Hydroxyapatite를 이식한 임플란트 주위 골결손부에서 rhPDGF-BB와 rhBMP-2가 골내 임플란트 osseointegration에 미치는 영향: Micro-CT 분석과 조직학적 평가

박지현,황순정,김명진,Park, Jee-Hyun,Hwang, Sun-Jung,Kim, Myung-Jin 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.6

Purpose: Platelet derived growth factor(PDGF)-BB and bone morphogenetic protein(BMP)-2 are well-known representative growth factors. The purposes of this study were to investigate the effect of rhPDGFBB and rhBMP-2 on osseointegration of titanium implants at periimplant bone defects grafted with hydroxyapatite and to evaluate the feasibility of imaging bone structures around screw-type titanium implant with micro-CT. Materials and Methods: The first molar and all premolars in the mandible region of four beagle dogs were extracted. Following a healing period of 4 months, three $8{\times}8{\times}6mm$-sized bony defects were formed and screw-type titanium implants were placed with hydroxyapatite(HA) block and growth factors; Control group, PDGF group and BMP group. Two months post-implantation, the mandible was harvested. Bone volume(BV), bone-to-implant contact(BIC) and bone mineral density(BMD) were analyzed with micro-CT and histology. Results: According to micro-CT analysis, BV and BMD measures of PDGF and BMP group were significantly higher than control group(BV; PDGF group: $p{\fallingdotseq}0.011$, BMP group: $p{\fallingdotseq}0.006$/BMD; PDGF group: $p{\fallingdotseq}0.020$, BMP group: $p{\fallingdotseq}0.011$) and BIC measures of BMP group were significantly higher than PDGF group($p{\fallingdotseq}0.015$). In histologic evaluation, BIC measures of BMP group was significantly higher than PDGF group($p{\fallingdotseq}0.048$). The values of BV in histologic sections were higher than in micro-CT images and the values of BIC in micro-CT images were higher than in histologic sections. Conclusion: The findings of this experimental study indicates that the use of rhPDGF-BB and rhBMP-2 can increase new bone formation in a large bony defect around titanium implant, and rhBMP-2 is more effective than rhPDGF-BB. Micro-CT can be considered useful for assessment as a rapid and nondestructive method for 3-dimensional measurement of bone healing around implants. Further study is necessary, however, to remove metal artifacts around titanium implant and to standardize the method.

무선 랜에서 멀티미디어 데이터 통신을 위한 Mobile IP 핸드오프 프로토콜

박지현(Jee-Hyun Park),진현욱(Hyun-Wook Jin),유혁(Hyuck Yoo) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.2Ⅲ

본 논문은 무선 랜 환경에서 Mobile IP를 기반으로 하는 이동 호스트가 핸드오프를 수행할 때 발생될 수 있는 패킷 손실 제거하고, 멀티미디어 데이터의 특성을 고려한 핸드오프 프로토콜을 제안한다. 제안된 핸드오프 프로토콜은 Mobile IP의 확장으로 무선 랜 기술을 이용하며, 현재 FA(Foreign Agent)가 아닌 이동 호스트가 방문할 FA에 패킷을 버퍼링함으로써 패킷 손실을 제거하구, 버퍼링 된 패킷의 포워딩 시간을 최소로 한다. 제안된 핸드오프 프로토콜은 ns-2(network simulator)에서 시뮬레이션 되었고, 멀티미디어 데이터 통신에 사용되는 UDP의 성능이 향상됨을 보여주었다.

중학교 영재학생과 예비교사의 영(0)에 관한 인식과 오류

박지현 ( Jee Hyun Park ) 한국수학교육학회 2007 수학교육 Vol.46 No.4

DSP16210을 이용한 8 kbps CS-ACELP의 실시간 구현

박지현(Jee Hyun Park),박성일(Sung Il Park),정원국(Weon Gook Chung),임병근(Byoung Keun Lim) 대한전자공학회 1998 대한전자공학회 학술대회 Vol.1998 No.11

The Effects of Board Characteristics on Corporate Social Performance

Jee-Hyun Park(박지현),Yangmin Kim(김양민) 한국경영학회 2015 經營學硏究 Vol.44 No.4

The existing literature on the board-Corporate Social Performance(CSP) linkage has been challenged with regard to the incomplete theoretical modeling for the board of directors’ roles as well as Western-dominant research context. In order to fill these gaps, we not only offer a comprehensive view of theoretical approaches (agency and resource dependence theory), but also introduce the institutional context of Korea under which boards influence a similar and/or idiosyncratic pattern of decisions for CSP, the Western firms. Analyzing a pooled cross sectional sample of 1,277 firm-year observations during 2003-2007, we found that board size and average education level of board members are positively associated with CSP, whereas inside directors’ ownership is negatively associated with CSP in Korea. Theoretical contributions and practical implications are discussed.

