 의한 신부전증의 특성 및 기전 연구
신석준 ( Sin Seog Jun ),박호선 ( Park Ho Seon ),최영진 ( Choe Yeong Jin ),양철우 ( Yang Cheol U ),진동찬 ( Jin Dong Chan ),김용수 ( Kim Yong Su ),김진 ( Kim Jin ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.2
목 적 : 브롬산염은 급성 중독시에 용혈성 빈혈과 핍뇨를 동반된 급성 신부전중, 청각장애 및 시작장애를 유발하는 물질로 알려져 있다. 브롬산염에 의한 신손상의 기전으로 브롬산염에 의해 유발된 활성산소족에 의한 신세뇨관 괴사 등이 보고되었으나 아직 기전이 명확히 밝혀지지 않았다. 이 연구에서는 흰쥐에 브롬산칼륨을 투여하여 급성신부전을 유발한 후 신기능과 손상의 특성을 관찰하였다. 방 법 : Sprague-Dawley계 흰쥐 이용하여 정상 대조군은 같은 양의 생리식염수를, 실험군은 브롬산칼륨 ㎎/㎎ (B75군) 또는 150 ㎎/㎏ (B150군)을 복강내 주사한 후 24시간, 48시간, 1주 및 2주에 혈액과 24시간 소변을 수집하여 혈중요소질소, 혈청 크레아티닌 및 크레아티닌 청소율을 측정하고, 신조직의 변화를 PAS 염색으로 관찰하였으며, Na^(+)-K^(+)-ATPasealpha 1 및 aquaporin-2에 대한 면역조직화학 염색을 시행하여 정상 대조군과 비교 분석하였다. 결 과 : 브롬산칼륨을 투여한 쥐는 급성신부전이 유발되었고 B75군은 신기능이 저하되었다가 회복되었으나 B150군은 심한 핍뇨성 급성신부전이 유발되어 48시간 후에 모두 사망하였다. 광학현미경 소견상 브롬산칼륨을 투여한 쥐에서는 신세뇨관의 괴사를 관찰하였고, 괴사 정도는 피질에 비해 바깥수질 속줄무늬층에서, B75군에 비해 B150군에서 더욱 심했다. Na^(+)-K^(+)-ATPase-alpha 1의 발현은 피질 부위에서는 정상 대조군과 실험군의 차이가 없었으나 바깥수질 속줄무늬층 세뇨관에서는 B75군의 경우 48시간에서 발현이 감소하였다가 2주 후에 회복되었고 B150군에서는 24시간과 48시간에서 모두 발현이 감소하였다. 바깥수질 속줄무늬층에서 aquporin-2의 발현은 B75군에서는 증가하였으나 B150군에서는 감소하였다. 결 론 : 브롬산칼륨은 주로 바깥수질 속줄무늬층 굵은 오름부분의 세뇨관 손상을 유발하였다. 저용량 브롬산칼륨 투여시에는 Na+-K+-ATPase-alpha 1의 발현이 감소되어 다뇨성 급성 신부전이 유발되었지만 고용량 브롬산칼륨 투여시에는 심한 세뇨관 괴사에 의한 세뇨관 폐색으로 핍뇨가 발생하였다. Background : Plasma clearance of iohexol (Omnipaque?) which used widely in radiologic procedure is considered as useful method for estimation of GFR because iohexol is neither reabsorbed nor secreted from tubule after filtered as inulin and its extrarenal clearance is negligible. Plasma clearance of iohexol can be calculated from two compartment model or one compartment model with Brochner-Mortensen (B-M) modification which convenient and reliable. But there were controversies about sufficient sampling numbers and times for B-M modification of iohexol clearance. Methods : Nineteen healthy Koren without renal disease underwent measurement of iohexol clearance. Iohexol was given as a single iv dose, and 14 blood sample were drewn up to 300 min. A reference GFR was iohexol clearance calculated from two-compartment model using 14 samples (CL-T). From 8, 3 and 2 samples clearances were calculated by B-M modification (CL-M8, 3 and 2 respectively). The accuracy of estimates was evaluated as percent of estimates falling within 10% above or below the reference GFR. Accuracy of CCr and equations for GFR estimation were also compared. Results : CL-T, CL-M8, CL-M3 and CL-M2 were not different (101.9±24.0, 101.9±18.7, 101.7±18.6, 101.9±19.5 mL/min/1.73 m² respectively). Accuracy of CL-M8, 3 and 2 were not different (74%, 84% and 79% respectively, p>0.05). MDRD equation had higher accuracy (47%) compared with other equations. Conclusion : These results indicate that sampling number for measuring iohexol plasma clearance using simplified method might be reduced to only two without accuracy loss in Korean without renal disease. (Korean J Nephrol 2004;23(2):223-230)
미숙아에서 장막층의 섬유 끈에 의한 선천적 위 출구 폐쇄 1례
양소민 ( So Min Yang ),은호선 ( Ho Seon Eun ),이순민 ( Soon Min Lee ),장혜경 ( He Kyung Chang ),박국인 ( Kook In Park ),남궁란 ( Gung Ran Nam ) 대한주산의학회 2014 Perinatology Vol.25 No.4
Most of the gastric outlet obstruction symptoms like vomiting and abdominal distension were caused bycongenital anatomical abnormality in a neonate. Abnormal structures associated with congenital gastricoutlet obstruction have been categorized by its site and extent of obstruction. We report one case of persistingvomiting in a premature infant caused by serosal fibrous band in gastric outlet lesion, excluded from thecategory of congenital gastric outlet obstruction.
Angiotensin 2 Receptor Blocker를 사용한 산모로부터 출생 후 급성 신부전증을 보인 신생아 1례
이철 ( Chul Lee ),박민수 ( Min Soo Park ),박국인 ( Kook In Park ),남궁란 ( Ran Namgung ),이순민 ( Soon Min Lee ),은호선 ( Ho Seon Eun ),라정진 ( Jeong Jin Ra ) 대한주산의학회 2012 Perinatology Vol.23 No.4
Hypertension is common medical problem encountered during pregnancy. However medication administered for maternal hypertension may cause fetal or neonatal complications. Angiotensin converting enzyme inhibitor or angiotensin II receptor blocker are rarely used during pregnancy, and there are few reports about the effect of them, because administration of these drugs during pregnancy may cause oligohydramnios, renal tubular dysplasia, hypocalvaria, pulmonary hypoplasia, intrauterine growth retardation, neonatal anuria and persistent ductus arteriosus. We report a case of neonatal acute renal failure by angiotensin II receptor blocker during pregnancy. In this case, the neonate with meconium aspiration was admitted to neonatal intensive care unit (NICU). During the NICU stay, neonatal anuria occurred, and there was a medical history that his mother took Candesartan Cilexeril (Atacand(R)), one of angiotensin II receptor blockers during pregnancy. The neonate showed intrinsic acute renal failure, so fluid was restricted and diuretics were administered to the neonate, and after 10 days, anuria improved.