Transobturator tape수술 후 발생한 자궁동맥출혈에서 자궁동맥색전술을 이용한 성공적 치료

박지현 ( Jee Hyun Park ),최효성 ( Hyo Seong Choi ),박정우 ( Jung Woo Park ),이병익 ( Byoung Ick Lee ),조순구 ( Soon Gu Cho ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.12

Transobturator tape (TOT) operation for urinary stress incontinence is associated with less complication rate than Tension free vaginal tape (TVT). The two procedures yield similar rates of success. The TOT is lead through the obturator foramen, reducing the risk of bladder injury as well as damage of structures located in the Retzii cave, e.g. nerves and blood vessels. However the complications of TOT procedure may have several complications associated with obturator foramen. They are the injury of obturator nerve and vessels, abscess formation on th obturator foramen, vulvar hematoma, etc. There is no report the uterine artery injury after TOT procedure so far. Recently we experienced a case of successful control of bleeding of the uterine artery after TOT operation via uterine artery embolization. Therefore we report our case with brief review of the literatures.

엇갈린 선택: 기관투자자의 유형과 연구개발(R&D) 투자

박지현(Jee-Hyun Park),김양민(Yangmin Kim) 한국전략경영학회 2012 전략경영연구 Vol.15 No.3

본 연구는 (1) ‘기관투자자의 지분과 그들이 소유한 기업의 연구개발 투자 사이에 관계가 있는가’ 라는 해묵은 질문과 (2) ‘다양한 종류의 기관투자자들이 자신들이 지분을 소유한 기업의 연구개발 투자에 대하여 동일한 이해관계를 가질 것인가’의 두 가지 질문에 대한 답을 찾는데 그 목적이 있다. 기존의 관련 선행연구들은 대부분 첫 번째 질문에 대한 답을 찾고자 하였으나 일관된 결과를 도출하지 못하였다. 본 연구는 두 번째 질문에 대한 답을 찾음으로써 첫 번째 질문에 대한 해결의 실마리를 제시하고자 하였다. 이에 따라 본 연구는 기관투자자를 연금기관, 증권회사, 보험회사, 은행으로 세분화하여 각각의 기관투자자가 지분 소유 기업의 연구개발 투자에 미치는 영향을 분석하였다. 2002년과 2003년에 유가증권에 등록 된 198개의 기업을 대상으로 각각의 기관투자자와 연구개발 투자와의 관계를 분석한 결과 연금기관과 보험회사의 지분만이 각기 기업의 연구개발 투자와 정의 관계를 갖는 것으로 나타났다. 반면 증권회사나 은행의 지분은 연구개발 투자와 유의미한 관계를 나타내지 않았다. 이러한 결과는 모든 기관투자자들이 연구 개발 투자에 대해 통일된 입장을 갖는 것이 아니고, 각각의 기관투자자들은 기업의 연구 개발 투자에 대해 각기 다른 이해관계가 있다는 것을 시사한다. The purpose of this research is to determine whether there is a relationship between institutional investors" ownership and research and development (R&D) investment of the firms they own. Previous studies on this issue have been produced mixed results. The mixed results may be due to the assumption that every type of institutional investors has the same voice in R&D investment. In this paper, we argue that different types of institutional investors have different tastes for research and development investment. The theory and hypotheses were tested with a sample of 198 large publicly traded Korean companies from 2002 to 2003. The results indicate that only public pension fund ownership and insurance companies" ownership are positively associated with R&D investment. Banks’ and Security companies’ stock ownerships were not significantly associated with R&D investments. The findings suggest that institutional investors are heterogeneous regarding their preferences and tastes for R&D, and that researchers should distinguish public pension funds or insurance companies" ownership when they study the relationship between ownership structure and R&D investment.

傳統 胎敎의 文獻的 考察 및 禁忌 硏究

박지현(Jee hyun Park),배재룡(Jae Ryong Bae),하정아(Jeong A Ha),홍승철(Seung Cheol Hong) 대한의료기공학회 2009 醫療氣功 Vol.11 No.1

This study aims to investigate the educational significance in modern education by analysis on the contents of taboo in the Korean traditional prenatal education. For this study, the concrete matters are prepared for investigation as follows: First, the contents of prenatal education are analyzed with special reference to the Chinese bibliography and the Korean bibliography related to its own traditional prenatal education. Second, the contents of taboo in prenatal education are broadly classified into Chun-ki(天忌), Chi-ki(地忌), and In-ki(人忌), and in turn, In-ki is classified into taboo related to clothing, taboo related to food, Taboo related to housing, and man's taboo, and all of them are interpreted. Third, the characteristics of taboo in the Korean traditional prenatal education and its principle are analyzed, and its significance is researched from the modern educational point of view. This study attempts to classify the contents of taboo into Chun-ki, Chi-ki, In-ki, and man's taboo based upon analysis of the documentary records related to the traditionary prenatal education in China and Korea for the successful investigation. The characteristic such as common discipline, the time limit and prevention are induced on the basis of this investigation, and its modern educational significance as follows: First, prenatal education must be conduced as a part of youth education and preparatory parents education for the married couple. Second, man or husband plays a very important role of practising taboo in prenatal education. Third, taboo in prenatal education is very suggestive in the aspect of human relationship and mental health of the pregnant woman. Fourth, it prevents her obesity and strain. Fifth, the scientific proof and education of taboo related to food must be needed.

악하림프절 전이를 동반한 하악골의 법랑모세포종

박지현(Jee-Hyun Park),정재화(Jae-Hwa Jeong),윤필영(Pil-Young Yun),홍종락(Jong-Rak Hong),명훈(Hoon Myoung),황순정(Sun-Jung Hwang),서병무(Byoung-Moo Seo),최진영(Jin-Young Choi),이종호(Jong-Ho Lee),정필훈(Pill-Hoon Choung),김명진(Myung 대한구강악안면외과학회 2003 대한구강악안면외과학회지 Vol.29 No.5

Ameloblastomas are generally considered to be benign tumors of odontogenic epithelial origin with high local recurrence. Rarely ameloblastomas exhibit malignant behavior with development of metastases. In this report, we present a 19-year-old woman with ameloblastoma in the right ascending ramus and multiple recurrences. Eleven years after first therapy, ameloblastoma metastasized to ipsilateral submandibular lymph node. We also review literature about cause, treatment and work-up of malignant ameloblastoma.

DMBA 유도 햄스터 협낭 발암모델에서 세포증식 및 사멸과 p63 발현의 관계 분석

박지현(Jee-Hyun Park),이원덕(Won-Deok Lee),민철기(Chul-Gi Min),강진한(Jin-Han Kang),명훈(Hoon Myung),이종호(Jong-Ho Lee),김명진(Myung-Jin Kim) 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.3

Purpose: Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 and p63 have recently been identified. They share considerable sequence homology with p53 in the transactivation, DNA binding, and oligomerization domains, indicating possible involvement in carcinogenesis. Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. The aim of this study was to analyze expression of p63 in squamous cell carcinogenesis and to compare with immunochemical markers representing cell proliferation and apoptosis. Materials and Methods: Using the Syrian hamster oral cancer model, the fraction of apoptotic (apoptotic index-AI), proliferating (mitotic index-MI) and p63 expressing keratinocytes were examined at normal, dysplastic and malignant oral epithelium using the TUNEL assay, PCNA and p63 immunostaining. Results: p63 significantly increased between normal and dysplastic epithelium and between dysplastic and malignant epithelium. PCNA significantly increased between normal and dysplastic epithelium and between normal and malignant epithelium. However, increase between dysplastic and malignant epithelium, though still increasing, was not statistically significant. The percentage of TUNEL positive cells increased from normal to dysplastic epithelium and returned to normal keratinocyte level in the malignant epithelium. However, differences between tissue types were not significant. The ratio of MI:AI increased significantly only in the dysplastic-malignant epithelial transition. The increase of p63 expression closely reflected the change in the MI:AI ratio during oral carcinogenesis. Conclusion: The p63 may be associated with the regulation of epithelial proliferation and apoptosis in DMBA-induced hamster buccal pouch squamous cell carcinogenesis. Further study is required to investigate which p63 isoforms are involved in hamster buccal pouch carcinogenesis.